Joerg Gruenwald

Joerg Gruenwald
Analyze & Realize ag | A&R · R&D

PhD MSc

About

147
Publications
74,839
Reads
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3,367
Citations
Introduction
Joerg Gruenwald currently works at the R&D, Analyze & Realize ag. Joerg does research in Clinical Trials and Food Science. Their most recent publication is 'A Rosa canina – Urtica dioica – Harpagophytum procumbens/zeyheri Combination Significantly Reduces Gonarthritis Symptoms in a Randomized, Placebo-Controlled Double-Blind Study.'
Additional affiliations
May 2013 - present
analyze & realize GmbH
Position
  • Founder and Chief Scientific Advisor
May 2001 - May 2013
Analyze & Realize ag
Position
  • CEO
January 1995 - March 2001
Phytopharm
Position
  • CEO
Education
October 1970 - May 1978
Universität Heidelberg
Field of study
  • Botany, Pharmacology

Publications

Publications (147)
Article
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Cardiovascular diseases are the main cause of death in the industrialized world, with the main risk factors being elevated blood pressure and blood lipid levels, leading to arterial stiffness and arteriosclerosis. In this study, we examined the effect of aged garlic extract (AGE) on arterial elasticity, using the EndoPAT™ technology in subjects wit...
Article
Background: The successful use of rose hip for the treatment of osteoarthritis is well documented. Several randomized placebo controlled double-blind studies, as mono or combination therapy, have demonstrated treatment efficacy as well as excellent tolerability. Purpose: This review focuses on the molecular mechanism underlying the clinical effe...
Article
The special formulation MA212 (Rosaxan) is composed of rosehip (Rosa canina L.) puree/juice concentrate, nettle (Urtica dioica L.) leaf extract, and devilʼs claw (Harpagophytum procumbens DC. ex Meisn. or Harpagophytum zeyheri Decne.) root extract and also supplies vitamin D. It is a food for special medical purposes ([EU] No 609/2013) for the diet...
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Sedentary lifestyle and caloric overconsumption are the key determinants of the escalating obesity prevalence. Reducing dietary fat absorption may help to induce a negative energy balance and thus help in managing weight problem. Apart from approved drug therapies, weight problems may also be aided with alternative and natural treatments. This pape...
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Beta-glucans are a heterogeneous group of natural polysaccharides mostly investigated for their immunological effects. Due to the low systemic availability of oral preparations, it has been thought that only parenterally applied beta-glucans can modulate the immune system. However, several in vivo and in vitro investigations have revealed that oral...
Article
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Reducing the burden of pathogenic mutans streptococci is a goal of oral health. Lactobacillus paracasei DSMZ16671, even after heat-killing, specifically co-aggregates mutans streptococci in vitro and retains this activity in human saliva. In rats, it reduces mutans streptococcal colonization of teeth and caries scores. This pilot study sought to as...
Article
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Purpose The effect of brewers’ yeast (1,3)-(1,6)-beta-d-glucan consumption on the number of common cold episodes in healthy subject was investigated. Methods In a placebo-controlled, double-blind, randomized, multicentric clinical trial, 162 healthy participants with recurring infections received 900 mg of either placebo (n = 81) or an insoluble y...
Article
Objective: Larch arabinogalactan (ResistAid * ) may prevent cold infections due to its immune-stimulatory properties. In a placebo-controlled, double-blind, randomized clinical trial, the effect of a proprietary larch arabinogalactan preparation on the incidences of common colds and its effect on cold symptoms, as a well established model for immu...
Article
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Purpose: The efficacy of ProbiDefendum, a combination of the two lactobacilli Lactobacillus plantarum HEAL9 and Lactobacillus paracasei 8700:2, on the severity, duration and frequency of cold episodes was studied in a randomized, double blind, placebo controlled clinical trial. Methods: A total of 310 subjects with increased risk for common cold in...
Article
Regelmäßiger Verzehr von Obst und Gemüse kann vor zahlreichen Krankheiten schützen. Trotz des Wissens was gesund ist und dem Willen, die empfohlene Menge an Obst bzw. Gemüse pro Tag zu verzehren, ist es im Alltag oft schwierig, diese zu erreichen. Viele Menschen leiden unwissentlich unter einem Mikronährstoffdefizit, welches die Entwicklung von Kra...
