Johannes Steinhard

Johannes Steinhard
Ruhr-Universität Bochum | RUB · Fetal Cardiology-Zentrum für Angeborene Herzfehler-HDZ-NRW Bad Oeynhausen

MD

About

200
Publications
14,323
Reads
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834
Citations
Introduction
Multicenter Study: Tissue Doppler Imaging in Fetal Echo Fetal Cardiac Imaging Research Group Germany watch: youtube: fcirg
Additional affiliations
January 2020 - present
Center of Prenatal Medicine and Human Genetics Münster
Position
  • Practice Owner
February 2012 - present
Ruhr-Universität Bochum
Position
  • Head of Department
June 2011 - present
Center of Prenatal Medicine and Human Genetics Münster
Position
  • Partner
Education
October 1988 - June 1995
University of Münster
Field of study
  • Medicine

Publications

Publications (200)
Article
Objective The aim of the work was to provide an overview of currently available applications of artificial intelligence (AI) and simulation techniques in prenatal medicine with a focus on potentially improving education and training.Methods Existing AI applications and simulators in prenatal medicine are presented based on examples and studies.Conc...
Article
Full-text available
The aim of this study was to identify growth-restricted fetuses using biometric parameters and to assess the validity and clinical value of individual ultrasound parameters and ratios, such as transcerebellar diameter/abdominal circumference (TCD/AC), head circumference/abdominal circumference (HC/AC), and femur length/abdominal circumference (FL/A...
Article
Full-text available
Purpose Aim of our study was to compare the prognostic value of the Umbilical-to-Cerebral ratio (UCR) directly to the Cerebroplacental ratio (CPR) in the prediction of poor perinatal outcomes in pregnancies complicated by Fetal Growth Restriction (FGR). Methods A retrospective study was carried out on pregnant women with either a small-for-gestati...
Article
Full-text available
Objective To compare the fetal brain structures assessed in routine sonographic scans during the second and third trimesters in fetuses with and without congenital heart disease (CHD). Methods This is a retrospective cross-sectional single-center study. We measured the head circumference (HC), the transversal diameter of the cerebellum (TCD) and t...
Article
Objectives To assess the influence of frame rate settings on longitudinal strain (LS) and mechanical synchrony (SYN) values in Speckle Tracking Echocardiography (STE) of healthy fetuses. Methods In this prospective study, we collected transversal or apical four-chamber-views of 121 healthy fetuses between 20 and 38 weeks of gestation using three d...
Article
Objectives The aim of this study was to compare the second trimester thymus-thorax-ratio (TTR) between fetuses born preterm (study group) and those born after 37 weeks of gestation were completed (control group). Methods This study was conducted as a retrospective evaluation of the ultrasound images of 492 fetuses in the three vessel view. The TTR...
Article
Objectives: The aim of this study was to investigate the correlation between fetal thymus size measured during first-trimester screening and chromosomal anomalies. Methods: This study is a retrospective evaluation, in which the anterior-posterior diameter of the thymus in a midsagittal plane was measured in first-trimester ultrasound between 11+...
Article
Full-text available
PurposeThe aim of our study was to compare the maternal arterial stiffness in pregnant women with diabetic disease, hypertension and those with normal pregnancies.MethodsA cross-sectional study was performed involving 65 pregnant women with diabetic disease (DD group), 26 pregnant women with hypertension (RR group) and 448 women with normal pregnan...
Article
Objective To reveal the effect of a maternal human immunodeficiency virus (HIV) infection on the fetal thymus size. Methods The sonographic fetal thymus size was measured retrospectively in 105 pregnancies with maternal HIV infection and in 615 uncomplicated singleton pregnancies. The anteroposterior thymic and the intrathoracic mediastinal diamet...
Article
Background The aim of this study was to compare transabdominal and transcervical chorionic villus sampling (CVS) as well as amniocentesis (AC) with respect to their rates of premature delivery and fetal growth restriction. Methods We retrospectively evaluated the mentioned procedures of invasive prenatal testing performed in a single center betwee...
Article
Objective To compare myocardial strain and mechanical dyssynchrony in fetuses with congenital heart disease (CHD) to normal controls using speckle tracking echocardiography (STE). Methods In this comparative cross-sectional study 23 fetuses with CHD and 105 normal controls between 19 and 41 weeks of gestation were assessed with STE. The STE sample...
