Joel S Schuman

Joel S Schuman
NYU Langone Medical Center | NYUMC · Department of Ophthalmology

MD

About

670
Publications
85,958
Reads
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46,390
Citations
Additional affiliations
January 2016 - present
NYU Langone Medical Center, NYU School of Medicine, NYU Tandon School of Engineering
Position
  • Professor
July 2003 - June 2016
University of Pittsburgh
Position
  • Group Leader
July 2003 - June 2016
University of Pittsburgh
Position
  • Managing Director

Publications

Publications (670)
Preprint
Purpose To evaluate the reliability of the NIDEK Gonioscope GS-1 when used to grade the iridocorneal angle in a clinical setting. Methods A total of 20 participants (37 eyes) who were 18 or older and had glaucoma or were glaucoma suspects were enrolled from the NYU Langone Eye Center and Bellevue Hospital. During their usual ophthalmology visit, t...
Article
Full-text available
The field of ophthalmic imaging has grown substantially over the last years. Massive improvements in image processing and computer hardware have allowed the emergence of multiple imaging techniques of the eye that can transform patient care. The purpose of this review is to describe the most recent advances in eye imaging and explain how new techno...
Article
Purpose: The lamina cribrosa (LC) is a leading target for initial glaucomatous damage. We investigated the in vivo microstructural deformation within the LC volume in response to acute IOP modulation while maintaining fixed intracranial pressure (ICP). Methods: In vivo optic nerve head (ONH) spectral-domain optical coherence tomography (OCT) sca...
Article
Full-text available
Purpose: The lamina cribrosa (LC) has an important role in the pathophysiology of ocular diseases. The purpose of this study is to characterize in vivo, noninvasively, and in 3D the structure of the LC in healthy non-human primates (NHPs). Methods: Spectral-domain optical coherence tomography (OCT; Leica, Chicago, IL) scans of the optic nerve he...
Article
Full-text available
Glaucoma is the leading cause of global irreversible blindness, necessitating research for new, more efficacious treatment options than currently exist. Trabecular meshwork (TM) cells play an important role in the maintenance and function of the aqueous outflow pathway, and studies have found that there is decreased cellularity of the TM in glaucom...
Chapter
Advancements in ocular imaging over the past four decades have revolutionized glaucoma practice worldwide. As glaucomatous vision loss cannot be restored, early diagnosis, proper management, and timely intervention are essential to slow disease progression. The emergence of advanced computerized imaging modalities has shifted glaucoma assessment fr...
Article
Full-text available
Due to their similarities in anatomy, physiology, and pharmacology to humans, mice are a valuable model system to study the generation and mechanisms modulating conventional outflow resistance and thus intraocular pressure. In addition, mouse models are critical for understanding the complex nature of conventional outflow homeostasis and dysfunctio...
Article
Background: Since adult mammalian retinal ganglion cells cannot regenerate after injury, we have recently established a whole-eye transplantation (WET) rat model that provides an intact optical system to investigate potential surgical restoration of irreversible vision loss. However, it remains to be elucidated whether physiological axoplasmic tra...
Article
On September 3rd, 2020, the Collaborative Community on Ophthalmic Imaging (CCOI) conducted its first two-day virtual workshop on the role of artificial intelligence (AI) and related machine learning (ML) techniques for the diagnosis and treatment of various ophthalmic conditions. In a session entitled, “Artificial Intelligence For Glaucoma”, a pane...
Article
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Purpose: Growing evidence suggests that dendrite retraction or degeneration in a subpopulation of the retinal ganglion cells (RGCs) may precede detectable soma abnormalities and RGC death in glaucoma. Visualization of the lamellar structure of the inner plexiform layer (IPL) could advance clinical management and fundamental understanding of glauco...
Article
Full-text available
Purpose Vivid Vision Perimetry (VVP) is a novel method for performing in-office and home-based visual field assessment using a virtual reality platform and oculo-kinetic perimetry. The purpose of this study was to examine the reproducibility of the VVP “Swift” test and compare results with conventional standard automated perimetry (SAP) and spectra...
Article
We hypothesize that artificial intelligence applied to relevant clinical testing in glaucoma has the potential to enhance the ability to detect glaucoma. This premise was discussed at the recent Collaborative Community for Ophthalmic Imaging meeting, “The Future of Artificial Intelligence‐Enabled Ophthalmic Image Interpretation: Accelerating Innova...
