Jochen Türk

Jochen Türk
Institute of Energy and Environmental Technology e.V. (IUTA) · Environmental Hygiene & Micropollutants

PhD

About

112
Publications
15,395
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
2,198
Citations

Publications

Publications (112)
Article
Modern therapy strategies are based on patient-specific treatment where the drug and dose are optimally adapted to the patient's needs. In recent drugs, monoclonal antibodies (mAbs) are increasingly used as active ingredients. Their patient-specific formulations are not part of the pharmaceutical industry’s manufacturing process but are prepared fr...
Article
Full-text available
Pesticides such as organothiophosphates (OTPs) are neurotoxically active and enter the aquatic environment. Bioassays, using acetylcholinesterase (AChE), a suitable substrate and reactant, can be applied for the photometric detection of AChE-inhibiton (AChE-I) effects. The oxidized forms of OTPs, so-called oxons, have higher inhibition potentials f...
Article
Wastewater treatment plants (WWTPs) may represent point sources for microplastic discharge into the environment. Quantification of microplastic in effluents of WWTPs has been targeted by several studies although standardized methods are missing to enable a comparability of results. This study discusses theoretical and practical perspectives on best...
Chapter
In order to ensure a high level of product quality and safety, regular quality controls are mandatory, especially in the pharmaceutical industry. These quality controls are strictly regulated and require a high level of documentation. With the goal of complete traceability, these regulations are constantly being tightened, while a majority of labor...
Article
Full-text available
rationale of the study Three steroidal estrogens, 17α-ethinylestradiol (EE2), 17β-estradiol (E2), estrone (E1), and the non-steroidal anti-inflammatory drug (NSAID), diclofenac have been included in the first Watch List of the Water Framework Directive (WFD, EU Directive 2000/60/EC, EU Implementing Decision 2015/495). This triggered the need for mo...
Article
The prevalence of organic micropollutants (OMPs) in aquatic environment has expedited scientific and regulatory efforts to retrofit existing wastewater treatment plants (WWTPs). The current strategy involves WWTPs upgrading with post-ozonation i.e., ozone (O3) and/or peroxone process (O3+H2O2). Still, ozone-based degradation of OMPs faces several c...
Article
de Die Bestimmung der Wirkung von toxischen Verbindungen in Abwässern erfolgt mittels dünnschichtchromatographischer Verfahren. Für eine Automation der wirkungsbezogenen Analytik wurde eine bereits bestehende technische Lösung als Open-Source-Hardware-Ansatz in Kombination mit der additiven Fertigung adaptiert. Das System ist flexibel auf spezifisc...
Article
Monitoring of microplastics (MP) release into the aquatic environment is an important topic and proposed point sources for microplastics are wastewater treatment plants (WWTPs). Three full-scale WWTPs (A, B, C) were investigated to compare the effect of continuously and discontinuously backwashed sand filters to retain microplastics from secondary...
Article
Die verbreitetsten Verfahren zur Identifikation und zahlenmäßigen Quantifizierung von Mikroplastikpartikeln bis 10 µm bzw. 1 µm sind die mikro-Fourier Transformation-Infrarotspektroskopie und Raman-Mikrospektroskopie. Thermoanalytische Verfahren wiederum nutzen polymerspezifische Pyrolyse-Produkte, um Arten der einzelnen Polymere und deren Massenge...
Article
The aim of this interdisciplinary research project in North Rhine-Westphalia (NRW), Germany, entitled “Elimination of pharmaceuticals and organic micropollutants from waste water” involved the conception of cost-effective and innovative waste-water cleaning methods. In this project in vitro assays, in vivo assays and chemical analyses were performe...
Article
The drugs used for treatment during chemotherapy are manufactured individually for each patient in specialised pharmacies. Thorough quality control to confirm the identity of the delivered active pharmaceutical ingredient and the final concentration of the prepared application solution is not standardized yet except for optical or gravimetric testi...
Article
Effect-directed analysis (EDA) that combines effect-based methods (EBMs) with high-performance thin-layer chromatography (HPTLC) is a useful technique for spatial, temporal, and process-related effect evaluation and may provide a link between effect testing and responsible substance identification. In this study, a yeast multi endocrine-effect scre...
