Joël Schlatter

Joël Schlatter
Hôpital Universitaire Necker · 75015

PharmD

About

130
Publications
36,033
Reads
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636
Citations
Additional affiliations
March 2020 - April 2021
Hôpital "Villemin - Paul Doumer"
Hôpital "Villemin - Paul Doumer"
Position
  • Chef de service
February 2017 - February 2021
Hôpital Universitaire Necker
Position
  • Medical Professional
November 2000 - January 2017
Hôpital Jean-Verdier –  Hôpitaux Universitaires Paris-Seine-Saint-Denis
Position
  • Hospital Pharmacist
Education
November 1981 - November 1987
Université Paris-Sud 11
Field of study
  • Pharmacy

Publications

Publications (130)
Article
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Objective: The main purpose of this study was to carry out a global risk analysis (GRA) on the subcontracting circuit to determine and evaluate the risks linked to the future subcontracting process and to propose corrective actions for the most critical risks to ensure safety. This study must allow to conclude in an objective way to the feasibilit...
Article
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Ruxolitinib, used in children with steroid-refractory acute graft-versus-host (GVH) disease, is currently commercially available only as a tablet adult dosage. For the paediatric population, an oral liquid would be an adapted dosage formulation. The aim of this study was to develop ruxolitinib compounded oral suspensions at 2 mg/mL by using commerc...
Article
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Pachyonychia congenita (PC) is a genodermatosis associated with severe painful palmoplantar keratoderma (PPK) and thickened dystrophic nails caused by autosomal dominant-negative mutations in five genes encoding keratins 6A-B-C, 16, and 17. The mechanical, surgical, or medical options for painful PC are inefficient. Given ErbB/Her family members’ r...
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The new coronavirus disease 2019 (COVID-19) could be associated with elevated inflammatory cytokine levels, suggesting the involvement of cytokine release syndrome. This syndrome is characterized by release of interleukin 6 correlated with COVID-19 severity and mortality. Targeting IL-6 with Tocilizumab treatment could be a potential therapeutic op...
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Recent studies have highlighted the benefit of repurposing oral erlotinib (ERL) treatment in some rare skin diseases such as Olmsted syndrome. The use of a topical ERL skin treatment instead of the currently available ERL tablets may be appealing to treat skin disorders while reducing adverse systemic effects and exposure. A method to prepare 0.2%...
Article
Résumé Le voretigene neparvovec (VN) est la première thérapie génique en ophtalmologie indiquée chez des patients présentant une dystrophie rétinienne héréditaire liée à une mutation bi-allélique du gène RPE65. Sa récente autorisation européenne de mise sur le marché impose un cadre réglementaire et organisationnel strict pour son utilisation. Nous...
Article
Objectives: To determine the physicochemical stability of pemetrexed diarginine in original vials, and after dilution in two commonly used infusion fluids (0.9% sodium chloride, 5% dextrose) in polyolefin bags, stored under refrigeration (2-8°C) or at ambient temperature (22-25°C) exposed to light. Methods: Stability of pemetrexed diarginine inj...
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Purpose Ketamine is an anesthetic agent commonly used for the induction of anesthesia. Ketamine is also given to control pain, for treatment of posttraumatic stress disorder, and to induce bronchodilation in refractory asthma. Moreover, ketamine therapy is gaining ground as an intervention for patients with treatment-resistant depression and indivi...
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Pentobarbital is used as an alternative in pediatric sedative imaging procedures. Pentobarbital is only available as pharmaceutical powder. Regardless of its clinical use, its manipulation is necessary byhospital pharmacists that must prepare adapted dosage forms for pediatrics. The data presented in this article suggest that extemporaneous suspens...
Article
Ruxolitinib is a Janus Kinase inhibitor currently approved for the treatment of myelofibrosis. It is also a promising drug for the treatment of skin and infectious diseases. In terms of pharmaceutical stability, although ruxolitinib has been established as being sensitive to light, no data on photodegradation processes are available to date, while...
