John Kyriopoulos

• MD, MSc, MPH, PhD
• Professor Emeritus at National School of Public Health (EDSY)

Objective To investigate knowledge, perceptions and practices of parents of girls aged 11–18 years old in Greece toward HPV vaccination, and determine which factors are associated with parents' decision to vaccinate their daughters.MethodsA close-end questionnaire was constructed and telephone interviews were conducted upon informed consent. The sa...

Objective HIV prevalence has substantially increased over the years, leading to increased direct medical costs. The aim of the present study was to assess the long-term cost of HIV care in Greece incurred over the last decade. Methods In order to assess the long-term cost of HIV care, a cost analysis was undertaken for three discrete time points (...

Purpose – The purpose of this paper is to investigate the key determinants of dietary choices of the Greek population during a period of financial austerity. Design/methodology/approach – Data from the 2016 “Health and Welfare” Greek national cross-sectional survey, in a representative sample of 2,003 individuals, were examined. The survey was cond...

Objectives: To assess the financial impact of self-medication enhancement through a potential expansion of the over-the-counter (OTC) drug list in Greece. Methods: An analysis consisting of two scenarios was conducted. The first scenario estimated the financial effects of hypothetically switching 5% of the volume of the total sales of reimbursed...

Background Possession of private health insurance has been associated with personal and socioeconomic characteristics, such as income and age. The objective of the present study is to assess the individuals' personal characteristics associated with private health insurance possession in Greece. Methods The data used in the present analysis derived...

Objectives Historically, resource allocation decisions in healthcare are based on univariate approaches, inevitably overlooking value dimensions that are essential from a societal welfare maximization perspective. This article aims to present a wider perspective on decision making that incorporates societal values when prioritizing future resource...

Objective This analysis aimed to assess patient advocacy groups’ (PAGs) perspectives on patients’ and PAGs’ potential role in Health Technology Assessment (HTA) decision-making in Greece. Methods In total, 22 representatives of PAGs participated in a consensus panel meeting. Participants’ views were elicited via a consensus panel meeting, through...

Purpose Available treatment options for rheumatoid arthritis (RA) differ in important aspects. In this sense, each RA treatment option is accompanied by a spectrum of characteristics that collectively constitute its comprehensive “value,” as viewed from the physician's or the patient's perspective. The objective of this study was to perform a multi...

Purpose To estimate the net cost effect associated with the real-world practice of repeated use of designated single-use medical devices (SUDs) versus their proper single use in cataract surgery in Greece. Design A cost-benefit analysis model was constructed in the form of a decision tree. Methods A digital expert panel was assembled in order to...

Objectives Idiopathic pulmonary fibrosis (IPF) is a severe progressive disease with poor prognosis. Patients show an increased healthcare utilization pattern consisting of regular physician consultations and monitoring tests. The aim of the present study was to estimate healthcare resource utilization and out-of-pocket expenditures for IPF patients...

Quality of life (QoL) is considered a multidimensional concept, which includes both subjective and objective components. Health, social, physical, and macroeconomic environment, personality, lifestyle, and demographic and socioeconomic factors are considered the most important determinants of QoL. However, little is known about the factors that inf...

Introduction: Community acquired pneumonia (CAP) is an acute respiratory infection with high clinical and economic burden, especially when hospitalisation is required. The present study aimed to assess the mean direct cost per CAP outpatient and inpatient care in Greece, in the absence of previous estimates. Methods: A retrospective analysis of...

Background HPV test appears to be more effective in cervical cancer (CC) screening. However, the decision of its adoption as a primary screening method by substituting the established cytology lies in the evaluation of multiple criteria. Aim of this study is to evaluate the economic and clinical impact of HPV test as primary screening method for CC...

This study aimed to investigate stakeholders' beliefs regarding Health Technology Assessment (HTA) in pharmaceutical policy in Greece. A qualitative research using semi‐structured interviews was performed. Interviewees were selected using purposive sampling amongst pharmaceutical market various stakeholders. According to stakeholders, there is an u...

Aim: To examine management of diabetes mellitus (DM) and patients' attitude towards DM in a random sample of the adult Greek population. Methods: s: We selected a random sample of adults with self-reported DM (n = 1002) from a population-based nationwide study using the effective random sampling technique. Collection of data was performed throug...

COST EFFECTIVENESS ANALYSIS OF ALEMTUZUMAB AS A TREATMENT OPTION FOR PATIENTS WITH MULTIPLE SCLEROSIS IN CYPRUS Kourkoulas N, Athanasakis K, Theodorou M, Kyriopoulos J OBJECTIVES: To evaluate the cost-effectiveness of alemtuzumab compared to other disease modifying treatment options for patients with relapsing-remitting multiple sclerosis (RRMS) f...

Background From a theoretical perspective, several studies indicate that happiness and health are—in some extent—interrelated. Despite the mechanisms explaining the relationship between happiness and health, there is still no consensus regarding this link. Using recently collected primary data, this study aims to examine the relationship between ha...

Objectives Generic substitution is a popular cost containment measure and was among the core priorities of the pharmaceutical policy agenda in Greece during the last years. This study aims to examine the determinants of patients’ attitudes towards generic substitution in Greece. Methods Using primary data from a nationally representative cross‐sec...

