João Ferreira

• Instituto Superior da Maia

Mycetoma is a chronic, localized, slowly progressive, granulomatous infection of the skin that may progress to subcutaneous tissue, muscle and bone. It is an infrequent manifestation of Nocardia infection that predominantly occurs on the lower extremities. A previously healthy, 17-year-old boy presented with a 3-month history of scalp abscesses. On...

The Egyptian Vulture Neophron percnopterus was once an abundant species in the Cabo Verde Islands. Since the 1960s though, and especially during the 1980–1990s, it consistently declined to near extinction. Evidence collected indicates a remnant population of about a dozen pairs or less, scattered through the desert rangelands of only three islands....

This study presents three genetic algorithms developed to solve a routing problem related with a transportation service for nonemergency patients in Portugal. A model based on an extension of the Team Orienteering Problem was developed to carry out several legal constraints. The results of computational experiments made to validate the adopted meth...

Ospreys bred along most of coastal Portugal until the beginning of the 20th century. Thereafter, a continuous decline due to persistent persecution and habitat loss led the species to extinction as a breeder in 2002, long after its disappearance from the rest of continental Iberia. Reintroduction by hacking was the only remaining option to restore...

Objective Retrospective case–control study of authors experience in the modified Bristow-Latarjet procedure for treatment of recurrent traumatic anterior glenohumeral dislocation with glenoid bone injury. Methods Sample with 102 recurrent glenohumeral dislocation cases submitted to modified Bristow-Latarjet procedure. Indications included situatio...

Resumo Objetivo Descrever a abordagem cirúrgica das luxações acromioclaviculares agudas e apresentar os desfechos clínicos e funcionais obtidos em uma coorte de pacientes. Métodos Estudo observacional retrospectivo que incluiu 153 pacientes com luxação aguda da articulação acromioclavicular operados entre 1999 e 2015. A avaliação clínica incluiu...

Resumo Objetivo Estudo retrospectivo sobre a experiência dos autores na operação de Bristow‐Latarjet modificada como tratamento da luxação glenoumeral anterior traumática recidivante com lesão óssea glenoidea. Métodos Amostra com 102 casos de luxações glenoumerais submetidos à cirurgia de Bristow‐Latarjet modificada. As indicações foram situações...

Objective This study aims to describe the surgical approach to such injuries and to present the clinical and functional outcomes obtained in a cohort of patients. Methods This is an observational retrospective study that included 153 patients with acute acromioclavicular joint dislocation, operated between 1999 and 2015. Clinical evaluation includ...

Within the framework of the Osprey (Pandion haliaetus) reintroduction in Portugal, which began in 2011 in the Alqueva reservoir and aims at establishing a founder breeding population in the area, 12 nestlings were translocated in 2015, 6 from Sweden and 6 from Finland. These young finished their development in the hacking tower at the shore of the...

A fauna piscícola representa um dos elementos biológicos obrigatórios na avaliação do estado ecológico de rios no âmbito da Directiva-Quadro da Água/Lei da Água (DQA/LA). Para tal, tinha sido desenvolvido o índice piscícola para rios vadeáveis portugueses (F-IBIP) – uma das ferramentas oficiais do Estado português no âmbito da DQA/LA. Contudo, não...

Recent works undertaken in Sabor valley, Northeast Portugal, revealed an important Upper Paleolithic sequence to the North of Douro River in a region with little Paleolithic evidence. Previous Upper Paleolithic occupation evidence in the region had only been identified and studied in Côa Valley, to the south of Douro River. Foz do Medal site is loc...

Recent archaeological work in northeast Portugal has led to the identification of two Upper Paleolithic sites in an area traditionally considered lacking in Old Stone Age evidence: Tras-os-Montes. The new research reveals the existence of the first Upper Paleolithic sequence to the north of the Portuguese Douro (Duero). The Middle Solutrean site of...

The use of quartz is well documented during prehistory, being the predominant raw material in the Upper Paleolithic sites located in NW Iberia. The prehistoric occupations from Sabor valley also present a preference for this lithology through the long occupation sequence, although a large range of regional and exogenous lithic raw materials are als...

