João Borges

João Borges
University of Aveiro | UA · CICECO - Centre for Research in Ceramics and Composite Materials

Ph.D. in Chemistry
Assistant Researcher designing soft supramolecular biomaterials to interface with living systems | Chair of the IYCN

About

87
Publications
6,333
Reads
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1,160
Citations
Introduction
João Borges is an Assistant Researcher and PI of a R&D project at CICECO, University of Aveiro (UA). He graduated and received his PhD in Chemistry from the University of Porto in 2008 and 2013, respectively. From 2013-2018, he worked as a postdoctoral researcher at the University of Minho (3B’s Research Group) and UA (CICECO). His research interests lie on the rational design, synthesis and development of biomimetic soft supramolecular biofunctional materials to instruct cell behavior.
Additional affiliations
April 2021 - June 2021
University of Aveiro, Department of Chemistry, CICECO - Aveiro Institute of Materials
Position
  • Researcher
February 2019 - March 2021
University of Aveiro, Department of Chemistry, CICECO - Aveiro Institute of Materials
Position
  • Fellow
April 2016 - January 2019
University of Aveiro, Department of Chemistry, CICECO - Aveiro Institute of Materials
Position
  • PostDoc Position
Education
January 2009 - February 2013
University of Porto
Field of study
  • Chemistry
September 2004 - July 2008
University of Porto
Field of study
  • Chemistry

