Jörn M. Schattenberg

• M.D.
• Head of Department at Universitätsklinikum des Saarlandes

Severe alpha‐1 antitrypsin deficiency (AATD) is a rare genetic condition characterised by low systemic levels of alpha‐1 antitrypsin due to its retention in the liver. Consequently, it predisposes individuals to the development of chronic obstructive pulmonary disease and liver cirrhosis. Much progress has been made to non‐invasively monitor liver...

Introduction The prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD) may be as high as 38% in the adult population with potential serious complications, multiple comorbidities and a high socioeconomic burden. However, there is a general lack of awareness and knowledge about MASLD and its progressive stages (metabolic dysf...

Background Screening for liver disease in the general population requires accurate non-invasive tests (NITs). A head-to-head comparison of NITs for early detection of clinically relevant liver disease among the target population for screening is lacking. Methods Among meta-cohort (Rotterdam Study and NHANES) with metabolic dysfunction aged 18-80 y...

The human microbiome, distributed across various anatomical sites, holds promise for identifying diagnostic biomarkers and therapeutic targets in disease. In inflammatory bowel disease (IBD), including ulcerative colitis (UC), interactions between the gut and oral microbiomes are crucial for understanding disease mechanisms and guiding intervention...

Background This study utilised the Global Burden of Disease data (2010–2021) to analyse the rates and trends in point prevalence, annual incidence and years lived with disability (YLDs) for major chronic liver diseases, such as hepatitis B, hepatitis C, metabolic dysfunction‐associated liver disease, cirrhosis and other chronic liver diseases. Met...

Purpose: To determine the prevalence of retinal vascular anomalies in the general population in Germany and to analyse potential associations with ocular and systemic factors. Methods: The Gutenberg Health Study is a population-based cohort study, including 15,010 participants aged 35-74 years. We performed fundus photographs of the macula and t...

Metabolic dysfunction-associated steatotic liver disease (MASLD) is emerging as a leading cause of chronic liver disease. In recent years, artificial intelligence (AI) has attracted significant attention in healthcare, particularly in diagnostics, patient management, and drug development, demonstrating immense potential for application and implemen...

Background and aims Tinnitus, characterized by the conscious perception of sound without external acoustic stimulation, presents a multifaceted challenge. Recent research suggests a potential association between tinnitus and cardiovascular health. To elucidate these associations further, we examined the prevalence of tinnitus alongside its distress...

Background The continuum of metabolic syndrome encompasses a spectrum of dysfunctions impacting obesity‐linked insulin resistance, glucose homeostasis, lipid metabolism and pro‐inflammatory immune responses. The global prevalence of metabolic diseases, including diabetes, chronic liver disease, cardiometabolic disease and kidney disease, has surged...

Purpose To investigate potential gender- and age-specific changes over time in vision-related quality of life (VRQoL) on a population-based level. Further, factors associated with changes in VRQoL will be explored. Methods The Gutenberg Health Study is a population-based, prospective, observational, single-center cohort study in Germany. VRQoL was...

Background The collagen-rich tumor stroma plays a crucial role in biliary tract cancer (BTC). Collagen biomarkers of type I collagen (reC1M), type III collagen (PRO-C3), type IV collagen (C4G), type VIII collagen (PRO-C8), type XI collagen (PRO-C11), type XVII collagen (PRO-C17) and type VIII collagen (TUM) may be used as potential non-invasive bio...

Background & Aims This study used the Global Burden of Disease data (2010–2021) to analyze the rates and trends of point prevalence, annual incidence, and years lived with disability (YLDs) for metabolic dysfunction-associated steatotic liver disease (MASLD) in 204 countries. Methods Total numbers and age-standardized rates per 100,000 population...

Simple Summary Liver diseases are a significant contributor to global mortality, representing an escalating public health concern worldwide. Natural compounds, particularly herbal derivatives, remain a primary source for therapeutic agents in liver disease management. Among these, curcumin, the principal active compound in turmeric, has demonstrate...

A major histologic feature of cirrhosis is the loss of liver architecture with collapse of tissue and vascular changes per unit. We developed qVessel to quantify the arterial density (AD) in liver biopsies with chronic disease of varied etiology and stage. 46 needle liver biopsy samples with chronic hepatitis B (CHB), 48 with primary biliary cholan...

Background and Aims The performance of non‐invasive liver tests (NITs) is known to vary across settings and subgroups. We systematically evaluated whether the performance of three NITs in detecting advanced fibrosis in patients with metabolic dysfunction‐associated steatotic liver disease (MASLD) varies with age, sex, body mass index (BMI), type 2...

