Jonathan Talamo

• MD
• Professor (Associate) at Harvard Medical School

Purpose To evaluate effects of sodium iodide (NaI) on riboflavin concentration in corneal stroma before and during ultraviolet A (UVA) light exposure using a novel transepithelial corneal collagen crosslinking (CXL) procedure (EpiSmart CXL system, CXL Ophthalmics, Encinitas CA). Methods Riboflavin solutions with NaI (Ribostat, CXL Ophthalmics, Enc...

Purpose: To assess the efficacy and safety of a sustained-release intracanalicular dexamethasone insert for the treatment of postoperative ocular inflammation and pain in patients having cataract surgery. Setting: Twenty-one United States sites. Design: Prospective multicenter randomized parallel-arm double-masked vehicle-controlled phase 3 st...

Purpose: To assess the rate of unplanned vitrectomies with femtosecond laser-assisted cataract surgery (FLACS) compared to conventional phacoemulsification at a single, high-volume, multi-surgeon ambulatory surgical center. Methods: Retrospective, comparative study of phacoemulsification cases performed in a community-based ambulatory surgical c...

Purpose To evaluate the collective user experience with an image-guided femtosecond laser (FSL) for cataract surgery in a high-volume, multi-surgeon, ambulatory surgical center. Subjects and methods A detailed online survey was distributed to all surgeons in a single ambulatory surgical center who had performed cataract surgery using a FSL since i...

Purpose: To compare the corneal stromal riboflavin concentration and distribution using 2 transepithelial corneal crosslinking (CXL) systems. Setting: Absorption Systems, San Diego, California, USA. Design: Experimental study. Methods: The stromal riboflavin concentration of 2 transepithelial CXL systems was compared in rabbit eyes in vivo....

Corneal cross linking (CXL) has significant supporting evidence suggesting that it stabilizes keratoconus (KC) and increases corneal rigidity. Randomized clinical trials demonstrating this in a statistically significant manner would still be welcomed however. Stabilizing KC rarely leads to significant improvement in the visual acuity or visual qual...

Purpose The purpose of this study was to determine an arcuate incision (AI) nomogram to treat astigmatism during femtosecond laser-assisted cataract surgery. Methods This is a retrospective, cohort study. Femtosecond laser (FSL)-assisted transepithelial AIs were created at a 9.0 mm optical zone, 80% depth, centered on the limbus. We modified the m...

Purpose The purpose of this study is to evaluate the patient experience of sustained release dexamethasone intracanalicular insert (Dextenza™) following cataract surgery as part of a Phase III clinical trial program. Methods This cross-sectional, qualitative evaluation involved individual interviews lasting approximately 45 minutes. Patients from...

PURPOSE: To compare effective phacoemulsification time (EPT) for the removal of brunescent cataracts treated with femtosecond laser assisted cataract surgery with standard cataract phacoemulsification techniques. SETTING: Ruhr University Eye Hospital, Bochum, Germany. DESIGN: Comparative prospective case study. METHODS: The Lens Opacities Classific...

To determine the value of intraoperative aberrometry in cases of toric intraocular lens (IOL) implantation and positioning. In this non-randomized retrospective comparative trial, two groups of eyes underwent cataract extraction with toric IOL implantation: the aberrometry group (n = 37 eyes), where toric IOL power and alignment were determined bef...

The use of the femtosecond laser (FSL) in cataract surgery may represent the largest advancement in the field since the inception of phacoemulsification. The goal of this review is to outline the benefits of and barriers to this technology. There are several significant potential benefits of the FSL in cataract surgery over conventional manual cata...

To determine criteria for keratoconus or postoperative LASIK ectasia progression or improvement based on Pentacam HR (Oculus Optikgeräte GmbH) measured steepest corneal curvature. Sixty-one eyes from 41 patients with keratoconus or postoperative LASIK ectasia were evaluated. Each eye was measured 5 times with the Pentacam HR during the same clinic...

The lens capsule is the outer lining of the crystalline lens, and its elastic properties directly influence accommodation. Elasticity of the lens capsule and accommodative amplitude decrease over time, due to physiologic, age-related changes. The anterior capsule thickens by approximately 1.2 % per year due to regeneration of lens epithelial cells...