Publications

Publications (87)
Article
Dendrimers are powerful synthetic macromolecular architectures for a wide variety of bioapplications owing to their unique and superior features, including monodispersity, well-defined and highly branched architecture, multivalency, tunable size and shape, good water solubility, bioavailability, and precisely controllable size at the nanometer-scal...
Article
DNA is one of the most exciting biomolecules in nature for developing supramolecular biofunctional nanoarchitectures owing to the highly specific and selective interactions between complementary Watson‐Crick base pairing. Herein, simple and one‐pot synthetic procedures have been implemented for producing a library of DNA nucleobase derivatives endo...
Book
This book, encompassing 28 chapters, covers many aspects of soft matter in the biomedical context and is organized into four main sections, providing the readers with a comprehensive overview of the fundamental concepts, sources, and properties of soft matter (Chapters 1–8), bioinspired materials and surfaces (Chapters 9–13), soft nanobiomaterials...
Article
Full-text available
The development of complex and large 3D vascularized tissue constructs remains the major goal of tissue engineering and regenerative medicine (TERM). To date, several strategies have been proposed to build functional and perfusable vascular networks in 3D tissue-engineered constructs to ensure the long-term cell survival and the functionality of th...
Article
Full-text available
We have studied the effect of chitosan sponges, produced from chitosan batches with distinct degree of deace-tylation (DDA) and molecular weight (Mw), on the adhesion, growth and differentiation of primary human os-teoblasts with an aim to offer a suitable tool for guided bone regeneration. All the chitosan sponges revealed similar microstructure,...
Chapter
Natural polysaccharides are a major class of biomacromolecules with a high degree of biocompatibility, biodegradability, and ability to mimic the natural extracellular matrix (ECM) microenvironment and, therefore, have been receiving increasing attention. Polysaccharides often exhibit interesting and advantageous properties, including bioactivity,...
Article
Full-text available
Valuing diversity leads to scientific excellence, the progress of science and most importantly, it is simply the right thing to do. We can value diversity not only in words, but also in actions.
Article
Full-text available
Valuing diversity leads to scientific excellence, the progress of science and, most importantly, it is simply the right thing to do. We must value diversity not only in words, but also in actions.
Article
Full-text available
Valuing diversity leads to scientific excellence, the progress of science and, most importantly, it is simply the right thing to do. We must value diversity not only in words, but also in actions.
Article
Full-text available
Valuing diversity leads to scientific excellence, the progress of science and most importantly, it is simply the right thing to do. We can value diversity not only in words, but also in actions.
Article
Full-text available
Valuing diversity leads to scientific excellence, the progress of science and most importantly, it is simply the right thing to do. We can value diversity not only in words, but also in actions.
Article
The Periodic Table of Younger Chemists (PTYC) arose from a group of aspiring scientists in attendance at the 2017 World Chemistry Leadership Meeting in Sao Paulo, Brazil. This project was a celebration of the 100 th anniversary of IUPAC and the International Year of the Periodic Table. IUPAC and the International Younger Chemists Network (IYCN) joi...
Article
Full-text available
Valuing diversity leads to scientific excellence, the progress of science and, most importantly, it is simply the right thing to do. We must value diversity not only in words, but also in actions.
Article
The build-up and degradation of cytocompatible nanofilms in a controlled fashion have great potential in biomedical and nanomedicinal fields, including single-cell nanoencapsulation (SCNE). Herein, we report the fabrication of biodegradable films of cationic starch (c-ST) and anionic alginate (ALG) by electrostatically driven layer-by-layer (LbL) a...
Article
A high demand for materials with defined geometry and size is required in a wide range of fields. Inorganic compounds, especially silica‐based, arise as a cheap source and chemically flexible for the purpose. Silica display unique properties, like easy functionalization and good optical features making an interesting material to manipulate. In this...
Article
Full-text available
Bottom‐up tissue engineering is a promising approach for designing modular biomimetic structures that aim to recapitulate the intricate hierarchy and biofunctionality of native human tissues. In recent years, this field has seen exciting progress driven by an increasing knowledge of biological systems and their rational deconstruction into key core...
Article
The supramolecular presentation of extracellular matrix components on surfaces provides a platform for the investigation and control of cell behavior. Hyaluronan (HA) is one of the main components of the extracellular environment and has been shown to play an important role in different cancers and their progression. However, current methods of HA...
Conference Paper
Despite significant research efforts to date, the lack of vascularization in tissue engineered constructs remains one of the major challenges in tissue engineering and regenerative medicine (TERM) strategies. The inefficiency of nutrient and oxygen delivery within highly intricate structures hinders their scale-up and translation into clinical setu...
Conference Paper
Layer-by-Layer is a straightforward technology enabling the fabrication of highly ordered polymeric multilayered thin platforms for a wide range of applications, including tissue engineering and regenerative medicine fields. Its highly versatility allows the combination of a myriad of building blocks either materials and living cells assembled into...
Article
Full-text available