Article
A process combining three steps has been developed as tertiary treatment for waste water in order to remove micropollutants not eliminated by a conventional waste water treatment plant (WWTP). These three processes are ozonation, photocatalysis and granulated activated carbon adsorption. This process has been developed through three scales: laborat...
Article
Die Kopplung von Hochleistungsflüssigkeitschromatographie (HPLC) und Massenspektrometrie (MS) gehört zu den geläufigen Kopplungstechniken der modernen instrumentellen Analytik, v. a. in der Analyse von Biomolekülen wie monoklonalen Antikörpern. Das dabei am häufigsten verwendete Interface basiert auf dem Prinzip der Elektrospray-Ionisierung (ESI)....
Conference Paper
Full-text available
Background and importance Several studies have shown that antineoplastic drug contamination is found on various work surfaces in hospitals and varies widely on wards. The MASHA project (research about environmental contamination by cytotoxics and management of safe handling procedures) was to set up to conduct new research, in cooperation with the...
Article
The field of high resolution mass spectrometry has undergone a rapid progress in the last years due to instrumental improvements leading to a higher sensitivity and selectivity of instruments. A variety of qualitative screening approaches, summarized as non-target screening, have been introduced and have successfully extended the environmental moni...
Article
Full-text available
The combination of a representative microplastic sampling method and a fast-quantitative analysis using Pyrolysis-GC-MS (Py-GC-MS) for investigation of the microplastic load and mass balances is presented in this work. A representative microplastic filtration requires a method allowing quick extraction of the sample. The developed steel based casca...
Technical Report
Full-text available
This guideline is intended to show fundamental aspects in the use of high performance liquid chromatography in combination with high resolution mass spectrometry. Aside from technical information pertaining to devices and potential contamination in sampling and measurements, this also includes data evaluation and quality assurance measures. The gui...
Article
To reduce the discharge of trace organic compounds into water bodies associated with potential toxic effects such as endocrine disruption, new advanced treatment methods are being investigated at several wastewater treatment plants (WWTPs). One of the most studied and already implemented technologies is ozonation. However, ozonation only partially...
Article
The objective of this study was to develop and validate an innovative technology to ensure efficient elimination of different types of micropollutants and toxic compounds in waste water. The process is a tertiary treatment process, which can be easily integrated into municipal and industrial waste water treatment plants. It is based on oxidation by...
Article
Regarding endocrine disrupting chemicals, an impact on aquatic organisms at already very low concentrations is observed. Consequently, there is a need for sensitive analytical methods. Currently, no instrumental analysis methods exist that fulfil this requirement. To overcome these limitations, effect-based methods (EBMs) are one option for screeni...
Article
Surface waters, especially in densely populated areas, are facing multiple anthropogenic pressures. Micro pollutants are of growing concern. Improved analytical methods are used to focus on substances like ICM with a (high) potential of hazardous effects against water organisms or the water quality in general ICM are essential for instance in compu...
Article
Full-text available
Correction Authorship: Linda Gehrmann and Helena Bielak contributed equally to this work and are regarded as joint first authors.
Article
The present study was conducted to investigate sediment accumulation patterns of PAHs, PCBs, flame retardants and pesticides along 100 m transects downstream from three different combined sewer overflows (CSOs). Additionally, the concentrations of PAHs and PCBs were quantified to allow a characterization of the sediment quality. The suspect screeni...
Preprint
Full-text available
Complex mixtures of chemicals in waste and finally in surface water may pose a risk to the environment and also to human health. This contamination of surface water cannot be addressed with chemical analysis alone. Tools are required to detect and assess these micropollutants which might cause adverse effects. Effect-directed analysis (EDA) with ef...
Conference Paper
Full-text available
Background Patient-specific preparations have become a central therapy concept in oncological treatment. The highly potent cytostatic agents are characterised by a narrow therapeutic range. Therefore, exact dosage is important, as lower amounts reduce the effectiveness and higher doses increase the risk of severe side effects. Compound confusion ca...
