John De la ParraThe Rockefeller Foundation · Food Initiative
John De la Parra
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Citations since 2016
16 Research Items
Dr. John de la Parra is an ethnobotanist and plant chemist with expertise in food crops and medicinal plants. His research has focused on new techniques for the optimization of valuable chemical attributes of plants in field and controlled environment agriculture, as well as the promotion of a sustainable food system that includes the knowledge held by indigenous populations.
A number of experiments have recently focused on melting transitions near room temperature of supported bismuth clusters, which is in marked contrast to the melting point of the bulk (544K). In order to understand the size dependence of the temperature effect, we are preparing to carry out Monte Carlo simulations of the caloric curves for large bis...
Bacterial pathogens have evolved to regulate virulence gene expression at critical points in the colonization and infection processes to successfully cause disease. The Shigella species infect the epithelial cells lining the colon to result in millions of cases of diarrhea and a significant global health burden. As antibiotic resistance rates incre...
p>A student-led research seminar was utilized to develop and validate an innovative 4-part undergraduate chemistry laboratory module that exposes students to a more environmentally benign method for the extraction and analysis of pharmaceutical-precursor alkaloids from the leaves of a medicinal plant, the Madagascar periwinkle. This plant is well k...
The present invention relates methods of detecting, diagnosing, and treating diabetes and prediabetes in women. Provided herein are methods of treating diabetes in a human female subject, comprising obtaining a sample of the female subject's menstrual fluid; separating proteins of the menstrual fluid; measuring the presence, absence, or level of g...
The Shigella species are Gram-negative, facultative intracellular pathogens that invade the colonic epithelium and cause significant diarrheal disease. Despite extensive research on the pathogen, comprehensive understanding of how Shigella initiates contact with epithelial cells remains unknown. Shigella maintains many of the same Escherichia coli...
Ethnobotany (the scientific study of traditional plant knowledge) has aided the discovery of important medicines. However, as single-molecule drugs or synergistic mixtures, these remedies have faced obstacles in production and analysis. Now, advances in bioreactor technology, metabolic engineering, and analytical instrumentation are improving the p...
Controlled Biosynthesis and Diversification of Plant-Derived Pharmaceuticals
In this curriculum reform we are seeking to redesign learning in the general chemistry laboratory making use of the unique attributes of this environment to introduce experiential learning early in the laboratory curriculum and to link students’ laboratory work with active departmental research. We focused on development of core skills such as inqu...
A desire for resource sharing and the discovery of converging interests has led to the development of a strong relationship between a research laboratory and a curriculum committed to bringing real-world science to advanced undergraduate students. Many principles covered in a first year college chemistry course may seem abstract to students new to...
This plant was found to contain novel compounds that may have exhibited some anti-trypanosomal activity.
J Nat Prod. 1994 Jul;57(7):917-23.
Novel bioactive diterpenoids from Aframomum aulacocarpos.
Ayafor JF1, Tchuendem MH, Nyasse B, Tillequin F, Anke H.
This plant (a tropical weed) reportedly produces high levels of vindoline and catharanthine. (Plant Sci. 2001 Apr;160(5):971-977. Terpenoid indole alkaloid profile changes in Catharanthus pusillus during development. Zárate R, Dirks C, van der Heijden R, Verpoorte R.)
African Sleeping Sickness (Western) is caused by the protozoan Trypanosoma brucei gambiense and is transmitted by the tsetse fly (genus Glossina). It constitutes 98% of all cases (WHO). African Sleeping Sickness (Eastern) is caused by the protozoan Trypanosoma brucei rhodesiense. I am looking for traditional plant based therapies for this disease.