Johana Rondevaldova

Czech University of Life Sciences Prague | CULS · Department of Crop Sciences and Agroforestry in Tropics and Subtropics

Several Ranunculaceae species are used in folk medicine to eliminate pathologies associated with oxidative stress as well as parasitic infections; however, a number of studies confirming their pharmacological properties is limited. In this study, 19 ethanolic extracts obtained from 16 Ranunculaceae species were assayed for in vitro antioxidant, ant...

Recently, neglected and underutilized species (NUS) have deservedly come to the forefront of scientific interest because they can contribute to the human nutrition, due to the content of bioactive substances such as antioxidants. Despite the great diversity and rich tradition in the use of Philippine NUS, the nutritional properties of many edible p...

Recently, neglected and underutilized species (NUS) have deservedly come to the forefront of scientific interest because they can contribute to the human nutrition, due to the content of bio-active substances such as antioxidants. Despite the great diversity and rich tradition in use of Philippine NUS, the nutritional properties of many edible plan...

Citation: Okpala, O.E.; Rondevaldova, J.; Osei-Owusu, H.; Kudera, T.; Kokoskova, T.; Kokoska, L. Susceptibility of Staphylococcus aureus to Anti-Inflammatory Drugs with a Focus on the Combinatory Effect of Celecoxib with Oxacillin In Vitro. Molecules 2024, 29, 3665. Abstract: Musculoskeletal infections (MIs) are among the most difficult-to-treat st...

The fluctuation in yield, composition, antibacterial and antioxidant activity of the essential oil (EO) of rockrose (Cistus ladanifer L.) obtained from two locations in central Spain was analysed and compared over the course of one year. Fifteen kilograms of C. ladanifer, collected monthly or fortnightly from two sites with different plant age (7 a...

Diarrhoea remains an important public health concern, particularly in developing countries, and has become difficult to treat because of antibacterial resistance. The development of synergistic antimicrobial agents appears to be a promising alternative treatment against diarrhoeic infections. In this study, the combined effect of tetracycline toget...

Minerals, although required in relatively small amounts, play crucial roles in many vital processes of the human body, and their deficiency can cause several serious health issues. Seaweeds and seagrasses, traditionally consumed as vegetables in coastal areas worldwide, are generally known as a rich source of macro- and microminerals in concentrati...

Although some underutilized tropical fruits and vegetables have been found to be rich in antioxidants and micronutrients, the phytochemical and nutritional properties of most of them are still not fully explored. The objective of the present study was to evaluate 22 neglected fruits/vegetables consumed in Cambodia for their antioxidant activity (DP...

Diarrheal infections, which are commonly treated by antibiotics, are still responsible for over 4 to 5 million cases of human deaths annually. Moreover, the rising incidence of antibiotic resistance and its negative effect on beneficial bacteria (e.g., Bifidobacteria ) of the gut microbial community are another problem.

Combinatory action of antimicrobial agents such as essential oils (EOs) show to be an effective strategy to overcome the problem with increasing antibiotic resistance of microorganisms, including Staphylococcus aureus. The objective of this study was to evaluate in vitro antimicrobial interactions between Origanum vulgare and Thymus vulgaris EOs ag...

Infections caused by Staphylococcus aureus are a serious global threat, and with the emergence of antibiotic resistance, even more difficult to treat. One of the possible complications in antistaphylococcal therapy represents negative interactions of antibiotics with food. In this study, the in vitro interaction between oxacillin and crude palm see...

Aims: The objective of the study was to evaluate antimicrobial interactions between two volatile agents, Cinnamomum cassia essential oil (CCEO) and 8-hydroxyquinoline (8-HQ) against Staphylococcus aureus strains in liquid and vapour phases. Methods and results: In vitro antimicrobial effect of CCEO in combination with 8-HQ was evaluated against...

Plant-derived compounds (carvacrol, cinnamaldehyde, eugenol, 8-hydroxyquinline, thymol, and thymoquinone) were assessed for their in vitro growth-inhibitory effect against Pseudomonas aeruginosa. For this purpose, the broth microdilution volatilization method evaluating antibacterial activity simultaneously in liquid and vapour phase was used. This...

Staphylococcus aureus is a major human pathogen that is responsible for both hospital- and community-acquired infections. Stilbenes are polyphenol compounds of plant origin known to possess a variety of pharmacological properties, such as antibacterial, antiviral, and antifungal effects. This study reports the in vitro growth-inhibitory potential o...

Essential oils isolated from six Philippine plant species, namely Alpinia brevilabris C. Presl, Alpinia cumingii K. Schum., Alpinia elegans (C. Presl) K. Schum., Callicarpa micrantha Vidal, Cinnamomum mercadoi S. Vidal, and Piper quinqueangulatum Miq. were assessed for their in vitro growth-inhibitory effect against pneumonia causing bacteria (Haem...

