Johann Lechner

Clinic for Integrative Dentistry, Munich, Germany for · Diagnosis and Surgery

Background Platelet-rich fibrin (PRF) blood concentrates are used in oral implantology and defect surgery to promote osteoneogenesis in Bone Marrow Defects in Jawbone (BMDJ), according to the morphology of fatty-degenerative osteonecrosis also called FDOJ. Question Can the benefit of PRF on alveolar osteoneogenesis be confirmed by cytokine analysi...

Abstract: The presently used impulse echo ultrasound examination is not suitable to provide relevant and reliable information about the jawbone, because ultrasound (US) is almost completely reflects from the hard cortical jawbone. At the same time, "focal osteoporotic bone marrow defects" (BoneMarrowDefects = BMD) in jawbone are the subject of scie...

Introduction: Exceedingly high levels of the chemokine CCL5/RANTES have been found in fatty degenerated osteonecrotic alveolar bone cavities (FDOJ) and aseptic ischemic osteolysis of the jaw (AIOJ) from toothless regions. Because CCL5/RANTES seems to have a prominent role in creating the COVID-19 “cytokine storm”, some researchers have used the mon...

Introduction: Osteoimmunology recognizes the relationship between bone cells and immune cells. Chronic osteoimmune dysregulation is present in bone marrow defects of the jaw (BMDJ) as fatty-degenerative osteonecrosis (FDOJ). In comparison to samples from healthy jaw bone, the cytokine analysis of samples of BMDJ/FDOJ from 128 patients showed downr...

Objective Bone marrow defects of the jaw (BMDJ) surrounding dental implants, in combination with impaired bone-to-implant contact (BIC), are difficult to detect in X-rays. This study evaluated BMDJ surrounding titanium (Ti-Impl) and ceramic (Cer-Impl) dental implants and incomplete BIC using a new trans-alveolar ultrasonography device (TAU) with nu...

Background Apical periodontitis (AP) is one of the most common endodontic diseases associated with osteo destructive cytokine production. The literature also reports cytokine studies in fatty degenerative osteonecrotic bone marrow defects (BMDJ/FDOJ) independent of AP. Objective We compare the RANTES/CCL5 (R/C) chemokine production between AP and...

Purpose The presence of bone marrow defects of the jawbone (BMDJ) is associated with increased levels of inflammatory cytokines such as RANTES/CCL5. The purpose of this study was to analyze if BMDJ therapy under real-world conditions reduces RANTES/CCL5 serum levels in BMDJ patients. Patients and Methods During this retrospective study, 113 BMDJ p...

Background This case report demonstrates the value of ultrasound measurements, and immunological and toxicological diagnostics in addition to current x-ray imaging procedures to diagnose hidden oral and maxillofacial infections. Using a clear scheme shows the procedure of the authors’ steps. The positive impact on the patient’s dermatological clini...

The interest in the application of TAU-n lies in the decrease in bone density in BMDJ/FDOJ owing to osteolysis. The upper limit of DVT HU values of interest with respect to BMDJ/FDOJ is +300, as at this point there is a transition to healthy cancellous bone. Values over +300 HUs thus fall outside the necessary detection range of TAU-n. The HU value...

Background: The role played by signaling pathways in the cell-cell communication associated with multiple sclerosis (MS) progression has become a critical area in research. Chemokine RANTES (regulated upon activation, normal T-cell expressed and secreted), also named chemokine C-C motif ligand 5 (CCL5; R/C), is a protein that has been investigated...

Background Cytokines, especially chemokines, are of increasing interest in immunology. This study characterizes the little-known phenomenon of “bone marrow defects of the jawbone” (BMDJ) with known overexpression of the chemokine RANTES/CCL5 (R/C). Purpose Our investigation clarifies why BMDJ and the intensity of local R/C overexpression are chall...

Purpose This paper aims to demonstrate the additional benefit of ultrasound in the diagnosis of chronic osteolysis and osteonecrosis (bone marrow defects) of the jaw shown in a clinical case report. Patients and Methods A case of chronic fatigue syndrome (CFS) in a young man presenting the typical, ambiguous symptoms, which were accompanied by hea...

