Jörn Diedrichsen

Jörn Diedrichsen
The University of Western Ontario | UWO · The Brain and Mind Institute, Departments for Computer Science & Statistics

Ph.D.

About

244
Publications
39,950
Reads
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15,405
Citations
Citations since 2017
106 Research Items
9033 Citations
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201720182019202020212022202305001,0001,500
201720182019202020212022202305001,0001,500
Introduction
In the motor control group, we are studying how the brain learns to produce skilful movements. What are the computational principles that underlie the control and learning of these movements? Which brain areas are involved? How does the brain compensate after damage? We are using a combination of behavioral experiments in humans, functional imaging, and brain stimulation. A special focus of our group is the use of computational models to link these levels in a theory-driven manner.
Additional affiliations
September 2015 - present
Western University
Position
  • Western Research Chair
October 2009 - August 2015
University College London
Position
  • Professor (Full)
Description
  • Group leader at the ICN
June 2006 - September 2009
Bangor University
Description
  • Senior Lecturer
Education
October 2001 - May 2003
University of California, Berkeley
Field of study
  • Statistics
January 1999 - May 2003
University of California, Berkeley
Field of study
  • Psychology

Publications

Publications (244)
Article
Fine finger movements are controlled by the population activity of neurons in the hand area of primary motor cortex. Experiments using microstimulation and single-neuron electrophysiology suggest that this area represents coordinated multi-joint, rather than single-finger movements. However, the principle by which these representations are organize...
Article
Full-text available
The aim of this study was to derive a comprehensive picture of the functional organization of the human cerebellum. To do this, a group of participants was scanned over the course of four fMRI sessions while performing a diverse MDTB. Task-evoked activation patterns were leveraged to derive a functional parcellation of the cerebellar cortex. Using...
Article
Although it is widely accepted that the brain represents movement sequences hierarchically, the neural implementation of this organization is still poorly understood. To address this issue, we experimentally manipulated how participants represented sequences of finger presses at the levels of individual movements, chunks, and entire sequences. Usin...
Article
The brain's function is to enable adaptive behavior in the world. To this end, the brain processes information about the world. The concept of representation links the information processed by the brain back to the world and enables us to understand what the brain does at a functional level. The appeal of making the connection between brain activit...
Preprint
Full-text available
While fMRI studies have documented cerebellar activity across a wide array of tasks, the functional contribution of the cerebellum within these task domains remains unclear. Here we present a new framework to address this problem, asking if neocortical inputs to the cerebellum are gated in a task-dependent manner. We tested this idea in the context...
Article
Full-text available
Musician's dystonia presents with a persistent deterioration of motor control during musical performance. A predominant hypothesis has been that this is underpinned by maladaptive neural changes to the somatotopic organisation of finger representations within primary somatosensory cortex. Here, we tested this hypothesis by investigating the finger-...
Article
A deep understanding of the neural architecture of mental function should enable the accurate prediction of a specific pattern of brain activity for any psychological task, based only on the cognitive functions known to be engaged by that task. Encoding models (EMs), which predict neural responses from known features (e.g., stimulus properties), ha...
Article
The integration of somatosensory signals across fingers is essential for dexterous object manipulation. Previous experiments suggest that this integration occurs in neural populations in the primary somatosensory cortex (S1). However, the integration process has not been fully characterized, as previous studies have mainly used two-finger stimulati...
Preprint
Full-text available
While resting-state fMRI studies have provided a broad picture of the connectivity between human neocortex and cerebellum, the degree of convergence of cortical inputs onto cerebellar circuits remains unknown. Does each cerebellar region receive input from a single cortical area or convergent inputs from multiple cortical areas? Here we use task-ba...
Article
Electrophysiological studies in monkeys show that finger amputation triggers local remapping within the deprived primary somatosensory cortex (S1). Human neuroimaging research, however, shows persistent S1 representation of the missing hand’s fingers, even decades after amputation. Here, we explore whether this apparent contradiction stems from und...
