Joao M. P. Coelho

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Verified

Joao verified their affiliation via an institutional email.

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• PhD
• Researcher at University of Lisbon

Basal cell carcinoma (BCC) is the most common type of skin carcinoma worldwide. BCC development is the result of a complex interaction between environmental, phenotypic, and genetic factors. While conventional treatments such as surgery and topical therapies have demonstrated variable efficacy (some of them with limited efficacy), they are not free...

Superficial cancers typically refer to cancers confined to the surface layers of tissue. Low-targeting therapies or side effects prompt exploration of novel therapeutic approaches. Gold nanoparticles (AuNPs), due to their unique optical properties, serve as effective photosensitizers, enabling tumor ablation through photothermal therapy (PTT). PTT...

Gold nanoparticles (AuNPs)-mediated Photothermal Therapy (PTT) is a minimally-invasive therapeutic approach that uses AuNPs to convert light into heat, leading to the thermal ablation of tumors. Thus, the efficacy of this strategy strongly relies on the photothermal conversion potential of AuNPs. The ability to convert light into heat can be enhanc...

The Near-InfraRed Planet Searcher or NIRPS is a precision radial velocity spectrograph developed through collaborative efforts among laboratories in Switzerland, Canada, Brazil, France, Portugal and Spain. NIRPS extends to the 0.98-1.8 $\mu$m domain of the pioneering HARPS instrument at the La Silla 3.6-m telescope in Chile and it has achieved unpa...

PLATO (PLAnetary Transits and Oscillations of stars) is ESA's M3 mission designed to detect and characterise extrasolar planets and perform asteroseismic monitoring of a large number of stars. PLATO will detect small planets (down to <2 R_(Earth)) around bright stars (<11 mag), including terrestrial planets in the habitable zone of solar-like stars...

Prostate cancer (PCA) is the second most common cancer diagnosis in men and the fifth leading cause of death worldwide. The conventional treatments available are beneficial to only a few patients and, in those, some present adverse side effects that eventually affect the quality of life of most patients. Thus, there is an urgent need for effective,...

The prevalence of digital devices in modern society has raised concerns about the potential negative effects of blue-light emissions on eye health and biological rhythms. Research into blue light emissions from digital devices and their potential impact on eye health emphasizes the importance of understanding and quantifying the extent and scope of...

The prevalence of digital devices in modern society has raised concerns about the potential neg-ative effects of blue light emissions on eye health and biological rhythms. Research into blue light emissions from digital devices and their potential impact on eye health emphasizes the importance of understanding and quantifying the extent and scope o...

The pandemic and lockdown caused by COVID-19 accelerated digitalization. Personal digital devices, emitting high-energy light, namely in the blue wavelength, have raised concerns about possible harmful effects on users’ eyes. Scientific research history has shown a relationship between exposure to blue light and changes in ocular structures. The ma...

Aerogels are materials with unique properties, among which are low density and thermal conductivity. They are also known for their exquisite biocompatibility and biodegradability. All these features make them attractive for biomedical applications, such as their potential use in photothermal therapy (PTT). This technique is, yet, still associated w...

Breast cancer is a high-burden malignancy for society, whose impact boosts a continuous search for novel diagnostic and therapeutic tools. Among the recent therapeutic approaches, photothermal therapy (PTT), which causes tumor cell death by hyperthermia after being irradiated with a light source, represents a high-potential strategy. Furthermore, t...

Magnetic nanoparticles (MNPs) have been studied for diagnostic purposes for decades. Their high surface-to-volume ratio, dispersibility, ability to interact with various molecules and superparamagnetic properties are at the core of what makes MNPs so promising. They have been applied in a multitude of areas in medicine, particularly Magnetic Resona...

The focusing of light through turbid media like biological tissues is strongly hindered by the scattering of light which limits its safe practice and application in medicine. In order to control this phenomenon, we shaped the incident wavefront using three algorithms including a four-element division algorithm, a partitioning algorithm, and simulat...

The measurement of the refractive index of optical glass samples is a common and fundamental activity in numerous fields of expertise. Several measurement techniques exist with relative accuracies from 10−2 to, at least, 10−7 with complexities that are inversely related to the corresponding uncertainty. We describe an implementation of a technique...