Article
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Purpose: In a placebo-controlled, double-blind, randomized clinical trial, the effect of an insoluble yeast beta-glucan preparation on the incidences of common colds and its effect on common cold symptoms were compared to placebo. Methods: 100 healthy participants with recurring infections were randomly assigned to receive either placebo or yeast b...
Article
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An evidence-based systematic review of cinnamon (Cinnamomum spp.), including written and statistical analysis of scientific literature, expert opinion, folkloric precedent, history, pharmacology, kinetics/dynamics, interactions, adverse effects, toxicology, and dosing, by the Natural Standard Research Collaboration is discussed in this monograph.
Article
Rhodiola-rosea-Wurzelextrakte werden traditionell als Tonikum zur körperlichen und mentalen Unterstützung angewandt. Neuere klinische Untersuchungen belegen, dass sie auch erfolgreich zur Behandlung von stressbedingten körperlichen und geistigen Erschöpfungszuständen (Burnout- Syndrom), bei milden Depressionen und generellen Angstzuständen eingeset...
Article
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In the present study, the immune-modulating efficacy of a polyphenol-rich beverage on symptoms associated with the common cold was evaluated. For this purpose, ninety-eight patients reporting common cold symptoms that began no longer than 24 h before the study intervention were randomly assigned to consume either the test beverage or placebo twice...
Article
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Cinnamon has been used as a spice and as traditional herbal medicine for centuries. The available in vitro and animal in vivo evidence suggests that cinnamon has anti-inflammatory, antimicrobial, antioxidant, antitumor, cardiovascular, cholesterol-lowering, and immunomodulatory effects. In vitro studies have demonstrated that cinnamon may act as an...
Article
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In a reference-controlled double-blind trial in patients with acute pharyngitis the effects of a newly developed lozenge containing 8 mg of benzocaine (p-aminobenzoic acid ethyl ester, CAS 94-09-7) were compared with those of an identically dosed commercial pastille. 246 patients were randomized to receive either the lozenges (group A, n = 123) or...
Article
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Two studies were undertaken to assess the efficacy and safety of three thixotropic nasal sprays (IQM11, IQM12, IQM13) on seasonal allergic rhinitis (SAR). The three nasal sprays differ only with respect to the emulsifying agent used in the formulation. In the prospective, randomized, cross-over pilot study, 16 patients with a history of SAR receive...
Article
Mental state disorder, like agitation, nervousness, and/or disturbed sleep, may already be signs for a burnout syndrome. A burnout syndrome is a characterized as a long-term emotional, physical, and mental exhaustion. In this drug monitoring study, 105 patients with symptoms of agitation, nervousness and/or sleep disturbance were treated with 2 dos...
Article
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On average 12% of the population worldwide suffer from acute or chronic constipation. Pathological intestine alterations, an unhealthy diet with reduced liquid intake, and little exercise are potential reasons. Often the motility of the intestine is disturbed. Changing nutrition habits or lifestyle is not always successful. In such cases, laxatives...
Article
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A total of 177 patients with moderate-to-severe hip or knee osteoarthritis (OA) were tested over a period of 26 weeks in a two-center, two-armed, randomized, double-blind, comparison study. The aim was to see if a combination of glucosamine sulfate (1500 mg/day) and the omega-3 polyunsaturated fatty acids eicosapentaenoic acid (EPA) and docosahexae...
Article
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An evidence-based systematic review including written and statistical analysis of scientific literature, expert opinion, folkloric precedent, history, pharmacology, kinetics/dynamics, interactions, adverse effects, toxicology, and dosing.
Article
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Most episodes of recurrent herpes labialis are self-limited and mild, but can be troublesome when they occur frequently with painful and unsightly lesions. Therefore, there has been much interest in developing agents that can suppress outbreaks in addition to being therapeutically effective. The objective of the present study was to examine the pro...