Article
Intracranial pressure (ICP) has been proposed to play an important role in the sensitivity to intraocular pressure (IOP) and susceptibility to glaucoma. However, the in vivo effects of simultaneous, controlled, acute variations in ICP and IOP have not been directly measured. We quantified the deformations of the anterior lamina cribrosa (ALC) and s...
Conference Paper
Glaucoma is primarily considered an eye disease with widespread involvements of the brain. Yet, it remains unclear how cerebrovasculature is regulated in glaucoma and how different brain regions coordinate functionally across disease severity. To address these questions, we applied a novel whole-brain relative cerebrovascular reactivity (rCVR) mapp...
Chapter
Recent artificial intelligence advances in ophthalmology, especially deep learning (DL), have shown enormous potential with vast quantities of data. Unlike diabetic retinopathy and age-related macular degeneration where early DL initiatives in ophthalmology focused on, there have been limited but expanding efforts for utilizing DL algorithms to imp...
Article
Full-text available
Purpose: To characterize the visual pathway integrity of five glaucoma animal models using diffusion tensor imaging (DTI). Methods: Two experimentally induced and three genetically determined models of glaucoma were evaluated. For inducible models, chronic IOP elevation was achieved via intracameral injection of microbeads or laser photocoagulat...
Preprint
Full-text available
Vision loss causes dramatic changes in brain function which are thought to facilitate behavioral adaptation. One interesting prospect is that the cholinergic signals are involved in this blindness-induced plasticity. Critically, the nucleus basalis of Meynert is the principal source of the cholinergic signals, however, no studies have yet investiga...
Article
Full-text available
Purpose: Intraocular pressure (IOP) is currently the only modifiable risk factor for glaucoma, yet glaucoma can continue to progress despite controlled IOP. Thus, development of glaucoma neurotherapeutics remains an unmet need. Scutellarin is a flavonoid that can exert neuroprotective effects in the eye and brain. Here, we investigated the neurobeh...
Article
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Background: This review explores the bioethical implementation of artificial intelligence (AI) in medicine and in ophthalmology. AI, which was first introduced in the 1950s, is defined as "the machine simulation of human mental reasoning, decision making, and behavior". The increased power of computing, expansion of storage capacity, and compilati...
Article
Early detection and monitoring are critical to the diagnosis and management of glaucoma, a progressive optic neuropathy that causes irreversible blindness. Optical coherence tomography (OCT) has become a commonly utilized imaging modality that aids in the detection and monitoring of structural glaucomatous damage. Since its inception in 1991, OCT h...
Article
Introduction: Cyclodestructive procedures involve destroying part of the ciliary epithelium to reduce production of aqueous humor and lower intraocular pressure (IOP). Due to its complication rate, cycloablation was historically reserved for eyes with refractory glaucoma that have failed previous filtration procedures, have poor vision and IOP cont...
Preprint
Full-text available
Glaucoma is the leading cause of irreversible blindness with trabecular meshwork (TM) dysfunction resulting in elevated intraocular pressure and retinal ganglion cell (RGC) damage leading to vision loss. In this study, we discovered that secretome, derived from human TM stem cells, via minimal invasive periocular injection, can reduce intraocular p...
Preprint
Full-text available
Alterations in the retinal oxygen saturation (sO2) and oxygen consumption are associated with nearly all blinding diseases. A technology that can accurately measure retinal sO2 has the potential to improve ophthalmology care significantly. Recently, visible-light optical coherence tomography (vis-OCT) showed great promise for noninvasive, depth-res...
Article
Full-text available
Artificial intelligence (AI)-based diagnostic algorithms have achieved ambitious aims through automated image pattern recognition. For neurological disorders, this includes neurodegeneration and inflammation. Scalable imaging technology for big data in neurology is optical coherence tomography (OCT). We highlight that OCT changes observed in the re...
Article
Full-text available
Objective To update the consensus recommendations for reporting of quantitative optical coherence tomography (OCT) study results, thus revising the previously published Advised Protocol for OCT Study Terminology and Elements (APOSTEL) recommendations. Methods To identify studies reporting quantitative OCT results, we performed a PubMed search for...
Article
Glaucoma is a neurodegenerative disease that causes progressive, irreversible vision loss. Currently, intraocular pressure (IOP) is the only modifiable risk factor for glaucoma. However, glaucomatous degeneration may continue despite adequate IOP control. Therefore, there exists a need for treatment that protects the visual system, independent of I...
Article
Full-text available
Objective Familial Dysautonomia (FD) disease, lacks a useful biomarker for clinical monitoring. In this longitudinal study we characterized the structural changes in the macula, peripapillary and the optic nerve head (ONH) regions in subjects with FD. Methods Data was consecutively collected from subjects attending the FD clinic between 2012 and 2...
