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Joerg Goldhahn

Joerg Goldhahn
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Joerg verified their affiliation via an institutional email.
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Joerg verified their affiliation via an institutional email.
ETH Zurich | ETH Zürich · Department of Health Sciences and Technology

Prof. Dr. med.

About

192
Publications
68,920
Reads
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6,461
Citations
Additional affiliations
January 2021 - present
ETH Zurich
Position
  • Director
August 2016 - January 2022
ETH Zurich
Position
  • Medical Director
September 2002 - July 2003
Innsbruck Medical University
Position
  • Head of Research

Publications

Publications (192)
Article
Wearable sensors are a recent paradigm in healthcare, enabling continuous, decentralized, and non- or minimally invasive monitoring of health and disease. Continuous measurements yield information-rich time series of physiological data that are holistic and clinically meaningful. Although most wearable sensors were initially restricted to biophysic...
Article
On October 5, 2023, a seminar on next-generation digital biomarkers was conducted at ETH Zurich, Switzerland. A consortium of interdisciplinary experts from engineering and translational medicine discussed the emergence of wearable device-based body-fluid analysis such as for sweat, interstitial fluid, and breath, and their translation from bench t...
Article
Full-text available
The ability to team up and safely work in any kind of healthcare team is a critical asset and should be taught early on in medical education. Medical students should be given the chance to “walk the talk” of teamwork by training and reflecting in teams. Our goal was to design, implement and evaluate the feasibility of a simulation-based teamwork tr...
Cover Page
Full-text available
Biological age assesses health more accurately than chronological age. While a straightforward clinical test to assess the biological age has yet to be devised, sweat analysis provides insights into key biomarkers of biological aging. In pages 1113-1116 of this issue, Niederberger and colleagues discuss how the knowledge gained in fundamental resea...
Article
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Breakthroughs in medical research in the last century have led to a significant extension of the human lifespan, resulting in a shift towards an elderly population worldwide. Due to the ongoing progress of global development towards elevated standards of living, this study specifically examines Switzerland as a representative nation to explore the...
Article
The silent pandemic of bacterial antimicrobial resistance is a leading cause of death worldwide, prolonging hospital stays and raising health-care costs. Poor incentives to develop novel pharmacological compounds and the misuse of antibiotics contribute to the bacterial antimicrobial resistance crisis. Therapeutic drug monitoring (TDM) based on blo...
Article
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Introduction: Digital health technologies (DHTs) provide opportunities for real-time data collection and assessment of patient function. However, use of DHT-derived endpoints in clinical trials to support medical product labelling claims is limited. Methods: From November 2020 through March 2021, the Clinical Trials Transformation Initiative (CT...
Article
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The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) induces B and T cell responses, contributing to virus neutralization. In a cohort of 2,911 young adults, we identified 65 individuals who had an asymptomatic or mildly symptomatic SARS-CoV-2 infection and characterized their humoral and T cell responses to the Spike (S), Nucleocapsid...
Article
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Background: Digital measures offer an unparalleled opportunity to create a more holistic picture of how people who are patients behave in their real-world environments, thereby establishing a better connection between patients, caregivers, and the clinical evidence used to drive drug development and disease management. Reaching this vision will re...
Article
A real-time, noninvasive, and clinically applicable aging test in humans has yet to be established. Herein we propose a sweat- and wearable-based test to determine biological age. This test would empower users to monitor their aging process and take an active role in managing their lifestyle and health.
Article
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Background: Despite acquiring vast content knowledge about the functioning of the human body through university teaching, medical students struggle to transfer that knowledge to one of the core disciplinary practices – differential diagnosis. The authors aimed to overcome this problem by implementing computer-based virtual environment simulations i...
Article
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Osteoarthritis (OA) is a common, debilitating, chronic disease with no disease-modifying drug approved to date. We discovered LNA043—a derivative of angiopoietin-like 3 (ANGPTL3)—as a potent chondrogenesis inducer using a phenotypic screen with human mesenchymal stem cells. We show that LNA043 promotes chondrogenesis and cartilage matrix synthesis...
Article
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Objectives: Augmented reality (AR), which entails overlay of in situ images onto the anatomy, may be a promising technique for assisting image-guided interventions. The purpose of this study was to investigate and compare the learning experience and performance of untrained operators in puncture of soft tissue lesions, when using AR ultrasound (AR...