Chapter
This chapter looks at current trends in the functional beverages industry and at the functional ingredients used to realize and meet consumer demand. The chapter fi rst describes the health benefi ts of polyphenols, carotenoids, oils, sterols, natural stimulants and botanicals and discusses their value for functional beverages. Future trends for th...
Article
Natural substances are generally preferred over chemical ones and are generally seen as healthy. The increasing demand for natural ingredients, improving health and appearance, is also attracting beverages as the fastest growing segment on the functional food market. Functional beverages are launched as fortified water, tea, diary or juices claimin...
Article
Durch die hormonelle Umstellung in den Wechseljahren kommt es zur Senkung des Östrogenspiegels und Steigerung des follikelstimulierenden Hormons. Dieses Ungleichgewicht kann Beschwerden verursachen, die häufig mit einer Hormontherapie behandelt werden, bei der oft Nebenwirkungen auftreten. Mit dem in dieser Anwendungsbeobachtung vorgestellten Melis...
Article
Plant based products have great acceptance worldwide. Aside from the classical medical and spice plants and the raw material for phytopharmaceuticals, culinary herbs and spices as well as herbal teas are a growing new market that will play an important role in the future of plants used as raw materials. These will find application in functional foo...
Article
Zielsetzung: In einer Anwendungsbeobachtung wurden Wirkung und Verträglichkeit des Homöopathikums[1] Adhatoda vasica bei Patienten im Alter von 12 bis 80 Jahren mit einer Hausstaubmilbenallergie untersucht. Methodik: Die Anwendungsbeobachtung wurde an 103 Patienten mit Symptomen einer Hausstaubmilbenallergie (mit mindestens 4 der Symptome laufende...
Article
Durchschnittlich erkrankt jeder Erwachsene 3- bis 4-mal pro Jahr an einer akuten Atemwegsinfektion. Immer mehr Menschen tendieren bei Erkältungen dazu, auf traditionell bewährte pflanzliche Hausmittel zurückzugreifen. Deshalb wurde die Wirkung von Klosterfrau® Melissengeist, ein traditionelles Phytopharmakon, bei grippalen Infekten in einer Anwendu...
Chapter
Regulation and definition of functional food and herbal products is not harmonized withinthe European Union (EU). Health claims are possible in Sweden and are regulated by theSwedish Code of Practice. Swedish food law prohibits claims that a food can prevent, relieve,or cure diseases.The Swedish Code of Practice allows generic claims related to wel...
Article
Pflanzliche Kombinationspräparate aus Thymiankraut und Primelwurzel sind für die Therapie der akuten Bronchitis sehr gut geeignet. Zwei klinische Studien an Erwachsenen (n = 340) zeigen, dass diese Kombinationspräparate einerseits im Vergleich zu Plazebo zu einer signifikant schnelleren Besserung der Bronchitis-Symptome führen und andererseits unab...
Article
Mineral nutrients, vitamins, and trace elements are essential for the growth and development of a multicellular organism. Today, an adequate supply of nutrients is often unattainable solely through a well-balanced diet, so a targeted, individually designed dietary supplement regime is necessary. Nutrient deficiency, which is impossible to detect th...
Article
During a 12-wk drug monitoring study, the efficacy and safety of a Rhodiola rosea extract given in combination with vitamins and minerals (vigodana(R)) were tested in 120 adults (83 women and 37 men, ages 50-89 y) with physical and cognitive deficiencies. Two different dosage regimens were chosen. One group of 60 patients (group 1) took 2 capsules...
Chapter
Glucosamine and chondroitin sulphate have clinically proved to be effective nutritional supplements in the therapy of arthrosis. In human chondrocytes, these nutritional supplements, in combination with vitamins and trace elements, inhibited the secretion of mediators like matrix metalloprotease-3 (MMP-3), prostaglandin E2 (PGE2), and interleukin-6...
Article
Im Rahmen einer Anwendungsbeobachtung wurde die Wirksamkeit und Verträglichkeit der Vitalstoffkombination vigodana® bei 120 älteren Erwachsenen (50 bis 89 Jahre) mit körperlichen und kognitiven Vitalitätsstörungen untersucht. Das Präparat besteht aus einer Kombination wichtiger Vitamine und Mineralstoffe und einem pflanzlichen Extrakt aus der Wurze...