This work presents an improved model to solve the non-emergency patients transport (NEPT) service issues given the new rules recently established in Portugal. The model follows the same principle of the Team Orienteering Problem by selecting the patients to be included in the routes attending the maximum reduction in costs when compared with indivi...

This paper describes the hybridization of an evolutionary algorithm with a greedy algorithm to solve a job-shop problem with recirculation. We model a real problem that arises within the domain of loads’ dispatch inside an automatic warehouse. The evolutionary algorithm is based on random key representation. It is very easy to implement and allows...

O transporte não urgente de doentes em Portugal foi alvo de reformulação legislativa de modo a reduzir os custos que acarretava. Neste artigo apresentam-se métodos heurísticos para a formação de agrupamentos de doentes a serem transportados na mesma viatura. São apresentados resultados computacionais que validam os algoritmos desenvolvidos. Os algo...

Nowadays, the collection of separated solid waste for recycling is still an expensive process, specially when performed in large-scale. One main problem resides in fleet-management, since the currently applied strategies usually have low efficiency. The waste collection process can be modelled as a vehicle routing problem, in particular as a Team O...

This paper presents a genetic algorithm for the Team Orienteering Problem with double Time Windows (TOPdTW). The aim is to study TOPdTW to model a real problem that arises within the operating rooms in a hospital. The Genetic Algorithm uses a peculiar way to construct solutions that only generates valid solutions, which improves the global performa...

Breeding Ospreys (Pandion haliaetus) were common in Portugal at the beginning of the 20th century. Thereafter, a continuous decline led them to as few as 3 pairs in 1978 when the species was rediscovered in the Southwest coast. Against all odds, this relict population managed to survive for 25 more years until the last individual disappeared after...

Psoriasis is a lifelong, chronic, and immune-mediated systemic disease, which affects approximately 1-3% of the Caucasian population. The different presentations of psoriasis require different approaches to treatment and appropriate prescriptions according to disease severity. The use of topical therapy remains a key component of the management of...

O estado do tempo e o clima são essenciais para a saúde e bem-estar das populações. No Instituto de Meteorologia, através da utilização de Sistemas de Informação Geográfica é divulgada informação georeferenciada, no âmbito da biometeorologia e saúde. Este trabalho pretende divulgar os produtos SIG, divulgados diariamente ao público que permitem car...

The Water Framework Directive (WFD), which established the use of hydromorphological quality elements to assess the ecological status of water bodies, has influenced the purpose and content of several European methods for characterizing physical structure and assessing habitat quality in rivers. The River Habitat Survey (RHS) is a WFD compliant met...

Artigo de comunicação apresentada em seminário internacional.

Tempestade de vento no contexto de uma ciclogénese explosiva 23 Dezembro 200

Com base num conjunto superior a 1000 amostragens piscícolas em rios portugueses (troços vadeáveis) realizadas por diversas entidades nacionais nos últimos 10 anos, seleccionou-se um grupo de 459 locais que cumprem critérios de normalização de amostragem, procedimentos no terreno, e acuidade nas identificações taxonómicas. Estes locais representam...

Comunicação póstyer apresentada em congresso internacional.

Comunicação póster apresentada em congresso internacional.

On 18th February 2008 high impact floods have occurred in Lisbon and Setúbal (Portugal). These floods have been compared by public opinion to the historical floods in Lisbon on November 1967. The results of the study that will be presented correspond to the developments achieved by a working group created in the Portuguese meteorological service (I...

The purpose of our visit was threefold: (i) to test River Habitat Survey (RHS) and macrophyte surveys on a selection of Mediterranean rivers in southern Portugal (16- 18 April 2009); (ii) to provide training for RHS surveyors in Portugal (20-23 April 2009); (iii) to give advice on an effective sampling and training strategy for RHS in Portugal.

No dia 18 de Fevereiro de 2008 ocorreram cheias na região de Lisboa e Setúbal com impactos severos na população e que foram comparadas pela opinião pública às cheias históricas de Novembro de 1967. Para além de inúmeras inundações, trânsito caótico, transbordo de ribeiras e cortes de luz e gás, houve a lamentar dois óbitos quando um automóvel foi a...

