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Introduction
Publications
Publications (58)
Background
Clinical practice suggests that older adults (i.e., ≥ 65 years of age) experience adverse drug reactions (ADRs) more often than younger patients (i.e., < 65 years of age). ADRs such as falls, extrapyramidal symptoms (EPS), metabolic disorders, sedation, and delirium are particularly worrisome and often associated with psychotropic drugs....
The precise diagnosis of mental disorders constitutes a formidable problem. Mental disorders are currently diagnosed based on clinical symptoms, which are often subjective. Various drug classes, traditionally referred to as “antidepressants,” “antipsychotics” and “mood stabilizers” are then used empirically to treat affected patients. The previous...
Introduction Pharmacoepidemiological data suggest that lithium prescriptions for bipolar disorder are gradually decreasing, with less attention having been paid to other indications.
Methods We examined lithium prescriptions between 1994 and 2017 in data provided by the Drug Safety in Psychiatry Program AMSP, including psychiatric hospitals in Germ...
Clozapine is a second-generation antipsychotic drug that offers superior treatment results in patients with schizophrenia but is also associated with significant risks. This study analyzes data on pharmacotherapy with clozapine and the associated adverse drug reactions (ADRs) in an inpatient setting including 38,349 patients. Data about the use of...
During injury rehabilitation and return to competition, various factors impact outcomes, such as psychological parameters, sleep quality, and vitamin D levels. Studies have demonstrated that both natural and artificial daytime lighting can enhance these variables, as well as human health and performance. However, research into therapeutic methods i...
Antipsychotic drugs were originally developed to treat the positive symptoms of schizophrenia (e.g., delusions, hallucinations). Nowadays, antipsychotic drugs are also commonly used in the treatment of geriatric patients, especially those suffering from dementia. When treating behavioural symptoms of dementia, the use of antipsychotic drugs should...
Background Approximately 15–25% of depressed patients suffer from difficult-to-treat depression (DTD). Patients with DTD require a thorough examination to avoid the oversight of treatable (psychiatric/somatic) comorbidities or (pseudo-)resistance to antidepressant drugs (ADs). Polymorphisms of the cytochrome P450 (CYP) enzymes 2D6 and 2C19, which p...
Clozapin gehört zu den psychopharmakologischen Arzneistoffen mit der komplexesten Handhabung. Dies liegt maßgeblich in seinen besonderen pharmakokinetischen und pharmakodynamischen Eigenschaften begründet. Durch die Beteiligung des Cytochrom-P450-Isoenzyms 1A2 (CYP1A2) ist die Verstoffwechslung von Clozapin anfällig für störende Einflüsse unter and...
The visual system and associated skills are of particular importance in stroke rehabilitation. The process of neuroplasticity involved in restoring cognitive function during this period is mainly based on anatomical and physiological mechanisms. However, there is little evidence-based knowledge about the effects of visual skills training that could...
Background
Older patients with alcohol use disorder are at particular risk of developing adverse drug reactions due to multimorbidity, polypharmacy, and altered organ function.
Objectives
In this study, we investigated the frequency and characteristics of potentially serious alcohol–medication interactions, potentially inappropriate medications (P...
https://link.springer.com/article/10.1007/s00702-024-02738-6?utm_source=rct_congratemailt&utm_medium=email&utm_campaign=oa_20240214&utm_content=10.1007/s00702-024-02738-6
Edema as an adverse drug reaction is a commonly underestimated yet potentially debilitating condition. This study analyzes the incidence of severe psychotropic drug-induced edema...
Maximal strength is a significant factor in achieving peak performance and injury prevention in athletes. In individualization strategies for the efficient development of athletes, it is necessary to consider the respective components separately. The purpose of this study was to systematically examine the effects of the different cycle phases on is...
Background
The admission decision after presentation in the psychiatric emergency room (PER) has potentially far-reaching consequences for the patient and the community. In a short amount of time, information must be collected and evaluated for a well-founded admission decision. The present study aimed to identify risk factors associated with inpat...
Levels of state and trait anxiety are relevant for performing artists and professional athletes to obtain optimal performance outcomes. However, evidence-based knowledge regarding the effectiveness of psychological interventions on performance anxiety is currently minimal. Thus, the objective of this systematic review with meta-analysis was to char...