Article
Full-text available
One important approach to human brain mapping is to define a set of distinct regions that can be linked to unique functions. Numerous brain parcellations have been proposed, using cytoarchitectonic, structural, or functional magnetic resonance imaging (fMRI) data. The intrinsic smoothness of brain data, however, poses a problem for current methods...
Article
Actions involving fine control of the hand, for example grasping an object, rely heavily on sensory information from the fingertips. While the integration of feedback during the execution of individual movements is well understood, less is known about the use of sensory feedback in the control of skilled movement sequences. To address this gap, we...
Article
To achieve fast feedback control of voluntary movements, the visual consequences of our motor commands need to be quickly identified and analyzed by the motor control processes in the brain. These processes work remarkably well even in complex visual environments and in the face of discrepancies between physical actuator and visually perceived effe...
Article
Full-text available
Motor planning plays a critical role in producing fast and accurate movement. Yet, the neural processes that occur in human primary motor and somatosensory cortex during planning, and how they relate to those during movement execution, remain poorly understood. Here we used 7T functional magnetic resonance imaging (fMRI) and a delayed movement para...
Article
It has been proposed that a form of cortical reorganization (changes in functional connectivity between brain areas) can be assessed with resting-state (rs) fMRI. Here we report a longitudinal data-set collected from 19 patients with subcortical stroke and 11 controls. Patients were imaged up to five times over one year. We found no evidence, using...
Preprint
Neuroscience has recently made much progress, expanding the complexity of both neural-activity measurements and brain-computational models. However, we lack robust methods for connecting theory and experiment by evaluating our new big models with our new big data. Here we introduce a new inferential methodology to evaluate models based on their pre...
Preprint
Full-text available
Musicians dystonia presents with a persistent deterioration of motor control during musical performance. A predominant hypothesis has been that this is underpinned by maladaptive neural changes to the somatotopic organisation of finger representations within primary somatosensory cortex. Here, we tested this hypothesis by investigating the finger-s...
Article
Full-text available
Representational similarity analysis (RSA) tests models of brain computation by investigating how neural activity patterns reflect experimental conditions. Instead of predicting activity patterns directly, the models predict the geometry of the representation, as defined by the representational dissimilarity matrix (RDM), which captures how similar...
Article
When reaching for an object with the hand, the gaze is usually directed at the target. In a laboratory setting, fixation is strongly maintained at the reach target until the reaching is completed, a phenomenon known as "gaze-anchoring". While conventional accounts of such tight eye-hand coordination have often emphasized the internal synergetic lin...
Article
Full-text available
How does the brain change during learning? In functional magnetic resonance imaging studies, both multivariate pattern analysis and repetition suppression (RS) have been used to detect changes in neuronal representations. In the context of motor sequence learning, the two techniques have provided discrepant findings: pattern analysis showed that on...
Preprint
Full-text available
The integration of somatosensory signals across fingers is essential for dexterous object manipulation. Previous experiments suggest that neural populations in the primary somatosensory cortex (S1) are responsible for this integration. However, the integration process has not been fully characterized, as previous studies have mainly used two-finger...
Preprint
Full-text available
Actions involving fine control of the hand, for example grasping an object, rely heavily on sensory information from the fingertips. While the integration of feedback during execution of individual movements is well understood, less is known about the use of sensory feedback in the control of skilled movement sequences. To address this gap, we trai...
Preprint
An important goal of human brain mapping is to define a set of distinct regions that can be linked to unique functions. Numerous brain parcellations have been proposed, using cytoarchitectonic data, structural or functional Magnetic Resonance Imaging (fMRI). The intrinsic smoothness of the brain data, however, poses a problem for current methods se...
Article
Full-text available
Background: Given that new therapeutic options for spinocerebellar ataxias are on the horizon, there is a need for markers that reflect disease-related alterations, in particular, in the preataxic stage, in which clinical scales are lacking sensitivity. Objective: The objective of this study was to quantify regional brain volumes and upper cervi...