A method for generating a radial alignment guide for an eye includes collecting preoperative corneal topography data. The data includes a corneal vertex location and a pupil center location for an eye that is not dilated. The method then includes locating a dilated pupil center for the eye after the eye is dilated. The method further includes deter...

To report the observation of prolonged reepithelialization after photorefractive keratectomy (PRK) associated with the use of besifloxacin 0.6% (Besivance; Bausch & Lomb, Rochester, NY) underneath bandage contact lenses (BCLs) placed during surgery. An office-based private practice and retrospective chart review. The healing parameters examined inc...

Purpose: To compare 2 optical patient interface designs used for femtosecond laser-assisted cataract surgery. Setting: Optimedica Corp., Santa Clara, California, USA, and Centro Laser, Santo Domingo, Dominican Republic. Design: Experimental and clinical studies. Methods: Laser capsulotomy was performed during cataract surgery with a curved c...

In laser cataract surgery, a PI allows the optical laser system to couple to the eye for image-guided treatments.

Textbook of Refractive Laser Assisted Cataract Surgery (ReLACS) is a comprehensive reference for the general ophthalmologist and cataract surgeon regarding the explosive new technology in femtosecond laser cataract surgery. Femtosecond laser allows extreme precision in surgery, and is used in refractive surgery and for ‘cuts’ in the cornea, leading...

To evaluate a femtosecond laser system to create the capsulotomy. Porcine and cadaver eye studies were performed at OptiMedica Corp., Santa Clara, California, USA; the human trial was performed at the Centro Laser, Santo Domingo, Dominican Republic. Experimental and clinical study. Capsulotomies performed by an optical coherence tomography-guided f...

About one-third of people in the developed world will undergo cataract surgery in their lifetime. Although marked improvements in surgical technique have occurred since the development of the current approach to lens replacement in the late 1960s and early 1970s, some critical steps of the procedure can still only be executed with limited precision...

Purpose: To assess the safety, efficacy and stability of CALAK (Corneal Augmentation Laser Assisted Keratophakia), a new surgical procedure to correct high or extreme myopia. Design and setting: Retrospective, non-comparative interventional case-series. Clinical office-basedprivate practice. Patients and Methods: Twenty-six eyes of 16 patients were...

To evaluate the efficacy of intracorneal ring segments to treat keratoconus and post-laser in situ keratomileusis (LASIK) keratectasia implanted by using either mechanical dissection or a femtosecond laser. Thirty-three eyes of 29 patients had intracorneal ring segments implanted by using mechanical dissection (17 eyes) or a femtosecond laser (16 e...

To compare flap thickness reproducibility of the femtosecond laser and two mechanical microkeratomes. Flap thickness for all eyes was measured as the difference between the preoperative (day of surgery) full corneal thickness and post-flap creation central stromal bed thickness using ultrasonic pachymetry. Flap thickness values produced by three di...

To evaluate the safety and efficacy of laser in situ keratomileusis (LASIK) to enhance refractive status following other corneal surgical procedures. Clinical office-based practice. Seventy-one eyes of 57 patients had LASIK for refractive errors following radial keratotomy (n = 22), astigmatic keratotomy (n = 13), photorefractive keratectomy (n = 1...

Gross examination of the 8.0-mm-diameter corneal button showed 2 ICR segments, one placed superiorly and the other placed inferiorly, with a 7.0-mm optical zone. The cornea was bisected for conventional histological analysis and transmission electron microscopy. Light microscopy showed a centrally thinned cornea with focal disruptions in the Bowman...

To assess risk factors for and incidence of diffuse lamellar keratitis (DLK) and to investigate whether microkeratome design is associated with the incidence of DLK. The Laser Eye Consultants of Boston, Boston and Waltham, Massachusetts, USA. In a retrospective nonrandomized comparative study, 1122 consecutive primary laser in situ keratomileusis (...

A 25-year-old man had bilateral LASIK for approximately -5.00 D. The BSCVA is now 20/40 with +0.75 -0.25 × 120 in the right eye, and the patient reports seeing 3 images. The LASIK flap with a superior hinge shows circular peripheral flap fibrosis, slight interface "haze," and vertical folds starting from the superior hinge to the center of the flap...