Background
The impact of long-term lithium treatment on weight gain has been a controversial topic with conflicting evidence. We aim to assess reporting of weight gain associated with lithium and other mood stabilizers compared to lamotrigine which is considered free of metabolic adverse drug reactions (ADRs).
Methods
We conducted a case/non-case...
Zusammenfassung
Antidepressiva, insbesondere die selektiven Serotoninwiederaufnahmehemmer (SSRI), sind die meistverordnete psychopharmakologische Arzneistoffgruppe, weshalb eine genaue Kenntnis der zu erwartenden unerwünschten Arzneimittelwirkungen unabdingbar ist. Das erhöhte Risiko für Blutungsereignisse ist vor allem bei Patienten, die mit SSRI...
Antipsychotic drugs were originally developed to treat the positive symptoms of schizophrenia (e.g., delusions, hallucinations). Nowadays, antipsychotic drugs are also commonly used in the treatment of geriatric patients, especially those suffering from dementia. When treating behavioural symptoms of dementia, the use of antipsychotic drugs should...
Mit über 2 Mrd. DDD stellen Arzneistoffe zur Behandlung der Depression, von Angststörungen, der bipolaren Störung und der Depression („Psychopharmaka“) eine der meist verordneten Arzneimittelgruppen dar. Dabei sind die seit vielen Jahren beobachteten Zuwächse vor allem auf steigende Verordnungen und Indikationsausweitungen von antidepressiven Arzne...
Neutropenia and agranulocytosis (N&A) are relatively rare, but potentially fatal adverse drug reactions (ADR). This study presents cases of N&A related to one or more antipsychotic drugs (APDs) in psychiatric inpatients. Data on APD utilization and reports of N&A caused by APDs were analyzed by using data from an observational pharmacovigilance pro...
Die umfassende Neubearbeitung des Handbuches liefert kompakte und klare Informationen zu allen in Deutschland, Österreich und der Schweiz erhältlichen Psychopharmaka. Die Einteilung der Psychopharmaka erfolgt nach dem jeweiligen Anwendungsbereich. So werden u.a. Antidepressiva, Antipsychotika, Anxiolytika, Hypnotika, Phasenprophylaktika, Substanzen...
Background
Prader–Willi syndrome (PWS) is a rare neurodevelopmental disorder based on a loss of paternally expressed genes in chromosome segment 15q11-13. Behavioral traits such as temper outbursts, stereotypic, and ritualistic behavior, as well as an increased risk of psychosis accompany the syndrome, representing a major issue in the treatment of...
The International Classification of Diseases (10 th Version) categorizes major depressive disorder (MDD) according to severity. Guidelines provide recommendations for the treatment of MDD according to severity. Aim of this study was to assess real-life utilization of psychotropic drugs based on severity of MDD in psychiatric inpatients. Drug utiliz...
Die Behandlung der Schizophrenie mit Clozapin eröffnet Chancen durch die besondere antipsychotische Wirkung, birgt aber auch durch die speziellen Risiken der Substanz Gefahren. Im vorliegenden Artikel werden die Chancen für die Behandlung, auf der anderen Seite aber auch relevante Risiken und Empfehlungen zum Umgang damit auf Grundlage des Projekts...
Dear Doctor Letters (DDLs, Direct Healthcare Professional Communications) from 2011 provided guidance regarding QTc-prolonging effects with risk of torsade de pointes during treatment with citalopram and escitalopram. This study examines the DDLs’ effects on prescription behavior. Data from 8842 inpatients treated with citalopram or escitalopram wi...
Objectives:
Successful treatment of delirium depends on the detection of the reversible contributers. Drugs with delirogenic properties are the most prevalent reversible cause of delirium.
Methods:
This observational study is based on data from AMSP (Arzneimittelsicherheit in der Psychiatrie), a multicenter drug surveillance program in German-sp...
Ziel der Studie war es zu überprüfen, ob die Verordnung „potenziell inadäquater Wirkstoffe“ (PIW) mit einem erhöhten Risiko für unerwünschte Arzneimittelwirkungen (UAW) einhergeht.
Methodik: 304 stationäre gerontopsychiatrische Patienten wurden in die Studie eingeschlossen. Anhand der klinischen Daten und Verlaufsdokumentationen wurden Hinweise auf...