Article
This study was undertaken to compare the effects on plasma cholesterol concentration of a new isolated soy protein in which the protein structure is kept in its native, nondenaturated form (verum 1) versus a conventional isolated soy protein (verum 2) and milk protein (placebo). This prospective, randomized, double-blind, placebo-controlled study w...
Article
Hitzewallungen und Schweißausbrüche zählen zu den häufigsten Symptomen im vegetativ-vasomotorischen Erscheinungsbild des postmenopausalen Hormonmangels. Allerdings leidet eine große Anzahl von Wechseljahrespatientinnen zusätzlich unter psychischen Symptomen wie depressiven Verstimmungen, Antriebslosigkeit oder Nervosität. Methoden: In einer doppelb...
Article
This randomised, double-blind, bicenter, placebo-controlled clinical trial investigated the effect of a daily application of 6g Kytta-Salbe f (3 x 2 g) over a 3 week period with patients suffering from painful osteoarthritis of the knee. The two hundred and twenty patients examined consisted of 153 women and 67 men of an average age of 57.9 years....
Article
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A randomized, placebo-controlled, double-blind clinical study was performed to investigate the dose-dependent response of serum cholesterol after consuming an ultra-heat-treated milk containing a soy protein preparation. Eighty hypercholesterolemic subjects were assigned to one of four study groups receiving 12.5 or 25 g soy protein (active treatme...
Article
The potential of existing and new botanicals to meet an increasing demand for anti-ageing products, is discussed. The various biological actives that interact with some mechanisms of ageing have been identified. There are environmental, chronological and harmonal factors to be considered, which can be reduced or influenced. Oxidation of biomolecule...
Article
In a single-blind, randomized, bi-centric, prospective study, the non-inferiority of a fixed combination of thyme fluid extract and primrose root fluid extract (Bronchicum Elixir S, fluid test medication) was evaluated by comparison to a fixed combination of thyme fluid extract and primrose root tincture (Bronchcium Tropfen, drops test medication)....
Article
Full-text available
An evidence-based ststematic review including written and statistical analysis of scientific literature, expert opinion, folkloric precedent, history, pharmacology, kinetics/dynamics, interaction, adverse effects, toxicology, and dosing.
Article
Zur Untersuchung der Wirksamkeit und Verträglichkeit von taxofit® Calcium + D3 + Vitamin K1 + Kupfer + Fluor-Tabletten zur Osteoporose-Prophylaxe und zur Minderung von rheumatoiden Beschwerden wurde über einen Zeitraum von 24 Wochen eine einarmige Studie durchgeführt. An ihr nahmen 60 postmenopausale Frauen mit rheumatoiden Beschwerden teil. Prophy...
Article
Full-text available
An evidence-based systematic review including written and statistical analysis of scientific literature, expert opinion, folkloric precedent, history, pharmacology, kinetics/dynamics, interactions, adverse effects, toxicology, and dosing.
Article
Full-text available
An evidence-based systematic review including written and statistical analysis of scientific literature, expert opinion, folkloric precedent, history, pharmacology, kinetics/dynamics, interaction, adverse effects, toxicology, and dosing.
Article
To investigate the efficacy of the fixed combination of black cohosh (Cimicifuga racemosa) and St. John's wort (Hypericum perforatum) extracts in women with climacteric complaints with a pronounced psychological component. In this double-blind randomized placebo-control study, 301 women experiencing climacteric complaints with psychological symptom...
Article
Herbal combinations of thyme and primrose root are very suitable for the therapy of acute bronchitis. Two clinical studies with adults (n = 340) document that on the one hand these combinations lead to a significantly quicker recovery of the bronchitis symptoms compared to a placebo treatment. On the other hand they cause a comparably quick symptom...
Article
In a single-blind, randomized, bi-centric, prospective study, the non-inferiority of a fixed combination of thyme fluid extract and primrose root fluid extract (Bronchicum (R) Elixir S, fluid test medication) was evaluated by comparison to a fixed combination of thyme fluid extract and primrose root tincture (Bronchcium (R) Tropfen, drops test medi...