Article
Full-text available
In this study, pharmaceutically active compounds (PhACs) were analyzed in the influent and effluent of a domestic wastewater treatment plant in Turkey and a municipal wastewater treatment plant in Germany and the toxicity of these wastewaters were estimated using a toxic unit (TU) approach. A total of 21 and 32 PhACs were detected in the domestic w...
Article
Endocrine-active substances can adversely impact the aquatic ecosystems. A special emphasis is laid, among others, on the effects of estrogens and estrogen mimicking compounds. Effect-based screening methods like in vitro bioassays are suitable tools to detect and quantify endocrine activities of known and unknown mixtures. This study describes th...
Article
Monoclonal antibodies are a group of commonly used therapeutics, whose occupational health risk is still discussed controversially. The long-term low-dose exposure side effects are insufficiently evaluated; hence, discussions are often based on a theoretical level or extrapolating side effects from therapeutic dosages. While some research groups re...
Conference Paper
Background In the last decade biopharmaceuticals became increasingly important. In 2016, nine out of 10 top-selling drugs were classified as biologics and their market share is still growing. The risk assessment of biopharmaceuticals from the occupational health perspective, however, is not completed. Especially the role of therapeutic monoclonal a...
Article
Effect-based methods including cell-based bioassays, reporter gene assays and whole-organism assays have been applied for decades in water quality monitoring and testing of enriched solid-phase extracts. There is no common EU-wide agreement on what level of bioassay response in water extracts is acceptable. At present, bioassay results are only ben...
Article
Full-text available
(Anti-)Estrogenic and (anti-)androgenic effects in wastewater during advanced treatment: Comparison of three in vitro bioassays L. Gehrmann & H. Bielak et al., 2016 Endocrine disrupting chemicals, which are discharged into the environment mainly by wastewater treatment plants (WWTP), have been shown to induce adverse effects in aquatic life and t...
Chapter
Full-text available
Moderne Kläranlagen reinigen Abwasser effizient von leicht abbaubaren organischen Stoffen und Nährstoffen. Sie sind aber nicht für die Eliminierung von Mikroschadstoffen konzipiert, so dass viele dieser Stoffe im Abwasser kaum abgebaut werden und somit über die Vorflut in Oberflächengewässer gelangen. Dieser Artikel geht unter anderem der Frage nac...
Article
Ozonation is used as additional wastewater treatment option to remove recalcitrant micropollutants. It also removes the estrogenic activity found in wastewater but not always the anti-estrogenic activity. This can be explained by an incomplete removal of anti-estrogenic micropollutants or by formation of transformation products (TPs) which retain t...
Article
Arxula adeninivorans-based yeast cell assays for the detection of steroid hormones demonstrated their efficiency for the determination of total hormone activity in a variety of samples using a microtiter plate format. In this study, a preliminary chromatographic separation using thin-layer chromatography plates is introduced in order to allow a rap...
Presentation
Full-text available
The aim of this study was to investigate the impact of ozone treatment on substances with endocrine activity in wastewater. More precisely, the degradation of substances with known endocrine potentials was related to the analysis of the biological activity after ozonation. Therefor wastewater samples were spiked with model substances, degradation w...
Article
Full-text available
Effluents from municipal wastewater treatment plants (WWTPs) are known to be point sources of micropollutants for surface waters. The aim of this study was to examine a reconstructed full-scale ozonation equipped with a pump-injector system for ozone (O3) dosage and a fluidized moving-bed reactor as biological posttreatment at a municipal WWTP util...
Chapter
Dieses Kapitel erläutert und kommentiert der wichtigsten Überlegungen in Bezug auf die Aspekte der Methodenentwicklung für die LC-MS-Kopplung. Heutzutage wird im Wesentlichen zwischen Targetanalytik und Screeninguntersuchungen differenziert. Bei der Targetanalytik existiert eine feste Liste an Substanzen, die in einer Probe nachgewiesen und deren K...
Chapter
This chapter presents some important observations with respect to the development of methods for liquid chromatography-mass spectrometry (LC/MS) coupling. It is based on a DIN specification from the field of environmental analysis, which regulates the approach used in the “determination of selected pharmaceutical ingredients and other organic mater...
