John Dashe

John Dashe
Wolters Kluwer Health · UpToDate

MD, PhD

About

20
Publications
1,462
Reads
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1,894
Citations
Citations since 2017
1 Research Item
316 Citations
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201720182019202020212022202301020304050
201720182019202020212022202301020304050
Additional affiliations
August 1994 - January 1999
Beth Israel Deaconess Medical Center
Position
  • Neurologist

Publications

Publications (20)
Article
Most strokes are attributed to atherosclerosis of neck and intracranial arteries, brain embolism from the heart, and penetrating artery disease; these are discussed in detail in many other books. This compendium fills an important niche by providing authoritative discussions on the other, less common causes of stroke, including various forms of ang...
Article
Micronutrient status can affect cognitive function in the elderly; however, there is much to learn about the precise effects. Understanding mediating factors by which micronutrient status affects cognitive function would contribute to elders' quality of life and their ability to remain in the home. The Nutrition, Aging, and Memory in Elders (NAME)...
Article
Among 407 New England Medical Center Posterior Circulation registry patients, 59% had strokes without transient ischemic attacks (TIAs), 24% had TIAs then strokes, and 16% had only TIAs. Embolism was the commonest stroke mechanism (40% of patients including 24% cardiac origin, 14% intraarterial, 2% cardiac and arterial sources). In 32% large artery...
Article
Inflammatory response is a critical component of the complex pathophysiological response to stroke. Vitamin C has been shown to have important roles in cell performance and vascular function. In this study, we compared the nutritional status and levels of inflammatory markers between stroke cases and controls and assessed which antioxidant was asso...
Article
Full-text available
Recent electrophysiological and histopathological reports point to motor neurons in the anterior horn of the spinal cord and the brainstem as targets of severe West Nile virus (WNV) infection. We report histopathological confirmation of this poliomyelitis-like syndrome in a patient with WNV infection in Massachusetts.
Article
We examined the effect of the neuroprotective and neuroreparative agent citicoline on the growth of cerebral ischemic lesions in a double-blind placebo-controlled study involving patients with acute ischemic stroke using diffusion-weighted magnetic resonance imaging (DWI). Patients with acute ischemic stroke symptom onset 24 hours or less before th...
Article
The aim of this study was to describe the clinico-radiological correlations of magnetic resonance (MR) perfusion and diffusion-weighted imaging (DWI) abnormalities in ischemic stroke. Eighteen patients had undergone MR imaging and clinical evaluation within 24 h of symptom onset and at or after 7 days. During the first 24 h the volume of perfusion...
Article
Several issues regarding ethnic-cultural factors, sex-related variation, and risk factors for stroke have been described in the literature. However, there have been no prospective studies comparing ethnic differences and stroke subtypes between populations from South America and North America. It has been suggested that natives from Buenos Aires, A...
Article
We examined the effect of the neuroprotective and neuroreparative agent citicoline on the growth of cerebral ischemic lesions in a double-blind placebo-controlled study involving patients with acute ischemic stroke using diffusion-weighted magnetic resonance imaging (DWI). Patients with acute ischemic stroke symptom onset 24 hours or less before th...
Article
Full-text available
The pathophysiology of borderzone infarcts is not well understood. We investigated whether combined diffusion-weighted imaging (DWI) and perfusion-weighted imaging (PWI) could identify pathophysiologically meaningful categories of borderzone infarcts. Seventeen patients with borderzone infarcts were identified from the Beth Israel Deaconess Medical...
Article
For large-scale stroke studies a measure of clinical neurological severity is often needed but may not be available. This issue has recently been addressed by Goldstein and Chilukuri [1] who described a number of stroke outcome studies that were limited by the lack of such a clinical measure of clinical severity. The authors demonstrated that a mod...
Article
This article has no abstract; the first 100 words appear below. Presentation of Case A 13-year-old right-handed girl was admitted to the hospital because of a relapsing–remitting neurologic disorder. She had had a normal childhood, although she was awkward at running, bicycle riding, and gymnastics. Twenty-six months before admission, she had an ac...
Article
To clarify the perioperative stroke risk in patients with carotid stenosis or occlusion having coronary artery bypass graft (CABG) surgery, we retrospectively reviewed the records of 1,022 patients who had CABG during a 2-year period (1992, 1993). Of these, 224 had preoperative carotid duplex studies, usually for bruit or remote symptoms. We analyz...
Article
Perfusion and diffusion-weighted magnetic resonance imaging (MRI) can demonstrate, respectively, cerebral ischemia and ischemic brain injury in the first several hours after onset of symptoms, when proton density and T2-weighted MRI may appear normal. It is hypothesized that these techniques could distinguish regions destined for infarction from th...
Article
Degenerating geniculate axon terminals in cat striate cortex have been previously described as electron-dense. After electrolytic lesion of the lateral geniculate nucleus, we observed degenerating terminals in layer 4 of striate cortex which were electron-lucent. The lucent terminals --which co-exist with the dense terminals--are characterized by a...

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