Poster
Full-text available
Die indirekte Messung der mechanischen atrioventrikulären Überleitungszeit (AVÜ) mittels Tissue Doppler Imaging, abgeleitet aus dem mittleren Anteil des RV-Myokards in einem apikalen Vier-Kammer-Blick (VKB), zeigte Überlegenheit gegenüber mit konventionellem Doppler ermittelten Intervallen.
Article
Full-text available
Purpose: The aim of our study was to compare thymus sizes in foetuses conceived using assisted reproductive technologies (ART) to those conceived naturally (control group). Methods: Sonographic foetal thymus size was assessed retrospectively in 162 pregnancies conceived using ART and in 774 pregnancies conceived naturally. The anteroposterior th...
Article
Objective To compare the fetal brain structures assessed in routine sonographic scans during the second and third trimesters in diabetic and normal pregnancies. Methods In this retrospective study, we measured the head circumference (HC), the transversal diameter of the cerebellum (TCD) and the sizes of the cisterna magna (CM), the cavum septi pel...
Article
Full-text available
Aims To determine if atrial tissue deformation (peak strain, PS) and time to peak strain (TTPS) can be assessed in the fetus, with identification of best echocardiographic plane. Materials and methods Pulsed-wave tissue Doppler study of a longitudinal and a transverse four-chamber view (FCV) in each of 20 healthy fetuses. Determination of PS and T...
Data
Sample curves of one heart cycle of peak longitudinal strain. The colours of the graphs correspond to the respective regions of interest (ROI): red, ROI 1 (right atrium); green, ROI 2 (left atrium). (EPS)
Data
Patient information and data of echocardiographic atrial measurements. (XLS)
Article
Full-text available
PurposeTo study the role of the TTR-RBP4-ROH complex components (transthyretin, serum retinol binding protein, retinol) and of angiogenic factors PlGF (placental growth factor) and sFlt-1 (soluble fms-like tyrosine kinase-1) in pregnancies complicated by small for gestational age infants (SGA). Methods Case control study conducted on maternal serum...
Article
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Purpose: To investigate the relationship between the thorax diameter and defect diameter of giant omphaloceles as a predictor for fetal outcome. Methods: In a retrospective study, 17 fetuses with isolated giant omphaloceles were included for evaluation. The anterior-posterior thorax diameter and the defect diameter were measured from ultrasound...
Article
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Purpose: To construct biventricular reference ranges for isovolumic time intervals (isovolumic contraction time, ICT; isovolumic relaxation time, IRT) and ejection time (ET) for colour tissue Doppler imaging (cTDI) between 15 and 37 weeks' in healthy fetuses. Methods: This was a prospective multicentre cross-sectional study involving 160 singlet...
Article
Purpose: Reference charts for biometric parameters are a substantial implement of prenatal ultrasound screening. Inaccurate reference charts lead to fault clinical decisions. In our daily practice we observed an over- and underestimation of biometric parameters. The aim of this study was to derive reference charts between the 15th and 20th weeks of...
Article
Full-text available
Purpose: To improve the outcome of fetuses with gastrochisis several studies evaluated prenatal predictors. But there are different guidelines established and therefore the prenatal care is not standardized. With our study we wanted to evaluate the outcome of fetuses with gastroschisis after modification of prenatal management strategies at the De...
Article
Objective: The aim of this study was to derive reference charts between the 15th and 20th week of gestation for biparietal diameter (BPD), occipito-frontal diameter (OFD), head circumference (HC), abdominal circumference (AC) and femur length (FL) compared to commonly used curves and to evaluate the impact of maternal body mass index (BMI), ultras...
Article
Objective: The levoatriocardinal vein is a pulmonary-systemic connection that provides an alternative drainage for pulmonary venous blood in left-sided obstructive lesions. It is thought to result from the persistence of anastomotic channels that connect the capillary plexus of the embryonic foregut to the cardinal veins. There are only few reports...
Article