The global impact of cancer emphasizes the importance of developing innovative, effective and minimally invasive therapies. In the context of superficial cancers, the development of a multifunctional nanoparticle-based system and its in vitro and in vivo safety and efficacy characterization are, herein, proposed as a proof-of-concept. This multifun...

Anaplastic thyroid carcinoma (ATC) is a very rare subtype of thyroid carcinoma and one of the most lethal malignancies. Poor prognosis is mainly associated with its undifferentiated nature, inoperability, and failing to respond to the typically used therapies for thyroid cancer. Photothermal Therapy (PTT) entails using light to increase tissues’ te...

Breast cancer is one of the most frequently diagnosed malignancies and common causes of cancer death in women. Recent studies suggest that environmental exposures to certain chemicals, such as 7,12-Dimethylbenzanthracene (DMBA), a chemical present in tobacco, may increase the risk of developing breast cancer later in life. The first-line treatments...

Observations of metal absorption systems in the spectra of distant quasars allow to constrain a possible variation of the fine-structure constant throughout the history of the Universe. Such a test poses utmost demands on the wavelength accuracy and previous studies were limited by systematics in the spectrograph wavelength calibration. A substanti...

Aims. We report on ESPRESSO high-resolution transmission spectroscopic observations of two primary transits of the highly-irradiated, ultra-hot Jupiter-size planet WASP-76b. We investigate the presence of several key atomic and molecular features of interest that may reveal the atmospheric properties of the planet. Methods. We extracted two transmi...

ESPRESSO is the new high-resolution spectrograph of ESO's Very-Large Telescope (VLT). It was designed for ultra-high radial-velocity precision and extreme spectral fidelity with the aim of performing exoplanet research and fundamental astrophysical experiments with unprecedented precision and accuracy. It is able to observe with any of the four Uni...

Cancer like melanoma is a complex disease, for which standard therapies have significant adverse side effects that in most cases are ineffective and highly unspecific. Thus, a new paradigm has come with the need of achieving alternative (less invasive) and effective therapies. In this work, biocompatible gold nanoparticles (GNPs) coated with hyalur...

The bright star $\pi$ Men was chosen as the first target for a radial velocity follow-up to test the performance of ESPRESSO, the new high-resolution spectrograph at the ESO's Very-Large Telescope (VLT). The star hosts a multi-planet system (a transiting 4 M$_\oplus$ planet at $\sim$0.07 au, and a sub-stellar companion on a $\sim$2100-day eccentric...

We characterized the transiting planetary system orbiting the G2V star K2-38 using the new-generation echelle spectrograph ESPRESSO. We carried out a photometric analysis of the available K2 photometric light curve of this star to measure the radius of its two known planets. Using 43 ESPRESSO high-precision radial velocity measurements taken over t...

We aim to confirm the presence of Proxima b using independent measurements obtained with the new ESPRESSO spectrograph, and refine the planetary parameters taking advantage of its improved precision. We analysed 63 spectroscopic ESPRESSO observations of Proxima taken during 2019. We obtained radial velocity measurements with a typical radial veloci...

Ultra-hot giant exoplanets receive thousands of times Earth’s insolation1,2. Their high-temperature atmospheres (greater than 2,000 kelvin) are ideal laboratories for studying extreme planetary climates and chemistry3–5. Daysides are predicted to be cloud-free, dominated by atomic species6 and substantially hotter than nightsides5,7,8. Atoms are ex...

Ultra-hot giant exoplanets receive thousands of times Earth's insolation. Their high-temperature atmospheres (>2,000 K) are ideal laboratories for studying extreme planetary climates and chemistry. Daysides are predicted to be cloud-free, dominated by atomic species and substantially hotter than nightsides. Atoms are expected to recombine into mole...

Optically tunable gold nanoparticles have been widely used in research with near-infrared light as a means to enhance laser-induced thermal therapy since it capitalizes on nanoparticles’ plasmonic heating properties. There have been several studies published on numerical models replicating this therapy in such conditions. However, there are several...

Photothermal therapy is a developing therapeutic technic mainly regarding the usage of nanoparticles considering their proneness to assemble around malignant tissue and induce their destruction by converting electromagnetic radiation into thermal radiation. In order to optimize this process, controlling the area of incidence in a way that it can fi...