Background The role of signaling pathways as part of the cell-cell communication within cancer progression becomes a crucial area. Chemokine RANTES (regulated upon activation, normal T-cell expressed and secreted), also known as the chemokine C-C motif ligand 5 (CCL5) (R/C), is a protein on which cancer research focus due to its link with aggressiv...

Introduction Bisphosphonate (BP)-related osteonecrosis of the jaw (BRONJ) is a complication of intravenous (IV) BP therapy. BP therapy locally affects the dentoalveolar area, while systemic effects are associated with parenteral/IV BP use. Despite numerous publications, the pathogenesis of BRONJ is not fully understood, as only some patients receiv...

Background Mitochondriopathy has recently been linked to several immune system diseases. Historically, there have been many conversations regarding the possible toxic effects of root-filled teeth (RFT), although discussions about the possible decreases in adenosine triphosphate (ATP) activity on the mitochondrial membrane, as caused by dental toxin...

Introduction The presently used impulse echo ultrasound examination is not suitable to provide relevant and reliable information about the jawbone, because ultrasound (US) almost completely reflects from the hard cortical jawbone. At the same time, “focal osteoporotic bone marrow defects” (BoneMarrowDefects = BMD) in jawbone are the subject of scie...

Immediate ceramic implantat versus endodontic treatment – A simple tool to implement an immunological-toxicological alternative

Introduction: There is considerable controversy surrounding craniosacral therapy (CsTh). To date, there have been few research studies examining the effects of CsTh when used to treat dysfunction of the musculature of the craniomandibular joint. Materials and Methods: Five craniosacral techniques (CsT) were used and their effects recorded with time...

The Effects of Craniosacral Techniques on the Kinematics of the Craniomandibular Joint – Kinematographic Validation Abstract: Introduction: There is considerable controversy surrounding craniosacral therapy (CsTh). To date, there have been few research studies examining the effects of CsTh when used to treat dysfunction of the musculature of the c...

Background Fatty degenerative osteonecrosis in the medullary spaces of the jawbone (FDOJ) may be identified as a lesser known source of RANTES/CCL5 (R/C) overexpression. The chemokine R/C also interferes with bone metabolism leading to osteolysis in areas affected by FDOJ. Many dental surgeries require functioning repair mechanisms and these may be...

Inhaltsverzeichnis Band III Einleitung 1. Einführung zu Band III  Von Erklärungsmodellen über wissenschaftliche Evaluation zur „Allgemeinen Anerkennung“  Hilferufe von Patienten mit Gesichtsschmerzen  FDOK oder NICO ist „Einzelerfindung“ des Autors  Ärztliche Ethik zwischen Therapieerfolg und Kostenerstattung 1.1 Krankheit systemisch be...

Background The immune and bone systems are closely linked via cytokine cross-talk. This interdisciplinary field of research is referred to as osteoimmunology and pertains to inflammatory and osteoarticular diseases that feature the primary expression of tumor necrosis factor-alpha (TNF-α) and IL-6. Objective Are there bone resorptive processes whe...

Background and introduction It is a well-known fact that titanium particles deriving from dental titanium implants (DTI) dissolve into the surrounding bone. Although titanium (TI) is regarded as a compatible implant material, increasing concern is coming up that the dissolved titanium particles induce inflammatory reactions around the implant. Spec...

Background Recent research on vitamin D indicates that our current understanding of the factors leading to chronic inflammation should be revised. One of the key mechanisms by which microbial immunosuppression occurs is the suppression of one of the most common endogenous cell nucleus receptors: the vitamin D receptor (VDR). Autoimmune diseases may...

Hintergrund: Diese Studie behandelt die Frage, ob allgemeine und weit verbreitete zahnärztliche Eingriffe, wie Zahnextraktionen und operative Entfernung von Weisheitszähnen, zu chronischer Kieferknochenentzündung führen. Eine mangelhafte Wundheilung im Kieferknochen kann über Entzündungsmediatoren eine versteckte Ursache chronischer Erkrankungen se...

