Jon Irazusta

Jon Irazusta
Universidad del País Vasco / Euskal Herriko Unibertsitatea | UPV/EHU

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193
Publications
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Publications

Publications (193)
Article
Physical exercise protects against age-related cognitive decline. Brain-derived neurotrophic factor (BDNF) may mediate some of the cognitive benefits of physical exercise, but the effect of physical exercise on serum BDNF is unclear. Indeed, differential findings have been reported depending on the characteristics of the participants and the intens...
Article
Full-text available
Maintaining the ability to walk is one of the significant challenges in people with multiple sclerosis (MS) for keeping a good quality of life as the disease and the aging process progresses. Overground robotic (OR) wearable exoskeletons are promising tools for gait rehabilitation, but currently there is no evidence of their clinical effects on pat...
Article
Decreased health-related quality of life (HRQoL) is common in patients with cancer. We investigated the effects of dietary intervention and baseline nutritional status on worsening of HRQoL in older patients during chemotherapy. In this randomized control trial assessing the effect on mortality of dietary advice to increase dietary intake during ch...
Preprint
Full-text available
BACKGROUND: In older patients, functional and cognitive status often decline after hospitalization. Although interventions based on physical exercise can revert these effects, participation in physical exercise interventions is low. This study aimed to identify determinants of refusal to participate in a physical exercise program in post-hospitaliz...
Preprint
Full-text available
BACKGROUND: Older patients often experience a decline in functional and cognitive status after hospitalization. Although interventions involving physical exercise are effective in improving functional performance, participation in physical exercise interventions among older individuals is low. We aimed to identify the factors that contribute to exe...
Article
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Multicomponent physical exercise is effective in curbing the effect of hospitalization in older adults. However, it is not well established which characteristics of the exercise interventions would optimize intervention sustainability and efficacy. This study compared the effects of two group-based multicomponent exercise interventions of different...
Article
Background and objectives: There is evidence that exercise interventions counteract the functional and cognitive decline experienced by long-term nursing home (LTNH) residents. To determine the most effective exercise intervention, we compared the effects of a multicomponent exercise intervention and a walking intervention on physical and cognitiv...
Article
Full-text available
Rennin-angiotensin system (RAS) has been involved in sperm function, even so, little is known about the implication of one of the RAS axis formed by Ang-(1–7) [angiotensin-(1–7)] and Mas receptor. Hence, in the present work, we focused on elucidating the function of the Mas receptor in human sperm. We analyzed the expression and localization of Mas...
Article
Objectives: To determine the effects of a multicomponent physical exercise program on cognitive and affective functioning among nursing home residents and to clarify whether there are any changes in serum levels of brain-derived neurotrophic factor (BDNF) among participants. Study design: This was a single-blind randomized controlled trial in te...
Article
Duñabeitia, I, Arrieta, H, Rodriguez-Larrad, A, Gil, J, Esain, I, Gil, SM, Irazusta, J, and Bidaurrazaga-Letona, I. Effects of massage and cold water immersion after an exhaustive run on running economy and biomechanics: A randomized controlled trial. J Strength Cond Res XX(X): 000-000, 2019-This study compares the effects of 2 common recovery inte...
Article
Background: the potential benefits of dual-task interventions on older adults living in long-term nursing homes (LTNHs) from a multidimensional perspective are unknown. We sought to determine whether the addition of simultaneous cognitive training to a multicomponent exercise program offers further benefits to dual-task, physical and cognitive per...
Article
Full-text available
Kirolariengan entrenamenduen edota txapelketen osteko errekuperazio desegokiak estres fisiologiko handia, gainkarga sintomak eta nekea eragin ditzake, errendimendua gutxituz. Hori dela eta, eguneroko entrenamenduak ziurtatzeko eta lesionatzeko arriskuak murrizteko fisioterapian hainbat agente fisiko erabiltzen ditu errekuperazio metodo gisa, hala n...