In-line Fabry–Perot cavities manufactured by a new technique using electric arc fusion of NIR laser microdrilled optical fiber flat tips were studied herein for refractive index sensing. Sensors were produced by creating an initial hole on the tip of a standard single-mode telecommunication optical fiber using a Q-switched Nd:YAG laser. Laser ablat...

This paper investigates the light propagation through several types of water by experimental and simulation. The Zemax-ray tracing software allowed to simulate the propagation of light in water and to observe the receiver response by reproducing the real conditions of propagation. The underwater environment has been reproduced by a 1.2 m long water...

The response of ultrashort-length CO 2 -induced long-period fiber grating (LPFG) sensors to torsion is reported. While engraving using CO 2 laser radiation, the fiber is submitted to high tension allowing the obtainment of gratings with shorter lengths, down to 2.4 mm, which is almost one order of magnitude lower than the usual. Also, the fiber is...

Sensing performances of ultrashort (as low as 2.4 mm) long-period fiber gratings fabricated with CO 2 laser radiation using commercial single mode fibers are presented. These lengths are, to our knowledge, the shortest of those found in the literature for this kind of sensors, approaching those typical in fiber Bragg gratings. Sensitivity to temper...

The first generation of E-ELT instruments will include an optical-infrared High Resolution Spectrograph, conventionally indicated as EELT-HIRES, which will be capable of providing unique breakthroughs in the fields of exoplanets, star and planet formation, physics and evolution of stars and galaxies, cosmology and fundamental physics. A 2-year long...

The first generation of E-ELT instruments will include an optical-infrared High Resolution Spectrograph, conventionally indicated as EELT-HIRES, which will be capable of providing unique breakthroughs in the fields of exoplanets, star and planet formation, physics and evolution of stars and galaxies, cosmology and fundamental physics. A 2-year long...

The first generation of E-ELT instruments will include an optical-infrared High Resolution Spectrograph, conventionally indicated as EELT-HIRES, which will be capable of providing unique breakthroughs in the fields of exoplanets, star and planet formation, physics and evolution of stars and galaxies, cosmology and fundamental physics. A 2-year long...

ESPRESSO is a high resolution UV-vis spectrograph that will be placed in the combined Coudé laboratory of the ESO VLT. The instrument is in its assembly phase and the Coudé optics will start to be mounted at the telescope in the first quarter of 2016. This paper describes the optics of the train and the strategies for its alignment taking into acco...

Background: Photothermal response of plasmonic nanomaterials can be utilized for a number of therapeutic applications such as the ablation of solid tumors. Methods & results: Gold nanoparticles were prepared using different methods. After optimization, we applied an aqueous plant extract as the reducing and capping agent of gold and maximized th...

An optical simulator of the human eye and its application to laser dazzle events are presented. The simulator combines optical design software (ZEMAX) with a scientific programming language (MATLAB) and allows the user to implement and analyze a dazzle scenario using practical, real-world parameters. Contrary to conventional analytical glare analys...

Targeted drug delivery is an important area of research that is anticipated to increase the efficacy of the drug and also reduce potential side effects. In this area, gold nanoparticles (GNPs) have been largely studied for therapeutic and diagnostic applications as safe and biocompatible delivery systems. Due to the strong and size-tunable surface...

Long period fiber gratings (LPFGs) are one of the most important fiber-based sensors. These optical devices are comparatively simple and in its most basic form, consists on a periodic modulation of the properties of an optical fiber (usually the refraction index of the core). These periodic structures operate in transmission mode and are manufactur...

Light has long being used in medicine; however, the high scattering of biological tissues always hindered its use. The aim of this work is the development of methodologies to focus light inside biological tissues. Geant4/GAMOS Monte Carlo platform was used to simulate the possibility of parameterize the time delay of multiple sources of external li...

Although light has long being used in medicine, scattering always hindered its use. This study intends to evolve into three different frontlines: development of methodologies to concentrate light inside biological tissues, development of an optical tissue phantom and development of multifunctional gold nanoparticles with therapeutic potential for t...