Article
Background Imatinib is a protein-tyrosine kinase inhibitor which is currently only commercially available as a tablet dosage form in the strength of 100mg and 400mg. The elaboration of new oral liquid formulations is suitable in pediatrics and for patients who have difficulties to swallow, notably in the absence of commercial forms. This enables th...
Article
Hydroxychloroquine is an antimalarial drug indicated in the treatment of acute attacks of malaria due to Plasmodium vivax, P. malariae, P. ovale, and susceptible strains of P. falciparum. It is also indicated for the treatment of rheumatoid arthritis, discoid and systemic lupus erythematosus, and more recently proposed in COVID-19 therapy. Hydroxyc...
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Congenital aniridia is a rare and severe panocular disease characterized by a complete or partial iris defect clinically detectable at birth. The most common form of aniridia occurring in around 90% of cases is caused by PAX6 haploinsufficiency. The phenotype includes ptosis, nystagmus, corneal limbal insufficiency, glaucoma, cataract, optic nerve,...
Article
Introduction L’association Ankyloblépharon-dysplasie Ectodermique-fente (Cleft) labio-palatine (syndrome AEC, MIM106260) est une forme rare de dysplasie ectodermique liée à une mutation hétérozygote dans le gène TP63 codant la protéine P63 qui participe à la prolifération et à la différentiation épidermique. Outre les manifestations listées dans l’...
Article
Introduction Les dermatophytoses superficielles étendues résistantes aux traitements usuels peuvent être secondaires à des facteurs liés à l’hôte (immunodépression) ou à la souche (résistance). Nous décrivons le 1er cas en France d’une dermatophytose corporelle étendue résistante à la terbinafine (TBF) en lien avec une infection à une souche de Tri...
Article
The aim of this study was to assess the impact of suspended drug by tablet crushing in our pediatric hospital in term of targeted dose and to identify parameters involved in the potential variability. Four usually crushed pediatric drug substances were selected: amiodarone, warfarin, hydrocortisone and captopril. Each tablet was crushed in a bag us...
Article
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Risk management for workers involved in the handling and preparation of cytotoxic drugs is challenging. This study aims to investigate drug contamination of the exterior surfaces of cytotoxic drug vials. Two batches of commercially available cytotoxic drugs in unprotected vials (ifosfamide, etoposide phosphate and cyclophosphamide) and plastic shri...
Article
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Hypersensitivity to etoposide phosphate has rarely been documented. We report a case of severe hypersensitivity reaction to etoposide phosphate in an old man. The patient experienced anaphylactic shock and has been hospitalized in intensive care unit. Vigilance is required regarding potential severe reactions with etoposide phosphate formulation. H...
Article
Voriconazole systemic use might be restricted by adverse events such as hepatotoxicity and neurotoxicity or drug-drug interactions. Topical application on skin could help to better treat local infection and limit unwanted whole-body exposure. Topical cream voriconazole was stable for 90 days under refrigerated condition. After oral voriconazole tre...
Article
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Background: Hodgkin lymphoma (HL) is the most common hematological malignancy during pregnancy. The first-line treatment for HL in pregnancy is the standard ABVD regimen without any drug and/or dose adjustment. However, data on chemotherapy during twin pregnancies are sparse, and a better understanding of the mechanisms involved in exposure to and...
Article
The purpose of this study was to describe rituximab biosimilar safety in adult hematology and pediatric nephrology units. Adverse events were classified using the Common Terminology Criteria for Adverse Events (CTCAE) classification. Fifty adult patients were enrolled for a total of 126 cures and 11 pediatric patients for a total of 24 biosimilar c...
Article
Purpose: Pentobarbital is a sedative agent to limit children motion during computed tomography or magnetic resonance imaging (MRI) and ensures the successful completion of the imaging procedure. However, data on rectal drug formulation and its stability in practice are not available. The aim of this study was to formulate and evaluate the stability...