Essential oils hydrodistilled from seven Cambodian plant species (Alpinia oxymitra, Boesenbergia rotunda, Cinnamomum cambodianum, Citrus lucida, Limnophila aromatica, Rhodamnia dumetorum, and Sindora siamensis) were tested for their in vitro growth-inhibitory effect against pneumonia causing bacteria (Haemophilus influenzae, Streptococcus pneumonia...

Carvacrol and thymol, both plant-derived volatile compounds, have extensively been studied individually as well as in combination with other agents for their antimicrobial activity in liquid phase. However, in contrast to well-established assays for testing of antimicrobial combinatory effects in liquid media, there are no standardized methods for...

Context: In many regions of Indonesia, there are numerous traditional herbal preparations for treatment of infectious diseases. However, their antimicrobial potential has been poorly studied by modern laboratory methods. Objective: This study investigates in vitro antimicrobial activity of 49 ethanol extracts from 37 plant species used in Indonesia...

Purpose: To investigate the in vitro growth-inhibitory effect of Calophyllum inophyllum, a medicinal plant traditionally used to cure gastrointestinal disorders caused by diarrhoea-causing bacteria. Methods: The minimum inhibitory concentration (MIC) of C. inophyllum ethanol leaf extract was determined against six diarrhoea-causing bacteria, namely...

Staphylococcal infections are often hard to treat due to increasing resistance, especially to β-lactams. Previous studies described the synergy between common antibiotics and isoflavonoids; however, little is yet known about the combinatory effects of antibiotics with products of human isoflavone metabolism. In this study, demethyltexasin (DT), a h...

With aim to develop effective proof-of-concept approach which can be used in a development of new preparations for the inhalation therapy, we designed a new screening method for simple and rapid simultaneous determination of antibacterial potential of plant volatiles in the liquid and the vapour phase at different concentrations. In addition, EVA (...

Herbal medicine therapy is traditionally practiced by indigenous healers in Bolivia for hundreds years. Due to the great geographical and ecological diversity, there are thousands of native plants, which are utilized against diverse types of diseases. Nowadays, there is a worldwide problem connected with possible loss of ethnobotany knowledge becau...

To overcome the escalating problems associated with infectious diseases and drug resistance, discovery of new antimicrobials is crucial. The present study aimed to carry out in vitro antimicrobial analysis of 15 medicinal plant species selected according to their traditional medicinal uses in Gurage and Silti Zones, south central Ethiopia. Ethanol...

Thymoquinone (Tq) has been reported to potentiate the in vitro growth-inhibitory activity of some antibiotics especially against Staphylococcus aureus. However, it has been shown that Tq vapors can affect the results of susceptibility testing by standard broth microdilution method. Therefore, we made a comparative experiment with and without ethyle...

Eyebright, Euphrasia rostkoviana Hayne (Scrophulariaceae), is a medicinal plant traditionally used in Europe for the treatment of various health disorders, especially as eyewash to treat eye ailments such as conjunctivitis and blepharitis that can be associated with bacterial infections. Some Euphrasia species have been previously reported to conta...

Bacterial infections are in less-developed countries traditionally treated by remedies prepared from medicinal plants. Embelia schimperi (Vatke) is a plant used as a taenicide or disinfectant in Ethiopia, very often taken mixed with another plant species. In the present study, we examined two extracts prepared from seeds and twigs with leaves of E....

Plumbagin (5-hydroxy-2-methyl-1,4-naphthoquinone), a bicyclic naphthoquinone naturally distributed among Plumbago species, has been reported to have antimicrobial activity against a wide range of microorganisms. In this study, plumbagin was examined for its combinatory antimicrobial effect with tetracycline or oxacillin against nine strains of Stap...

Unlabelled: In this study, we tested 15 naturally occurring isoflavones and their metabolites for their possible antibacterial properties against nine Gram-positive and Gram-negative bacteria. The in vitro antibacterial activity was determined using the broth microdilution method, and the results were expressed as minimum inhibitory concentrations...

The broth microdilution (BMD) method is widely used for the determination of minimum inhibitory concentrations of antimicrobial agents, including volatile oils and their components. In this series of various experiments, we have demonstrated the influence of thymoquinone (TQ) vapor on the results of the BMD test performed with Staphylococcus aureus...

Context: Traditional medicinal plants have long been used in Ethiopia to treat human and livestock ailments. Despite a well-documented rich tradition of medicinal plant use in the country, their direct antimicrobial effects are still poorly known. Objective: To investigate the antimicrobial activity of 19 medicinal plant species that were selected...

Epigallocatechin gallate (EGCG), the major catechin contained in tea leaves, is known to possess the synergistic anti-staphylococcal activity in combination with various β-lactam antibiotics and tetracycline. In the present study, we explored the in vitro combinatory effect of EGCG in combination with oxytetracycline against eight standard strains...