Article
Full-text available
Unfortunately, the given name of the seventh author was incorrectly tagged in the xml data, therefore it is abbreviated wrongly as ‘‘IM’’ in Pubmed.
Preprint
Deep convolutional neural networks have shown outstanding performance in medical image segmentation tasks. The usual problem when training supervised deep learning methods is the lack of labeled data which is time-consuming and costly to obtain. In this paper, we propose a novel uncertainty-guided semi-supervised learning based on a student-teacher...
Article
Full-text available
Primary open-angle glaucoma (POAG), is a heritable common cause of blindness world-wide. To identify risk loci, we conduct a large multi-ethnic meta-analysis of genome-wide association studies on a total of 34,179 cases and 349,321 controls, identifying 44 previously unreported risk loci and confirming 83 loci that were previously known. The majori...
Article
Full-text available
Purpose: The purpose was to establish the position of the fovea centralis to the optic nerve via en-face, near-infrared spectral domain optical coherence tomography (NIR-OCT) in healthy patients. This may shed light on physiological variability and be used for studying subtle cases of foveal ectopia in macular pathology and after retinal detach-men...
Article
Full-text available
Timely ophthalmologic consultation is important to ensure patients receive high quality ophthalmologic care in the Emergency Department (ED). Tele-ophthalmology may prove useful in safely and efficiently managing ED eye-related complaints. Prior to implementing such a solution, current consultation patterns must be understood. We aimed to assess ca...
Article
Background Glaucoma filtration surgery (GFS) is limited by subconjunctival, episcleral and scleral fibrosis sealing the trabeculectomy and scarring the filtering bleb. Mitomycin‐C (MMC) is commonly applied intraoperatively to the subconjunctival and/or intrascleral space to reduce scarring and promotes GFS success but is associated with postoperati...
Preprint
Purpose Growing evidence suggests, in glaucoma, the dendritic degeneration of subpopulation of the retinal ganglion cells (RGCs) may precede RGCs soma death. Since different RGCs synapse in different IPL sublayers, visualization of the lamellar structure of the IPL could enable both clinical and fundamental advances in glaucoma understanding and ma...
Preprint
Full-text available
Intracranial pressure (ICP) has been proposed to play an important role in the sensitivity to intraocular pressure (IOP) and susceptibility to glaucoma. However, the in vivo effects of simultaneous, controlled, acute variations in ICP and IOP have not been directly measured. We quantified the deformations of the anterior lamina cribrosa (ALC) and s...
Article
Full-text available
Purpose To describe the efficacy and safety of open versus closed conjunctival implantation of the XEN45 Gel Stent. Design Retrospective multicenter study. Subjects 137 patients with glaucoma who underwent XEN45 implantation via open or closed conjunctival methods. The XEN45 was implanted as a stand-alone procedure or at the time of cataract surg...
Chapter
Optical Coherence Tomography (OCT) is pervasive in both the research and clinical practice of Ophthalmology. However, OCT images are strongly corrupted by noise, limiting their interpretation. Current OCT denoisers leverage assumptions on noise distributions or generate targets for training deep supervised denoisers via averaging of repeat acquisit...
Article
Full-text available
In April 2019, the US Food and Drug Administration, in conjunction with 11 professional ophthalmic, vision science, and optometric societies, convened a forum on laser-based imaging. The forum brought together the Food and Drug Administration, clinicians, researchers, industry members, and other stakeholders to stimulate innovation and ensure that...
Article
Full-text available
Purpose: The prevailing theory about the function of lamina cribrosa (LC) connective tissues is that they provide structural support to adjacent neural tissues. Missing connective tissues would compromise this support and therefore are regarded as "LC defects", despite scarce actual evidence of their role. We examined how so-called LC defects alte...
Article
Full-text available
Purpose: Mitomycin C is routinely applied during trabeculectomy surgeries to enhance bleb survival after glaucoma filtration surgery. The current approach involves placing cellulose sponges soaked in mitomycin C at a standard concentration onto bare sclera for a predetermined duration, which varies among surgeons. The purpose of this study was to...
Preprint
Optical Coherence Tomography (OCT) is pervasive in both the research and clinical practice of Ophthalmology. However, OCT images are strongly corrupted by noise, limiting their interpretation. Current OCT denoisers leverage assumptions on noise distributions or generate targets for training deep supervised denoisers via averaging of repeat acquisit...