Article
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P63 is a major transcription factor regulating skin development and homeostasis. It controls many genes involved in cell proliferation, adhesion, and early differentiation. P63 is mutated in several rare syndromes called p63-related ectodermal dysplasia syndromes (ED). The main forms are EEC and AEC syndromes due to p63 missense mutations on the DB...
Article
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Objective The global professional risk assessment applied to the central unit of antineoplastic agent preparations is part of a mandatory approach required by the European legislation for workers. This study identified the hazardous situations related to the staff activity and then enabled the preparation of a formal plan of occupational prevention...
Article
Introduction Inspirée de la « chambre des erreurs », une unité de reconstitution centralisée (URC) de préparations cytotoxiques a été dupliquée avec l’insertion d’erreurs estimées à haut risque. L’objectif était d’évaluer le niveau de formation et de connaissances du personnel affecté à l’URC et du personnel participant aux gardes et astreintes de...
Article
Introduction Des études ont déjà rapporté des contaminations des surfaces par des cytotoxiques au sein d’unités de reconstitution centralisée et ce au-delà des seuils recommandés par le projet MASHA conduit par la Société Européenne de Pharmacie Oncologique (SEPO). Ainsi, pour protéger le personnel, des mesures de protection et décontamination des...
Article
To prevent the incidence of risks imputable to human error during the process of preparing the infusion pump, clarity in teaching and learning are required. Because traditional classroom training is difficult and time-consuming, the aim of the present study was to challenge the implementation of an e-learning education program for syringe pump use....
Article
Background: The risk of medication errors related to drug preparation unit cannot be totally avoided because of human interference. The aim of this study is to investigate the background and knowledge of the pharmacy staff by replicating the cytotoxic preparation unit with potential errors. Methods: A 10-m2 room was provided to duplicate the cen...
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Purpose: Complications of the intrathecal route may cause potential toxicity related to the medical device and properties of the administered drug and/or excipient. A description of clinical and histological effects of polyethylene glycol and miripirium after Depo-Medrol injection, and the adverse reactions of particulate methylprednisolone acetat...
Article
The complexity and vulnerability of the pediatric population make them unique to risk management. Risk analysis is particularly demanding here and requires comprehensive identification of hazardous situations. Few data are published on methods to prevent medication errors in pediatric inpatients, reducing the possibility for healthcare institutions...
Article
Background Our hospital organization raised the possibilities of outsourcing their sterile pediatric chemotherapy preparations to another hospital conditional on analyzing the potential hazardous events that need to be anticipated. Methods The study was conducted by a multidisciplinary working group from September 2015 to January 2016 with the sup...
Article
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Objectives: The efficacy and safety of an oral pentobarbital suspension for sedation during pediatric MR imaging were assessed. Methods: Data were recorded from October 2016 to January 2017. The exact dose of oral pentobarbital suspension was given for each child with an oral syringe. Parameters recorded included the patient's age and weight, th...
Article
Introduction La sclérose tubéreuse de Bourneville est une maladie rare qui induit des lésions dermatologiques, dont les angiofibromes faciaux qui sont esthétiquement et psychologiquement très handicapant. Les traitements disponibles (lasers, chirurgie, dermabrasion) présentent une variabilité interindividuelle, avec parfois des séquelles importante...
Book
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Depuis plusieurs années, la gestion des risques a trouvé sa place dans les organisations complexes que sont les établissements de santé en France. Il s’agit néanmoins d’une notion « récente » qu’il faut encore définir, faire découvrir et surtout légitimer. Pour anticiper et agir face aux agressions potentielles, tous les acteurs, qu’ils soient ingé...
Article
Objectives This study was designed to assess the physicochemical stability of warfarin sodium liquid formulations stored at room temperature and under refrigeration. Methods Formulations of warfarin sodium 1mg/mL were prepared from either powder or tablets dispersed in mixture containing deionised water, glycerin, sodium phosphate and strawberry a...
Article
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Rationale, aims and objectives: Errors in hospitals during the preparation and administration of intravenous drugs to infants and children have been reported to a rate of 13% to 84%. This study aimed to investigate the potential for hazardous events that may lead to an accident for preparation and administration of drug injection in a pediatric de...
