Johnson SamuelInstitute of Bioinformatics and Applied Biotechnology | IBAB · Bioinformatics & Biotechnology
Researcher in Structural Biology | Looking for PhD positions
Johnson is a Postgraduate fellow at IBAB Bangalore & was previously an Intern at Garden City University • He has specializations in the respective areas of Biotechnology & Bioinformatics • Having worked in the areas of high throughput antigen screening, vaccine development, Pharmacodynamics & related aspects of Computational biology, Johnson is currently working on in-silico analysis of potent viral components responsible for their pathogenicity • ORCID ID : https://orcid.org/0000-0001-9454-0144
Docking studies are simple when it is a one ligand-one protein approach. However, what is the protocol for studying the combinational effect of 2 drug molecules on a particular protein, where we gotta study their effect on the protein when the 2 drug molecules are bound to each other? Should the 2 drugs be first docked with each other, & then the resulting structure would be docked with the protein? Or is it some other protocol that has to be followed?
[P.S: Sequential docking is not a part of the plan.]
On the recent times, few viral diseases have become the greatest concern of the Human population. With their property of rapidly evolving and getting mutated, most of the viral entities had been posing severe challenges to the conventional methods of discovering a medicine. The recent outbreak of Novel coronavirus best demonstrates this scenario. But with the recent advancements in the field of the computational biology new explorations are being made to tackle any such situations. And with the advent of highly advanced super computers and powerful databases coming into the picture, the field of lead medicine candidate discovery is taking new dimensions. From analyzing the viral pathogen for potent vaccine components to performing simulations to study the properties of the drug component structure, in-silico techniques have contributed, and are still contributing for the research in health and medicine. This work is a study that is done using such an approach to understand the pathogenicity of certain viral organisms, and analyze the causative agents for the same, using in-silico screening methods.
Air pollution is one of the biggest challenges, which most growing metropolitan cities come up with. In India this pollution rate increases in parallel to the rate of modernization. And the causative pollutants in the air have a wide range of impacts on the organisms around. Therefore the idea of bio filtration that involves the use of activated carbon particles can be a suitable remedy for keeping the levels of increasing air pollution in check. Activated carbon basically is a method of filtering that uses a bed of activated carbon to remove contaminants and impurities such as VOC (volatile organic compounds), toxic gases, excess smoke, particulate matters in air etc., by chemical adsorption. Their efficiency status lies in the fact that, a single gram of activated carbon has a surface area in excess of almost 3,000 square meters (32,000 sq. ft.); i.e., approximately about 4 tennis courts, as determined typically by nitrogen gas adsorption. Installation of these carbon models in the signal posts, electricity posts of highly crowded places, incineration areas and areas prone to high levels of air pollutants, can reduce the toxic particulate matters in the air thereby improvises the quality of air in the respective area. The disposal of this carbon material is also not necessary; because by the process of reactivation, which involves heating the spent carbon In a high temperature furnace, the contaminants are vaporized thereby restoring the carbon’s original pore structure, allowing for its reuse.
A project of designing a medical application, whose sole objective is to innovate the e-medicine sector, with a set of new upgrades and features to the existing technology.