John Baeten

• Biomedical Engineer
• Marquette University

Objective: The aim of this study was to introduce a gelatin/bovine serum albumin (BSA) tissue standard, which provides dissolution properties identical to those of biological tissues. Further, the study evaluated whether the utilization of endodontic activating devices led to enhanced phantom dissolution rates. Materials and methods: Bovine pulp...

Abstract Purpose Currently available oral cancer screening adjuncts have not enhanced clinical screening methods due to high false positives and negatives, highlighting the need for a molecularly specific technique for accurate screening of suspicious oral lesions. The purpose of this study was to evaluate the in vivo screening accuracy of an oral...

Objectives: To evaluate SmearOFF, 7% maleic acid (MA) and two different preparations of ethylenediaminetetraacetic acid (EDTA) in smear layer removal. Materials and methods: Fifty single-rooted teeth were separated into five groups, instrumented and irrigated as follows: (1) SmearOFF, (2) 7% MA, (3) 18% EDTA (pH 11.4), (4) 17% EDTA (pH 8.5) and (5)...

Preheating of dental composites enhances their flowability and can improve marginal adaptation and decrease voids leading to more successful restorations. The aim of this research is to study the influence of preheating temperature on the rheological properties of four contemporary nanohybrid dental resin composites. The rheological measurements on...

Objective: This study evaluated intracanal smear layer removal using syringe and needle irrigation (ie, conventional irrigation [CI]) with and without adjunctive activation using EndoActivator® or EndoUltra®. Materials and methods: Thirty-five premolars were divided into three experimental groups (n = 10) and a control (n = 5): (1) CI, (2) CI pl...

Oral and pharyngeal cancers combined rank within the top ten most common malignancies in the world for men, with an estimated global incidence of oral cancer alone at approximately 275,000 [1]. Over 90 % of oral cancers affecting the lips, gingiva, tongue, buccal mucosa, floor of mouth and hard palate arise from the squamous epithelium and are thus...

Background: Aberrant sialylation is accepted as a carcinogenic biomarker. In previous work, fluorescently labeled wheat germ agglutinin (WGA) distinguished between cancerous and normal oral biopsies. The purpose of this study was to investigate WGA-fluorescein isothiocyanate (FITC) as a point-of-care tool for detecting oral malignant and dysplasti...

Background: Oral cancer is the sixth most common cancer in the US and the third most prevalent cancer in developing countries [1]. Many oral cancers are diagnosed late stage, resulting in poor patient prognosis and a low five year survival rate [1]. This is primarily due to lack of methods to detect/distinguish the multitude of normal and benign va...

A generally non-acidic hemostatic agent, having a relatively neutral pH comprising a magnesium compound, such as a magnesium chloride, a magnesium sulfate and/or a magnesium acetate based compound. The resultant agent is generally less caustic than previous agents, when using a similar amount of active material.

Aberrant glycosylation during carcinogenesis results in altered glycan expression on oral cancer cells. The objective of this study was to detect this atypical glycosylation via imaging of fluorophore-conjugated lectins. Paired normal and tumor tissue from seven patients with oral squamous cell carcinoma were investigated for sialic acid expression...

Objectives: Optical molecular imaging has the potential to detect precancerous/cancerous changes prior to development of clinically obvious lesions by resolving disease specific molecular probes. Alteration of carbohydrate profiles on the cell surface offer a novel class of biomarkers, since aberrant glycosylation occurs in carcinogenesis. Lectins,...

Aberrant glycosylation during carcinogenesis results in altered glycan expression on oral cancer cells. The objective of this study was to detect this atypical glycosylation via imaging of fluorophore-conjugated lectins. Paired normal and tumor tissue from seven patients with oral squamous cell carcinoma were investigated for sialic acid expression...

Since optoacoustic tomography is considered a high-resolution modality, determination of the absolute detection limit, as it relates to the sensitivity of biomarker detection is not straightforward. This is due to the fact that experimental determination of the sensitivity as a function of target size remains difficult since no established techniqu...

Optical imaging of breast cancer has been considered for detecting functional and molecular characteristics of diseases in clinical and preclinical settings. Applied to laboratory research, photonic investigations offer a highly versatile tool for preclinical imaging and drug discovery. A particular advantage of the optical method is the availabili...

Optoacoustic imaging is emerging as a noninvasive imaging modality that can resolve optical contrast through several millimeters to centimeters of tissue with the resolution achieved by ultrasound imaging. More recently, applied at multiple illumination wavelengths, multispectral optoacoustic tomography (MSOT) offered the ability to effectively vis...

The availability of fluorescence standards is necessary in the development of systems and methods for fluorescence imaging. In this study, two approaches for developing diffuse fluorescence materials to be used as standards or phantoms in diffuse fluorescent tomography applications were investigated. Specifically, silicone rubber and polyester cast...