Article
Full-text available
Age-related strength and muscle mass loss is further increased after acute periods of inactivity. To avoid this, resistance training has been proposed as an effective countermeasure, but the additional effect of a protein supplement is not so clear. The aim of this study was to examine the effect of a whey protein supplement enriched with leucine a...
Article
Full-text available
Bone is influenced by physical activity (PA) throughout life, but childhood and adolescence provide a key opportunity to maximize peak bone mass. Thus, it is important to identify the relationship between PA practiced in childhood and young adulthood to design a promotion plan for bone health. The purpose of this study was to analyze the relationsh...
Article
In this work, a heuristic as operational tool to estimate the lactate threshold and to facilitate its integration into the training process of recreational runners is proposed. To do so, we formalize the principles for the lactate threshold estimation from empirical data and an iterative methodology that enables experience based learning. This stra...
Article
In the current context of an aging population in many developed countries, the issue of healthy aging is at the forefront of the political, scientific, and technological concerns. The frailty accompanying the late years of elderly people (>70 years old) deserves special consideration due to its great economical and personal costs and the workload i...
Article
Objectives To determine the strength of the association between objectively and subjectively measured physical activity (PA) and cardiovascular risk factors (CVRF) in a sample of older adults to assess which measure of PA is most appropriate for use in this population. Study design and outcome measures The study was a cross-sectional analysis of a...
Article
Full-text available
OBJECTIVES: To determine the effect of multicomponent exercise on frailty and related adverse outcomes in residents of long-term nursing homes (LTNHs). DESIGN: A single-blind randomized controlled trial. SETTING: Ten LTNHs in Gipuzkoa, Spain. PARTICIPANTS: The study sample comprised 112 men and women aged 70 years or older who scored 50 or higher o...
Preprint
https://arxiv.org/abs/1903.02318 In this work, a heuristic as operational tool to estimate the lactate threshold and to facilitate its integration into the training process of recreational runners is proposed. To do so, we formalize the principles for the lactate threshold estimation from empirical data and an iterative methodology that enables ex...
Preprint
In this work, a heuristic as operational tool to estimate the lactate threshold and to facilitate its integration into the training process of recreational runners is proposed. To do so, we formalize the principles for the lactate threshold estimation from empirical data and an iterative methodology that enables experience based learning. This stra...
Article
Full-text available
G-protein coupled receptors (GPCRs) belong to the seven transmembrane receptor superfamily that transduce signals via G proteins in response to external stimuli to initiate different intracellular signaling pathways which culminate in specific cellular responses. The expression of diverse GPCRs at the plasma membrane of human spermatozoa suggests t...
Article
Full-text available
Background The purpose of the Aging-ONDUAL-TASK study is to determine if a supervised dual-task program carried out in long-term nursing homes is able to attenuate frailty in a greater extent than the same multicomponent exercise program alone. Methods This multicenter randomized controlled trial will include 188 participants who will be randomly...
Article
Background: Myostatin has been proposed as a candidate biomarker for frailty and sarcopenia. However, the relationship of myostatin with these conditions remains inconclusive. Objective: To determine the association of serum myostatin concentration with body composition, physical fitness, physical activity level, and frailty in long-term nursing ho...
Article
The aim of this cross-sectional study was to study the relative importance of dietary habits and aerobic capacity in parameters related to cardiovascular risk in 271 female and 95 male health-science students (mean age = 19.1 ± 1.4 years). In females, fatty-meat consumption predicted triglycerides (β = .649, p < .001) and high-density lipoprotein (...
Article
Full-text available
Angiotensin-converting enzyme functions in the male reproductive system, but the extent of its function in reproduction is not fully understood. The primary objective of this work was to investigate the relationship between the testicular isoform of angiotensin-converting enzyme present in human spermatozoa and semen parameters, human embryo qualit...