Article
Selecting hand actions to manipulate an object is affected both by perceptual factors and by action goals. Affordances may contribute to “stimulus–response” congruency effects driven by habitual actions to an object. In previous studies, we have demonstrated an influence of the congruency between hand and object orientations on response times when...
Article
Full-text available
When performing a long chain of actions in rapid sequence, future movements need to be planned concurrently with ongoing action. However, how far ahead we plan, and whether this ability improves with practice, is currently unknown. Here, we designed an experiment in which healthy volunteers produced sequences of 14 finger presses quickly and accura...
Article
Full-text available
Animal neuroimaging studies can provide unique insights into brain structure and function, and can be leveraged to bridge the gap between animal and human neuroscience. In part, this power comes from the ability to combine mechanistic interventions with brain-wide neuroimaging. Due to their phylogenetic proximity to humans, nonhuman primate neuroim...
Preprint
Full-text available
Motor planning plays a critical role in producing fast and accurate movement. Yet, the neural processes that occur in human primary motor and somatosensory cortex during planning, and how they relate to those during movement execution, remain poorly understood. Here we used 7T functional magnetic resonance imaging (fMRI) and a delayed movement para...
Article
How is the primary motor cortex (M1) organized to control fine finger movements? We investigated the population activity in M1 for single finger flexion and extension, using 7T functional magnetic resonance imaging (fMRI) in female and male human participants and compared these results to the neural spiking patterns recorded in two male monkeys per...
Preprint
Full-text available
Individual fingers in the primary somatosensory cortex (S1) are known to be represented separately and adjacently, forming a cortical hand map. Electrophysiological studies in monkeys show that finger amputation triggers increased selectivity to the neighbouring fingers within the deprived S1, causing local reorganisation. Neuroimaging research in...
Preprint
Full-text available
Selecting hand actions to manipulate an object is affected both by perceptual factors and by action goals. Affordances are associated with the automatic potentiation of motor representations to an object, independent of the goal of the actor. In previous studies, we have demonstrated an influence of the congruency between hand and object orientatio...
Article
Many motor skills are learned with the help of instructions. In the context of complex motor sequences, instructions often break down the movement into chunks which can then be practiced in isolation. Thus, instructions shape an initial cognitive representation of the skill, which in turn guides practice. Are there ways of breaking up a motor seque...
Preprint
Full-text available
When performing a long chain of actions in rapid sequence, future movements need to be planned concurrently with ongoing action. However, how far ahead we plan, and whether this ability improves with practice, is currently unknown. Here we designed an experiment in which healthy volunteers produced sequences of 14 finger presses quickly and accurat...
Preprint
How does the brain change during learning? In functional magnetic resonance imaging studies, both multivariate pattern analysis and repetition suppression (RS) have been used to detect changes in neuronal representations. In the context of motor sequence learning, the two techniques have provided discrepant findings: pattern analysis showed that on...
Article
Full-text available
Significance The cerebellum has long been recognized as a partner of the cerebral cortex, and both have expanded greatly in human evolution. The thin cerebellar cortex is even more tightly folded than the cerebral cortex. By scanning a human cerebellum specimen at ultra-high magnetic fields, we were able to computationally reconstruct its surface d...
Preprint
Representational similarity analysis (RSA) tests models of brain computation by investigating how neural activity patterns change in response to different experimental conditions. Instead of predicting activity patterns directly, the models predict the geometry of the representation, i.e. to what extent experimental conditions are associated with s...
Article
Full-text available
Recovery of skilled movement after stroke is assumed to depend on motor learning. However, the capacity for motor learning and factors that influence motor learning after stroke have received little attention. In this study, we first compared motor skill acquisition and retention between well-recovered stroke patients and age- and performance-match...
