John Woodland

John Woodland
University of Cape Town | UCT · Drug Discovery and Development Centre (H3D)

PhD

About

10
Publications
643
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75
Citations

Publications

Publications (10)
Article
Full-text available
John Woodland and Kelly Chibale retrace the tumultuous history of quinine from a medicine — used as a tool for colonialism — to a puzzling chemical target, a fluorescence standard and a key ingredient in popular drinks.
Article
A novel diazaspiro[3.4]octane series was identified from a Plasmodium falciparum whole-cell high-throughput screening campaign. Hits displayed activity against multiple stages of the parasite lifecycle, which together with a novel sp3-rich scaffold provided an attractive starting point for a hit-to-lead medicinal chemistry optimization and biologic...
Article
Full-text available
Millions of women are exposed simultaneously to antiretroviral drugs (ARVs) and progestin-based hormonal contraceptives. Yet, the reciprocal modulation by ARVs and progestins of their intracellular functions is relatively unexplored. We investigated the effects of tenofovir disoproxil fumarate (TDF) and dapivirine (DPV), alone and in the presence o...
Article
Steroid hormones regulate a variety of physiological processes, including reproductive function, and are widely used in hormonal therapy. Synthetic progestogens, or progestins, were designed to mimic progesterone (P4) for use in contraception and hormonal replacement therapy in women. Medroxyprogesterone acetate (MPA) and norethisterone (NET) are t...
Article
It is well established that chloroquine, a quinoline antimalarial, inhibits hemozoin formation in the malaria parasite. Counterintuitively, this archetypal antimalarial is also used in the treatment of diseases in which hemozoin biocrystallization does not play a role. Hence, we decided to investigate whether chloroquine possesses binding targets o...
Article
Full-text available
High usage of progestin-only injectable contraceptives, which include the intramuscular injectables depo-medroxyprogesterone acetate (DMPA-IM, Depo-Provera) and norethisterone (NET) enanthate (NET-EN or Nur-Isterate), correlates worldwide with areas of high HIV-1 prevalence. Epidemiological data show a significant association between usage of DMPA-...
Data
Fig A. Gating strategy employed in this study. Table A. Frequencies of PBMC leukocytes and cells expressing CD25 or CCR5 in PBMCs stimulated with 100 nM MPA versus control for 24 hours. Table B. Density of CD25 or CCR5 in PBMC leukocytes stimulated with 100 nM MPA versus control for 24 hours. Table C. Frequencies of PBMC leukocytes and cells expres...
Article
Fluorescent derivatives of the archetypal antimalarial quinine and its diastereomer, quinidine, suitable for cellular imaging have been synthesised by attaching the small extrinsic fluorophore, NBD. Interactions of these derivatives with ferriprotoporphyrin IX were evaluated to verify that insights generated by live-cell imaging were relevant to th...

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