Regulated-on-activation, normal T cell expressed and secreted (also called RANTES, CCL5 or R/C) is a chemotactic cytokine that plays a key role in recruiting immune cells to inflammatory sites. R/C is involved in the pathogenesis of many systemic immune-mediated diseases (SIDs) and is upregulated in fatty-degenerative osteolysis jawbone (FDOJ) cavi...

Background: This study compares the radiographic distribution of apical periodontitis (AP) in rootfilled and endodontically treated teeth among healthy controls and patients with systemic diseases; the incidence of AP was almost twice as high in the latter group.Objective: The question arises as to whether the biogenic amines (mercaptan/thioether/h...

Of the definitions listed in the International Statistical Classification of Diseases and Related Health Problems, tenth revision (ICD-10), two disease descriptions can be found together: “idiopathic aseptic bone necrosis” and “avascular bone necrosis.” The relevant literature on both the conditions abbreviates both as “aseptic ischemic osteonecros...

This study elucidates the question of whether chronic inflammation in the jawbone contributes to the development of Chronic Fatigue Syndrome (CFS). Fatty degenerative osteonecrosis in jawbone (FDOJ) may contribute to CFS by induction of inflammatory mediators. We examined seven cytokines by multiplex analysis in jawbone samples from two groups of p...

Despite significant therapeutic advances most malignancies, as well as adenocarcinomas of the breast, remained incurable. At the same time, the importance of the microenvironment surrounding the tumor cells with "silent inflammation" increases. Objective: To check the suspected tumor-relevant inflammatory cytokine sources in fatty-degenerative oste...

Hintergrund Trotz erheblicher therapeutischer Fortschritte sind die meisten malignen Erkrankungen unheilbar geblieben. Gleichzeitig nimmt die Bedeutung der Mikroumgebung, die die Tumorzellen mit „Silent Inflammation“ umgibt, zu. Zielsetzung: Um den Verdacht auf tumorrelevante inflammatorischen Zytokin-Quellen in fettig-degenerativ veränderten Osteo...

Abstract Fulltext References Tables & Figures Download PDF Background and Introduction: The transition from acute local inflammation following wisdom tooth surgery to a chronic stage of "Silent Inflammation" could be a neglected cause of unexplained medical conditions. Case Report: Here we will refer to an unusual case of recurrent syncope in a...

Seit Jahrzehnten werden Phänomene wie „Kieferostitis“ und „NICO“ als sogenannte „Herde“ mit Allgemeinerkrankungen in kausale Verbindung gebracht. Auch Energieleitbahnen der chinesischen Akupunkturlehre dienten bislang als ganzheitliche Funktions- und Erklärungsmodelle. Die Forschungen der Autoren zeigen mit modernen Labormethoden, dass überaktivier...

Einleitung: Die vorliegende Studie versucht, die mögliche ursächliche Rolle einer chronisch-subklinischen Entzündung im Kieferknochen bei Patienten mit atypischen Gesichtsschmerzen (AGS) und Trigeminusneuralgie (TRN) durch lokale Überexpression des Chemokins R/C/CCL5 (R/C) aufzuklären. Neurone enthalten Opioid-Rezeptoren, die auch Anti-Schmerz-Reak...

Abstract: Die Diskussion zeigt, dass eine Erweiterung von Band I „Kavitätenbildende Osteolysen des Kieferknochens - Systemisch-ganzheitliche Wirkungen der aseptischen Osteonekrosen „Kieferostitis“ und „NICO“ im Kiefer - Dokumentation und Einführung in eine immunbiologisch und kieferchirurgisch erweiterte Therapie chronischer Krankheiten“ aus 2011 n...

Einleitung: Es besteht ein Bedarf an Aufklärung wieweit das häufigste zahnärztliche Diagnoseinstrument – ein zweidimensionales Übersichtsröntgen (2D-OPG) - zur Aufdeckung fettig-degenerativer Osteolysen (FDOK) im Markraum von Kieferknochen geeignet ist. Material und Methoden: Zur qualitativen Bewertung zahnloser Kieferknochenabschnitte werden 2D-OP...

