Johanna J M Takkenberg

Johanna J M Takkenberg
Erasmus MC | Erasmus MC · Department of Cardio-Thoracic Surgery

Professor

About

364
Publications
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17,413
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Publications

Publications (364)
Article
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Introduction This study aims to provide an overview of outcomes after right ventricular outflow tract (RVOT) reconstruction using different valve substitutes in different age groups for different indications. Methods The literature was systematically searched for articles published between January 2000 and June 2021 reporting on clinical and/or ec...
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Objectives: The emergence of big cardio-thoracic surgery datasets that include not only short-term and long-term discrete outcomes but also repeated measurements over time, offers the opportunity to apply more advanced modeling of outcomes. This article presents a detailed introduction to developing and interpreting linear mixed-effects models for...
Article
Purpose Right heart failure is a major contributor to mortality and morbidity after left ventricular assist device implantation (LVAD). Previously our group developed a logistic regression-based model to predict right heart failure (RHF)after LVAD implantation, the EUROMACS RHF Risk Score, with currently the best but yet moderate discriminative abi...
Article
The aim of this study was to improve insight into male-female differences in patients undergoing ascending aortic aneurysm surgery. Consecutive patients that underwent ascending aortic aneurysm surgery between 01/1991-12/2016 were retrospectively analyzed. Patient and procedural characteristics, 30-day mortality, and survival were compared between...
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Background and objectives In personalised external aortic root support (PEARS), a custom-made, macroporous mesh is used to stabilise a dilated aortic root and prevent dissection, primarily in patients with genetically driven aortopathies. Data are needed on the safety and postoperative incidence of aortic events. Methods We present a multicentre...
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Importance: There is no ideal valve substitute for young adults requiring aortic valve replacement. Multicenter data supporting use of the Ross procedure with respect to long-term postoperative valve-related mortality and reintervention, as well as function of the autograft and pulmonary homograft, are needed. Objective: To determine the long-te...
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Background: In response to an increased need for patient information in congenital heart disease, we previously developed an online, evidence-based information portal for patients with congenital aortic and pulmonary valve disease. To assess its effectiveness, a stepped-wedge cluster randomised trial was conducted. Methods: Adult patients and ca...
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This heart team review gives an overview of the current status of SDM in heart teams, and investigates the perceived needs for implementation of a SDM approach in clinical practice through an exploratory cross-sectional survey (N=101) and in-depth interviews (N=9) among an international community of heart team physicians specialized in HVD. Althoug...
Article
Background Aortic diameters are known to increase with age. However, longitudinal data on normal thoracic aortic growth rate over the adult life course are lacking. To better understand and recognize pathological aortic growth and factors influencing aortic dilatation, it is crucial to study aortic growth patterns in the general population. Purpos...
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Objective Thoracic aortic disease (TAD) may have substantial impact on health-related quality of life (HRQOL). We described HRQOL in patients with TAD, cardiovascular screening participants and their partners; identified factors associated with HRQOL; and explored lived experiences and feelings of anxiety or depression using a mixed methods design....
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PurposeWith the increasing interest in treatment decision-making based on risk prediction models, it is essential for clinicians to understand the steps in developing and interpreting such models.MethodsA retrospective registry of 20 Dutch hospitals with data on patients treated for castration-resistant prostate cancer was used to guide clinicians...
Article
Patients with congenitally determined aortic root aneurysms are at risk of aortic valve regurgitation, aortic dissection, rupture and death. Personalised external aortic root support (PEARS) may provide an alternative to aortic root replacement. This was a multi-centre, prospective cohort of all consecutive patients who received ExoVasc mesh implan...
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OBJECTIVES Data on the impact and course of uncorrected tricuspid regurgitation (TR) during left ventricular assist device (LVAD) implantation are scarce and inconsistent. This study explores the clinical impact and natural course of uncorrected TR in patients after LVAD implantation. METHODS The European Registry for Patients with Mechanical Circ...
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Objectives Aortic valve disease is the most frequent indication for heart valve replacement with the highest prevalence in elderly. Tissue-engineered heart valves (TEHV) are foreseen to have important advantages over currently used bioprosthetic heart valve substitutes, most importantly reducing valve degeneration with subsequent reduction of re-in...
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Hereditary thoracic aortic diseases (HTAD) such as Marfan syndrome (MFS) affect multiple organ systems and provide a risk of acute aortic dissection, which causes lifelong uncertainties. Although health‐related quality of life (HRQOL) was found to be reduced in HTAD patients, no studies have evaluated male–female‐specific aspects of HRQOL and copin...
Article