Article
Objective: To investigate the reliability of a novel method to measure neck surface electromyography (SEMG), kinematics, and pain during active movements in participants with neck pain. Methods: This test-retest study evaluated 23 participants with chronic neck pain. Each was measured twice within a single session. Three-dimensional kinematics a...
Article
Full-text available
Objective: To determine whether obesity, physical fitness, and physical activity parameters are associated with the enzymatic activity of serum dipeptidyl peptidase IV (sDPPIV) in a sample of healthy women and men. Design and methods: We have correlated parameters of obesity, physical fitness, and physical activity with sDPPIV activity in 374 healt...
Article
Objectives: This study compared the effects of a capacitive-resistive electric transfer therapy (Tecar) and passive rest on physiological and biomechanical parameters in recreational runners when performed shortly after an exhausting training session. Design: Randomized controlled crossover trial. Setting: University biomechanical research laborato...
Article
Full-text available
Background Few studies have simultaneously examined changes in physical, cognitive and emotional performance throughout the aging process. Methods Baseline data from an ongoing experimental randomized study were analyzed. Physical activity, handgrip, the Senior Fitness Test, Trail Making Test A, Rey Auditory-Verbal Learning Test, Quality of Life-A...
Article
Full-text available
Aim: The aim of this study was to determine the relationships between biomechanical parameters of the gait cycle and race walking economy in world-class Olympic race walkers. Methods: Twenty-One world-class race walkers possessing the Olympic qualifying standard participated in this study. Participants completed an incremental race walking test sta...
Presentation
Full-text available
Backgrounds Cancer survivors experience long-term negative effects of treatment such as pain, fatigue, an accelerated functional decline, and reduced health-related quality of life (HRQoL) (1,2). Nevertheless, there is a lack of studies associating functional parameters, physical activity, nutritional state, and fatigue parameters conducted in olde...
Article
Full-text available
We investigated whether heart rate (HR)-derived parameters are accurate performance predictors in endurance recreational runners. One hundred thirty recreational athletes completed an incremental running test (4´running + 1´rest). After each stage, we recorded HR, % of maximum HR (%HRmax), and blood lactate. We also assessed HR after each recovery...
Article
Full-text available
Understanding the modifiable factors that improve and maximize peak bone mass at an early age is necessary to design more effective intervention programs to prevent osteoporosis. To identify these modifiable factors, we analyzed the relationship of physical activity (PA), physical fitness, body composition, and dietary intake with bone stiffness in...
Article
Full-text available
To investigate the impact of a multicomponent exercise program on anthropometry, physical function, and physical activity on older adults living in long-term nursing homes (LTNH), we conducted a randomized controlled trial involving 112 participants aged 84.9 ± 6.9 years. Participants were randomly assigned to an intervention (IG) or control group...
Article
Aims: The sperm plasma membrane contains specific ion channels and transporters that initiate changes in Ca2+, Na+, K+ and H+ ions in the sperm cytoplasm. Ion channels are key regulators of the sperm membrane potential, cytoplasmic Ca2+ and intracellular pH (pHi), which leads to regulate motility, capacitation, acrosome reaction and other physiolo...
Data
Early embryo quality at day 2 and their association with percentage of positive-testicular angiotensin-converting enzyme sperm cells and number of testicular angiotensin-converting enzyme molecules per sperm cells
Data
Embryo developmental phase at blastocyst stage at day 5 and their association with percentage of positive-testicular angiotensin-converting enzyme sperm cells and number of testicular angiotensin-converting enzyme molecules per sperm cells
Data
ASEBIR grading system for embryo quality on day 2 of development.
Data
ASEBIR grading system for embryo quality on day 3 of development.
Data
Histogram of percentage of positive-tACE sperm cells measured by flow cytometry (n = 3 patients).
