Jonathan Hinton

Jonathan Hinton
University Hospital Southampton NHS Foundation Trust · Wessex Cardiothoracic Centre

About

30
Publications
1,323
Reads
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75
Citations
Citations since 2017
30 Research Items
75 Citations
201720182019202020212022202305101520
201720182019202020212022202305101520
201720182019202020212022202305101520
201720182019202020212022202305101520
Introduction
Skills and Expertise

Publications

Publications (30)
Article
Introduction High sensitivity troponin (hs-cTn) concentrations above the manufacturer recommended upper limit of normal (ULN) are frequently seen in patients without a clinical presentation consistent with type 1 myocardial infarction. There is increasing evidence that these concentrations may act as a marker of prognosis in a range of conditions....
Conference Paper
Introduction High sensitivity troponin (hs-cTn) concentrations above the manufacturer recommended upper limit of normal (ULN) are frequently seen in patients without a clinical presentation consistent with type 1 myocardial infarction. There is increasing evidence that these concentrations may act as a marker of prognosis in a range of conditions....
Article
In the evaluation and management of patients with stable chest pain/chronic coronary syndrome, cardiologists need to be able to weigh up the relative merits of managing these patients using either optimal therapy alone or optimal therapy plus revascularization. These decisions rely on an understanding of both the presence and the degree of coronary...
Article
Objectives: The diagnosis and clinical implications of periprocedural myocardial infarction (PPMI) following coronary artery bypass grafting (CABG) are contentious, especially the importance of PPMI in the interpretation of trial data. Methods: Consecutive patients admitted to a cardiothoracic critical care unit over a 6-month period following o...
Article
Introduction High-sensitivity troponin (hs-cTn) assays now form a key component of the diagnostic pathways for patients presenting to emergency medical services with chest pain. However, hs-cTn concentrations above the manufacturer-provided upper limit of normal (ULN) are now frequently reported in patients presenting with conditions not traditiona...
Article
Introduction The diagnosis and clinical implication of periprocedural myocardial infarction (PPMI) following coronary artery bypass grafting (CABG) is contentious, especially given its importance in the interpretation of trial data. Two accepted definitions of PPMI yield discrepant results. Little is known about the association between the diagnosi...
Article
This was an observational study of the 1-year outcomes of the 20,000 patients included in the original CHARIOT study. The aim of the study was to assess the association between high sensitivity troponin I (hs-cTnI) concentration and 1 year mortality in this cohort. The original CHARIOT study included a consecutive cohort of in- and out-patients und...
Conference Paper
Introduction High sensitivity troponin (hs-cTn) concentrations above the manufacturer recommended upper limit of normal (ULN) are seen frequently in patients without a clinical presentation consistent with an acute coronary syndrome. There is increasing evidence that these concentrations may act as a marker of prognosis in a range of conditions. Ho...
Conference Paper
Full-text available
Introduction The diagnosis and clinical implication of periprocedural myocardial infarction (PPMI) following coronary artery bypass grafting (CABG) is contentious, especially given its importance in the interpretation of trial data. Two accepted definitions of PPMI yield discrepant results. Little is known about the association between the diagnosi...
Conference Paper
Introduction High-sensitivity troponin (hs-cTn) assays now form a key component of the diagnostic pathways for patients presenting to emergency medical services with chest pain. However, hs-cTn concentrations above the manufacturer-provided upper limit of normal (ULN) are now frequently reported in patients presenting with conditions not traditiona...
Article
Objectives: To describe the distribution of high-sensitivity troponin in a consecutive cohort of patients in critical care units, regardless of clinical indication, and its association with clinical outcomes. Design: Prospective observational study. Setting: Single-center teaching hospital. Patients: Consecutive patients admitted to two adul...
Article
Background: Contemporary sensitivity troponin (cs-cTn) concentrations above the upper limit of normal (ULN) are seen in a wide range of clinical conditions and evidence is growing that suggests cs-cTn may be a biomarker of future morbidity and mortality. Objectives: Our aim was to test the hypothesis that cs-cTn, measured in the emergency depart...
Article
Background High sensitivity troponin (hs-cTn) concentrations above the manufacturer's upper limit of normal (ULN) are frequently seen outside the context of MI, particularly in critical care units. The current evidence regarding the prognostic value of hs-cTn in critical care settings is discrepant. Purpose To describe the distribution of hs-cTn i...
Article
Introduction: High sensitivity troponin (hs-cTn) assays are central to the diagnosis of myocardial infarction (MI). Their increased sensitivity has facilitated rapid pathways for the exclusion of MI. However, hs-cTn is now more readily detectable in patients without symptoms typical of MI, in whom a degree of myocardial injury is assumed. Recently...
Article
Computed tomography coronary angiography is emerging as the preferred diagnostic tool for patients with chest pain. Additional knowledge of the extent and distribution of myocardial ischemia enables tailored patient management. Computed tomography-derived fractional flow reserve (FFRCT) employs computed tomography coronary angiography raw data proc...
Article
Full-text available
There is a large body of evidence suggesting that having knowledge of the presence and extent of coronary atheroma and whether it is causing downstream myocardial ischaemia facilitates optimal diagnosis and management for patients presenting with chest pain. Despite this, the use of coronary pressure wire in routine practice is surprisingly low and...
Article
Full-text available
Introduction Troponin elevation is central to the diagnosis of acute type 1 myocardial infarction. It is, however, elevated in a range of other conditions, including type 2 myocardial infarction, and this setting is increasingly associated with adverse clinical outcomes. Patients within intensive care frequently have at least one organ failure toge...
Article
Full-text available
Pseudo-aneurysms are a rare, potentially life threatening complication of a myocardial infarction. We present the case of a 45 year old male who was brought to the emergency department in extremis and had a previous history of a late presentation inferior ST-elevation myocardial infarction treated percutaneously. Clinical examination revealed evide...
Article
Objective To assess the frequency and impact of incidental findings (IF) on CT during work-up for transcatheter aortic valve intervention (TAVI). Methods A consecutive cohort of patients referred for consideration of TAVI who underwent a CT scan between 2009 and 2018 were studied retrospectively. CT reports were reviewed for the presence of IFs an...
Conference Paper
Background The use of high-sensitivity troponin (hs-cTn) is established in guideline-directed clinical practice to facilitate the diagnosis or exclusion of myocardial infarction (MI). The manufacturer provided 99th percentile for this assay is derived from a small population of relatively healthy individuals but is used as an “upper limit of normal...
Article
Full-text available
Objective To determine the distribution, and specifically the true 99th centile, of high sensitivity cardiac troponin I (hs-cTnI) for a whole hospital population by applying the hs-cTnI assay currently used routinely at a large teaching hospital. Design Prospective, observational cohort study. Setting University Hospital Southampton NHS Foundatio...
Article
Pericardiocentesis is a potentially life-saving emergency procedure most commonly performed for cardiac tamponade; in specific circumstances, it can also be performed to aid diagnosis. A subxiphoid approach without imaging guidance has been the technique of choice, but because of the high complication rate associated with this approach, a range of...
Article
The progression and expansion of treatments available for patients with cardiovascular disease depends on reliable, safe and effective arterial access. Owing to the superficial nature of the radial artery, major complications relating to cannulation occur less frequently and are simpler to manage. Therefore, radial access has become the favoured ac...
Article
Physical activity (PA) has been demonstrated to have a powerful role in reducing cardiovascular risk and is therefore universally recommended by international guidelines. Although there is a dose-dependent risk reduction with increasing levels of PA, there is some concern that extreme levels of PA can result in adverse cardiovascular outcomes. It i...

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