About
25
Publications
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1,151
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Introduction
Ophthalmologist, Physician-Scientist
Current institution
Additional affiliations
May 2019 - February 2022
March 2007 - February 2011
March 2006 - February 2007
Education
January 2011 - January 2015
March 2002 - February 2006
February 2000 - January 2002
Publications
Publications (25)
Angiogenesis is a multistep process that requires coordinated migration, proliferation, and junction formation of vascular endothelial cells (ECs) to form new vessel branches in response to growth stimuli. Major intracellular signaling pathways that regulate angiogenesis have been well elucidated, but key transcriptional regulators that mediate the...
Primary cilia exert a profound impact on cell signalling and cell cycle progression. Recently, actin cytoskeleton destabilization has been recognized as a dominant inducer of ciliogenesis, but the exact mechanisms regulating ciliogenesis remain poorly understood. Here we show that the actin cytoskeleton remodelling controls ciliogenesis by regulati...
To evaluate the accuracy, validity, and reliability of a newly developed infrared optical head tracker (IOHT) using Nintendo Wii remote controllers (WiiMote; Nintendo Co. Ltd., Kyoto, Japan) for measurement of the angle of head posture.
The IOHT consists of two infrared (IR) receivers (WiiMote) that are fixed to a mechanical frame and connected to...
To evaluate the validity and test-retest reliability of a contour-based 3-dimensional (3-D) monitor distance stereotest (distance 3-D stereotest) and to measure the maximum horizontal disparity that can be fused with disparity vergence for determining the largest measurable disparity of true stereopsis.
Observational case series.
Sixty-four normal...
To evaluate the long-term correlation of visual outcome and macular thickness after vitrectomy for idiopathic epiretinal membrane and to identify prognostic factors for good visual outcome.
Retrospective, observational case series.
We reviewed the records of 52 patients with idiopathic epiretinal membrane who were treated with vitrectomy and could...
RNA binding proteins are important regulators of T cell activation, proliferation, and cytokine production. The zinc finger protein 36 (ZFP36) family genes (Zfp36, Zfp36l1, and Zfp36l2) encode RNA binding proteins that promote the degradation of transcripts containing AU-rich elements. Numerous studies have demonstrated both individual and shared f...
Background
Central retinal artery occlusion (CRAO) is an ischemic stroke of the eye. The atherosclerotic lesions in the intracranial segment of the carotid artery (CA) and the ophthalmic artery (OphA) are not well defined. We aimed to investigate the cerebral angiographic features of CRAO patients and assess the relationship between the angiographi...
Importance:
Central retinal artery occlusion (CRAO) is associated with and shares common risk factors with cardiovascular diseases. Over the past several decades, the incidence rates of stroke and ischemic heart disease have substantially decreased in high-income industrialized countries. However, little is known regarding current trends in CRAO i...
Purpose:
To investigate whether the parafoveal capillary architecture predicts clinical course and visual outcomes after ERM surgery.
Methods:
A total of 71 eyes of 71 patients treated with vitrectomy for idiopathic ERM were enrolled. The parafoveal capillary displacement and fractal geometries were compared according to the stage of ERM. Correl...
Angiogenesis is a multistep process that requires coordinated migration, proliferation, and junction formation of vascular endothelial cells (ECs) to form new vessel branches in response to growth stimuli. Major intracellular signaling pathways that regulate angiogenesis have been well elucidated, but key transcriptional regulators that mediate the...
The activation of transcriptional coactivators YAP and its paralog TAZ has been shown to promote resistance to anti-cancer therapies. YAP/TAZ activity is tightly coupled to actin cytoskeleton architecture. However, the influence of actin remodeling on cancer drug resistance remains largely unexplored. Here, we report a pivotal role of actin remodel...
The actin cytoskeleton has been implicated in the assembly of cilia, but roles of actin-dependent motor proteins in ciliogenesis remain unclear. Myosin heavy chain 10 (MYH10), one of the isoforms of non-muscle myosin II, is known to mediate centrosome reorientation during cell migration. Here we show that MYH10 is required for centriole migration t...
To investigate the validity and reliability of Microsoft Kinect-based head tracker (KHT) for measuring head posture.
Considering the cervical range of motion (CROM) as a reference, one-dimensional and three-dimensional (1D and 3D) head postures of 12 normal subjects (28–58 years of age; 6 women and 6 men) were obtained using the KHT. The KHT was va...
Single umbilical artery (SUA) is the most common malformation of the umbilical cord. However, there have been no studies on the ocular findings in SUA, except for one case report. This study aimed to investigate the ocular findings in children with SUA.
Fourteen children (eight boys and six girls) with SUA were evaluated retrospectively. All childr...
: To analyze the long-term changes of peripapillary retinal nerve fiber layer (RNFL) thickness before and after panretinal photocoagulation (PRP) in patients with severe diabetic retinopathy.
: In this retrospective observational case series, we reviewed the records of 46 patients (68 eyes) with severe diabetic retinopathy, who were treated with PR...
Objective evaluation results using optometric device to measure accommodative responses in viewing a real object and integral imaging are presented. From the empirical results between the real object and an integrated three-dimensional (3D) image, we find that over 73% of participants keep eyes on the real integrated 3D image instead of a display p...
Accommodative response measurement according to angular resolution in autostereoscopic display based on lenticular lens and lens array method is presented. Conflict between accommodation and convergence is one of the most dominant factors leading to visual fatigue in viewing three-dimensional display. The conflict originates from directional rays t...
A 68-year-old woman presented with a visual field defect in her right eye. The fundus of her right eye showed multiple telangiectatic vessels, retinal hemorrhages, and subretinal exudates in the inferior peripheral retina. Nine months later, the subretinal exudates extended to the fovea despite treatment with laser photocoagulation. Cryotherapy was...
Purpose: To report a case of orbital leiomyoma presenting with proptosis.
Case summary: A 69‐year‐old woman presented with a 3‐month history of proptosis in her left eye. Intraocular pressure was 17 mmHg in her right eye and 23 mmHg in her left eye. There was a left hypotropia on upgaze. A fundus examination showed retinal folds in the superotempor...
Purpose: To describe the clinical features and surgical outcomes of congenital cataracts in patients with oculocerebrorenal syndrome.
Methods: We retrospectively analyzed the age, sex, types of cataracts, operation method and time, perioperative visual acuity, postoperative intraocular pressure, and associated ocular disease in 10 patients (20 eyes...