To search for novel mutations that cause corneal stromal dystrophies and to confirm or revise the clinical diagnosis of patients with these mutations. Through review of the records of the Cogan Eye Pathology Laboratory at the Massachusetts Eye and Ear Infirmary, Boston, and of clinical records, we ascertained 14 unrelated patients with the clinical...

To report the management and outcome of late-onset traumatic dislocation of laser in situ keratomileusis (LASIK) flaps. Retrospective, observational case series. Four patients with late-onset LASIK flap dislocation occurring after mechanical trauma at various intervals (10 days-2 months) after the procedure. In all cases of postoperative traumatic...

To review the management and results of cases with severe flap wrinkling or dislodgment after laser in situ keratomileusis (LASIK). University Eye Center, Department of Ophthalmology and Visual Sciences, Prince of Wales Hospital, The Chinese University of Hong Kong. Four patients with severe flap wrinkling or dislodgment after LASIK are described....

Pentoxifylline (PTX) is a methylxanthine derivative that, besides its hemorrheologic properties, possesses multiple physiologic effects at the cellular level. It has been used in keloid prevention due to its ability to inhibit the secretion of collagen and glycosaminoglycans from activated fibroblasts. Ten New Zealand White (NZW) rabbits underwent...

To report a newly recognized cause of late onset of corneal haze following photorefractive keratectomy (PRK). A 35-year old woman who underwent uneventful PRK and subsequently developed viral keratoconjunctivitis 1 year after treatment. During resolution of the viral keratoconjunctivitis, the patient developed extensive central corneal subepithelia...

Purpose: To evaluate the visual outcomes in patients having photorefractive keratectomy (PRK) to correct residual myopia after radial keratotomy (RK).Setting: Nine refractive surgery centers in the United States and one in South Korea.Methods: This retrospective analysis comprised 38 eyes of 32 patients treated with PRK after,RK and followed for 12...

The purpose of the study is to compare alcohol-assisted versus mechanical debridement of the corneal epithelium before photorefractive keratectomy (PRK) for low-to-moderate myopia. A prospective study was performed on a group of consecutive patients operated on at the Massachusetts Eye and Ear Infirmary from February to April 1996 and followed for...

The corneal epithelium is generally removed before photoablation in photorefractive keratectomy (PRK) because laser transepithelial PRK may result in surface irregularity caused by variability in epithelial thickness and differing ablation rates between epithelium and stroma. We compared the effects of mechanical deepithelialization with chemical e...

Purpose, The corneal epithelium is generally removed before photoablation in photorefractive keratectomy (PRK) because laser transepithelial PRK may result in surface irregularity caused by variability in epithelial thickness and differing ablation rates between epithelium and stroma. We compared the effects of mechanical deepithelialization with c...

Pellucid marginal degeneration of the cornea (1,2) is an idiopathic condition characterized by noninflammatory, nonulcerative thinning of the inferior, peripheral cornea. Occasionally the condition is complicated by acute corneal hydrops (3). We describe a patient with findings suggestive of pellucid marginal corneal degeneration who experienced ac...

To compare 18% ethanol versus mechanical epithelial debridement in a group of patients having photorefractive keratectomy (PRK) for low to moderate myopia or astigmatism. Hospital San Jose de Monterrey, Mexico. This prospective, paired study comprised 18 patients who had bilateral PRK between June 1994 and March 1995. One eye had ethanol (alcohol)...

Water exposure has been commonly cited in the literature as a significant risk factor for the development of Acanthamoeba keratitis. The purpose of this study was to test the hypothesis that the incidence of tap and contaminated water exposure in Acanthamoeba keratitis patients is no higher than in the normal contact lens population. We retrospecti...

To summarize the initial results of excimer laser photorefractive keratectomy (PRK) in 114 eyes of 89 patients using the Coherent-Schwind system and assess its safety, efficacy, and predictability. Hospital San Jose de Monterrey-ITESM, Mexico. The Coherent-Schwind Keratom excimer laser was used to correct low myopia (manifest spherical equivalent f...

To evaluate postkeratoplasty astigmatism between two suture techniques 2 to 4 years postoperatively in a group of patients previously studied 9 months postoperatively. Thirty-two patients who underwent penetrating keratoplasty were randomly assigned to one of two groups. Group 1 (16 patients) had a 24-bite single running 10-0 nylon suture with post...