This study investigates the association between self-reported birth weight (BW) and the frequency of cataract and pseudophakia in a large population-based cohort in Germany, as part of the Gutenberg Health Study (GHS). Slit lamp examination and Scheimpflug imaging of 8205 participants, aged 35 to 74, were assessed and signs of cataract or pseudopha...

Background The global burden of metabolic diseases is increasing, but estimates of their impact on primary liver cancer are uncertain. We aimed to assess the global burden of primary liver cancer attributable to metabolic risk factors, including high body mass index (BMI) and high fasting plasma glucose (FPG) levels, between 1990 and 2021. Methods...

Background and Aims Metabolic dysfunction‐associated steatotic liver disease (MASLD) and its more severe subtype, metabolic dysfunction‐associated steatohepatitis (MASH), are highly prevalent and strongly associated with obesity and type 2 diabetes (T2D). This study sought to identify challenges to the diagnosis, treatment and management of people...

Background Loneliness has become a major public health issue of the recent decades due to its severe impact on health and mortality. Little is known about the relation between loneliness and social anxiety. This study aimed (1) to explore levels of loneliness and social anxiety in the general population, and (2) to assess whether and how loneliness...

Background The liver-heart axis potentially influences the risk of mortality in patients with heart failure. We aimed to identify the clinical utility of the fibrosis-4 (FIB-4) index in patients with heart failure for predicting mortality in the context of metabolic dysfunction-associated steatotic liver disease (MASLD).

Background An increasing number of HCC develops in the context of metabolic dysfunction-associated steatotic liver disease and its inflammatory form, metabolic dysfunction–associated steatohepatitis, even in the absence of cirrhosis. Chronic metabolic inflammation is the driving force of metabolic dysfunction–associated steatotic liver disease prog...

Background Reliable, noninvasive tools to diagnose at-risk metabolic dysfunction–associated steatohepatitis (MASH) are urgently needed to improve management. We developed a risk stratification score incorporating proteomics-derived serum markers with clinical variables to identify high-risk patients with MASH (NAFLD activity score >4 and fibrosis s...

https://www.aasld.org/liver-meeting-tlm-2024

https://www.aasld.org/liver-meeting-tlm-2024

https://www.aasld.org/liver-meeting-tlm-2024

Zusammenfassung Die Ausbildung einer cholezystokolischen Fistel als Komplikation der chronischen Cholezystitis und/oder Cholangitis ist sehr selten und lässt sich ohne moderne Bildgebung kaum nachweisen. Dennoch sind akute abdominelle Beschwerden eine häufige Ursache einer Vorstellung von Patienten in einer stationären Notaufnahme. Der vorliegende...

Background and Aims We report the findings of survodutide, a novel dual agonist, for the treatment of metabolic dysfunction-associated steatohepatitis (MASH). Methods In this multinational, double-blind, phase 2 trial, 295 people aged 18 – 80 years with biopsy-proven MASH (NAS Score ≥4), liver fibrosis (stage F1–F3), and body mass index (BMI) ≥ 25...

Introduction Primary biliary cholangitis (PBC) is a rare autoimmune cholestatic liver disease characterised by the destruction of interlobular bile ducts, resulting in cholestasis and biliary fibrosis. Elafibranor, a dual peroxisome proliferator-activated receptor-alpha/delta agonist, significantly improved prognostic biomarkers of cholestasis at W...

Introduction Pruritis is a common symptom of primary biliary cholangitis (PBC) that negatively impacts quality of life (QoL). In the phase III ELATIVE® trial (NCT04526665), elafibranor, a dual peroxisome proliferator-activated receptor-alpha/delta agonist, significantly improved prognostic biomarkers of cholestasis in PBC. We report the effect of e...

Background Psychological resilience is known as a protective factor against mental health disorders for which valid measures are indispensable. The present work aims to evaluate the Resilience Scale-5 (RS-5) psychometrically, and provide norm values. Methods Data from the Gutenberg Health Study (GHS), encompassing 7,496 participants aged 25 to 86,...

The human microbiome emerges as a promising reservoir for diagnostic markers and therapeutics. Since host-associated microbiomes at various body sites differ and diseases do not occur in isolation, a comprehensive analysis strategy highlighting the full potential of microbiomes should include diverse specimen types and various diseases. To ensure r...

People with type 2 diabetes mellitus (T2DM) show a high prevalence of steatotic liver disease (SLD), and especially metabolic dysfunction-associated steatotic liver disease (MASLD), with liver fibrosis. Their health-related quality of life (HRQL) is affected by multiple in part overlapping factors and aggravated by metabolic and liver-related comor...