Article
Digital health and digital pharma are considered supportive tools for patients and healthcare providers (HCPs), making the market highly attractive for industry players. Not surprisingly, Tech Giants have started to move into this area. We utilized established management models and publicly available information sources, such as annual company repo...
Article
Background: Despite acquiring vast content knowledge about the functioning of the human body through university teaching, medical students struggle to transfer that knowledge to one of the core disciplinary practices – differential diagnosis (DD). The authors aimed to overcome this problem by implementing computer-based virtual environment (CVE) si...
Article
Zusammenfassung. Die einheitliche, systematische Besprechung der Austrittsbereitschaft von Patientinnen und Patienten während der interprofessionellen Visite kann dazu beitragen, Spitalaustritte zu beschleunigen. Eine interprofessionelle Visite erfordert jedoch von allen Beteiligten fachliche Kompetenzen und Wissen über die interprofessionelle Zusa...
Article
The increase of chronic and complex medical disorders challenges actors in the health care system and affects the entire health care system in Switzerland. Through an interprofessional exchange between medical and health care professionals, the individual needs of patients can be better addressed, which has a positive impact on patients’ treatments...
Article
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Zusammenfassung: Die Zunahme an chronischen und komplexen Erkrankungen fordert verschiedene Akteure des Gesundheitswesens heraus und betrifft das gesamte Gesundheitssystem der Schweiz. Durch einen interprofessionellen Austausch der Fachpersonen aus Medizin und Gesundheit kann besser auf die individuellen Bedürfnisse der Patientinnen und Patienten e...
Article
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COVID-19 has turned the 2020 spring semester upside down. Three days before the start of the block week of the “Teamwork” module, the Federal Office of Public Health (FOPH) announced the ban on live interaction, which made it impossible to conduct five days of practice in the simulation centre of the University Hospital of Zurich. But how can the t...
Article
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After an Achilles tendon (AT) injury, the decision to return to full weightbearing for the practice of sports or strenuous activities is based on clinical features only. In this study, tendon stiffness and foot plantar pressure, as objective quantitative measures that could potentially inform clinical decision making, were repeatedly measured in 15...
Article
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Introduction: A major challenge in the monitoring of rehabilitation is the lack of long-term individual baseline data which would enable accurate and objective assessment of functional recovery. Consumer-grade wearable devices enable the tracking of individual everyday functioning prior to illness or other medical events which necessitate the moni...
Article
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Zusammenfassung. Bei sich stetig ändernden Lebensstilen und einer immer älter, aber auch dynamischer werdenden Gesellschaft kommt der Erhaltung und Gesundheit sowie der Verbesserung der Behandlung eine zentrale Rolle zu. Gleichzeitig revolutionieren die Entwicklungen in der Bioinformatik, den molekularen Biowissenschaften und den bildgebenden Verfa...
Article
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The European Union’s new regulatory framework for medical devices has central implications for the development of new devices, particularly by start-ups.
Article
475 LONGITUDINAL ASSESSMENT OF CARTILAGE COMPOSITION BY HIGH-FIELD MRI IN PATIENTS WITH LOW-GRADE KNEE CARTILAGE INJURY C. Scotti 1, D. Laurent 1, V. Juras 2, V. Mlynarik 2, M. Schreiner 2, P. Szomolanyi 2, S. Zbyn 2, J. Goldhahn 3, H. Haber 1, E. Kubiak 1, R. Roubenoff 1, S. Marlovits 4, M. Schieker 1, S. Trattnig 2. 1 Novartis Inst. for BioMed. R...
Article
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In the clinical field of diagnosis and monitoring of bone diseases, high-resolution peripheral quantitative computed tomography (HR-pQCT) is an important imaging modality. It provides a resolution where quantitative bone morphometry can be extracted in vivo on patients. It is known that HR-pQCT provides slight differences in morphometric indices co...
Data
All relevant data including statistical analyses and R scripts. (ZIP)
Article
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Machines that can learn and correct themselves already perform better than doctors at some tasks, says Jörg Goldhahn, but Vanessa Rampton and Giatgen A Spinas maintain that machines will never be able to replicate the inter-relational quality of the therapeutic nature of the doctor-patient relationship.