Article
Full-text available
Despite numerous studies, there is little agreement about what brain changes accompany motor sequence learning, partly because of a general publication bias that favors novel results. We therefore decided to systematically reinvestigate proposed functional magnetic resonance imaging correlates of motor learning in a preregistered longitudinal study...
Article
Full-text available
Despite numerous studies, there is little agreement about what brain changes accompany motor sequence learning, partly because of a general publication bias that favors novel results. We therefore decided to systematically reinvestigate proposed functional magnetic resonance imaging correlates of motor learning in a preregistered longitudinal study...
Article
Full-text available
Despite numerous studies, there is little agreement about what brain changes accompany motor sequence learning, partly because of a general publication bias that favors novel results. We therefore decided to systematically reinvestigate proposed functional magnetic resonance imaging correlates of motor learning in a preregistered longitudinal study...
Chapter
The sixth edition of the foundational reference on cognitive neuroscience, with entirely new material that covers the latest research, experimental approaches, and measurement methodologies. Each edition of this classic reference has proved to be a benchmark in the developing field of cognitive neuroscience. The sixth edition of The Cognitive Neuro...
Article
Beyond being essential for long-term motor-skill development, movement repetition has immediate benefits on performance, increasing speed and accuracy of a second execution. While repetition effects have been reported for single reaching movements, it has yet to be determined whether they also occur for movement sequences, and what aspects of seque...
Preprint
Full-text available
How is the primary motor cortex (M1) organized to control fine finger movements? We investigated the population activity in M1 for single finger flexion and extension, using 7T functional magnetic resonance imaging (fMRI) in female and male human participants, and compared these results to the neural spiking patterns recorded in two male monkeys pe...
Article
Humans have the remarkable ability to hold, grasp, and manipulate objects. Previous work has reported rapid and coordinated reactions in hand and shoulder muscles in response to external perturbations to the arm during object manipulation; however, little is known about how somatosensory feedback of an object slipping in the hand influences respons...
Preprint
Full-text available
Recovery of skilled movement after stroke is assumed to depend on motor learning. However, the capacity for motor learning and factors that influence motor learning after stroke have received little attention. In this study we firstly compared motor skill acquisition and retention between well-recovered stroke patients and age- and performance-matc...
Preprint
Despite numerous studies, there is little agreement about what brain changes accompany motor sequence learning, partly because of a general publication bias that favors novel results. We therefore decided to systematically reinvestigate proposed functional magnetic resonance imaging (fMRI) correlates of motor learning in a preregistered longitudina...
Preprint
Full-text available
Beyond being essential for long-term motor-skill development, movement repetition has immediate benefits on performance, increasing speed and accuracy of a second execution. While repetition effects have been reported for single reaching movements, it has yet to be determined whether they also occur for movement sequences, and what aspects of seque...
Article
Full-text available
Conceptual knowledge is fundamental to human cognition. Yet, the extent to which it is influenced by language is unclear. Studies of semantic processing show that similar neural patterns are evoked by the same concepts presented in different modalities (e.g., spoken words and pictures or text). This suggests that conceptual representations are “mod...
Preprint
Humans have the remarkable ability to hold, grasp, and manipulate objects. Previous work has reported rapid and coordinated reactions in hand and shoulder muscles in response to external perturbations to the arm during object manipulation; however, little is known about how somatosensory feedback of an object slipping in the hand influences respons...
Article
As a sequence of movements is learned, serially ordered actions get bound together into sets to reduce computational complexity during planning and execution. Here, we investigated how actions become naturally bound over the course of learning and how this learning affects cortical representations of individual actions. Across 5 weeks of practice,...
Preprint
Full-text available
Cortical reorganization has been suggested as mechanism for recovery after stroke. It has been proposed that a form of cortical reorganization (changes in functional connectivity between brain areas) can be assessed with resting-state fMRI. Here we report the largest longitudinal data-set in terms of overall sessions in 19 patients with subcortical...