Hollow dead spaces in the jawbone known popularly as “cavitations,” and as “NICO,” might serve as a fundamental cause of neuropathic pain, through the inflammatory cytokines that they produce. Opioid receptors mediate anti-pain responses in both the peripheral and central nervous systems, and RANTES is able to enhance the pain response. Data demons...

Introduction. In this study, we elucidate the possible causative role of chronic subclinical inflammation in jawbone of patients with atypical facial pain (AFP) and trigeminal neuralgia (TRN) in the local overexpression of the chemokine regulated on activation and normal T-cell expressed and secreted (RANTES/C-C motif ligand 5 CCL5). Neurons contai...

Introduction: Neurons contain opioid-receptors which transmit anti-pain-reactions as well in peripheral as in central nervous system. Opiod containing remedies sensitize in an agonistic contrary effect the opioid-receptors and block the conduction of pain. Pro-inflammatory chemokines like RANTES CCL5 de-sensitize, µ-opioid-receptors in periphery se...

Background This research elucidates the question of whether common and widespread dental procedures (DP) like root filling (RF) and the removal of wisdom teeth (WT) contribute to chronic inflammation in the jawbone. Dentists, in carrying out these DP, can set off defective wound healing in the jawbone in ignorance of its connection to inflammatory...

Diese DEGUZ-Monografi e 02 ist die zweite in einer Reihe von wissenschaftlich abgesicherten DEGUZ-Publikationen. DEGU-Monografi en werden von in der DEGUZ organisierten Ärzten und Zahnärzten erstellt zur Dokumentation und inhaltlichen Bestimmung dessen, was Um-welt-ZahnMedizin für chronisch Kranke, aber auch gesunde Menschen im Vorfeld systemisch-i...

Persistent microorganisms in endodontically treated teeth produce volatile sulfur compounds (VSC) such as methyl mercaptan, hydrogen sulfide, and thioether. In this retrospective study, we evaluated the ex vivo immune response of peripheral blood mononuclear cells to sulfur compounds in 354 patients with systemic diseases. These systemic findings a...

Jawbone cavitations (JC) are hollow dead spaces in jaw bone with dying or dead bone marrow. These areas are defined as fatty degenerative osteonecrosis of jawbone (FDOJ). or “Neuralgia Inducing Cavitational Osteonecrosis/NICO” and may produce facial pain. They have been linked with the immune system and chronic illnesses. Little is known about the...

Introduction There is a need to clarify the extent to which the most common diagnostic tool in dentistry – two-dimensional panoramic tomography (2D-OPG) – is suitable for identifying fatty degenerative osteolysis of jawbone (FDOJ). Materials and methods To obtain a qualitative assessment of edentulous jawbone sections, the results from 2D-OPG with...

Background: Hollow spaces in the jawbone have been defined as fatty degenerative osteonecrosis of jawbone (FDOJ) and have been linked with a dysregulated immune system. Little is known about the underlying relationship. Objectives: Samples of FDOJ were analyzed to assess expression of cytokines which can play a role in the pathogenesis of breast...

BACKGROUND: Hollow spaces in the jawbone have been defined as fatty degenerative osteonecrosis of jawbone (FDOJ) and have been linked with a dysregulated immune system. Little is known about the underlying relationship. OBJECTIVES: Samples of FDOJ were analyzed to assess expression of cytokines which can play a role in the pathogenesis of breast ca...

Schwermetalle aus zahnärztlichen Sanierungsmaterialien können den Gesamtorganismus belasten und zu gesundheitlichen Störungen führen. Das Ausmaß der Störungen ist abhängig von der Konstitution des Patienten und der Menge der Metallexposition. Der Nachweis ist meist nicht allein mittels Röntgen zu erbringen, die Patienten zeigen häufig trotz positiv...