Article
A perforation sensor was realized with gas diffusion electrodes and galvanic silver deposition. This innovative metal system having electro-chemically active surfaces was developed to sensitively and selectively indicate a certain sufficient threshold value for the amount of the selected airborne molecular contamination (AMC) in the air stream of a...
Poster
Full-text available
Die Untersuchungen dieser Studie befassen sich mit jenen Kombinationseffekten, die auftreten können, wenn Arzneimittel mit unterschiedlichen hormonellen Wirkungen in einem Gemisch auftreten. Um nachvollziehen zu können, ob Transformationsprodukte durch den Einsatz von Ozon zu einem auftretenden Effekt beitragen, wurde der Abbau von Modellsubstanzen...
Article
A perforation sensor was realized with gas diffusion electrodes and galvanic silver deposition. This innovative metal system having electro-chemically active surfaces was developed to sensitively and selectively indicate a certain sufficient threshold value for the amount of the selected airborne molecular contamination (AMC) in the air stream of a...
Article
Full-text available
Nebivolol (NEB) is one of the top-sold prescription drugs belonging to the third generation of beta-blockers. However, so far, occurrence data in the environment are lacking. Within this study NEB has been found for the first time in effluent samples of wastewater treatment plants in Germany with an average concentration of 13 ng L⁻¹.
Article
Full-text available
The aim of the study was to present first preliminary characterization of Turkish hospital wastewaters, their environmental risk, and a method for toxicity assessment. The hospital wastewater samples were collected from two of the largest medical faculty hospitals and a training and research hospital in Istanbul, Turkey. The samples from the select...
Chapter
This chapter explains the possibilities of the hyphenation between (U)HPLC systems with modern mass spectrometers. One central issue is the differentiation between target analysis, suspected-target and non-target screening for the individual fields of application, and kind of mass spectrometers. Method development for multicomponent target analysis...
Article
A fast quantification method for the determination of 11 antineoplastic drugs from wipe samples was developed using micro-scale liquid chromatography in combination with tandem mass spectrometry. The extraction efficiency from the wipes has been investigated using different extraction solvents. The results indicate that a mixture of 70/30 water/iso...
Article
Hydrothermal carbonization (HTC) has become an esteemed method to convert sewage sludge into biochar. Besides dewatering and disinfection the process is suggested to reduce the micropollutant load, which would be beneficial for the use of biochar as fertilizer. This study was designed to examine reduction of micropollutants and formation of transfo...
Article
Anilines as archetypes for aromatic amines, which play an important role in the production of, e.g., dyestuffs, plastics, pesticides or pharmaceuticals were investigated in their reaction with ozone. Due to their high reactivity towards ozone (1.2 × 105–2.4 × 106 M−1 s−1) the investigated aniline bearing different substituents are readily degraded...
Article
Ciprofloxacin (CIP) is a broad-spectrum antibiotic with five pH dependent species in aqueous medium, which makes its degradation behavior difficult to predict. For the identification of transformation products and prediction of degradation mechanisms, a new experimental concept making use of isotopically labeled compounds together with high resolut...
Article
Background Contamination with cytotoxic drugs in hospital units has been reported in several studies in the past few years. No multicentre studies have been conducted in different European hospitals. Purpose To obtain an overview of the current situation in European hospitals concerning cytotoxic contamination at various sites, including drug prepa...
Chapter
The entry of micropollutants into the water cycle is ofgrowing concern. This is also reflected by the EU WaterFramework Directive and new guidelines for wastewatertreatment plant effluents. Ozonation seems to be a goodanswer to this problem. The wastewater treatment plantsBad Sassendorf, Duisburg-Vierlinden and Schwerte wereextended by a full-scale...
Chapter
Full-text available
To gain biologically and chemically safe conditions in aquatic systems, as required by the EU Water Framework Directive, advanced oxidation processes are the only conceivable possibility to remove pharmaceuticals and their metabolites from waste water. Water treatment plants are not designed for the complete mineralization of these substances, so t...