Poster
Full-text available
Poster presented at OHBM 2019. This work compares multiple multivariate connectivity metrics and their sensitivity to noise using simulations on activation patterns elicited by a deep neural network (AlexNet) to presentation of visual stimuli.
Article
An impressive body of research over the past 30 years has implicated the human cerebellum in a broad range of functions, including motor control, perception, language, working memory, cognitive control, and social cognition. The relatively uniform anatomy and physiology of the cerebellar cortex has given rise to the idea that this structure perform...
Article
Full-text available
This technical note describes a variational or Bayesian implementation of representational similarity analysis (RSA) and pattern component modelling (PCM). It considers RSA and PCM as Bayesian model comparison procedures that assess the evidence for stimulus or condition-specific patterns of responses distributed over voxels or channels. On this vi...
Preprint
Full-text available
Do different languages evoke different conceptual representations? If so, greatest divergence might be expected between languages that differ most in structure, such as sign and speech. Unlike speech bilinguals, hearing sign-speech bilinguals use languages conveyed in different modalities. We used functional magnetic resonance imaging and represent...
Article
Do different languages evoke different conceptual representations? If so, greatest divergence might be expected between languages that differ most in structure, such as sign and speech. Unlike speech bilinguals, hearing sign-speech bilinguals use languages conveyed in different modalities. We used functional magnetic resonance imaging and represent...
Article
The ability to perform complex sequences of movements quickly and accurately is critical for many motor skills. While training improves performance in a large variety of motor-sequence tasks, the precise mechanisms behind such improvements are poorly understood. Here we investigated the contribution of single-action selection, sequence pre-planning...
Article
Full-text available
People vary in their capacity to learn and retain new motor skills. Although the relationship between neuronal oscillations in the beta frequency range (15–30 Hz) and motor behaviour is well established, the electrophysiological mechanisms underlying individual differences in motor learning are incompletely understood. Here, we investigated the deg...
Article
OBJECTIVE Patients with chronic stroke have been shown to have failure to release interhemispheric inhibition from the intact to the damaged hemisphere prior to movement execution (pre‐movement‐IHI). This inhibitory imbalance was found to correlate with poor motor performance in the chronic stage after stroke, and has since become a target for ther...
Article
Full-text available
A key question in neuroscience is how cortical organisation relates to experience. Previously we showed that amputees experiencing highly vivid phantom sensations maintain cortical representation of their missing hand (Kikkert et al., 2016). Here, we examined the role of sensory hand experience on persistent hand representation by studying individu...
Preprint
Full-text available
The ability to perform complex sequences of movements quickly and accurately is critical for many motor skills. While training improves performance in a large variety of motor-sequence tasks, the precise mechanisms behind such improvements are poorly understood. Here we investigated the contribution of single-action selection, sequence pre-planning...
Article
We investigated motor skill learning using a path tracking task, where human subjects had to track various curved paths at a constant speed while maintaining the cursor within the path width. Subjects' accuracy increased with practice, even when tracking novel untrained paths. Using a 'searchlight' paradigm, where only a short segment of the path a...
Preprint
Full-text available
We investigated motor skill learning using a path tracking task, where human subjects had to track various curved paths at a constant speed while maintaining the cursor within the path width. Subjects’ accuracy increased with practice, even when tracking novel untrained paths. Using a “searchlight” paradigm, where only a short segment of the path a...
Article
We investigated motor skill learning using a path tracking task, where human subjects had to track various curved paths at a constant speed while maintaining the cursor within the path width. Subjects' accuracy increased with practice, even when tracking novel untrained paths. Using a "searchlight" paradigm, where only a short segment of the path a...
Article
Fine-grained activity patterns, as measured with functional magnetic resonance imaging (fMRI), are thought to reflect underlying neural representations. Multivariate analysis techniques, such as representational similarity analysis (RSA), can be used to test models of brain representation by quantifying the representational geometry (the collection...