Jörg Scheidt

Hof University of Applied Sciences · Institute of Information Systems (iisys)

Background The Migraine Disability Assessment (MIDAS) is widely used. However, there are limited data on how much a reduction in the MIDAS score indicates a change that matters to the patient. Methods Data from the DMKG (i.e. German Migraine and Headache Society) Headache Registry were used to determine the minimal important difference (MID) of th...

Background Abnormalities in electrocortical parameters and persistence of afterimage after visual stimulation are known to occur in migraine patients. The results of studies on Contingent Negative Variation (CNV) and afterimage persistence in migraine patients suggest a link between these two phenomena and a connection to the pathomechanism of migr...

SelEe is a German citizen science project aiming to develop a smartphone app for a patient-managed record. The goal is to study rare diseases with the support of interested citizens and people affected by rare diseases. We established a core research team, including professional researchers (leading the project) and citizens. Citizens have the oppo...

Background Triptans are effective for many migraine patients, but some do not experience adequate efficacy and tolerability. The European Headache Federation (EHF) has proposed that patients with lack of efficacy and/or tolerability of ≥ 2 triptans (‘triptan resistance’) could be considered eligible for treatment with the novel medications from the...

Background: It is known from studies that migraine patients show a higher amplitude of the early component of the contingent negative variation (iCNV) 1 , a habit deficit 1 and a prolonged afterimage duration 2 compared to healthy subjects. The aim of the present study is to examine whether there is a relationship between these phenomena. Methods:...

Background: Most migraine patients need an effective acute medication. Real-world data can provide important information on the performance of acute migraine medication in clinical practice. Methods: We used data from the German Migraine and Headache Society Headache Registry, where patients rate efficacy and tolerability of and satisfaction wit...

Background Although good treatment options exist for many headache disorders, not all patients benefit and disability continues to be large. To design strategies for improving headache care, real-world data observing standard care is necessary. Therefore, the German Migraine and Headache Society (DMKG) has established the DMKG Headache Registry. He...

Following publication of the original article [1], the authors identified an error in the author name of Theresa Klonowski. The incorrect author name is: Theresa Klonowki. The correct author name is: Theresa Klonowski. The author group has been updated above and the original article [1] has been corrected.

Background Due to their low prevalence (< 5 in 10,000), rare diseases are an important area of research, with the active participation of those affected being a key factor. In the Citizen Science project “SelEe” (Researching rare diseases in a citizen science approach), citizens collaborate with researchers using a digital application, developed as...

This citizen science project CLUE compared the attack frequency between school and vacation periods among adolescents. The data collection process adopted in citizen science projects opens up the possibility of conducting analyses by including a large number of participants over a long period and across different regions. The data on 684 migraine a...

Hintergrund Real-world-Daten über die Versorgung von Kopfschmerzpatienten/-innen in Deutschland sind rar. Deswegen hat die DMKG ein deutschlandweites Kopfschmerzregister initiiert, an dem aktuell 20 Praxen und Kopfschmerzzentren teilnehmen. Das Register erfasst die Behandlung sowohl im Querschnitt als auch im Verlauf, und sowohl aus Sicht der Patie...

Background The aim of this work is to analyze reports of migraine attacks collected online in the citizen science project CLUE with respect to gender- and migraine type-specific differences in drug effectiveness and pain perception. Citizen science project data collection opens the possibility to examine these differences based on a large number of...

Citizen science allows involving interested citizen in the entire research process in science. In the past, various citizen science projects have been performed in different research fields, especially in human medicine. We conducted a rapid scoping review to determine which citizen projects in human medicine already used software-based systems to...

Background Migraine is common in childhood, peaks in adolescents and persists into adulthood in at least 40% of patients. There is need for early interventions to improve the burden of disease and, if possible, reduce chronification. The aim of the project is to compare two types of ambulatory treatment strategies regarding their effect on headache...