Article
The goal of this randomized, double-blind crossover clinical trial in 50 healthy volunteers sensitive to acidic foods was to evaluate whether Ester-C calcium ascorbate causes fewer epigastric adverse effects than are produced by regular ascorbic acid (AA). Volunteers were randomly separated into 2 groups of 25. The study comprised an observation pe...
Article
Full-text available
Soy protein is effective in lowering plasma cholesterol, LDL cholesterol and triglyceride concentrations. It has not been conclusively answered, whether and to what extent other soy constituents may also contribute to this effect. To investigate the change in blood lipid levels after application of two soy-based supplements containing soy protein e...
Article
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The lipid-lowering effect of a soy-based protein supplement was evaluated in an 8-week randomized, placebo-controlled trial in patients with hypercholesterolemia. A total of 117 patients (63 men and 54 women) received soy protein, either 15 or 25 g/d or placebo. In the active treatment groups low-density lipoprotein cholesterol levels decreased sig...
Article
Full-text available
An evidence-based systematic review including written and statistical analysis of scientific analysis of scientific literature, expert opinion, folkloric precedent, history, pharmacology, kinetic/dynamics, interactions, adverse effect, toxicology, and dosing.
Article
Wirksamkeit und Verträglichkeit eines Kombinationspräparates aus Thymian und Primelwurzel bei Patienten mit akuter Bronchitis / Eine doppelblinde, rando-misierte, multizentrische, Plazebo-kon-trollierte, prospektive Studie In einer doppelblinden, randomisier-ten, multizentrischen, Plazebo-kontrol-lierten, prospektiven Studie wurde die klinische Wir...
Article
In this double-blind, randomized, placebo-controlled, prospective study, the clinical efficacy and tolerability of oral Hypericum extract STW 3-VI (Laif) 900 mg once daily was compared with that of placebo. A total of 140 outpatients (94 women; 46 men) with moderate depressive disorders and a 17-item Hamilton Depression Scale (HAMD-17) score of 20...
Article
This 12-week drug-monitoring study was conducted to evaluate the efficacy of Sanhelios Mussel Lyprinol Lipid Complex on 50 adult men and women with inflammatory rheumatoid arthritis. A total of 34 patients required drug therapy before and during the study. By the end of the study, 21 (62%) patients were able to reduce their dosage and 13 were able...
Chapter
Für standardisierte und klinisch geprüfte Rosskastaniensamenextrakte gilt die Anwendung gegen Beschwerden bei chronischer venöser Insuffizienz als gesichert. Die traditionelle Anwendung zur Besserung des Befindens bei müden Beinen beruht auf der Überlieferung und langjährigen Erfahrungen. Im folgenden Beitrag werden die Inhaltsstoffe, die für ihre...
Article
In this article some of the main findings of our independent expert reports on the safety and efficacy of kava (Piper methysticum) are presented, including a detailed case analysis of all reported 79 cases reports of severe hepatotoxic events supposed to be related to the intake of kava products.
Article
Full-text available
Recently, insoluble fibre from carob pulp has been found to affect blood lipids in animals in a similar manner as soluble dietary fibre. To investigate whether a carob pulp preparation containing high amounts of insoluble fibre has a beneficial effect on serum cholesterol in humans. Volunteers (n = 58) with hypercholesterolemia were recruited to pa...
Article
Abnormal lipid levels contribute significantly to the risk of coronary heart disease, a major cardiovascular disease and a serious health problem. Various dietary and pharmacologic treatments have been devised to reduce elevated blood cholesterol levels. Soy protein, soluble fiber, and plant sterol/ester-containing margarines are promising new food...
Article
There are considerable differences in the classification of botanical products in the overall world market. In the US, the category of dietary supplements holds the largest share of the whole botanical market with over 80%. The over-the-counter (OTC) status plays a minor role with only about 3%. In Europe, however, the dietary supplement segment on...
Article
Within the group of botanical products there is a large range of variation with regard to their properties. Some products are identical to foods while others come close to or are medicines. Botanical products are regulated differently within the different member states of the European Union (EU) and globally. They are regulated either as food or as...