John Bradley

Pfizer · Global Innovative Pharma

Chinese translation Many patients with rheumatoid arthritis (RA) do not achieve adequate and safe responses with disease-modifying antirheumatic drugs (DMARDs). Tofacitinib is a novel, oral, Janus kinase inhibitor that treats RA. To evaluate the efficacy and safety of tofacitinib in combination with nonbiologic DMARDs. 1-year, double-blind, randomi...

Inflammation is associated with dysfunctional HDL. Rheumatoid arthritis (RA) is a chronic inflammatory disease with significantly elevated cardiovascular risk in spite of low LDL and HDL cholesterol (C) levels. Using stable isotope methods, we examined underlying metabolic mechanisms for the reduced cholesterol levels in active RA and for the chang...

Background: Rheumatoid arthritis is a heterogeneous chronic disease, and no therapeutic agent has been identified which is universally and persistently effective in all patients. We investigated the effectiveness of tofacitinib (CP-690,550), a novel oral Janus kinase inhibitor, as a targeted immunomodulator and disease-modifying therapy for rheuma...

Table S1. Characteristics and main findings of studies included in the analyses. Description: Microsoft Word table containing the following information for each of the 28 studies included in the analyses: study publication(s); study design; anti-tumor necrosis factor (anti-TNF) groups (anti-TNF naïve, first-, second- or third-time switchers and the...

The long-term treatment of rheumatoid arthritis (RA) most often involves a sequence of different therapies. The response to therapy, disease progression and detailed knowledge of the role of different therapies along treatment pathways are key aspects to help physicians identify the best treatment strategy. Thus, understanding the effectiveness of...

Objective: To study the clinical effectiveness of Swedish massage in fibromyalgia syndrome [FMS]. Methods: Swedish massage [SM] was compared with standard physician care [SC] without or with interim follow-up telephone calls [SCPC] in 37 subjects. Results: Baseline Arthritis Impact Measurement Scales [AIMS] of physical activity, depression, anxiety...