Type 2 topoisomerases, in particular the alpha isoform in human cells, play a key role in cohesion and sister chromatid separation during mitosis. These enzymes are thus vital for cycling cells and are obvious targets in cancer chemotherapy. Evidence obtained in yeast and Xenopus model systems indicates that conjugation of topoisomerase 2 with smal...

Chromatin states have to be faithfully duplicated during DNA replication to maintain cell identity. It is unclear whether or how ATP-dependent chromatin-remodelling factors are involved in this process. Here we provide evidence that the Williams syndrome transcription factor (WSTF) is targeted to replication foci through direct interaction with the...

Mammalian topoisomerase IIalpha (topo IIalpha) plays a vital role in the removal of topological complexities left on DNA during S phase. Here, we developed a new assay to selectively identify sites of catalytic activity of topo IIalpha with subcellular resolution. We show that topo IIalpha activity concentrates at replicating heterochromatin in lat...

Preliminary data on litho stratigraphy and biostratigraphy of the Belverde borehole (http://www. dct.Jct.unl.pt/ SondagemISondagem/colunalindex_col.html) is presented. The borehole attained 619,77 m of depth, crossing 130 m of Plio-Pleistocene and 460 m of Miocene dep osits. Main lithologies are fine sands , marl s and biocalcarenites. A coral reef...

Preliminary data on lithostratigraphy and biostratigraphy of the Belverde borehole (http://www.dct.fct.unl.pt/Sondagem/Sondagem/coluna/index_col.html) is presented. The borehole attained 619,77 m of depth, crossing 130 m of Plio-Pleistocene and 460 m of Miocene deposits. Main lithologies are fine sands, marls and biocalcarenites. A coral reef was r...

Preliminary data concerning the Belverde borehole (coordenates: 38º35’34.1’’/9º8’24.7’’) are presented. The borehole reached 619,77 m. It crossed 130,31m of Pleisto-Pliocene continental deposits, 460 m of Miocene (mainly marine deposits; some marsh ones also occur). At the lower part, a coral reef with 50m thick was recognised. It overlays red cont...

Keywords: borehole; Lower Tagus Basin; Neogene; stratigraphy; Belverde; Setúbal Peninsula; Portugal. Preliminary data concerning the Belverde borehole (coordenates: 38º35’34.1’’/9º8’24.7’’) are presented. The borehole reached 619,77 m. It crossed 130,31m of Pleisto-Pliocene continental deposits, 460 m of Miocene (mainly marine deposits; some marsh...

Preliminary data concerning the Belverde borehole (coordenates: 38º35’34.1’’/9º8’24.7’’) are presented. The borehole reached 619,77 m. It crossed 130,31m of Pleisto-Pliocene continental deposits, 460 m of Miocene (mainly marine deposits; some marsh ones also occur). At the lower part, a coral reef with 50m thick was recognised. It overlays red cont...

Gene expression can be silenced by proximity to heterochromatin blocks containing centromeric alpha-satellite DNA. This has been shown experimentally through cis-acting chromosome rearrangements resulting in linear genomic proximity, or through trans-acting changes resulting in intranuclear spatial proximity. Although it has long been been establis...

At present several lines of evidence indicate that the nucleus is functionally compartmentalized into discrete structures with defined properties. For instance, it is well established that the molecular machines involved in replication, transcription, and RNA processing assemble into morphological entities but it remains unclear whether these corre...

Coiled bodies and interchromatin granules are distinct subnuclear domains that contain splicing small nuclear ribonucleoproteins (snRNPs) and protein-splicing factors. Here we have studied the morphogenesis of coiled bodies and clusters of interchromatin granules in relation to the onset of transcriptional activity in early hamster embryos. The res...

Small nuclear ribonucleoprotein particles (snRNPs) and several additional protein factors are required for the correct splicing of pre-mRNAs. Recent advances in microscopic techniques and in the molecular dissection of the splicing machinery are making it possible to directly visualize how transcription and processing of pre-mRNA are organized with...