Article
Objective: To investigate T2 mapping as a possible marker for low-grade human articular cartilage lesions during a one-year follow-up, possible changes during the follow-up and compare the reliability and sensitivity of these measurements on high-field (3 T) and ultra-high-field (7 T) MRI scanners. Design: Twenty-one patients with femoral, tibia...
Article
Full-text available
Pain and loss of function – both problems cause patients to visit a musculoskeletal specialist. Therefore, both lead symptoms should serve as a benchmark for new therapeutic approaches. New technologies generating digital biomarkers have the potential to significantly change musculoskeletal trials. However, more work is needed to agree upon data an...
Article
Full-text available
Background: Early identification of people at risk for a contralateral hip fracture would be desirable to favorably influence patients' prognosis. A recent systematic review failed to depict stringent patterns of risk parameters to be used for decision-making in clinical practice. Objective: To perform a consensus study using the Delphi method t...
Article
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Bimagrumab (BYM338) is a novel fully human monoclonal antibody that exerts strong promyogenic effects on skeletal muscle by blocking activin type II receptors (ActRII). We investigated whether such blockade of ActRII by bimagrumab manifests any detrimental effect on outcomes of bone healing in a rat fibula osteotomy model. Animals (n = 150) were di...
Article
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Objectives: To compare reporting outcomes of radiolographic complications conducted by an independent review board and the responsible on-site study personnel in a multicenter study about locking plate fixation of proximal humeral fractures. Design: Prospective, multicenter study SETTING:: Nine Level I trauma centers PATIENTS:: 150 patients (age...
Article
Background: The exact role of platelet-rich plasma (PRP) in rotator cuff tendon reconstruction remains unclear. Purpose/hypothesis: This study investigated whether an intraoperative pure PRP injection, compared with a local anesthetic injection, improves patient-reported outcomes at 3 and 6 months after arthroscopic rotator cuff repair. The hypo...
Article
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Background: Early identification of hip fracture (HF) patients bearing an increased risk for a contralateral occurrence would allow providing preventive measures timely. Objectives: To summarize the available evidence describing risk scores, prognostic instruments, or (groups of) parameters predicting contralateral HFs at the time point of the f...
Article
Background: Screw anchorage in osteoporotic bone is still limited and makes treatment of osteoporotic fractures challenging for surgeons. Conventional screws fail in poor bone quality due to loosening at the screw-bone interface. A new technology should help to improve this interface. In a novel constant amelioration process technique, a polymer s...
Article
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A bone loading estimation algorithm was previously developed that provides in vivo loading conditions required for in vivo bone remodelling simulations. The algorithm derives a bone's loading history from its microstructure as assessed by high-resolution (HR) computed tomography (CT). This reverse engineering approach showed accurate and realistic...
Article
Objectives: To compare radiological complication reporting outcomes undertaken by an independent review board and the responsible on-site study personnel in a multicenter study about locking plate fixation of proximal humeral fractures. Design: prospective, multicenter study SETTING:: Level I trauma centers PATIENTS:: One-hundred and fifty patie...
Article
Full-text available
Introduction: The aim of this prospective, multicentre study was to evaluate the influence of local bone mineral density (BMD) on the rate of mechanical failure after locking plate fixation of closed distal radius fractures. Materials and methods: Between June 2007 and April 2010, 230 women and 19 men with a mean age of 67 years were enrolled. D...
Article
Background: There is biomechanical evidence that bone density predicts the mechanical failure of implants. The aim of this prospective study was to evaluate the influence of local bone mineral density on the rate of mechanical failure after locking plate fixation of proximal humeral fractures. Methods: We enrolled 150 patients who were from fift...
Article
Current evidence indicates that fracture healing assessment is limited to the use of one or two domains (such as pain, range of motion or mobility) in any single study. Functional outcome measures, which include physician-rated or observer-based impairment ratings and patient self-reported or observer-based activity limitation measures, better posi...
Preprint
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Falls have significant impact on affected individuals. They may lead to injuries including fractures, hospitalization, decrase in mobility, and loss of independence. Therefore, falls constitute a relevant outcome parameter in clinical trials. However, especially elderly and frail patients may forget to report or neglect falls. The use of fall-detec...