Mit seinem neuen Buch „Kavitätenbildende Osteolysen des Kieferknochens“ dokumentiert der ganzheitlich orientierte Zahnarzt J. Lechner unbekannte systemische Wirkungen der aspetischen Osteonekrosen „Kieferostitis“ und „NICO“ im Kiefer; auf 274 Seiten und mit über 270 Literaturzitaten wird der Begriff „Zahn-Störfelder“ auf eine neue wissenschaftliche...

DEGUZ-Monografi e 01 ist die erste in einer Reihe von wissenschaftlich abgesicherten DE-GUZ-Publikationen. DEGU-Monografi en werden von in der DEGUZ organisierten Ärzten und Zahn-ärzten erstellt zur Dokumentation und inhaltlichen Bestimmung dessen, was Umwelt-ZahnMedi-zin für chronisch Kranke, aber auch gesunde Menschen im Vorfeld systemisch-immuno...

Background: Jawbone cavitations (JC) are hollow dead spaces in jaw bone with dying or dead bone marrow. These areas are defined as fatty degenerative osteonecrosis of jawbone or „Neuralgia Inducing Cavitational Osteonecrosis/NICO“ and may produce facial pain. They have been linked with the immune system and chronic illnesses. Little is known about...

Jawbone cavitations (JC) are hollow dead spaces in jawbones with dying or dead bone marrow. These areas are defined as fatty degenerative osteonecrosis of the jawbone or neuralgia-inducing cavitational osteonecrosis and may produce facial pain. These afflictions have been linked to the immune system and chronic illnesses. Surgical debridement of JC...

Biogene amines (Mercaptane/Thioether/Hydrogensulfide) originating from endodontic treated teeth may show chronic-subtoxic and immunological systemic effects, which are discussed according to resulting problems. For the precise and undogmatic diagnosis of root canal treated teeth the author presents a multidimensional concept consisting of local...

Abstract: Bead-based analysis of fatty degenerated tissue of human jaw bone (NICO) in 17 different patients for eight immune mediators showed increased concentrations of chemokine RANTES. The chemokine RANTES is a well known and important inflammatory mediator involved in the regulation of many autoimmune diseases. The author´s conclusion is that R...

Bead-based analysis of fatty degenerated tissue of human jaw bone (NICO) in 17 different patients for eight immune mediators showed increased concentrations of chemokine RANTES. The chemokine RANTES is a well known and important inflammatory mediator involved in the regulation of many autoimmune diseases. The author´s conclusion is that RANTES deri...

IMICO - Is Missing Evidence in X-rays the Prove for Missing Clinicai Existence? The existence of NICO is largely denied today in main stream dentistry. The reason is that normal X-ray do not show the process of bone marrow osteolytic NICO. The author compares in several clinical cases X-rays and other radiographic imaging with a computer-assisted t...

The existence of NICO is largely denied today in main stream dentistry. The reason is that normal X-ray do not show the process of bone marrow osteolytic NICO. The author compares in several clinical cases X-rays and other radiographic imaging with a computer-assisted through-transmission alveolar sonography called CAVITAT, which proves superior to...

Aim of the study: In the practice of the author astounding improvements of systemic complaints which accompanied apparently rheumatic, neuralgic and other chronically inflammatory systemic diseases are consistently observed after cleaning pain free, radiographically normal edentulous areas of the jaw. These are marked by fatty-degenerative osteonec...

Zusammenfassung Die klassische „Chronische Kieferostitis” oder NICO (Neuralgia Inducing Cavitational Osteonecrosis) ist ein Phänomen, das in der Medizin bis heute kaum wahrgenommen wird. NICO ist eine Mangelversorgung in Form einer chronisch-trophischen Störung im Kieferknochen. Sie zeichnet sich histologisch aus durch Vermehrung der Fettzellen und...

ZusammenfassungZiel: Erfassung allgemein beschreibender Merkmale, der Anwendung von komplementären diagnostischen Testverfahren und Aspekten des therapeutischen Vorgehens von Mitghedern der Internationalen Gesellschaft für Ganzheitliche Zahn-Medizin im Rahmen eines Qualitätssicherungsvorhabens. Methodik: An alle 1017 Mitglieder der Internationalen...