Joel OnojaUniversity of Nigeria Nsukka, Nsukka · Department of Pharmacognosy and Environmental Medicine
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Backgound Alzheimer’s disease (AD) is a progressive and fatal neurodegenerative disease, clinically characterized by memory and cognitive dysfunction. AD affects about 35 million people worldwide today and is estimated to nearly double every 20 years. Cnidoscolus aconitifolius (Miller) I.M. Johnston has been reported in Nigerian ethnomedicine as a...
Purpose: To investigate the acetylcholinesterase (AChE) inhibitory potential of columbin and also to assess its binding affinity against AChE protein. Methods: Crystals of columbin were isolated from the ethyl acetate fraction of Tinospora cordifolia using column chromatography and its structure was determined using x-ray crystallography. Ellman co...
Inhibition of acetylcholinesterase (AChE) is a promising strategy for the management of Alzheimer’s disease (AD). Prolyl endopeptidase (PEP) is a post-proline cleaving enzyme that plays an important role in learning and memory. This study explore the AChE and PEP inhibitory activities of compounds from T. cordifolia. Their affinity for different bi...
This study aimed to investigate in vivo anti-malarial effect of methanolic extract of Cleome viscosa whole plant and fractions (n-hexane and ethyl acetate) against early, established and residual malaria infections. The in vivo anti-malarial effect against early infection, curative effect against established infection and prophylactic effect agains...