Data
Early embryo quality at day 3 and their association with percentage of positive-testicular angiotensin-converting enzyme sperm cells and number of testicular angiotensin-converting enzyme molecules per sperm cells
Article
Full-text available
Numerous studies have reported the benefits of physical exercise in older adults. However, studies performed in long-term nursing home (LTNH) residents are scarce. A literature search was conducted to identify physical exercise intervention studies that were randomized and controlled and that assessed gait ability in older LTNH residents using both...
Article
Full-text available
Osteoporosia osasun-publikoan nabarmenezko garrantzia duen gaixotasuna da. Gero eta gehiago dira gaixotasun hau pairatzen duten pertsonak eta gaur egun arte egindako esku hartzeak ez dira guztiz eraginkorrak. Bizi-ohitura den ariketa fisikoa hezur-dentsitatearen metaketa eta mantentze prozesuen garrantzizko mugatzailea da. Gainera, hezur eta giharr...
Article
Full-text available
Lactate threshold is considered an essential parameter when assessing performance of elite and recreational runners and prescribing training intensities in endurance sports. However, the measurement of blood lactate concentration requires expensive equipment and the extraction of blood samples, which are inconvenient for frequent monitoring. Furthe...
Article
Loss of functioning and age-related health problems tend to appear earlier in individuals with intellectual disability (ID) than in their non-disabled peers. The Feldenkrais method (FM) is a movement-based form of learning that enhances body balance and physical functioning. We carried out an intervention based on Awareness Through Movement, a form...
Conference Paper
Introduction Lactate threshold is an important parameter to consider when planning the season training (Billat, 2003). However, its calculation requires costly equipment usually only available in specialized centers. This restricts its applicability to few athletes, especially if frequent monitoring is sought. Therefore, the aim of this study is to...
Conference Paper
Introduction Certain heart rate (HR)-derived parameters are predictors of endurance performance and are also used for prescribing and monitoring training intensities (Lamberts et al., 2010; Vesterinen et al., 2016). Despite this evidence, HR monitoring is still not accepted as a gold standard to predict performance. In the present work, we investig...
Article
Garcia-Gil, M, Torres-Unda, J, Esain, I, Duñabeitia, I, Gil, SM, Gil, J, and Irazusta, J. Anthropometric parameters, age, and agility as performance predictors in elite female basketball players. J Strength Cond Res 32(6): 1723-1730, 2018-In addition to technical, tactical, and psychological skills, performance in playing basketball depends on anth...
Article
A side effect of increased life expectancy is a surge in sequelae of diseases and injuries, which in turn increase the duration of life with disability among the elderly. The aim of this study was to ascertain the physical activity and nutritional parameters that better predict cardiovascular risk in a cohort of older women. A cross-sectional study...
Article
Full-text available
Background There is increasing evidence suggesting that cognition and physical frailty interact within a cycle of decline associated with aging which has been called cognitive frailty. Exercise programs have demonstrated to be an effective tool to prevent functional and cognitive decline during aging, but little is known about their potential to re...
Article
Full-text available
The presence of endogenous opioid peptides in different testicular cell types has been extensively characterized and provides evidence for the participation of the opioid system in the regulation of testicular function. However, the exact role of the opioid system during the spermatogenesis has remained controversial since the presence of the mu-,...
Data
Effect of selective MOR-agonist morphine on spermatogenic cell cycle. Flow cytometry histogram of spermatogenesis cell cycle measured by propidium iodide in control (green) and morphine-treated samples (red: 10−6 M) for short- (A) and long-term exposure (B). Representative plot from six experiments. Changes on percentages of 1c, 2c and 4c DNA-conta...
Data
Effect of selective KOR-agonist morphine on spermatogenic cell cycle. Flow cytometry histogram of spermatogenesis cell cycle measured by propidium iodide in control (green) and U50488-treated samples (red: 10−6 M) for short- (A) and long-term exposure (B). Representative plot from six experiments. Changes on percentages of 1c, 2c and 4c DNA-contain...