Background The aim of this work is to analyze the reports on cluster headache attacks collected online in the citizen science project CLUE with respect to the effectiveness of drugs taken during the attacks. The collection of data within the framework of citizen science projects opens up the possibility of investigating the effectiveness of acute m...

ZUSAMMENFASSUNG Trotz hoher Prävalenz von Kopfschmerzerkrankungen und bedeutender Beeinträchtigung vieler Betroffener ist die Versorgung von Menschen mit häufigen Kopfschmerzen in Deutschland unzureichend. Zur Verbesserung der Versorgung und Erhebung von Daten zur Versorgungs- und Kopfschmerzforschung richtet die Deutsche Migräne- und Kopfschmerzge...

In this paper, we describe a new algorithm designed to generate lexical resources in the field of sentiment analysis. For this approach, based on corpora of customer reviews, we determine words and phrases as candidates for our sentiment lexicon solely by calculating a word co-occurrence measure and by considering word frequencies. The sentiment va...

In this paper we introduce the design and technical implementation of the citizen science project Migraine Radar. The goal of the project is to establish a large collection of migraine attack data in order to explore the trigger factors of migraine attacks. A main focus is the investigation of the influence of environmental factors like weather or...

About 10% of the population suffers from migraine. Nevertheless, despite this large number of affected persons, most of the traditional epidemiological studies, analyzing triggers of migraine, are based only on small groups of patients – usually up to 200 participants. Furthermore, these studies are often limited in relation to regional extensions...

Background Medical symptoms independent of body location burden individuals to varying degrees and may require care by more than one expert. Various paper and computer-based tools exist that aim to comprehensively capture data for optimal clinical management and research. MethodsA web-based interdisciplinary symptom evaluation (WISE) was newly desi...

Approximately 10% of the human population suffers from migraine. In particular, weather is one of the most prominent triggers. However, a correlation between weather and migraine attacks is not proven yet. For this reason, our project aims to get a better understanding of migraine attack triggers. In order to achieve this, we collected about 20 000...

Mit der zunehmenden Menge textueller Daten im Web 2.0 wächst auch die Notwendigkeit der maschinellen Auswertung dieser Daten, beispielsweise um in Texten geäußerte Meinungen aufzuspüren (Opinion Mining). Im vorliegenden Beitrag wird das Aspect-based Opinion Mining – ein Verfahren mit sehr hohem Detaillierungsgrad – für deutschsprachige Texte anhand...

Approximately 10% of the human population suffers from migraine. In particular, weather is one of the most prominent triggers. However, a correlation between weather and migraine attacks is not proven yet. For this reason, our project aims to get a better understanding of migraine attack triggers. In order to achieve this, we collected about 20 000...

Zusammenfassung Weltweit leiden ca. 10% der Bevölkerung an Migräne. Vor allem das Wetter wird oft als Auslöser genannt – wissenschaftlich nachgewiesen ist ein Zusammenhang jedoch noch nicht. Ziel des Projektes ist es daher, Auslöser von Migräneattacken besser zu verstehen. Dazu wurden in vier Jahren ca. 20 000 Attacken mit den zugehörigen Ortsdaten...

In this work, we present a system called PoliTwi, which was designed to detect emerging political topics (Top Topics) in Twitter sooner than other standard information channels. The recognized Top Topics are shared via different channels with the wider public. For the analysis, we have collected about 4,000,000 tweets before and during the parliame...

In this paper, we present a study of aspect-based opinion mining using a lexicon-based approach. We use a phrase-based opinion lexicon for the German language to investigate, how good strong positive and strong negative expressions of opinions, concerning products and services in the insurance domain, can be detected. We perform experiments on hand...

Online consumer reviews constitute an integral aspect of electronic transactions as they play a part in lowering customer uncertainty during purchase decision making. This paper studies the aspect of negativity exhibited on the justification of its valence by the review text (as a dependent variable) and the influence of product price and product t...

