João C. Teixeira

João C. Teixeira
Australian National University | ANU · College of Asia & the Pacific

PhD
ARC DECRA Fellow Australian National University

About

26
Publications
14,693
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411
Citations
Introduction
I am an ARC DECRA Fellow at Evolution of Cultural Diversity Initiative within the School of Culture, History and Language at the Australian National University. My research uses evolutionary biology and population genetics to understand the demographic and adaptive history of humans and closely related species. I am particularly interested in Pleistocene human evolution, historical human migrations and the maintenance of advantageous genetic diversity in natural populations.
Additional affiliations
February 2018 - present
University of Adelaide
Position
  • Research Associate
Description
  • Human evolution and the colonisation of Sahul. Supervisors: Ray Tobler and Alan Cooper.
May 2016 - July 2017
Institut Pasteur
Position
  • PostDoc Position
Description
  • Natural selection and the evolution of immune genes in humans and closely-related species. Supervisor: Lluis Quintana-Murci
September 2011 - April 2016
Max Planck Institute for Evolutionary Anthropology
Position
  • PhD Student
Description
  • Long-term balancing selection in the genomes of humans and other great apes. Supervisors: Aida Andrés and Svante Pääbo
Education
September 2011 - April 2016
Max Planck Institute for Evolutionary Anthropology
Field of study
  • Evolutionary Genetics
September 2009 - July 2011
University of Porto
Field of study
  • Forensic Genetics
September 2005 - September 2009
University of Porto
Field of study
  • Biology