Article
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Objective: Bariatric surgery offers a highly effective mode of treatment for obese patients. Some procedures such as bypass cause an alteration in normal gastrointestinal tract with possible consequences for the uptake of orally administered drugs. Methods: We assessed the literature to ascertain whether the use of oral drugs and especially oral...
Article
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Hydroxycarbamide, available as tablets, is a pharmacological agent for fetal hemoglobin induction such as sickle cell anemia. The need for alternative dosage form options for patients unable to take tablets led hospital pharmacies to prepare solutions and suspensions. The objective of this study was to determine the stability of hydroxycarbamide in...
Article
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This study aimed to develop a reverse phase high-performance liquid chromatographic method with UV detection for the determination of indocyanine green in human plasma. A simple mobile phase consisting of 0.1M acetate buffer pH 3 and acetonitrile (55:45, v/v) was pumped at a flow rate of 1.2 mL/min through a reverse phase XBridge™ BEH C18 column ma...
Article
Study objective: To assess the stability of pharmaceutical suxamethonium (succinylcholine) solution for injection by validated stability-indicating chromatographic method in vials stored at room temperature. Methods: The chromatographic assay was achieved by using a detector wavelength set at 218 nm, a C18 column, and an isocratic mobile phase (...
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Adapted forms for administration to infants are limited. The proposed study was performed to propose oral liquid formulations of idebenone in Ora-Plus and either Ora-Sweet or Ora-Sweet SF, Ora-Blend, Ora-Blend SF, and Inorpha. Each formulation was stored in 30-ml amber glass bottle at 5 or 25°C for 90 days. Idebenone content in these suspensions, d...
Article
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A stability-indicating assay by reversed-phase high performance liquid chromatography method was developed and validated for the determination of sulthiame (STM). The chromatographic separation was achieved on a reversed-phase NovaPack C18 column and an isocratic mobile phase consisting of deionized water:methanol (70:30, v/v). The flow rate was 1....
Article
The excreta management of elderly patients treated by chemotherapy is not regularly dealt by a pragmatic process depending cancer treatments. It involves identifying the excreta toxicity, including their chemical classification, cytotoxic nature, renal or fecal exposition time of the drugs. Protective measures must be described to avoid the risk of...
Data
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Article
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A stability-indicating method was validated for the determination in pharmaceutical forms of idebenone a coenzyme Q10-like compound. The assay was achieved by liquid chromatography analysis using a reversed-phase C18 column and a detector set at 480 nm. The optimized mobile phase consisted of isocratic flow rate at 1.0 mL/min for 3 min with methano...
Article
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A stability-indicating assay by reversed-phase high performance liquid chromatography (RP-HPLC) method was developed for the determination of pentobarbital sodium in oral formulations: a drug used for infant sedation in computed tomography (CT) or magnetic resonance imaging (MRI) scan. The chromatographic separation was achieved on a reversed-phase...
Book
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Ce guide se compose d’une partie sur des généralités spécifiques de la pédiatrie (législation, aspects techniques, erreurs médicamenteuses…), puis d’une partie comprenant plus de 90 monographies de principes actifs. Chaque monographie détaille les indications A.M.M. et hors A.M.M. et les posologies pédiatriques, les propriétés physico-chimiques du...
Article
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This study aimed to develop a solid-phase extraction gas chromatography-selected ion monitoring-mass spectrometry method for the determination of methadone (MDN) and 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine (EDDP) in human plasma. The linear response was obtained over the concentration range from 10 to 2000 ng/mL for MDN and EDDP. The abso...
Article
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The physical and chemical stability of a preservative-free oral solution of hydrocortisone succinate was studied at different pH values and storage temperatures. Oral solutions of hydrocortisone 1 mg/mL were prepared by dissolving hydrocortisone succinate powder in citrate buffers at pH 4.0, 5.5, and 6.5, or with sterile water (pH 7.4) stored in am...