Hollow multilayered capsules have shown massive potential for being used in the biomedical and biotechnology fields, in applications such as cellular internalization, intracellular trafficking, drug delivery, or tissue engineering. In particular, hollow microcapsules, developed by resorting to porous calcium carbonate sacrificial templates, natural...
Article
Soft interfacial materials, such as self-assembled polymer membranes, are gaining increasing interest as biomaterials since they can provide selective barriers and/or controlled affinity interactions important to regulate cellular processes. Herein,...
Article
The successful buildup of biomimetic supramolecular multilayered nanobiomaterials comprising high-molecularweight alginate biopolymer and low-molecular-weight selfassembling peptide amphiphile is reported by João Borges, João F. Mano, and co-workers in article number 1605122, through combination of self-assembly and a layer-by-layer approach. The p...
Article
Developing complex supramolecular biomaterials through highly dynamic and reversible noncovalent interactions has attracted great attention from the scientific community aiming key biomedical and biotechnological applications, including tissue engineering, regenerative medicine, or drug delivery. In this study, the authors report the fabrication of...
Article
Fiber-based techniques hold great potential towards the development of structures that mimic the architecture of fibrous tissues, such as tendon. Microfluidics and polyelectrolyte complexation are among the most widely used techniques for the fabrication of fibrous structures. In this work, we combined both techniques to generate hydrogel fibers wi...
Conference Paper
Tendons are responsible for force transmission between muscles and bones, assuring body movement. Given the poor healing capacity of tendons, tissue engineering strategies have been focused on translating tendon architecture and functionality into biomimetic materials. In the present study, multicomponent hydrogel fibers were fabricated by combinin...
Article
Full-text available
In this work, three-dimensional (3D) self-sustaining, spiral-shaped constructs were produced through a combination of ionotropic gelation, to form cell-encapsulated alginate fibers, and a perfusion-based layer-by-layer (LbL) technique. Single fibers were assembled over cylindrical molds by reeling to form spiral shapes, both having different geomet...
Article
This work investigates the influence of the hydration level on the molecular mobility and glass transition dynamics of free-standing chitosan/alginate (CHT/ALG) nanolayered systems. Nonconventional dynamic mechanical analysis identifies two relaxation processes assigned to the α-relaxation of the two biopolymers, respectively, CHT and ALG, when imm...
Article
Layer-by-Layer (LbL) assembly is a simple and highly versatile method to modify surfaces and fabricate robust and highly-ordered nanostructured coatings over almost any type of substrate. Such versatility enables the incorporation of a plethora of building blocks, including materials exhibiting switchable properties, in a single device through a mu...
Article
This article presents an overview of the different types of intermolecular interactions behind the fabrication of multilayer assemblies using the layer-by-layer (LbL) assembly approach. It comments on the potential impact of each type of intermolecular interaction and materials assembled through them on the development of advanced functional system...
Conference Paper
Full-text available
The conformational stability and functionality of supported proteins is a topic of great interest for applications in nanomedicine, bioanalysis, biocatalysis, energy conversion and storage, and many other fields. Proteins supported onto hydrophobic surfaces exhibit poor conformational stability due to the establishment of strong interactions with t...
Article
Protein adsorption is a delicate process which results from the balance between the properties of proteins and their solid supports. Although the relevance of some of these parameters has been already unveiled, the precise involvement of electrostatics and other weaker intermolecular forces require further comprehension. Aiming to contribute to thi...
Article
Full-text available
The use of agar-based biomaterials for the development of emerging areas, such as tissue engineering or ‘smart materials’ production has recently gained great interest. Understanding how these gel-forming polysaccharides self-organise in aqueous media and how these associations can be tuned to meet the specific needs of each application is thus of...
Article
Full-text available
The limited stability and randomorientation of antibodies passively adsorbed onto solid supports are some of the main factors limiting the analytical performance of immune-based assay systems. Although the use of specific antibody-binding proteins led to significant enhancements in sensitivity, several uncertainties related to the orientation of th...
Article
Full-text available
Chitosan is a natural polysaccharide which strongly interacts with whey proteins in solution. Certain protein–polyelectrolyte complexes and electrostatically assembled thin films have been shown to be good platforms for the preservation of globular and small proteins in their native state mainly due to the hydrophilic nature of these polyelectrolyt...
Article
Thin films composed of oleylamine (OLA) and double-stranded deoxyribonucleic acid (dsDNA from Salmon testes) have been successfully constructed on polycrystalline Au surfaces using the electrostatic adsorption and self-assembly (SA) technique. The formation of the Au/OLA/dsDNA films was followed step-by-step by Quartz Crystal Microbalance with ener...
Article
Chitosan ultrathin films have been formed on polycrystalline Au substrates using the LbL technique with the purpose of studying its interaction with bovine β-lactoglobulin (β-LG) at the solid–liquid interface. The immobilization of chitosan was followed by Quartz Crystal Microbalance with energy dissipation (QCM-D), Cyclic Voltammetry (CV) and Elec...
Article
Gold nanorods (AuNRs) with an aspect ratio of 2.33 or 3.16 were self-assembled onto 1,6-hexanedithiol-modified gold electrodes based on covalent interaction at a solution temperature of 35 °C. The formation of the 1,6HDT/AuNR bilayers as a function of the nanorods' adsorption time was studied by atomic force microscopy and quartz crystal microbalan...