Purpose Tricuspid regurgitation (TR) is common in patients with orthotopic heart transplantation (HTX). Nevertheless, the clinical impact and the long-term outcome of TR remains controversial. In this study we aim to elucidate the clinical impact and long-term outcome of TR, taking into account its dynamic nature. Methods All consecutive adults pa...
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Objectives: This study provides an overview of the change over a 45-year time period in the characteristics and outcome of patients with tricuspid valve disease undergoing surgical tricuspid valve replacement (TVR). Methods: The characteristics and outcomes of all consecutive TVRs from November 1972 to November 2017 at Erasmus MC were collected...
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Objectives: Timing of pulmonary valve replacement (PVR) remains one of the most heavily debated topics in congenital cardiac surgery. We aimed to analyse the temporal evolution of QRS duration before and after PVR. Methods: We included 158 consecutive patients who underwent PVR after previous correction with transannular patch. All 3549 availabl...
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Background: Orthotopic heart transplantation (OHT) is the gold standard treatment in end-stage heart disease. Controversy remains whether bicaval OHT is superior to biatrial OHT in both early and late outcomes. This study aimed to provide an overview of the early and late outcomes in patients who underwent a bicaval or biatrial OHT. Methods: A s...
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Background This study evaluates clinical and echocardiographic outcomes in patients who underwent tricuspid valve replacement (TVR) for carcinoid heart disease (CaHD) stratified to prosthesis type (biological vs mechanical). Methods All patients undergoing TVR for CaHD between 1991 and 2017 were analyzed retrospectively in four tertiary centers. Co...
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Background: Risk visualizations are often employed to support risk communication. However, their effectiveness in communication of single absolute risks remains unclear. We investigated the effectiveness of risk visualizations in conveying verbatim knowledge of single absolute risks among the general population. Methods: Randomly sampled members...
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Often, in follow‐up studies, patients experience intermediate events, such as reinterventions or adverse events, which directly affect the shapes of their longitudinal profiles. Our work is motivated by two studies in which such intermediate events have been recorded during follow‐up. In both studies, we are interested in the change of the longitud...
Article
Tricuspid regurgitation (TR) is a frequent and complex problem, commonly combined with left-sided heart disease, such as mitral regurgitation. Significant TR is associated with increased mortality if left untreated or recurrent after therapy. Tricuspid regurgitation was historically often disregarded and remained undertreated. Surgery is currently...
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Objectives: Tricuspid regurgitation (TR) is common in patients receiving a left ventricular assist device (LVAD). Controversy exists as to whether concomitant tricuspid valve surgery (TVS) is beneficial in currently treated patients. Therefore, our goal was to investigate the effect of TVS concomitant with a LVAD implant. Methods: The European R...
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Introduction: This study aims to provide a contemporary overview of outcomes after tricuspid valve surgery for functional tricuspid regurgitation(TR). Methods: The literature was systematically searched for papers published between January 2005 and December 2017 reporting on clinical/echocardiographic outcomes after tricuspid valve surgery for f...
Article
Objective: To evaluate perspectives of the multidisciplinary team concerning shared decision-making (SDM) in treatment decisions for older patients with metastatic castration-resistant prostate cancer (mCRPC). Materials and methods: A survey among Dutch healthcare providers was conducted to assess healthcare providers' perspectives on patient in...
Article
Background: Although the descending aortic diameter is larger in smokers, data about thoracic aortic growth is missing. Our aim is to present the distribution of thoracic aortic growth in smokers and to compare it with literature of the general population. Methods: Current and ex-smokers aged 50-70 years from the longitudinal Danish Lung Cancer...
Article
Aortic valve surgery in non-elderly patients represents a very challenging patient population. The younger the patient is at the point of aortic valve intervention, the longer their anticipated life expectancy will be, with longer exposure to valve-related complications and risk for re-operation. Although the latest international guidelines recomme...
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Selecting the optimal surgical treatment strategy in patients below the age of 65 years (i.e., non-elderly patients) with aortic valve or aortic root disease remains challenging. The objective of the current study is to summarize contemporary research on clinical and quality of life outcomes after aortic valve replacement (AVR) and aortic root surg...
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Objectives: This study aims to explore male-female differences in baseline and procedural characteristics, and outcomes of patients undergoing isolated or concomitant tricuspid valve (TV) surgery. Methods: All TV procedures registered between 2007 and 2016 in the database of the Netherlands Association for Cardio-Thoracic Surgery were analysed....
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Purpose This study explores the course of uncorrected tricuspid regurgitation (TR) after left ventricular assist device (LVAD) implantation and the clinical impact of pre-LVAD TR on 30-day and late mortality. Methods The European Registry for Patients with Mechanical Circulatory Support (EUROMACS) was used to identify adult patients undergoing LVA...
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Introduction: Current guidelines recommend patients with thoracic aortic disease (TAD) including inherited aortopathies to avoid heavy exercise. However, evidence supporting the negative advice on exercise is scarce. We aimed to provide an up-to-date systematic review of the available evidence on risks and benefits of exercise and sports participat...
