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Introduction
Skills and Expertise
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July 2000 - December 2006
Publications
Publications (31)
Objectives The purpose of this trial was to evaluate the efficacy and safety of recently developed suppositories containing free fatty acids as a bowel-cleansing agent prior to flexible sigmoidoscopy and compare them with Klyx (docusate sodium/sorbitol).
Design A controlled, non-inferiority, single-blind, randomised study on outpatients undergoing...
Barrett's esophagus, with gastroesophageal reflux disease and obesity as risk factors, predisposes to esophageal adenocarcinoma (EAC). Recently a British Genome Wide Association Study identified two Barrett's esophagus susceptibility loci mapping within the Major Histocompatibility Complex (MHC; rs9257809) and closely to the Forkhead-F1 (FOXF1; rs9...
Esophageal cancer (EC), mainly consisting of squamous cell carcinoma (ESCC) in the Eastern world and adenocarcinoma (EAC) in the Western world, is strongly associated with dietary factors such as alcohol use. We aimed to clarify the modifying role in EC etiology in Caucasians of functional genotypes in alcohol-metabolizing enzymes. In all, 351 Cauc...
Background
Identifying and monitoring high-risk patients can aid the prevention of esophageal cancer (EC). The interaction of environmental risk factor exposure and genetic susceptibility may contribute to the etiology of EC. Biotransformation enzymes such as Glutathione S-Transferases (GSTs ) detoxify mutagenic and genotoxic compounds and therefor...
Barrett's esophagus, with gastroesophageal reflux disease and obesity as risk factors, predisposes to esophageal adenocarcinoma (EAC). Recently a British genome wide association study identified two Barrett's esophagus susceptibility loci mapping within the major histocompatibility complex (MHC; rs9257809) and closely to the Forkhead‐F1 (FOXF1; rs9...
Susceptibility to esophageal carcinoma (EC) is influenced by the interaction between genetic and environmental factors. To clarify the etiology of EC, several genome-wide association studies have identified single nucleotide polymorphisms (SNPs) in PCLE1 and RFT2 genes as esophageal squamous cell carcinoma (ESCC) susceptibility loci in Asian popula...
Esophageal cancer (EC) has a globally increasing incidence with poor curative treatment options and survival rates. Crucial risk factors are exposure to toxins or carcinogens. Microsomal epoxide hydrolase (mEH) is a biotransformation enzyme essential for the detoxification of xenobiotics. Polymorphisms in exon 3 and exon 4 of the microsomal epoxide...
Esophageal cancer (EC) has a globally increasing incidence with poor curative treatment options and survival rates. Environmental and dietary factors have crucial roles in esophageal carcinogenesis. Polymorphisms in the UGT genes, a superfamily of enzymes essential for the detoxification of carcinogens, may alter enzyme activity and subsequently ma...
To determine whether -1195 A-->G and/or -765 G-->C polymorphisms in Cyclooxygenase-2 (COX-2) may have a risk modifying effect on the development of esophageal carcinoma in a Dutch Caucasian population.
Two study groups were recruited, 252 patients with esophageal carcinoma and 240 healthy controls, matched for race, age, gender and recruiting area....
En el presente caso clínico se describe una peliosis esplénica y un síndrome vascular de Ehlers-Danlos (SED) concurrentes en un paciente de 59 años de edad. Tras la rotura esplénica debida a la peliosis, el período postoperatorio complicado sugirió la posibilidad de un SED vascular. Este diagnóstico se confirmó con los exámenes genéticos, que revel...
Nous rapportons un cas de péliose splénique associée à un syndrome vasculaire d'Ehlers-Danlos (SED) chez un homme de 59 ans. Après une rupture splénique liée à la péliose, des suites opératoires compliquées ont suggéré la possibilité d'un SED vasculaire. Ce diagnostic a été confirmé par le dépistage génétique, qui a montré l'existence d'une mutatio...
Four patients, aged 67, 52, 56 and 64 years, respectively, undergoing percutaneous colostomy or jejunostomy are presented to illustrate current options for percutaneous endoscopic access to the digestive tract. The first patient had Parkinson's disease and required percutaneous jejunostomy for continuous post-pyloric administration of medication. T...
This case report describes concurrent splenic peliosis and vascular Ehlers-Danlos syndrome (EDS) in a 59-year-old male patient. After splenic rupture due to peliosis, the complicated postoperative period hinted at the possibility of vascular EDS. This diagnosis was confirmed by genetic testing, which revealed a novel point mutation in the COL3A1 ge...
Patients with intestinal failure, predominantly caused by short-bowel syndrome, have impaired quality of life due to the frequent development of complications. Dietary modifications have an established role in the treatment of short-bowel syndrome. Treatment of short-bowel syndrome includes optimising the balance of fluids and nutrients in the pres...
For patients with severe intestinal failure caused by short-bowel syndrome, pharmacological treatment options are available that can reduce the period in which parenteral nutrition is required. Appropriate agents include acid inhibitors, bile-salt binders, inhibitors of motility and secretion, antibiotics and pre- and probiotics. A number of intest...
The aim of this study was to investigate prospectively the rectal wall (Rwall) spatial dose distribution, toxicity, and mucosal changes after prostate cancer radiotherapy with or without an endorectal balloon (ERB).
A total of 24 patients with ERB and 24 without ERB (No-ERB) were treated with three-dimensional conformal radiotherapy (3D-CRT) to a d...
Few studies have described patients with foregut dysmotility in inflammatory bowel disease. The aim of this case series was to evaluate clinical characteristics of 5 patients with inflammatory bowel disease and symptoms and signs of upper gut dysmotility.
We describe a series of four patients with Crohn's disease and one with indeterminate colitis...
The aim of the study was to quantify the inter-relationship between bone mineral density and physical activity, muscle strength, and body mass composition in a group of healthy 16-20-year-old women.
A cross-sectional study.
Reykjavik area.
Two-hundred and fifty-four Icelandic Caucasian women aged 16, 18 and 20 years, randomly selected from the regi...
Hypovitaminosis D has been shown to be associated with low bone mineral density in middle-aged and elderly women. The aim of this study was to evaluate whether such an association might exist in adolescent and young adult girls, approaching peak bone mass.
Cross-sectional study carried out in late winter.
Reykjavik area at latitude 64 degrees N.
Tw...
Objective:
The aim of this study was to evaluate at which age peak bone mass is reached among Icelandic women. Previous studies on this subject have been conflicting indicating that this might be reached sometime between the age of 16 and 35 years. We have also analyzed associated nutritional and physical factors which might be of use for preventi...
To evaluate whether there is an association between BsmI-vitamin-D receptor (VDR) gene polymorphism and combined bone mass in the spine and proximal femur in a group of adult Icelandic women with high and low bone mineral density (BMD).
Comparison of distribution of VDR genotypes (BB, Bb and bb) and allele frequency (B and b) in two groups of women...
To evaluate whether there is an association between calcium intake in adolescent girls and bone mineral density (BMD). Also, the relationships between BMD, various anthropometric factors and grip strength were evaluated.
Cross-sectional comparison of BMD, calcium intake and grip strength in 13 and 15 year age groups, randomly selected.
Ten secondar...
Neðst á síðunni er hægt að nálgast greinina í heild sinni með því að smella á hlekkinn View/Open Objective: The aim of this study was to evaluate at which age peak bone mass is reached among Icelandic women. Previous studies on this subject have been conflicting indicating that this might be reached sometime between the age of 16 and 35 years. We h...