Publications

Publications (26)
Article
Full-text available
The tropical archipelago of Wallacea contains thousands of individual islands interspersed between mainland Asia and Near Oceania, and marks the location of a series of ancient oceanic voyages leading to the peopling of Sahul—i.e., the former continent that joined Australia and New Guinea at a time of lowered sea level—by 50,000 years ago. Despite...
Article
Full-text available
The hominin fossil record of Island Southeast Asia (ISEA) indicates that at least two endemic ‘super-archaic’ species—Homo luzonensis and H. floresiensis—were present around the time anatomically modern humans arrived in the region >50,000 years ago. Intriguingly, contemporary human populations across ISEA carry distinct genomic traces of ancient i...
Article
Full-text available
The Southern Cone of South America (SCSA) is a key region for investigations about the peopling of the Americas. However, little is known about the eastern sector, the Argentinian Pampas. We analysed 18 mitochondrial genomes—7 of which are novel—from human skeletal remains from 3 Early to Late Holocene archaeological sites. The Pampas presents a di...
Article
Full-text available
The current rate of species extinction is rapidly approaching unprecedented highs, and life on Earth presently faces a sixth mass extinction event driven by anthropogenic activity, climate change, and ecological collapse. The field of conservation genetics aims at preserving species by using their levels of genetic diversity, usually measured as ne...
Article
Full-text available
Mesoamerica is a historically and culturally defined geographic area comprising current central and south Mexico, Belize, Guatemala, El Salvador, and border regions of Honduras, western Nicaragua, and northwestern Costa Rica. The permanent settling of Mesoamerica was accompanied by the development of agriculture and pottery manufacturing (2500 BCE–...
Preprint
Full-text available
The hominin fossil record of Island Southeast Asia (ISEA) indicates that at least two endemic super-archaic species, Homo luzonensis and H. floresiensis, were present around the time anatomically modern humans (AMH) arrived in the region >50,000 years ago. Contemporary human populations carry signals consistent with interbreeding events with Deniso...
Preprint
Full-text available
The current rate of species extinction is rapidly approaching unprecedented highs and life on Earth presently faces a sixth mass extinction event driven by anthropogenic activity, climate change and ecological collapse. The field of conservation genetics aims at preserving species by using their levels of genetic diversity, usually measured as neut...
Article
Full-text available
We report detailed peptide binding affinities between 438 HLA Class I and Class II proteins and complete proteomes of seven pandemic human viruses, including coronaviruses, influenza viruses and HIV‐1. We contrast these affinities with HLA allele frequencies across hundreds of human populations worldwide. Statistical modelling shows that peptide bi...
Preprint
Full-text available
The role of selection in shaping genetic diversity in natural populations is an area of intense interest in modern biology, especially the characterization of adaptive loci. Within humans, the rapid increase in genomic information has produced surprisingly few well-defined adaptive loci, promoting the view that recent human adaptation involved nume...
Article
Full-text available
Who are we? Where did we come from? Why are we here? These fundamental questions have been widespread throughout human history, shared across different cultures from distant epochs and geographical locations. The search has been as much a philosophical as an empirical one, capturing the imagination of the philosopher, the theologian, the artist and...
Article
Selective pressures imposed by pathogens have varied among human populations throughout their evolution, leading to marked inter-population differences at some genes mediating susceptibility to infectious and immune-related diseases. Here, we investigated the evolutionary history of a common polymorphism resulting in a T529 versus C529 change in th...
Article
Full-text available
The dispersal of anatomically modern human populations out of Africa and across much of the rest of the world around 55 to 50 thousand years before present (ka) is recorded genetically by the multiple hominin groups they met and interbred with along the way, including the Neandertals and Denisovans. The signatures of these introgression events rema...
Preprint
Full-text available
As anatomically modern humans (AMH) migrated out of Africa and around the rest of the world, they met and interbred with multiple extinct hominid species. The traces of genetic input from these past interbreeding events, recorded in the genomes of modern populations, have created a powerful record of recent human migrations. The first of these even...
Preprint
As anatomically modern humans (AMH) migrated out of Africa and around the rest of the world, they met and interbred with multiple extinct hominid species. The traces of genetic input from these past interbreeding events, recorded in the genomes of modern populations, have created a powerful record of recent human migrations. The first of these even...
Preprint
Full-text available
Selective pressures imposed by pathogens have varied among human populations throughout their evolution, leading to marked inter-population differences at some genes mediating susceptibility to infectious and immune-related diseases. A common polymorphism resulting in a C 529 versus T 529 change in the Cadherin-Related Family Member 3 ( CDHR3 ) rec...
Article
Full-text available
Balancing selection maintains advantageous diversity in populations through various mechanisms. While extensively explored from a theoretical perspective, an empirical understanding of its prevalence and targets lags behind our knowledge of positive selection. Here we describe the Non-Central Deviation (NCD), a simple yet powerful statistic to dete...
Preprint
Full-text available
Balancing selection maintains advantageous diversity in populations through various mechanisms. While extensively explored from a theoretical perspective, an empirical understanding of its prevalence and targets lags behind our knowledge of positive selection. Here we describe the Non-Central Deviation ( NCD ), a simple yet powerful statistic to de...
Article
The first documents mentioning Jewish people in Iberia are from the Visigothic period. It was also in this period that the first documented anti-Judaic persecution took place. Other episodes of persecution would happen again and again during the long troubled history of the Jewish people in Iberia and culminated with the Decrees of Expulsion and th...
Article
Full-text available
Balancing selection maintains advantageous genetic and phenotypic diversity in populations. When selection acts for long evolutionary periods selected polymorphisms may survive species splits and segregate in present-day populations of different species. Here, we investigate the role of long-term balancing selection in the evolution of protein-codi...
Preprint
Full-text available
Balancing selection maintains advantageous genetic and phenotypic diversity in populations. When selection acts for long evolutionary periods selected polymorphisms may survive species splits and segregate in present-day populations of different species. Here, we investigate the role of long-term balancing selection in the evolution of protein-codi...
Article
Full-text available
The European Journal of Human Genetics is the official Journal of the European Society of Human Genetics, publishing high-quality, original research papers, short reports, News and Commentary articles and reviews in the rapidly expanding field of human genetics and genomics.
Article
Full-text available
Most human polymorphisms are neutral or slightly deleterious, but some genetic variation is advantageous and maintained in populations by balancing selection. Considered a rarity and overlooked for years, balanced polymorphisms have recently received renewed attention with several lines of evidence showing their relevance in human evolution. From t...
Article
The majority of genetic studies on Jewish populations have been focused on Ashkenazim, and genetic data from the Sephardic original source, the Iberian Peninsula, are particularly scarce. Regarding the mitochondrial genome, the available information is limited to a single Portuguese village, Belmonte, where just two different lineages (a single one...
Article
The cultural phenomenon of Crypto-Judaism, defined as the secret adherence to Judaism while publicly professing another faith, arose in Portugal in the beginning of the 16th century after the Decree of Expulsion and the establishment of the Inquisition. Surprisingly, the scientific community acknowledged the persistence of Crypto-Judaic communities...