Preprint
Falls have significant impact on affected individuals. They may lead to injuries including fractures, hospitalization, decrase in mobility, and loss of independence. Therefore, falls constitute a relevant outcome parameter in clinical trials. However, especially elderly and frail patients may forget to report or neglect falls. The use of fall-detec...
Article
Background and purpose: Osteoporotic fractures are an increasing problem in the world due to the ageing of the population. Different models of orthogeriatric co-management are currently in use worldwide. These models differ for instance by the health-care professional who has the responsibility for care in the acute and early rehabilitation phases...
Chapter
Zur Behandlung eines zerstörten Ellenbogens gibt es viele Operationsmöglichkeiten, abhängig von Diagnose, Alter und Aktivitätslevel. Dieses Kapitel behandelt Indikationen, Planung, Operationstechnik und Resultate der Resurfacing-Arthroplastik am Ellenbogen. Auch wenn mehrere Ellenbogen-Resurfacing-Prothesen zur Verfügung stehen, so beschreibt vorli...
Chapter
Da das Ellenbogengelenk eine zentrale Rolle bei wichtigen Aktivitäten des täglichen Lebens und der daraus resultierenden Lebensqualität spielt, sollten diese Aspekte auch bei der initialen Befunderhebung sowie im weiteren Verlauf erhoben werden. Publizierte Richtlinien geben einen guten Anhalt über die in Frage kommenden Messinstrumente. In unserer...
Article
Full-text available
Although replacement of the elbow joint is a complex procedure there is not much clinical evidence that contributes to surgical decision-making, mainly due to small clinical samples and short follow-up. Therefore, we performed a long-term analysis up to 30 years after implantation of a GSB III total elbow prosthesis to quantify long-term outcome an...
Article
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Introduction: Lack of standardization of outcome measurement has hampered an evidence-based approach to clinical practice and research. Methods: We adopted a process of reviewing evidence on current use of measures and appropriate theoretical frameworks for health and disability to inform a consensus process that was focused on deriving the mini...
Article
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The objective was to identify all outcome measures used in studies on trapeziometacarpal osteoarthritis (TMC OA) and evaluate their measurement properties. In a two-step systematic literature review, we first identified studies including TMC OA patients and extracted all outcome measures. They were categorized according to the Outcome Measures in R...
Article
Peripheral quantitative computed tomography (pQCT) is receiving considerable attention in the diagnosis and monitoring of human bone diseases. It is well accepted that lower image resolution compared to micro-computed tomography (micro-CT) affects bone morphometry. With advances in micro-CT evaluation techniques such as sample-specific remodeling s...
Article
Full-text available
The use of patient-reported outcome questionnaires is recommended in studies of the orthopaedic field. Reliable, validated tools are necessary to ensure the comparability of results across different studies, centers, and countries. The patient-rated wrist evaluation (PRWE) is a widely accepted and commonly used outcome measure in the self-evaluatio...
Article
Total ankle arthroplasty (TAA) subjects often suffer pain on the anteromedial side of their ankle joint. Whether this prevalent pain is caused by a changed motion pattern of the TAA is unclear. Therefore, this study assessed the kinematic differences in the motion of the TAA components during gait, comparing TAA subjects with elevated versus absent...
Article
Objective: To quantify and compare the sensitivity to change of 5 outcome instruments for the elbow joint. Methods: In a prospective cohort study (n = 65), outcome was measured by the Short Form 36 (SF-36), the Disabilities of the Arm, Shoulder, and Hand questionnaire (DASH), the modified American Shoulder and Elbow Surgeons questionnaire for th...
Article
Full-text available
Understanding the functionality of total ankle arthroplasties (TAA) requires thorough knowledge of the kinematics during activities of daily life. Videofluoroscopy enables the in vivo measurement of the 3D kinematics of implant components more accurately than by means of skin marker tracking. The aim of the present preliminary study was to quantify...
Article
Full-text available
Osteoporotic fracture healing is critical to clinical outcome in terms of functional recovery, morbidity, and quality of life. Osteoporosis treatments may affect bone repair, so insights into their impact on fracture healing are important. We reviewed the current evidence for an impact of osteoporosis treatments on bone repair. Treatment with bisph...
Article
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Daily function plays an important role in the quality of life for patients suffering from pathology of the upper extremity. The recovery of functions of daily living determines the success or failure of the treatment for the patient. The goal of this study was to establish and validate a score set measuring quality of life, and objective and subjec...