Joel P Joseph

Joel P Joseph
Indian Institute of Science | IISC · Centre for BioSystems Science and Engineering

M.Tech

About

12
Publications
23,510
Reads
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267
Citations
Citations since 2016
12 Research Items
267 Citations
20162017201820192020202120220204060
20162017201820192020202120220204060
20162017201820192020202120220204060
20162017201820192020202120220204060
Additional affiliations
October 2017 - present
Manipal Academy of Higher Education
Position
  • Fellow
July 2017 - September 2017
ITC Life Science & Technology Center
Position
  • Trainee
February 2016 - May 2017
SRM Institute of Science and Technology
Position
  • Research Assistant
Description
  • Assisted the Faculty in conducting Laboratory sessions on Animal Cell Culture, Gene Expression, and rDNA Technology.
Education
July 2015 - June 2017
SRM Institute of Science and Technology
Field of study
  • Genetic Engineering
September 2011 - June 2015

Publications

Publications (12)
Article
Full-text available
In the recent times, stem cell biology has garnered the attention of the scientific fraternity and the general public alike due to the immense therapeutic potential that it holds in the field of regenerative medicine. A breakthrough in this direction came with the isolation of stem cells from human embryo and their differentiation into cell types o...
Article
Hypoxia, a condition of low oxygen tension in tissues, has emerged as a crucial factor in tumor pathophysiology. Hypoxic microenvironment gives rise to altered cellular metabolism and triggers varied molecular responses. These responses promote tumor progression and confer radiation resistance and chemo resistance to tumors. The predominant molecul...
Article
Full-text available
Studies revealing molecular mechanisms underlying neural specification have majorly focused on the role played by different transcription factors, but less on non-nuclear components. Earlier, we reported mitochondrial superoxide dismutase (SOD2) to be essential for self-renewal and pluripotency of mouse embryonic stem cells (mESCs). In the present...
Article
Full-text available
Sepsis is a dysregulated host immune response to microbial invasion or tissue damage, leading to organ injury at a site distant from that of the infection or damage. Currently, the widely used mice models of sepsis include lipopolysaccharide (LPS)- induced endotoxemia, cecal ligation and puncture (CLP), and monobacterial infection model systems. Th...
Article
Full-text available
The ability of a mitochondrion to undergo fission and fusion, and to be transported and localized within a cell are central not just to proper functioning of mitochondria, but also to that of the cell. The cytoskeletal filaments, namely microtubules, F-actin and intermediate filaments, have emerged as prime movers in these dynamic mitochondrial sha...
Chapter
Stem cells have emerged as a promising source of cell-based therapy in regenerative medicine with several stem cell-based products currently in clinical trials. Despite the immense therapeutic potential, their isolation from some of the emerging sources and their characterization has been naïve owing to the lack of standard markers for the same. So...
Article
Full-text available
Cyclophosphamide (CYP) is an alkylating agent widely used as an anti-neoplastic drug to treat cancer. Hemorrhagic cystitis (HC) is one of the toxicities caused by prolonged cyclophosphamide (CYP) treatment. We investigated the mucosal changes in the urinary bladder of rats with cyclophosphamide (CYP) induced hemorrhagic cystitis by Lectin histochem...
Article
Studies conducted in the past decade have reported Nucleostemin (NS) as a nucleolar protein that has a role in self-renewal and cell cycle regulation in cancer/stem cells, but is absent in differentiated cells. The localization and expression pattern of NS has always been disputed, as reports indicate its varied levels among tissues and cells. This...
Chapter
In an adult human body, somatic stem cells are present in small amounts in almost all organs with the function of general maintenance and prevention of premature aging. But, these stem cells are not pluripotent and are unable to regenerate large cellular loss caused by infarctions or fractures especially in cells with limited replicative ability su...
Poster
Cyclophosphamide is an alkylating agent that is widely used as an anti-neoplastic drug in treatment of different types of cancer. Hemorrhagic cystitis is one of the toxicities caused by prolonged cyclophosphamide treatment. The mucosal changes in the urinary bladder of rats with cyclophosphamide induced hemorrhagic cystitis were investigated by Lec...
Conference Paper
The protozoan parasites Trypanosoma brucei and Trypanosoma cruzi are the etiological agents of Human African Trypanosomiasis (sleeping sickness) and American Trypanosomiasis (Chaga’s disease) that affect over 65 million people in the world. Trypanosomiases fall under the umbrella of Neglected Tropical Diseases (NTDs) due to the fact that little res...
Poster
Water is one of the most essential components of a living system as it forms an indispensable part of all physiological processes. The deterioration in its quality due to the presence of microbial pathogens, heavy metals, and deleterious chemicals causes an impairment in the regulatory mechanisms associated with the cellular functions, thus leading...

Questions

Question (1)
Question
How do I confirm whether the ligation has occurred? Is there any method to confirm whether the ligation has happened, using the ligated product, other than to check with antibiotic selection post transformation?

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Projects

Projects (2)
Archived project
Project
Differential expression pattern of Nucleostemin in cell lines (Stem cells, cancerous cells and normal cells) and also in animal models