The physical mechanisms involved in the writing process of long period fiber gratings (LPFG) using mid-infrared radiation emitted by CO2 lasers limit the obtained characteristics, in particular the minimum period that can be achieved. In order to evaluate the performances of a new methodology developed by us, we analyzed its capability to produce g...

We present a model in which polymeric spherical microstructures embedded with a light absorbing dye are shown to attain the phase transition temperature necessary for the release of a drug contained in its polymeric matrix into the surrounding medium. By numerically solving the heat diffusion equation and considering a Gaussian near-infrared source...

Cancer cells can be easily killed when they reach a temperature above 40 degrees. This is known as hyperthermia and the incorporation of nanoparticles (NPs) is helpful to locally rise the temperature. The local heating of NPs could also be used to deliver drugs encapsulated in a specific location inside a body. To achieve the local heating it is ne...

ESPRESSO is the next generation ground based European exoplanets hunter. It will combine the efficiency of modern echelle spectrograph with extreme radial-velocity and spectroscopic precision. It will be installed at Paranal's VLT in order to achieve two magnitudes gain with respect to its predecessor HARPS, and the instrumental radial-velocity pre...

ESPRESSO is a fibre-fed, cross-dispersed, high-resolution, echelle spectrograph. Being the first purpose of ESPRESSO to develop a competitive and innovative high-resolution spectrograph to fully exploit the VLT (Very Large Telescope), and allow new science, it is important to develop the VLT array concept bearing in mind the need to obtain the high...

MOONS is a new Multi-Object Optical and Near-infrared Spectrograph selected by ESO as a third generation instrument for the Very Large Telescope (VLT). The grasp of the large collecting area offered by the VLT (8.2m diameter), combined with the large multiplex and wavelength coverage (optical to near-IR: 0.8μm - 1.8μm) of MOONS will provide the Eur...

The acronym ESPRESSO stems for Echelle SPectrograph for RockyExoplanets and Stable Spectroscopic Observations; this instrument will be the next VLThigh resolution spectrograph. The spectrograph will be installed at the Combined- Coud´eLaboratory of the VLTand linked to the four 8.2mUnit Telescopes (UT) through four optical Coud´etrains. ESPRESSO wi...

In this paper we report the development of an optical simulator that can be used in the development of methodologies for compensate/decrease the light scattering effect of most biological tissues through phase-shaping methods. In fact, scattering has long been a major limitation for the medical applications of lasers where in-depth tissues concerns...

The optics of the human eye have for several years been the subject of careful physiological study. This study has led to the development of models characterizing its operation and allowed to predict its behavior. In general, these models are based on empirical data derived from statistical studies on specific populations. At the same time, differe...

The mid-infrared radiation produced by CO2 lasers is being widely used to produce long period fiber gratings (LPFG) with several advantages over other methods. Several techniques can be used to irradiate the fiber in order to produce the necessary effect. Using a cylindrical lens to create a line of light or scanning of a spot over the fiber are th...

The use of CO2 lasers in the production of optical fiber sensors is a well proven application, especially in writing long period fiber gratings. The mid-infrared radiation (MIR) emitted by these lasers is highly absorbed by the glass optical fibers commonly used as fiber-based sensors, and the consequent heating easily leads to melting. Making use...

ESPRESSO is a fibre-fed, cross-dispersed, high-resolution, echelle spectrograph. Being the first purpose of ESPRESSO to develop a competitive and innovative high-resolution spectrograph to fully exploit the VLT (Very Large Telescope), and allow new science, it is important to develop the VLT array concept bearing in mind the need to obtain the high...

ESPRESSO is the next generation European exoplanet hunter, combining the efficiency of a modern echelle spectrograph with extreme radial velocity and spectroscopic precision. ESPRESSO will be installed in the Combined Coudé Laboratory of the VLT and linked to the four Unit Telescopes (UT) through optical coudé trains, operated either with a single...

In the last years, mid-infrared radiation emitted by CO2 lasers has become increasing popular as a tool in the development of long-period fiber gratings. However, although the development and characterization of the resulting sensing devices have progressed quickly, further research is still necessary to consolidate functional models, especially re...

Nowadays, laser processing of optical fibers in the production of fiber-based sensors is an important research theme. In particular, the use of infrared radiation has directed attention as new applications were found and new short pulsed laser technology have been developed. In this chapter we will describe the main technology used and the physical...