Purpose: To assess the time intervals of the cardiac cycle in healthy fetuses in the second and third trimester using color tissue Doppler imaging (cTDI) and to evaluate the influence of different sizes of sample gates on time interval values. Materials and Methods: Time intervals were measured from the cTDI-derived Doppler waveform using a small a...
Article
Objective: The aim of this study was to compare transabdominal chorionic villus sampling, transcervical chorionic villus sampling and amniocentesis with respect to their total fetal loss rates. Methods: We retrospectively evaluated procedures of invasive prenatal testing performed during a 14-year period (2001-2014) including 936 amniocentesis p...
Article
Purpose To evaluate pre- and post-procedure myocardial function in monochorionic twins with TTTS who underwent laser ablation of placental anastomoses using pulsed wave tissue Doppler imaging (pw TDI). Materials and Methods 20 monochorionic twin gestations with TTTS were included and underwent laser ablation at our center between 2011 and 2014. Pri...
Article
Ziel: Die Wave Intensity (WI) Analyse ist eine neue nicht-invasive sonographische Methode zur Untersuchung des Zusammenhangs zwischen der Blutflusswelle und der Gefaswandsteifigkeit. Ziel der Studie ist die Messung des Augmentation Index und der Pulswellengeschwindigkeit mittels WI Analyse in der Arteria carotis communis im Schwangerschaftsverlauf....
Article
Postnatal outcome of fetuses with hypoplastic left heart syndrome (HLHS) is mainly determined by right ventricular function. Our study examines, whether there are differences in the right ventricular function of fetuses with HLHS compared to healthy fetuses during gestation. A prospective study was conducted including 20 fetuses with HLHS and 20 ge...
Article
Purpose: To examine the relationship between cardiac tissue Doppler and peripheral vascular Doppler measurements in fetal anemia. Materials and methods: We analyzed high frame rate cardiac Tissue Doppler Imaging (TDI) data files of 26 anemic fetuses. The peak systolic tissue velocity (PSV), peak systolic displacement (PD), and peak systolic stra...
Article
Ziel: Stenose oder vorzeitige Verschluss des Ductus arteriosus (DA) sind seltene Ereignis wahrend des fotalen Lebens, die oft zu fetaler und neonataler Morbiditat und Mortalitat fuhrt. Ursachlich wurden Medikamenteeinnahmen (FANS, besonders Indometacin und Kortikosteroide), Ernahrungseinflusse (Polyphenol-reiche Lebensmittel, Teesorten), strukturel...
Article
Fragestellung: Evaluierung der Korrelation zwischen cTDI Messungen des ventrikularen Myokards gesunder Feten und gewahlter ROI-Grose. Methodik: Praliminare prospektive multizentrische cTDI Querschnittsstudie an 40 gesunden Feten. Alle eingeschlossenen Feten waren gesund, im Sinusrhythmus und wiesen ein strukturell regelrechtes Herz auf. Alle Unters...
Article
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Ziel: Wir beschreiben weltweit erstmalig den Einsatz der von uns entwickelten „Butterfly“-Methode in der fetalen M-Mode Echokardiografie zur erweiterten Diagnostik von fetalen Herzrhythmusstorungen und dem Cropping zur prazisen Definition eines fetalen Herzzykluses in unterschiedlichen Softwaretools verschiedener Ultraschallhersteller. Methodik: Ve...
Article
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Aims: To evaluate the intra-operator reliability of tissue Doppler imaging-based quantitative cervical elastography in at-term pregnancies. Methods: Three series of two cycles of manual gentle compression-relaxation of the cervix were performed by one gynecologist in 11 consecutive at-term pregnancies through the vaginal probe. The compression m...
Article
Objectives: The purpose of this study is to evaluate the cardiac function in anemic fetuses by tissue Doppler imaging (TDI) measuring the myocardial peak systolic strain (PS) in fetuses before and after intrauterine transfusion (IUT) of red blood cells. Methods: In our prospective clinical study in anemic fetuses, high-frame-rate TDI data files...
Article
Full-text available
Purpose: To evaluate the reliability of cervical elastography as a new ultrasound tool for cervical stiffness assessment in pregnancy. Materials and methods: Pilot prospective cohort study including 10 consecutive unselected pregnancies in the late first and second trimester. Ultrasound was performed by two blinded experienced operators using a...
Article
Early expression of syndecan-1, a regulator of growth factor and chemokine function, in animal and human abortuses or placenta at delivery suggests a potential role during embryonic development. The aim of this study was to examine the correlation between early placental syndecan expression and fetal outcome in ongoing pregnancies. Prospective immu...