Johannes Petzold

Johannes Petzold
Universitätsklinikum Carl Gustav Carus Dresden · Klinik und Poliklinik für Psychiatrie und Psychotherapie

MD PhD

About

40
Publications
3,784
Reads
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126
Citations
Additional affiliations
April 2020 - September 2021
University of California, Los Angeles
Position
  • PostDoc Position
July 2014 - February 2020
Universitätsklinikum Carl Gustav Carus Dresden
Position
  • Medical Doctor

Publications

Publications (40)
Article
Methamphetamine use is surging globally as a cause of morbidity and mortality. Treatment is typically sought in early abstinence, when craving and depressive symptoms are intense, contributing to relapse and poor outcomes. To advance an understanding of this problem and identify therapeutic targets, we conducted a retrospective analysis of brain st...
Article
Full-text available
Background Integrated care is a promising model for pregnant and parenting women with problems related to methamphetamine use. Yet more research is imperative to guide services for this vulnerable population as methamphetamine use contributes to housing instability, which is associated with heavier use and overdose death. Method This prospective o...
Article
Full-text available
Background: Methamphetamine use is a rapidly increasing cause of morbidity and mortality. Pregnant women and new parents who consume methamphetamine are at high risk since they seldom seek health services despite having multiple needs. We addressed this care gap by implementing an easily accessible program that pools resources from psychiatric, obs...
Preprint
Full-text available
Previous studies indicate a role of dopamine in hippocampus-dependent spatial navigation. Although neural representations of direction are an important aspect of spatial cognition, it is not well understood whether dopamine directly affects these representations, or only impacts other aspects of spatial brain function. Moreover, both dopamine and s...
Article
Full-text available
Rationale Inhibition is a core executive function and refers to the ability to deliberately suppress attention, behavior, thoughts, and/or emotions and instead act in a specific manner. While acute alcohol exposure has been shown to impair response inhibition in the stop-signal and Go/NoGo tasks, reported alcohol effects on attentional inhibition i...
Article
Full-text available
Background: It is well established that even moderate levels of alcohol affect cognitive functions such as memory, self-related information processing and response inhibition. Nevertheless, the neural mechanisms underlying these alcohol-induced changes are still unclear, especially on the network level. The default mode network (DMN) plays an impor...
Article
Methamphetamine abuse leads to devastating consequences, including addiction, crime, and death. Despite decades of research, no medication has been approved by the U.S. Food and Drug Administration for the treatment of Methamphetamine Use Disorder. Thus, there is a need for new therapeutic approaches. Animal studies demonstrate that methamphetamine...
Article
Full-text available
Methamphetamine use disorder (MUD) is increasing worldwide and commonly associated with learning deficits. Little is known the about underlying trajectories, i.e., how the affected higher-order cognitive functions develop over time and with respect to abstinence and relapse. A probabilistic reversal learning (PRL) paradigm was implemented to uncove...
Article
Perceptual decisions entail the accumulation of evidence until a decision criterion is reached. The amount of noise in this process is inversely related to the behavioral performance of the decision-maker. Hence, reducing the amount of perceived noise could improve performance in perceptual decisions. In this study, we investigated whether providin...
Article
Full-text available
AimMethamphetamine (MA) abuse and dependence are increasing worldwide and are commonly associated with cognitive deficits. Some studies indicate that such impairments can improve if users become abstinent, but overall results remain inconclusive. Hence, we have performed a longitudinal case-control study investigating key surrogates for attention a...
Article
Full-text available
Background: Methamphetamine abuse is expanding in Europe, leading to a shortfall in medical care for related disorders in many regions. Research focusing on the effectiveness and feasibility of methamphetamine-specific treatment programs is scarce, especially in short-term settings. Methods: To this end, we treated 31 patients with methamphetamine...
Thesis
Full-text available
Background: The valuation of risks and the speed with which decisions are made and acted upon are important characteristics of everyone’s personality. These characteristics exist along a continuum that ranges from weak to strong expressions of impulsivity. In certain situations it is crucial to decide and react quickly. Yet these qualities can prov...
Article
Full-text available