To evaluate whether supplementing incisional keratotomy bulk or gape with a biocompatible material enhances the refractive effect. Refractive Surgery Laboratory, Massachusetts Eye and Ear Infirmary, Boston. Collagen punctal plugs were implanted into astigmatic keratotomy (AK) incisions in the right eyes of five rabbits and six adult cats. The left...

To compare the potential for thermal injury to ocular structure resulting from phacoemulsification ultrasound energy and erbium:YAG (Er:YAG) laser output. Morse Laser Laboratory, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston. Ultrasonic phacoemulsification energy and ER:YAG laser output (10 J/cm2, 10 Hz, 0.3 watts) sufficient...

Adequate centration of keratorefractive surgical procedures is essential for a successful outcome. An accurate technique to mathematically describe the centration and topography of the ablation zone after photorefractive keratectomy (PRK) would be valuable in assessing the effects of these variables on subsequent visual results. A vector center of...

Purpose. To evaluate postkeratoplasty astigmatism between two suture techniques 2-4 years after surgery with and without suture removal in a group of patients previously studied at 9 months follow-up. Methods. Thirty-two penetrating keratoplasty patients were randomized into two groups. The first group (16 patients) had a 24-bite single running 10-...

Purpose. Compare subjective and objective outcomes after photorefractive keratectomy (PRK) for moderate myopia. Methods. Vision, manifest refraction (MR), keratometry and subjective quiestionares were obtained preoperatively and postoperately in 29 eyes of 20 myopes who underwent PRK. Mean preoperative MR was -7.00 diopters (D). Results. At 12 mont...

A prospective, multicenter, clinical study to evaluate a standardized surgical (Genesis) protocol which includes combined-technique radial incisions in patients seeking reduction of their physiologic myopia. The combined incisions were designed to incorporate the safety of the centrifugal incision technique with the efficacy of the centripetal inci...

Background and Objective We investigated the transient thermal behavior of vitreous in order to understand the local thermal effects of laser output, and to predict the potential for unintentional injury during Er:YAG laser vitreoretinal surgery.Study Design/Materials and Methods The output of a free-running Er:YAG laser (2.94 μm, 300 μs FWHM) was...

To identify potential differences in time to diagnosis and final visual outcome between contact lens and noncontact lens users with Acanthamoeba keratitis. Prior studies have shown early diagnosis and therapy to be related to outcome but have not analyzed differences among patients with and without contact lenses. A retrospective analysis of 11 con...

We used Maddox double-rod measurements to determine if positionally induced ocular cyclotorsion occurs when a patient moves from the seated to supine position. Maddox double-rod measurements were determined twice while patients (N = 30) viewed a fixation light at a distance of 7 feet in both the seated and supine positions. The difference between a...

We investigated the accuracy of a conventional videokeratography instrument (Corneal Analysis System, EyeSys Laboratories) to measure contour information using specialized software developed by the manufacturer. Seven calibrated spheres were measured and the results tabulated. A contour resolution for all spheres for all reflected rings was found t...

To summarize the initial results of excimer laser photorefractive keratectomy (PRK) on 89 eyes of 80 patients with moderate myopia (myopia of -6.00 to -8.00 diopters [D]; mean -6.98 +/- 0.90 D) at nine investigational sites. All treatments used an argon fluoride excimer laser (VISX, Inc, Santa Clara, Calif) using standard settings. Sixty eyes recei...

As with any keratorefractive procedure, the results of excimer photorefractive keratectomy (PRK) are dependent on accurate centration. Although ablation decentration is a recognized complication, to our knowledge, methods for correction of this uncommon but significant complication have not been described in detail. We report herein a case of succe...

We present measurements of the Er:YAG laser drilling rate in human cataractous lens and describe a simple model for mid-infrared laser thermoablation. Lens slabs were immersed in saline and subjected to the output of a free-running Er:YAG laser (2.94 micrometers ). The laser output was directed through a fiberoptic to a 400 micrometers quartz tip....