Auf einen Blick
Zusammenfassung Mit weit über 2 Milliarden DDD stellen die Psychopharmaka eine der größten Arzneimittelgruppen dar. Dabei sind die seit vielen Jahren beobachteten Zuwächse vor allem auf steigende Verordnungen und Indikationsausweitungen von Antidepressiva zurückzuführen sowie geringere Zunahmen bei den Neuroleptika (Antipsychotika)....
Galactorrhea is a well-known adverse drug reaction (ADR) of numerous antipsychotic drugs (APD) and is often distressing for those affected. Methodological problems in the existing literature make it difficult to determine the prevalence of symptomatic hyperprolactinemia in persons treated with APDs. Consequently, a large sample of patients exposed...
Objectives
To investigate the relationship between patient age and the selection and dosage of antipsychotic drugs (APDs) for treatment of schizophrenia. We describe age effects for multiple individual APDs, thus allowing comparisons between drugs.
Methods
Prescription data of 32,062 inpatients with schizophrenia from 2000 to 2017 were obtained fr...
Urological adverse drug reactions (UADR) are common during treatment with psychotropic medication. The aim of this study was to provide a systematic description of the differential profile of UADR of psychotropic drugs in a large naturalistic population. Data stems from psychiatric hospitals collected by AMSP (Arzneimittelsicherheit in der Psychiat...
Posttraumatic stress disorder (PTSD) is a debilitating psychiatric disorder with limited approved pharmacological treatment options and high symptom burden. Therefore, real-life prescription patterns may differ from guideline recommendations, especially in psychiatric inpatient settings. The European Drug Safety Program in Psychiatry (“Arzneimittel...
Background
Several researchers have shown higher concentration-dose ratios of psychotropic drugs in women and the elderly. Therefore, lower dosages of psychotropic drugs may be recommended in women and the elderly. This study describes sex- and age-related dosage of psychotropic drugs prescribed to patients with major depressive disorder (MDD) in r...
Zusammenfassung
Seit Dezember 2020 stehen in der Europäischen Union Impfstoffe gegen SARS-CoV-2 zur Verfügung. Psychisch erkrankte Personen haben ein erhöhtes Risiko für einen schweren oder tödlichen Verlauf einer SARS-CoV-2-Infektion. So stellt sich die Frage, inwiefern Interaktionen zwischen den neuen SARS-CoV-2-Impfstoffen und Psychopharmaka zu...
Hyponatremia (HN) is the most common electrolyte imbalance (defined as a serum sodium concentration Na(S) of < 130 mmol/l) and often induced by drugs including psychotropic drugs. AMSP (Arzneimittelsicherheit in der Psychiatrie) is a multicenter drug surveillance program that assesses severe or unusual adverse drug reactions (ADRs) occurring during...
Studies have consistently determined that patients with acute psychosis are more likely to be involuntarily admitted, although few studies examine specific risk factors of involuntary admission (IA) among this patient group. Data from all patients presenting in the psychiatric emergency department (PED) over a period of one year were extracted. Acu...
We describe the case of a 59‐year‐old woman who exhibited psychotic symptoms, cognitive dysfunction, and restlessness. While the clinical picture and 18F‐FDG PET/CT suggested the presence of a tauopathy, especially frontotemporal dementia or progressive supranuclear palsy, genetic testing eventually revealed Huntington's disease. We describe the ca...
Objectives
Aim of this study was to describe atypical dyskinesias (AtypDs) occurring during treatment with antipsychotic drugs (APDs). AtypDs are dyskinesias showing either an unusual temporal relationship between onset of treatment and start of the adverse drug reaction (ADR) or an unusual presentation of clinical symptoms.
Methods
Data on the ut...
Data on drug prescription for outpatients with major depressive disorder (MDD) suggest women are more likely to be treated with psychotropic drugs, while data on sex differences regarding pharmacological treatment of psychiatric inpatients are currently not available. Drug utilization data from the program "Drug Safety in Psychiatry" (German: Arzne...
Both inflammation and smoking can influence a drug’s pharmacokinetic properties, i.e., its liberation, absorption, distribution, metabolism, and elimination. Depending on, e.g., pharmacogenetics, these changes may alter treatment response or cause serious adverse drug reactions and are thus of clinical relevance. Antipsychotic drugs, used in the tr...