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Risk prediction models in cardiac surgery tend to lose their predictive performance over time. This statistical primer aims to provide an overview of updating methods with their strengths and weaknesses. This is important, as model updating may be an efficient and good alternative to the de novo development of risk models. The discussed methods are...
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Background To support decision-making in aortic valve replacement in nonelderly adults, we aim to provide a comprehensive overview of reported outcome after bioprosthetic aortic valve replacement and to translate this to age-specific patient outcome estimates. Methods and Results A systematic review was conducted for papers reporting clinical outc...
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OBJECTIVES Since 1988, our centre employs vertical plication repair with deattachment and reattachment of the tricuspid valve for Ebstein anomaly. This study describes the characteristics and long-term outcomes of our single-centre cohort. METHODS Data from all patients operated on between 1988 and 2016 were retrospectively collected. Kaplan–Meier...
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Background To support decision-making in aortic valve replacement in children and adults, we provide a comprehensive overview of outcome after the Ross procedure. Methods and Results A systematic search was conducted for publications reporting clinical outcome after the Ross procedure, published between January 1, 2000, and November 22, 2017. Repo...
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Background: As a living heart valve substitute with growth potential and improved durability, tissue-engineered heart valves (TEHVs) may prevent reinterventions that are currently often needed in children with congenital heart disease. We performed early health technology assessment to assess the potential cost-effectiveness of TEHVs in children r...
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Objectives: Our aim was to provide estimates of patient-reported health-related quality of life (HRQoL), use of informal care and productivity in patients after surgical aortic and pulmonary valve replacement and transcatheter aortic valve implantation. Methods: Consecutive cohorts of 1239 adult patients who had surgical aortic valve replacement...
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Background To assess the current state of patient information and decision-making in congenital aortic and pulmonary valve disease, we conducted a survey among patients, parents and physicians. Methods A questionnaire was sent by ground mail to 157 adults and 32 parents of children who previously underwent surgery for congenital aortic or pulmonar...
Article
OBJECTIVES: This study aims to explore male-female differences in baseline and procedural characteristics, and outcomes of patients undergoing isolated or concomitant tricuspid valve (TV) surgery. METHODS: All TV procedures registered between 2007 and 2016 in the database of the Netherlands Association for Cardio-Thoracic Surgery were analysed. Log...
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Objective: To support decision-making in aortic valve replacement (AVR) in elderly patients, we provide a comprehensive overview of outcome after AVR with bioprostheses. Methods: A systematic review was conducted of studies reporting clinical outcome after AVR with bioprostheses in elderly patients (mean age ≥70 years; minimum age ≥65 years) pub...
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Objectives: Current national registries are lacking detailed pathology-driven analysis and long-term patients outcomes. The Heart Valve Society (HVS) aortic valve (AV) repair research network started the Aortic Valve Insufficiency and ascending aorta Aneurysm InternATiOnal Registry (AVIATOR) to evaluate long-term patient outcomes of AV repair and...
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Objective The outcome of female patients after adult cardiac surgery has been reported to be less favourable compared with the outcome of male patients. This study compares men with women with respect to patient and procedural characteristics and early mortality in a contemporary national cohort of patients who underwent aortic valve (AV) and combi...
Article
Objectives: Although homografts are often the preferred valve conduits for right ventricular outflow tract (RVOT) reconstruction, data on long-term homograft-related outcomes, durability and impact on quality of life (QoL) are scarce. The aim of this study was therefore to describe the long-term homograft function, clinical outcomes and QoL after...
Article
Regression modelling is an important statistical tool frequently utilized by cardiothoracic surgeons. However, these models-including linear, logistic and Cox proportional hazards regression-rely on certain assumptions. If these assumptions are violated, then a very cautious interpretation of the fitted model should be taken. Here, we discuss sever...
Article
Background There is no published evidence on pregnancy after right ventricular outflow tract (RVOT) reconstruction with an allograft. Objectives The aim of this study was to describe pregnancy outcomes in women with allografts in the RVOT position. Methods A retrospective cohort study of consecutive female patients who received allografts in the...
Article
Missing data are a common challenge encountered in research which can compromise the results of statistical inference when not handled appropriately. This paper aims to introduce basic concepts of missing data to a non-statistical audience, list and compare some of the most popular approaches for handling missing data in practice and provide guidel...
Chapter
Outcomes after tricuspid valve surgery were initially extremely poor but have improved over time thanks to innovations in diagnostics, guidelines for treatment, emerging surgical experience and technical advances. This chapter provides a contemporary overview of patient and procedural characteristics of tricuspid valve repair and replacement and ea...