Many factors trigger migraine attacks. Weather is often reported to be one of the most common migraine triggers. However, there is little scientific evidence about the underlying mechanisms and causes. In our pilot study, we used smartphone apps and a web form to collect around 4,700 migraine messages in Germany between June 2011 and February 2012....

In this paper we present an approach to generate lists of opinion bearing phrases with their opinion values in a continuous range between -- 1 and 1. Opinion phrases that are considered include single adjectives as well as adjective-based phrases with an arbitrary number of words. The opinion values are derived from user review titles and star rati...

The beam and detector, used for the NA48 experiment, devoted to the measurement of Re(ε′/ε), and for the NA48/1 experiment on rare KS and neutral hyperon decays, are described.

A new precision measurement of the Ξ0 mass has been performed at the NA48 experiment at the CERN SPS. The value obtained is [1314.82±0.06 (stat.) ±0.2 (syst.)] MeV/c2. The branching ratios of Xi;0 radiative decays have been measured as: Br(Ξ0 → Λγ) = [1.90 ± 0.34(stat.) ± 0.19(syst.)] · 10-3 and Br(Ξ0 → ∑0γ) = [3.14 ± 0.76(stat.) ± 0.32(syst.)] · 1...

The NA48 experiment at CERN has performed a new measurement of direct CP violation, based on data taken in 1997 by simultaneously collecting KL and KS decays into π0π0 and π+π−. The result for the CP violating parameter is (18.5±4.5(stat)±5.8(syst))×10−4.

The decay rate of the neutral K meson K-L --> e(+)e(-)gamma has been measured with the NA48 detector at the CERN SPS. A total of 6864 events has been observed with an estimated background of 10 events. The branching ratio is Gamma(K-L --> e(+)e(-)gamma)/Gamma(K-L --> all) = (1.06 +/- 0.02(stat) +/- 0.02(sys) +/- 0.04(calc)) X 10(-5). The parameter...

We present the results for a direct search for light gluinos through the appearance of η→3π0 with high transverse momentum in the vacuum tank of the NA48 experiment at CERN. We find one event within a lifetime range of 10−9–10−3 s and another one between 10−10–10−9 s. Both events are consistent with the expected background from neutrons in the beam...

A study of the polarization of Lambda hyperons produced in inelastic pN reactions induced by the 450 CeV proton beam from the CERN SPS has been performed with the NA48 detector. The Lambda hyperons were detected at a fixed angle of 4.2 mrad in the momentum range from 50 GeV/c to 200 GeV/c. The polarization changes from -0.053 +/- 0.034 to -0.298 +/...

We present the results for a direct search for light gluinos through the appearance of $\eta\rightarrow 3\pin$ with high transverse momentum in the vacuum tank of the NA48 experiment at CERN. We find one event within a lifetime range of $10^{-9}-10^{-3}$\,s and another one between $10^{-10}-10^{-9}$\,s. Both events are consistent with the expected...

We present the results for a direct search for light gluinos through the appearance of $\eta\rightarrow 3\pin$ with high transverse momentum in the vacuum tank of the NA48 experiment at CERN. We find one event within a lifetime range of $10^{-9}-10^{-3}$\,s and another one between $10^{-10}-10^{-9}$\,s. Both events are consistent with the expected...

The decay rate of the neutral K meson $\mathrm{K_{L} \rightarrow e^{+}e^{-}\gamma}$ has been measured with the NA48 detector at the CERN SPS. A total of 6864 events has been observed with an estimated background of 10 events. The branching ratio is $\mathrm{\Gamma(K_{L} \rightarrow e^{+}e^{-}\gamma)/\Gamma(K_{L} rightarrow all) = (1.06 \pm 0.02_{st...

This report summarises results on rare decays of neutral kaons. Three different classes of decays are discussed. Most of the examples were taken from results of the NA31 experiment. Therefore, the experiment is described in the first chapter. Subject of the second chapter are decays allowing to measure the CP-violation (i.e. KL → π0e+e−) and some r...