Article
The two Arxula adeninivorans-based bioassays (A-YGS and A-YGFS) described here provide sensitive and reliable screening for glucocorticoids in aquatic environments. The biocomponents of A-YGS and A-YGFS were constructed to carry the human glucocorticoid receptor (hGRα) and the phytase gene (phyK, derived from Klebsiella sp. ASR1) or a fluorescence...
Article
We investigated the removal of twelve pharmaceuticals in sewage sludge by hydrothermal carbonization (HTC), which has emerged as a technology for improving the quality of organic waste materials producing a valuable biochar material. In this study, the HTC converted sewage sludge samples to a biochar product within 4h at a temperature of 210°C and...
Article
Full-text available
The interest in two-dimensional liquid chromatography separations is growing every year together with the number of open questions on the benefits of multidimensional systems in comparison to one-dimensional liquid chromatography. In order to solve some of these open questions this work presents a comparison of one-dimensional and microscale two-di...
Chapter
Neben den bereits angesprochenen Merkmalen, die bei der Kopplung von UHPLC-Systemen und Massenspektrometern beachtet werden müssen, sollen in diesem Kapitel vor allem auch die verschiedenen Screeningmethoden zum Beispiel Suspected-Target Screening und Non-Target Screening, die mit modernen Massenspektrometern möglich sind, erläutert werden. Gerade...
Article
An Arxula adeninivorans based microbial biosensor has been developed for the determination of pharmaceuticals and chemicals such as omeprazole, lansoprazole, ß-naphtoflavone and methylcholanthrene within 5 hours using biochemical detection and 4 hours and 10 minutes using amperometric detection. The biosensor consists of genetically modified A. ade...
Poster
Full-text available
Pharmaceuticals and their metabolites enter the hydrological cycle mainly through hospital effluents and private households. They were detected in surface and ground water in concentrations to μg/L and even after the water treatment process in drinking water. To gain biologically and chemically save conditions in aquatic systems, as required by the...
Article
Producing valuable biochar from waste materials using thermal processes like hydrothermal carbonization (HTC) has gained attention in recent years. However, the fate of micropollutants present in these waste sources have been neglected, although they might entail the risk of environmental pollution. Thus, an HPLC-MS/MS method was developed for 12 p...
Article
Eine Vielzahl von Beschäftigten im Gesundheitsbereich aber auch in Produktions-, Abfüll- und Transportbetrieben hat Umgang mit hochwirksamen Arzneimitteln, die eine potentielle Gefährdung darstellen. Für die Bewertung der beruflichen Exposition von Personen durch Zytostatika existieren bislang keine standardisierten, validierten Verfahren zum Biomo...
Article
The entry of pharmaceuticals into the water cycle from sewage treatment plants is of growing concern because environmental effects are evident at trace levels. Ozonation, UV- and UV/H2O2-treatment were tested as an additional step in waste water treatment because they have been proven to be effective in eliminating aqueous organic contaminants. The...
Article
The amount of organic micropollutants detected in surface waters increases steadily. Common waste water treatment plants are not built to remove these substances. Thus there is a need for new technologies. A promising technology is the use of advanced oxidation processes through which organic micropollutants can be removed from waste water. However...
Article
A novel multidimensional separation system based on on-line comprehensive two-dimensional liquid chromatography and hybrid high-resolution mass spectrometry has been developed for the qualitative screening analysis and characterization of complex samples. The core of the system is a consistently miniaturized two-dimensional liquid chromatography th...
Article
The ‘EstraMonitor’ was developed to provide an automated system for the detection of estrogenic compounds. It can be used for semi-online and continuous monitoring without additional instrumentation. Previously it was used to detect pure estrogenic molecules. In this investigation, the ‘EstraMonitor’ is used to detect the estrogenic activity in fiv...
Poster
Full-text available
Ciprofloxacin (CIP) is an antibiotic belonging to fluoroquinolone drugs, which has been widely used since 1987 for both humans and animals worldwide. CIP has been detected in hospital wastewater effluents and also in the effluent of wastewater treatment plants (WWTPs). This may lead to development of bacterial resistance resulting in toxic effects...