Jojanneke J G T van Summeren

• Doctor of Medicine
• Researcher at Nivel – Research for better care

Objective: To perform a systematic review of the literature examining the prevalence of bladder symptoms in children with functional constipation (FC), and to compare the prevalence of those symptoms between children with and without FC. Methods: In this systematic review 4 databases were searched to July 2018. Studies investigating the prevalen...

Objective: Functional constipation (FC) has a major impact on the health-related quality of life (HRQoL) of children. The aim of this study was to evaluate parent-child agreement on HRQoL in children (8-17 years) with FC in primary care. Methods: Children diagnosed with FC by their clinician were eligible. HRQoL was measured with the Defecation...

Background Our aim was to design a study to evaluate the effectiveness and cost-effectiveness of adding physiotherapy to conventional treatment for children with functional constipation in primary care. Physiotherapy is focusing on improving the coordination between the pelvic floor and abdominal musculature during bowel movement, while conventiona...

Background: Several methods have been developed to conduct and support medication reviews in older persons with multimorbidity. Assessing the patient's priorities for achieving specific health outcomes can guide the medication review process. Little is known about the impact of conducting such assessments. Aim: This pilot study aimed to determin...

Background We previously reviewed methods for estimating the timing of respiratory syncytial virus (RSV) epidemics. This study examines the impact of various estimation methods on determining the start, end, duration, and capture rate of RSV epidemics. Methods We applied eight estimation methods to RSV surveillance data from the Global Epidemiolog...

Background Data on economic costs of respiratory syncytial virus (RSV) infections among children in primary care are scarce, although most RSV-infections are managed in this setting. Aim To estimate outpatient costs for RSV-positive children aged < 5 years. Methods In the RSV ComNet prospective cohort, children < 5 years with acute respiratory in...

Background: Syndromic surveillance systems are crucial for the monitoring of population health and the early detection of emerging health problems. Internationally, there are numerous established systems reporting on different types of data. In the Netherlands, the Nivel syndromic surveillance system provides real-time monitoring on all diseases an...

Background Accurate cost estimates of respiratory syncytial virus (RSV) infections in primary care are limited, despite the majority of cases being managed in this setting. This study aims to estimate healthcare costs for children with RSV in primary care and the related costs of parental work absence. Methods Children < 5 years of age with sympto...

Background Vaccination is a key measure in influenza control, yet global coverage rates remain low, although previous research reported an increase in influenza vaccination coverage rates (VCR) after the onset of the COVID‐19 pandemic. This study aims to assess whether these changes were sustained over time by analyzing VCR trends from 2012 to 2023...

Respiratory syncytial virus (RSV) is the most common cause of acute respiratory infections in young children. Limited data are available on RSV disease burden in primary care and emergency departments (EDs). This review synthesizes the evidence on population‐based incidence rates of RSV infections in young children (< 5 years) in primary care and E...

Background Respiratory syncytial virus (RSV) infection in children under 5 years have a significant clinical burden, also in primary care settings. This study investigates the epidemiology and burden of RSV in Italian children during the 2019/20 pre-pandemic winter season. Methods A prospective cohort study was conducted in two Italian regions. Ch...

UNSTRUCTURED The present article introduces the Nivel Syndromic Surveillance system (NSSS), emphasizing its role in providing “real-time” information on infectious diseases and various health problems at the population level, in the Netherlands. Utilizing data from general practitioners’ (GPs) electronic health records (EHRs), the system allows for...

Background Syndromic surveillance systems are crucial for the monitoring of population health and the early detection of emerging health problems. Internationally, there are numerous established systems reporting on different types of data. In the Netherlands, the Nivel syndromic surveillance system provides real-time monitoring on all diseases and...

Background There is currently no standardised approach to estimate respiratory syncytial virus (RSV) epidemics’ timing (or seasonality), a critical information for their effective prevention and control. Aim We aimed to provide an overview of methods to define RSV seasonality and identify factors supporting method choice or interpretation/comparis...

Dr William John Paget, a Senior Scientist at the Netherlands Institute for Health Services Research (Nivel) and one of the principal investigators for PROMISE (Preparing for RSV Immunization and Surveillance in Europe), sadly and unexpectedly passed away on November 4, 2023. He was a connector always full of research ideas. In the many condolences...

Background RSV infections affects people of all ages but the seasonality of RSV among different age groups have not been thoroughly examined. In this study, we investigated changes in the age distribution of RSV cases during the course of annual epidemics. Methods We analyzed surveillance data (2008-2019) from the Netherlands, the city of Lyon (Fr...

Background: Respiratory syncytial virus (RSV) imposes a substantial burden on pediatric hospital capacity in Europe. Promising prophylactic interventions against RSV including monoclonal antibodies (mAb) and maternal immunizations (MI) are close to licensure. Therefore, we aimed to evaluate the cost-effectiveness of potential mAb and MI interventi...