Synaesthesia is a multimodal phenomenon in which the activation of one sensory modality leads to an involuntary additional experience in another sensory modality. To date, normal multisensory processing has hardly been investigated in synaesthetes. In the present study we examine processes of audiovisual separation in synaesthesia by using a simult...
Reporting of new or unexpected adverse drug reactions of medicines that are subject to additional monitoring ("black triangle" label), such as the antipsychotic drug cariprazine, is of paramount importance to improve pharmacotherapy safety.
Über 300 verschiedene Medikamente können die Lichtempfindlichkeit der Haut erhöhen. Arzneimittelbedingte Photosensibilisierung ist für bis zu 8 % aller kutanen unerwünschten Arzneimittelwirkungen verantwortlich und stellt somit ein häufiges klinisches Problem dar. Pathophysiologisch lassen sich arzneimittelinduzierte Photodermatosen in phototoxisch...
Insbesondere in der Arbeit mit durch Multimorbidität oder Polypharmazie vorbelasteten Patienten realisieren sich Risiken durch pharmakodynamische und pharmakokinetische Effekte. Im vorliegenden Fallbericht wird ein Verlauf bei einer Risikopatientin beschrieben und diskutiert, bei dem es nach neu initiierter Sertralin-Behandlung zu einer vorbestehen...
On March 11th, 2020, the outbreak of coronavirus disease 2019 (COVID-19) was declared a pandemic. Governments took drastic measures in an effort to reduce transmission rates and virus-associated morbidity. This study aims to present the immediate effects of the pandemic on patients presenting in the psychiatric emergency department (PED) of Hannove...
ZUSAMMENFASSUNG
Anticholinerge unerwünschte Arzneimittelwirkungen (UAW) stellen einen Begleiteffekt einer Vielzahl von Psychopharmaka dar und werden über einen Antagonismus an muskarinischen Acetylcholin-Rezeptoren vermittelt. Zu den klassischen anticholinergen UAW zählen Mundtrockenheit, Akkommodationsstörungen des Auges, tachykarde Herzrhythmuss...
Prader–Willi syndrome (PWS) is a rare neurodevelopmental disorder caused by lack of the paternal copy of maternally imprinted, paternally expressed genes at the chromosome 15q11‐13 region. In most cases, it is caused by a paternal deletion or a maternal disomy of chromosome 15. Behavioral problems with temper outbursts are common and often combined...
Background: Currently available data on the prescription practice among patients with major depressive disorder (MDD) reflect the outpatient setting. This is the first study to provide information on time trends of psychotropic drug utilization in psychiatric inpatients.
Method: Data stems from German-speaking psychiatric hospitals collected by the...
Objectives: Drug-induced liver injury has been associated with various antipsychotic drugs. Comparative studies between individual antipsychotic drugs are largely not available.
Methods: Antipsychotic drug utilization data and reports of severe antipsychotic drug-induced liver injury were assessed by using data from an observational pharmacovigilan...
Das Pisa-Syndrom (Pleurothotonus) wurde als Dystonie der Rumpfmuskulatur beschrieben im Sinne einer tonischen Seitwärtsflexion und einer leichten Rotation des Rumpfes in der Sagittalebene, die im Sitzen, Liegen, Stehen und Laufen persistiert. Ursprünglich wurde es als unerwünschte Arzneimittelwirkung (UAW) berichtet, später auch im Rahmen neurodege...
Zusammenfassung
Im Rahmen der aktuellen coronavirus disease 2019 (COVID-19)-Pandemie müssen sich viele Bereiche der Medizin umstrukturieren. Dies betrifft auch die Versorgung von Patienten mit psychischen Erkrankungen. Die Therapie psychischer Erkrankungen umfasst psychotherapeutische und psychopharmakologische Interventionen. Letztere können mit e...
Antidepressants, especially selective serotonin reuptake inhibitors (SSRIs), are among the most commonly prescribed psychotropic drugs in Germany. Adverse drug reactions (ADRs) such as sexual dysfunction that occur during treatment with antidepressant drugs are numerous. In addition to ADRs, for example in the form of loss of libido, which occur du...
Post-injection delirium/sedation (PDSS) is one of the most relevant severe adverse drug reactions (ADR) occurring after intramuscular injection of long-acting olanzapine. PDSS is observed in 0.1% of injections of olanzapine pamoate. In most cases, the course of PDSS is self-limiting; however, admission to the hospital for the monitoring of vital si...