The research on the use of fiber sensors based on long-period fiber gratings inscribed by CO2 laser mid-infrared radiation has increased in the last years. In this paper, a set of analytical expressions are used to model the interaction between laser radiation and an optical fiber and to determine the resulting refractive index change. Thermal and...

This paper presents the research made at the Laboratory of Optics, Lasers and Systems (LOLS) of the Faculty of Sciences of University of Lisbon, Portugal, in the field of fiber-based sensors. Three areas are considered: sensor encapsulation for natural aqueous environments, refractive index modulation and laser micropatterning. We present the main...

Due to its non-crystalline, amorphous structure, glass is particularly susceptible to radiation-induced coloration/discoloration. Oxide glasses reveal a variety of colors depending upon their composition when exposed to high energy radiations such as gamma and X-rays, and the colors induced have been explained in terms of the formation of color cen...

Metal nanoparticles inside glass present useful properties to photonic applications and have been object of several research works. In particular, laser beams have shown their potential in its creation and both ultraviolet beams with nanosecond pulses, and near-infrared beams with femtosecond pulses, have been used. In this paper, the authors add n...

ESPRESSO, the VLT rocky exoplanets hunter, will combine the efficiency of modern echelle spectrograph with extreme radial-velocity precision. It will be installed at Paranal on ESO's VLT in order to achieve a gain of two magnitudes with respect to its predecessor HARPS, and the instrumental radial-velocity precision will be improved to reach 10 cm/...

ESPRESSO is a fiber-fed, cross-dispersed, high-resolution, echelle spectrograph. Being the first purpose of ESPRESSO to develop a competitive and innovative high-resolution spectrograph to fully exploit the VLT (Very Large Telescope), and allow new science, it is important to develop the VLT array concept bearing in mind the need to obtain the high...

MOONS is a new conceptual design for a Multi-Object Optical and Near-infrared Spectrograph for the Very Large Telescope (VLT), selected by ESO for a Phase A study. The baseline design consists of 1000 fibers deployable over a field of view of 500 square arcmin, the largest patrol field offered by the Nasmyth focus at the VLT. The total wavelength c...

Local decolorizing of gamma-ray irradiated silicate glasses has been studied under thermal annealing by a laser beam. The influence of the beam's exposure time was studied, showing that an increase of the glass temperature on the irradiated areas can locally induce complete decolorizing (bleaching) of glass. In this work, the heat conduction differ...

Towards the development of new optical fiber sensors it was studied the application of nanosecond infrared laser radiation in the micropatterning of optical fibers. Nd:YAG laser pulses were focused on silica fibers by an apparatus projected to position the fiber regarding the laser beam and analyze the interaction. Experiments allowed determining t...

A simple method for determining the stress fields in transparent glass artwork pieces is presented. The proposed method is based on the principles of photoelasticity combining imaging and quantitative measures with an image processing algorithm. The main goal was to develop a methodology to help glass artists to determine the ability of their work...

The first purpose of ESPRESSO is to develop a competitive, innovative high-resolution spectrograph to fully exploit the potentiality of the Very Large Telescope (VLT) of the European Southern Observatory and to allow new science. It is thus important to develop the VLT array concept bearing in mind the need to obtain the highest stability, while pr...

In the field of aqueous environment studies, long-period fiber gratings are very attractive for the real-time monitoring of physical parameters, such as temperature and salinity. However, due to the fiber jacket removal, these are fragile devices when applied in real conditions, where mechanical loads and contamination with algae and other organic...

For the first time copper nanoparticles were formed inside Cu ion-doped glass after infrared irradiation by a nanosecond laser and sucessive annealing at 700 °C for 1 h. The surface plasmon resonance was observed in the absorption spectra of copper nanoparticles. Their spectral position is in good agreement with the values predicted by Mie theory f...

ESPRESSO, the Echelle SPectrograph for Rocky Exoplanets and Stable Spectroscopic Observations, will combine the efficiency of modern echelle spectrograph design with extreme radial-velocity precision. It will be installed on ESO&apos;s VLT in order to achieve a gain of two magnitudes with respect to its predecessor HARPS, and the instrumental radia...