Data
Localization of opioid receptors in mouse spermatozoa. Immunoflorescence analysis of MOR, DOR and KOR with male germ cell markers. Negative controls were treated with preimmune rabbit serum and secondary antibody alone. Nuclei were stained with Hoechst 33258. Representative photomicrographs are shown; n = 5. (JPG)
Data
Effect of selective DOR-agonist morphine on spermatogenic cell cycle. Flow cytometry histogram of spermatogenesis cell cycle measured by propidium iodide in control (green) and DPDPE-treated samples (red: 10−6 M) for short- (A) and long-term exposure (B). Representative plot from six experiments. Changes on percentages of 1c, 2c and 4c DNA-containi...
Article
Full-text available
Los objetivos de este estudio son, por un lado, determinar las características antropométricas y de fuerza (medida mediante test de hand-grip y salto vertical con brazos libres) comprándolo con otros deportes de raqueta, y por otro, analizar las características propias del juego durante el Campeonato de España de Pádel sub-23. Para ello 14 hombres...
Article
Full-text available
This study sought to determine the association of relative age and performance of young elite basketball players. The distribution of the birth dates, heights, positions, classification and performance of the male and female participants (n = 2395) of the U16, U18 and U20 European Basketball Championships were analysed. We found an over-representat...
Article
The acrosome reaction occurs in vivo following sperm capacitation and is essential for the acquisition of sperm fertilization ability. However, little is known about the molecular identity of the physiological acrosome reaction regulators. In addition to progesterone, which is produced by cumulus oophorus cells and known to regulate acrosome reacti...
Article
Objective: To investigate the presence of angiotensin II type 2 receptor (AT2R) in human spermatozoa and its implication in sperm fertility status. Design: We carried out expression assays for AT2R by reverse transcription-polymerase chain reaction, Western blot, immunofluorescence, and flow cytometry techniques in human sperm cells. Percentage...
Article
Full-text available
During a national championship, the anthropometric, physiological and maturation characteristics of 13-14-year-old players of elite basketball teams and their association with sport performance were analyzed. Body parameters (weight, height, skinfold thicknesses and lengths) were measured and physiological capacities assessed by sprint (20 m) and j...
Article
The most well-known physiological effect associated with opiod system is their efficacy in pain reduction or analgesia, although their effect on a variety of other physiological and physiophological functions has become apparent in recent years. This review is an attempt to clarify in more detail the epigenetic regulation of opioid system to unders...
Conference Paper
Full-text available
Ikerketa honetan, adin erlatiboaren eragina (Relative Age Effect: RAE) aztertu da saskibaloiko jokalari gazteen errendimenduan. Horretarako, Bizkaiko eta Europako saskibaloi txapelketetako jokalarien jaiotze data, altuera eta errendimenduarekin lotutako parametroak jaso dira. Aztertu diren txapelketa guztietan jokalari gehienak urte hasieran jaiota...
Article
The plasma activity of nine aminopeptidases was monitored over a year in first-episode psychotic patients. We observed significant differences in aminopeptidase B (APB), aminopeptidase N (APN) and dipeptidyl peptidase IV (DPPIV), but not in puromycin-sensitive aminopeptidase (PSA), prolyl endopeptidase (PEP), cysteine aminopeptidase (Cys-AP), aspar...
Article
Aminopeptidase N (APN; EC 3.4.11.2) is a membrane dimeric metallopeptidase involved in differentiation, development, and proliferative processes of several tissues. Recent studies have demonstrated the increased expression and activity of this enzyme in several cancers. However, there are no available data about the impact of this peptidase in the...
Article
Full-text available
Dipeptidyl-peptidase IV (EC 3.4.14.5) (DPPIV) is a serine peptidase involved in cell differentiation, adhesion, immune modulation and apoptosis, functions that control neoplastic transformation. Previous studies have demonstrated altered expression and activity of tissue and circulating DPPIV in several cancers and proposed its potential usefulness...