In an investigational procedure, excimer laser photorefractive keratectomy for severe myopia was performed at three clinical trial centers to determine the effectiveness of the multiple zone technique. A VisX Model Twenty/Twenty excimer laser (VisX, Santa Clara, California) was used to perform photorefractive keratectomy on 14 severely myopic eyes...

Refractive error is assessed in the seated position while keratorefractive procedures are performed in the supine position. Since position-induced ocular torsion could yield suboptimal results from improper axis alignment, this study was undertaken to ascertain whether ocular cyclotorsion occurs when a subject moves from a seated to supine position...

In a prospective randomized clinical trial we compared astigmatism after penetrating keratoplasty with two different suture techniques between two groups of patients (38 patients). The first group (18 patients) had a 24-bite single running 10-0 nylon suture (single running suture) with postoperative suture adjustment to decrease astigmatism. The se...

Surgical therapy for superficial corneal scars, dystrophies, or surface irregularities with the 193 nm excimer laser shows great promise. Depending upon the character of the pathology to be treated, different surgical strategies are required. Treatment strategies for three patients with diverse corneal pathology are presented. Focal surface irregul...

An optic nerve meningioma developed in an elderly woman and was followed for 13 years until her death. The optic nerve was initially normal. Over time it became swollen and then atrophic and developed retinal venous to choroidal venous collaterals. Five hundred serial sections were prepared through the optic nerve and for approximately 1.5 mm super...

A 193-nm excimer laser system was used to create deep stromal ablations in seven New Zealand white rabbits and shallow ablations in three. Eyes were randomized for treatment with topical mitomycin C, steroids, and erythromycin; topical steroids and erythromycin; or topical erythromycin only. All treatment regimens were instituted twice daily for 14...

• A 193-nm excimer laser system was used to create deep stromal ablations in seven New Zealand white rabbits and shallow ablations in three. Eyes were randomized for treatment with topical mitomycin C, steroids, and erythromycin; topical steroids and erythromycin; or topical erythromycin only. All treatment regimens were instituted twice daily for...

Little information on the natural course of corneal astigmatism following cataract surgery exists. We report a prospective, computerized analysis of postoperative astigmatism, based on keratometry measurements, of 137 cases of extracapsular cataract extraction with intraocular lens implantation performed by one surgeon. No sutures were cut postoper...

While the diagnostic value of vitreous culture in the management of bacterial endophthalmitis is well established, the therapeutic value of vitrectomy in this condition is debated. The present experimental study uses an aphakic model of Staphylococcus aureus endophthalmitis in the rabbit. Animals were treated with the following: (1) intravitreal an...

Recent reports have suggested a role for BW-B759U in the treatment of cytomegalovirus retinitis. The present study presents the ophthalmoscopic features in three treated patients, and examines the microscopic findings in the eyes of the first patient ever treated with BW-B759U for cytomegalovirus retinitis. Ophthalmoscopic findings of improvement o...

Intravitreal administration of broad-spectrum antibiotics is a widely accepted component of initial therapy for bacterial endophthalmitis. Four cases of culture-proved bacterial endophthalmitis are reported to demonstrate the safety of intravitreal administration of amikacin sulfate in conjunction with cephalosporins in patients. The benefits of us...

Transmission electron microscopy studies of cornea, iris and lens from a case of ocular siderosis due to a retained intraocular foreign body (IOFB) and vitreous hemorrhage are presented. We observed widespread degeneration of lens epithelium, iris stromal cells and iris pigment epithelium associated with intra- and extracellular siderosomes. A dire...

To study the effect of lens and vitreous surgery on the dose threshold of aminoglycoside-induced retinal toxicity, we performed extracapsular lens extraction (Group 1) or lensectomy and vitrectomy (Group 2) on Dutch Belted rabbits. A single dose of amikacin or gentamicin ranging from 100 to 4,000 micrograms was administered intravitreally. Retinal...

In order to assess diurnal variation of flow-volume curves and to determine whether small airways are involved in the diurnal variation of pulmonary function in asthmatic children, we studied eight asthmatics who were attending an asthma summer camp. Spirometry and maximal expiratory flow-volume curves with air and a helium-oxygen mixture were obta...

At sea level, it appears that oxygen desaturation does not occur in normal children at night and that the desaturation that occurs in moderately severe asthmatic children with therapeutic levels of theophylline does not approach dangerously low levels.