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Background: The rate of entry of cocaine into the brain is a critical factor that influences neuronal plasticity and the development of cocaine addiction. Until now, passive diffusion has been considered the unique mechanism known by which cocaine crosses the blood-brain barrier. Methods: We reassessed mechanisms of transport of cocaine at the blo...
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Transport across the BBB is a determinant of the rate and extent of drug distribution in the brain. Heroin exerts its effects through its principal metabolites 6-monoacetyl-morphine (6-MAM) and morphine. Morphine is a known substrate of P-glycoprotein (P-gp) at the blood-brain-barrier (BBB) however, little is known about the interaction of heroin a...
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A gas chromatography-mass spectrometry method was developed and validated for the simultaneous automated solid-phase extraction and quantification of cotinine and trans-3-hydroxycotinine in human urine. Good linearity was observed over the concentration ranges studied (R(2) > 0.99). The limit of quantification was 10 ng/mL for both analytes. The li...
Article
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A gas chromatography tandem mass spectrometry method for quantification of buprenorphine (BUP) and norbuprenorphine (NBUP) in brain and plasma samples from mice was developed and validated. Analytes were extracted from the brain or plasma by solid phase extraction and quantified within 20 minutes. Calibration was achieved by linear regression with...
Article
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Naturally occurring cannabinoids (phytocannabinoids) are biosynthetically related terpenophenolic compounds uniquely produced by the highly variable plant, Cannabis sativa. Natural and synthetic cannabinoids have been extensively studied since the discovery that the psychotropic effects of cannabis are mainly due to THC. However, cannabinoids exert...
Article
Traffic offences are a common cause of detention in police custody. We hypothesized that drug intoxication while driving could correspond to specific medical conditions of the detainees. Our objective was to evaluate medical features and addictive behaviours of suspected drug drivers and to collect data regarding assaults or injuries in these indiv...
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Full-text available
A stability-indicating reversed-phase high performance liquid chromatography (RP-HPLC) method was developed for the determination of betaxolol hydrochloride, a drug used in the treatment of hypertension and glaucoma. The desired chromatographic separation was achieved on a Nucleosil C18, 4 µm (150 × 4.6 mm) column, using isocratic elution at a 220...
Article
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Background. Cytoadherence and sequestration of erythrocytes containing mature stages of Plasmodium falciparum are central to the pathogenesis of severe malaria. The oral anthelminthic drug levamisole inhibits cytoadherence in vitro and reduces sequestration of late-stage parasites in uncomplicated falciparum malaria treated with quinine. Methods. F...
Article
The oral antihelmintic drug levamisole reduces sequestration of late stage parasites in falciparum malaria. Levamisole has been also identified as a cocaine adulterant. In the present study, authors developed a sensitive and selective HPLC-assay for the determination of levamisole in the plasma from patients with falciparum malaria. Chromatographic...
Article
Although many legal and clinical requirements are in effect for the preparation and administration of the antineoplasic drugs, limited data exist on the potential cytotoxic risk to healthcare personnel from exposure of excreta (urine, feces, expectorations, saliva, perspiration, and vomiting) from patients. A preliminary risk analysis was conducted...
Article
Stay safe, take no risk to his life, seems to be reasonable goal that everyone should continue. Some patients do not follow the recommendations of the caregivers, even when they are aware that the behavior of non-compliance is bad for them. The causes of this unreasonable conduct can be understood by the concept of weakness of will or akrasia, but...
Article
Background: Methanol, acetaldehyde, acetone, and ethanol, which are commonly used as biomarkers of several diseases, in acute intoxications, and forensic settings, can be detected and quantified in biological fluids. Gas chromatography (GC)-mass spectrometry techniques are complex, require highly trained personnel and expensive materials. Gas chro...
Article
Full-text available
A stability-indicating reversed-phase high performance liquid chromatography (RP-HPLC) method was developed for the determination of betaxolol hydrochloride, a drug used in the treatment of hypertension and glaucoma. The desired chromatographic separation was achieved on a Nucleosil C18, 4 μm (150 × 4.6 mm) column, using isocratic elution at a 220...