The full data set of the NA31 experiment at CERN has been used to analyse the decay mode K0L→e+e−γγ. A signal of 47 events has been observed with an estimated background of 6.9 events. The total number of kaon decays in the decay volume was determined to be (2.1±0.1stat)·109. This corresponds to a branching ratio of .

In a preliminary version of the NA48 experiment at the CERN SPS, in which an iron-scintillator sandwich calorimeter was used as a photon detector, the ratio of KL→πμνγ and KL→πμν decays was measured. The branching ratio BR(K)/(KL→πμν) is found to be (2.08±0.17 +0.16−0.21)×10−3, where the first error is statistical and the second systematic. The res...

The rate of the decay of the neutral K meson into KL 0 → μμγ has been measured with the NA48 detector at the CERN SPS. A total of 59 events has been observed with an estimated background of 14 events. The overall Kaon flux was determined to be 1.2 × 109. This observation corresponds to a branching ratio of (3.4 ± 0.6stat ± 0.4sys) × 10-7. Using thi...

A precision measurement of the K S mean lifetime has been performed by comparing, in the same experimental setup, the distributions of two-pion decays of neutral kaons produced by high energy proton-beryllium interactions in two targets at a relative distance variable between 112 and 160 m. The value obtained combining the results from π+π− and π0π...

A precision measurement of the KS mean lifetime has been performed by comparing, in the same experimental setup, the distributions of two-pion decays of neutral kaons produced by high energy proton-beryllium interactions in two targets at a relative distance variable between 112 and 160 m. The value obtained combining the results from π+π- and π0π0...

Data from the NA31 experiment at CERN have been used to measure the decay K-L --> pi(+/-)e(-/+)v gamma (K-e3 gamma(0)). 1384 +/- 53 events of this decay type have been observed, The decay rate relative to K-e3(0) is found to be Gamma(K-e3 gamma(0), E(gamma)* greater than or equal to 30 MeV, Theta(e-gamma)* greater than or equal to 20 degrees)/Gamma...

Data from the NA31 experiment at CERN have been used to measure the branching ratio of the double Dalitz decay of the long-lived neutral kaon. Eight events have been found with negligible background. The measured distribution of the angle between the planes of the two e+e−-pairs favours aCP=−1 state for the long-lived neutral kaon.

Data from NA31 experiment at CERN have been used to measure the decay KS → γγ. From 69 candidate events of the type K0 → γγ, 52 events can be attributed to KL → γγ and one event is expected from background processes. The ratio of the relative decay widths R = Γ(KS → γγ)Γ(KL → γγ) is measured to be R = 2.2 ± 1.0(stat.) ± 0.3(syst.) ± 0.2(ext.) where...

Data from the NA31 experiment at CERN have been used for a search for the decay mode KL → π0π0γ. After all cuts, three events remain in the signal region with an estimated background of 2.2 ± 0.9 events. The upper limit for the branching ratio of KL → π0π0γ is 5.6 × 10−6 at the 90% confidence level.

Mainz, Universiẗat, Diss., 1997.

In a preliminary version of the NA48 experiment at the CERN SPS, in which an iron- scintillator sandwich calorimeter was used as a photon detector, the ratio of K$_L \to \pi\mu\nu\gamma$ and K$_L \to \pi\mu\nu$ decays was measured. The branching ratio BR(K$_L \to \pi\mu\nu\gamma, \mbox{E}_\gamma^*\ge30~\mbox{MeV}$)/(K$_L \to \pi\mu\nu$) is found to...

The NA48 experiment at CERN has performed a new measurement of direct CP violation, based on data taken in 1997 by simultaneously collecting $kl$ and $ks$ decays into $pipin$ and $pipic$. The result for the CP violating parameter $ epr$ is $(18.5 pm 4.5 mathrm{(stat)} pm 5.8 mathrm{(syst)}) imes10^{-4}$.