Article
Collagen fibers organized circumferentially around the canal in the peripapillary sclera are thought to provide biomechanical support to the sensitive tissues within the optic nerve head (ONH). Recent studies have demonstrated the existence of a family of fibers in the innermost sclera organized radially from the scleral canal. Our goal was to dete...
Preprint
In optical coherence tomography (OCT) volumes of retina, the sequential acquisition of the individual slices makes this modality prone to motion artifacts, misalignments between adjacent slices being the most noticeable. Any distortion in OCT volumes can bias structural analysis and influence the outcome of longitudinal studies. On the other hand,...
Chapter
Optical coherence tomography (OCT) is an imaging technique that uses interferometry to reconstruct three-dimensional cross-sectional images of tissue. Today, OCT is widely employed for the diagnosis and management of glaucoma. This chapter will present various image patterns acquired from healthy individuals using four different commerically availa...
Article
Full-text available
Purpose To evaluate the accuracy at which visual field global indices could be estimated from Optical Coherence Tomography (OCT) scans of the retina using deep neural networks, and to quantify the contributions to the estimates by the macula (MAC) and the optic nerve head (ONH). Design Observational cohort study. Participants 10,370 eyes from 109...
Conference Paper
Full-text available
Glaucoma is a neurodegenerative disease of the visual system and is the leading cause of irreversible blindness worldwide. To date, its pathophysiological mechanisms remain unclear. This study evaluated the feasibility of advanced diffusion magnetic resonance imaging techniques for examining the microstructural environment of the visual pathway in...
Article
Background: Teleophthalmology programs are expanding, but have not been adapted into many emergency departments (EDs) in the United States. Introduction: Determining the potential demand for teleophthalmology services in the United States. EDs could enable development of new strategies to improve access to eye care in resource-limited regions....
Article
The direct analysis of 3D Optical Coherence Tomography (OCT) volumes enables deep learning models (DL) to learn spatial structural information and discover new bio-markers that are relevant to glaucoma. Downsampling 3D input volumes is the state-of-art solution to accommodate for the limited number of training volumes as well as the available compu...
Conference Paper
Purpose : Most in-vivo studies which involve the lamina cribrosa (LC) only focus on its anterior surface. In this study, we examine if microstructural deformations that occur in the anterior LC in response to acute IOP elevation are comparable to deformations within its depth. Methods : In-vivo optic nerve head (ONH) spectral-domain OCT scans (Leic...
Article
Purpose: To determine which spectral domain optical coherence tomography biomarkers of idiopathic macular hole (MH) correlate with the postoperative best-corrected visual acuity (BCVA) in anatomically closed MH. Methods: Retrospective analysis of spectral domain optical coherence tomography scans of 44 patients presenting with MH followed for a...
Article
Full-text available
The trabecular meshwork (TM) is an ocular tissue that maintains intraocular pressure (IOP) within a physiologic range. Glaucoma patients have reduced TM cellularity and, frequently, elevated IOP. To establish a stem cell‐based approach to restoring TM function and normalizing IOP, human adipose‐derived stem cells (ADSCs) were induced to differentia...
Article
Aims To evaluate the associations between retinal blood flow (RBF) and optical coherence tomography (OCT) structural measurements in normal-tension glaucoma (NTG) eyes with single-hemifield visual field (VF) damage by the Doppler OCT. Methods The Doppler OCT was used to measure temporal artery (TA) RBF and temporal vein (TV) RBF. Retinal nerve fib...
Article
Full-text available
Purpose: To validate the ability of visible-light optical coherence tomography (vis-OCT) in imaging the full Schlemm's canal (SC) and its surrounding limbal vascular network in mice in vivo through a compound circumlimbal scan. Methods: We developed an anterior segment vis-OCT system and a compound circumlimbal scanning method, which montages ei...
Chapter
Optical coherence tomography (OCT) has become the cornerstone technology in clinical and research imaging in the past two and half decades. OCT performs in vivo, real-time, noncontact scanning and provides cross-sectional and volumetric images with a resolution approaching that of histology. The technology has been used in various medical disciplin...
Conference Paper
Variable eye motions and refractions challenge the stability of clinical retinal oximetry. We developed adaptive spectroscopic techniques for visible-light optical coherence tomography to achieve highly stable measurements of oxygen concentration in human retinal blood vessels.
Article
Full-text available
To construct an optical coherence tomography (OCT) nerve fiber layer (NFL) parameter that has maximal correlation and agreement with visual field (VF) mean deviation (MD). The NFL_MD parameter in dB scale was calculated from the peripapillary NFL thickness profile nonlinear transformation and VF area-weighted averaging. From the Advanced Imaging fo...