Background: Diabetes mellitus (DM) is the most common metabolic disorder that increases the risk of cardiovascular disease by two to four times compared with the general population. There are limited data on the prevalence of heart diseases in subjects with DM in Greece. In this study, we examined the prevalence of self-reported DM as well as card...

A Cost-Of-Illness Analysis For Community Acquired Pneumonia In Greece Naoum P1, Liapikou A2, Toumbis M2, Athanasakis K1, Kyriopoulos J1 1National School of Public Health, Athens, Greece, 2Sotiria Chest Diseases Hospital, Athens, Greece Objectives: Community acquired pneumonia (CAP) is accompanied by a highclinical and economic burden, especially w...

OBJECTIVES: The clinical superiority of HPV testing for cervical cancer (CC) screening is steering the international society to lean in its favor. However, the choice between the different HPV testing methods is crucial, as it can determine the efficiency of the screening programs. Simultaneous 16/18 genotyping testing offers the potential to save...

Purpose: The present study aimed to perform a cost-effectiveness analysis of ingenol mebutate (IM) versus other topical alternatives for the treatment of actinic keratosis (AK). Methods: The analysis used a decision tree to calculate the clinical effects and costs of AK first-line treatments, IM (2-3 days), diclofenac 3% (for 8 or 12 weeks), imi...

Background Several studies suggest that socioeconomic status affects (SES) affects self-rated health (SRH), both in Greece and internationally. However, prior research mainly uses objective measures of SES, instead of subjective evaluations of individuals’ social status. Based on this, this paper aims to examine (a) the impact of the economic dowtu...

Objectives: Since 2010, the memoranda of understanding were implemented in Greece as a measure of fiscal adjustment. Public pharmaceutical expenditure was one of the main focuses of this implementation. Numerous policies, targeted on pharma spending, reduced the pharmaceutical budget by 60.5%. Yet, generics' penetration in Greece remained among th...

Greece has been facing a massive economic downturn during the last several years, which has several implications for living standards. This study aims to examine the relationship between several variables and self-rated health (SRH), focusing on the impact of household indebtedness on health. Our empirical strategy is based on an ordered logistic r...

Background Strokes attributed to atrial fibrillation (AF) represent a major cause of adult disability and a great burden to society and healthcare systems. Objectives Our objective was to assess the cost effectiveness of apixaban, a direct acting oral anticoagulant (DOAC), versus warfarin or aspirin for patients with AF in the Greek healthcare sett...

Objectives The aim of the study was to evaluate the cost-effectiveness (CE) of treatment with eplerenone versus standard care in adult patients with New York Heart Association class II chronic heart failure and reduced left ventricular ejection fraction from the perspective of the Greek national health care payer. Methods A discrete-event model si...

Objectives: To assess in daily practice in patients with rheumatoid arthritis (RA) the effect of treatment with first tumour necrosis factor-α inhibitor (TNFi) in quality of life (Qol), disease activity and depict possible baseline predictors for gains in Qol. Methods: Patients followed prospectively by the Hellenic Registry of Biologic Therapie...

Background The programme for fiscal consolidation in Greece has led to income decrease and several changes in health policy. In this context, this study aims to assess how economic crisis affected unmet healthcare needs in Greece. Methods Time series analysis was performed for the years 2004 through 2011 using the EU-SILC database. The dependent v...

Breast cancer is the most commonly diagnosed type of cancer in women and the primary cause of death by cancer in women globally. Early diagnosis and treatment can be achieved through screening, mainly mammographic; however, international experience has shown that women do not attend mammographic screening adequately. The aim of the present study wa...

Aim: To examine the predictors of direct costs of pediatric type 1 diabetes (T1D) in a hospital-based outpatient clinic in Greece. Methods: The outpatient records of 89 children and adolescents (mean age: 12.05 ± 5.15 y) with T1D followed in the Second Department of Pediatrics, University of Athens Medical School, were analyzed. Results: The m...

Introduction: Heart failure (HF) is characterized by substantial health and economic burden, mainly attributed to increased hospitalizations and readmissions. Its diagnosis remains challenging due to the non-specific nature of the initial symptoms of the disease. Recently, scientific evidence has highlighted the potential of natriuretic peptides (...

Introduction/ Study Objectives: Promoting generics consumption is considered as a key pharmaceutical policy measure. In Greece generics penetration in the pharmaceutical market was historically low and specific measures aiming at increasing generics’ market share were implemented. The aim was to explore perceptions and experiences of physicians and...

Analyses of the medical and economic burden of chronic disorders such as systemic lupus erythematosus (SLE) are valuable for clinical and health policy decisions. We performed a chart-based review of 215 adult SLE patients with active autoantibody-positive disease at the predefined ratio of 30% severe (involvement of major organs requiring treatmen...

Purpose: More than 3 million people worldwide suffer from end-stage renal disease (ESRD). Even though regular hemodialysis is considered very costly, it is still the most commonly used method of treatment in Greece. The aim of this study is to provide a current estimate of the annual patient cost for ESRD-related regular hemodialysis, especially d...

Objective: To compare both economic and clinical impact of alternative cervical cancer (CC) screening strategies for women 25 to 65 years old using different algorithms with primary screening methods including cytology alone or hrHPV test and genotyping. Methods: Screening and diagnosis of CC were modeled by a decision tree while the natural histo...

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