We previously reported that L-DOPA effects on reward-based decision-making in a randomized, placebo-controlled, double-blind, crossover study were consistent with an inverted U-shaped function whereby both low and high extremes of dopamine signaling are associated with high-impulsive choice. To test this hypothesis, we performed [18F]DOPA positron...
Article
Full-text available
Background: Despite various pharmacological and psychological treatment interventions, bipolar disorders rank among the leading causes of global disease burden. Group psychoeducation has been demonstrated an effective add-on to pharmacotherapy, but it may be difficult to implement in practice depending on the clinical setting and available human r...
Article
Full-text available
Background Gallbladder cancer (GBC) is a rare neoplasia of the biliary tract with high mortality rates and poor prognosis. Signs and symptoms of GBC are not specific and often arise at late stage of disease. For this reason, diagnosis is typically made when the cancer is already in advanced stages, and prognosis for survival is less than 5 years in...
Poster
In einer randomisierten, placebokontrollierten, doppelblinden Crossover-Studie konnten wir zeigen, dass L-DOPA-Effekte auf Entscheidungsverhalten (Belohnungsaufschub, Risikoverhalten bei Gewinnen, Verlustaversion) mit einer umgekehrten U-Funktion in Einklang zu bringen ist, in der eine niedrige als auch eine hohe Dopaminaktivität mit impulsiven Ent...
Article
Full-text available
In experimental psychology, subjects are often confronted with computer-based experimental paradigms. Creating such paradigms can require a lot of effort. PyParadigm is a newly developed Python library to ease the development of such paradigms by employing a declarative approach to build user interfaces (UIs). Paradigm specifications in this approa...
Article
Full-text available
Research has indicated a major role of dopamine in decision-making processes, but the underlying mechanisms remain largely unknown due to inconsistency in effects of dopaminergic drugs. To clarify the impact of dopamine on impulsive choice, we administered 150 mg L-DOPA to 87 healthy adults in a randomized, placebo-controlled, double-blind, crossov...
Article
Full-text available
Background Alterations of mental status are characteristic of psychiatric disorders but may also result from a multitude of organic causes. Generally, physical examination and blood analysis are a part of basic psychiatric differential diagnostics, whereas more sophisticated procedures (for example, brain imaging) are applied only in cases with pat...
Article
Zusammenfassung Lithium ist der Goldstandard in der Phasenprophylaxe Bipolarer Störungen und das einzige Medikament für das es eine überzeugende suizidpräventive Wirkung bei affektiven Erkrankungen gibt. Unter Berücksichtigung eines regelmäßigen Monitorings ist Lithium eine zumeist gut verträgliche und sichere Phasenprophylaxe, die nach sorgfältige...
Article
Full-text available
Biliary tract cancer (BTC) represents a malignant tumor of the biliary tract including cholangiocarcinoma (CCA) and the carcinoma of the gallbladder (GBC) with a 5-year survival rate between 5 and 18% due to late diagnosis and rapid disease progression. Chronic inflammation is one of the main risk factors for CCA and GBC in particular. IL-6, as a m...
Poster
Effektivität von Gruppenpsychoedukation und elektronischem Tagebuch bei bipolarer Störung – eine multizentrische, randomisierte, kontrollierte Studie
Poster
A multicenter randomized controlled trial of psychoeducational group therapy followed by daily mood charting in the long-term treatment of bipolar disorder
Article
Full-text available
Overexpression of the oncofetal insulin-like growth factor 2 mRNA-binding protein 2 (IMP2/IGF2BP2) has been described in different cancer types. Gallbladder carcinoma (GBC) is a rare but highly aggressive cancer entity with late clinical detection and poor prognosis. The aim of this study was to investigate the role of IMP2 in human GBC. Tissue mic...
Article
Den Stellenwert von Lithium als effektivstes Medikament in der Langzeitbehandlung bipolarer Erkrankungen bestätigen aktuelle Metaanalysen. Drei neuere Studien zeichnen nun ein differenziertes und auch kontrastierendes Bild im Vergleich zu atypischen Antipsychotika.
Poster
Dopaminergic effects on value-based decision making
Presentation
The role of the JAK/STAT pathway in gallbladder cancer
Presentation
The JAK/STAT pathway is activated in gallbladder carcinoma
Poster
Full-text available
Introduction: Carcinoma of the gallbladder is the most frequent malignancy within the biliary tract. Due to its very poor outcome, alternative therapeutic strategies, in particular based on the modulation of molecular pathways, are urgently required. The proto-oncogenic PI3K/Akt/mTOR pathway plays an important role in many human cancers, but especi...
Thesis
Full-text available
Introduction: Biliary tract cancer and its most frequent type, gallbladder cancer, are relatively seldom diseases with a very poor outcome. There are high risk areas, and the global incidence will increase notably in the future. The tumor suppressor PTEN and the proto-oncogenic PI3K/Akt pathway play an important role in many human cancer entities....

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