Background: WHO estimates that seasonal influenza epidemics result in three to five million cases of severe illness (hospitalisations) every year. We aimed to improve the understanding of influenza-associated hospitalisation estimates at a national and global level. Methods: We performed a systematic literature review of English- and Chinese-lan...

Background: Respiratory syncytial virus (RSV) commonly causes lower respiratory tract infections (LRTI) and hospitalisation in children. In 2019/20, the Europe-wide RSV ComNet standardised study protocol was developed to measure the clinical and socio-economic disease burden of RSV infections amongst children <5 years of age in primary care. RSV...

Background: Respiratory syncytial virus (RSV) commonly causes lower respiratory tract infections (LRTI) and hospitalisation in children. In 2019-2020, the Europe-wide RSV ComNet standardised study protocol was developed to measure the clinical and socio-economic disease burden of RSV infections amongst children <5 years of age in primary care. RSV...

Objective: Health care expenditures for children with functional constipation (FC) are high, while conservative management is successful in only 50% of the children. The aim is to evaluate whether adding physiotherapy to conventional treatment (CT) is a cost-effective strategy in the management of children with FC aged 4-18 years in primary care....

Background A better understanding of the burden of respiratory syncytial virus (RSV) infections in primary care is needed for policymakers to make informed decisions regarding new preventive measures and treatments. The aim of this study was to develop and evaluate a protocol for the standardised measurement of the disease burden of RSV infection i...

Since the introduction of non-pharmacological interventions to control COVID-19, respiratory syncytial virus (RSV) activity in Europe has been limited. Surveillance data for 17 countries showed delayed RSV epidemics in France (≥ 12 w) and Iceland (≥ 4 w) during the 2020/21 season. RSV cases (predominantly small children) in France and Iceland were...

Background: Respiratory syncytial virus (RSV) infections are one of the leading causes of lower respiratory tract infections and have a major burden on society. For prevention and control to be deployed effectively, an improved understanding of the seasonality of RSV is necessary. Objectives: The main objective of this study was to contribute to a...

Sinds de invoering van de COVID-19-maatregelen is in Europa nauwelijks circulatie van respiratoir synctieel virus (RS-virus). Alleen in Frankrijk en IJsland is in de winter van 2020-2021 een RS-virusepidemie vastgesteld; 4 maanden later dan gebruikelijk. Ook op het zuidelijk halfrond stopte de RS-viruscirculatie vanaf het invoeren van de COVID-19-m...

Background: In December 2019, a novel coronavirus named SARS-CoV-2 started circulating in China and this led to a major epidemic in Northern Italy between February and May 2020. Young children (aged <5 years) seem to be less affected by this coronavirus disease (COVID-19) compared to adults, although there is very little information on the circulat...

Temporal variation of respiratory syncytial virus (RSV) epidemics was recently reported to be determined by the dominant RSV subtype. However, when we repeated the analysis for 4 countries in the Northern and Southern Hemispheres, the dominant subtype did not seem to affect temporal variation of RSV epidemics.

Background Respiratory syncytial virus (RSV) is one of the leading causes of acute respiratory tract infections. To optimize control strategies, a better understanding of the global epidemiology of RSV is critical. To this end, we initiated the Global Epidemiology of RSV in Hospitalized and Community care study (GERi). Methods Focal points from 44...

Objective: To determine the effectiveness of physiotherapy plus conventional treatment compared with conventional treatment alone for the treatment of functional constipation in children age 4-17 years in primary care. Study design: Pragmatic randomized controlled trial with 8 months follow-up. Primary care physicians recruited children diagnose...

Aims: An increasing number of diagnostic and therapeutic medical devices are available to help patients and physicians manage pelvic floor symptoms in women. Many of these are presented at scientific conferences, and in the absence of a gold standard for evaluation, marketing has become more prominent than scientific evaluation. The goal of this s...

Patiënten die antibiotica gebruiken kunnen last krijgen van diarree. Wanneer zij behalve antibiotica ook probiotica krijgen, kan het risico op diarree met 60% verminderen. Maar omdat het risico laag is, moeten om één geval van diarree bij antibioticagebruik te voorkomen 42 mensen probiotica gebruiken. Dat ontdekten de auteurs van een Cochrane-revie...

Er is beperkt bewijs dat het voorschrijven van probiotica aan kinderen met functionele buikpijn effectief is. Het voorschrijven van extra vezels of medicatie heeft geen zin. Dat zijn de conclusies van twee recente Cochrane-reviews. De kwaliteit van het bewijs was echter laag tot gemiddeld en de meeste onderzoeken werden uitgevoerd in de derde lijn....

Objectives: To explore an outcome prioritization tool (OPT) in eliciting individuals' preferred health outcomes (remaining alive, maintaining independence, reducing pain, reducing other symptoms) in the context of medication review in family practice. Design: Cross-sectional pilot study with mixed-methods design. Setting: Family practice. Par...