Joanne E Given

Joanne E Given
Ulster University · Institute of Nursing and Health Research

MBChB, MSc, PhD

About

44
Publications
5,643
Reads
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258
Citations
Citations since 2016
34 Research Items
244 Citations
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20162017201820192020202120220102030405060
20162017201820192020202120220102030405060
20162017201820192020202120220102030405060
Introduction
I am a medically qualified doctor with a masters in Health Promotion and Population Health and a PhD in diabetes. My postdoctoral work used EUROmediCAT, a population based reproductive pharmacovigilance system to evaluate medication safety in pregnancy. In my current roles in EUROlinkCAT and ConcePTION I use linked administrative health data to evaluate morbidity in children with congenital anomalies and the risk of adverse neurodevelopmental outcomes following SSRI exposure in pregnancy.
Additional affiliations
April 2019 - April 2021
Ulster University
Position
  • Fellow
Description
  • Building an ecosystem for better monitoring and communication of medication safety in pregnancy and breastfeeding: validated and regulatory endorsed workflows for fast, optimised evidence generation
November 2018 - present
Ulster University
Position
  • Fellow
Description
  • To investigate morbidity among children with congenital anomalies up to ten years of age across Europe using linked data.
December 2015 - October 2018
Ulster University
Position
  • Research Associate
Description
  • Using administrative data for health research.
Education
October 2010 - March 2014
Ulster University
Field of study
  • Diabetes
October 2009 - September 2010
Ulster University
Field of study
  • Health Promotion and Population Health
October 2000 - June 2005
University of Dundee
Field of study
  • Medicine

Publications

Publications (44)
Article
Full-text available
Background Congenital anomalies are the leading cause of perinatal, neonatal and infant mortality in developed countries. Large long-term follow-up studies investigating survival beyond the first year of life in children with rare congenital anomalies are costly and sufficiently large standardized cohorts are difficult to obtain due to the rarity o...
Article
Full-text available
Objectives: Preterm children are exposed to many medications in neonatal intensive care units, but little is known about the effect of prematurity on medication use throughout infancy and childhood. We examined prescriptions of cardiovascular medication (CVM), antiseizure medication (ASM), antiasthmatic medication and antibiotics issued/dispensed...
Article
Full-text available
Background: Studies on medication safety in pregnancy are increasingly focusing on child neurodevelopmental outcomes. Establishing neurodevelopmental safety is complex due to the range of neurodevelopmental outcomes and the length of follow-up needed for accurate assessment. The aim of this study was to provide an inventory of European data source...
Article
Full-text available
Aim: To establish the prevalence of prescriptions dispensed in early pregnancy by maternal age and area deprivation, for women who gave birth in Northern Ireland (NI) 2011-2016. Study design: Population-based linked cohort study. Methods: The NI Maternity System (NIMATS) database was used to identify all births to resident mothers in NI betwee...
Article
Full-text available
Background The pharmacoepidemiology of the long-term benefits and harms of medicines in pregnancy and breastfeeding has received little attention. The impact of maternal medicines on children is increasingly recognised as a source of avoidable harm. The focus of attention has expanded from congenital anomalies to include less visible, but equally i...
Article
Full-text available
Background Congenital anomalies are a leading cause of childhood morbidity, but little is known about the long-term outcomes. Objective To quantify the burden of disease in childhood for children with congenital anomalies by assessing the risk of hospitalisation, the number of days spent in hospital and proportion of children with extended stays (...
Preprint
Electronic health care databases are increasingly being used to investigate the epidemiology of congenital anomalies (CAs) although there are concerns about their accuracy. The EUROlinkCAT project linked data from eleven EUROCAT registries to electronic hospital databases. The coding of CAs in electronic hospital databases was compared to the (gold...
Preprint
Purpose: Are children with major congenital anomalies more likely to develop type 1 diabetes, as indicated by prescriptions for insulin, than children without congenital anomalies? The aim of this study is to evaluate prescription rates of insulin/insulin analogues in children aged 0-9 years with and without major congenital anomalies.Methods: A EU...
Article
Background: Congenital anomalies are a major cause of perinatal, neonatal and infant mortality. Objectives: The aim was to investigate temporal changes and geographical variation in survival of children with major congenital anomalies (CA) in different European areas. Methods: In this population-based linkage cohort study, 17 CA registries mem...
Article
Full-text available
Objective To report and compare the proportion of children with and without congenital anomalies undergoing gastrostomy for tube feeding in their first 5 years. Methods A European, population-based data-linkage cohort study (EUROlinkCAT). Children up to 5 years of age registered in nine EUROCAT registries (national and regional) in six countries a...
Article
Full-text available
Objectives: Advances in surgical management strategies have substantially reduced fatality from congenital heart defects (CHD). Decreased infant mortality might be expected, consequentially to result in greater morbidity in older children due to complications later in childhood and adolescence. This study aims to evaluate the use of cardiovascular...
Article
OBJECTIVES To investigate the survival up to age 10 for children born alive with a major congenital anomaly (CA). METHODS This population-based linked cohort study (EUROlinkCAT) linked data on live births from 2005 to 2014 from 13 European CA registries with mortality data. Pooled Kaplan-Meier survival estimates up to age 10 were calculated for th...
Method
Full-text available
Sixteen EUROCAT congenital anomaly registries in nine countries across Europe participated in the EUROlinkCAT project assessing morbidity outcomes in children up to ten years of age born with a congenital anomaly. Each registry’s congenital anomaly data are already standardised according to EUROCAT’s definitions , but the local morbidity data are n...
Conference Paper
Full-text available
Background Interventions to tackle the social determinants of health can improve outcomes during pregnancy and early childhood, leading to better health across the life-course. Variation in content, timing, and implementation of policies across the 4 UK nations holds great potential for quasi-experimental evaluations. We aimed to adapt systematic r...
Article
Full-text available
EUROCAT is a European network of population-based congenital anomaly (CA) registries. Twenty-one registries agreed to participate in the EUROlinkCAT study to determine if reliable information on the survival of children born with a major CA between 1995 and 2014 can be obtained through linkage to national vital statistics or mortality records. Live...
Article
Full-text available
Introduction Congenital anomalies (CAs) are a major cause of infant mortality, childhood morbidity and long-term disability. Over 130 000 children born in Europe every year will have a CA. This paper describes the EUROlinkCAT study, which is investigating the health and educational outcomes of children with CAs for the first 10 years of their lives...
Method
Full-text available
EUROlinkCAT developed a common data model (CDM) to enable local data on mortality to be standardised to EUROlinkCAT’s data structure i.e. each variable in the EUROlinkCAT WP3 standardised dataset has a common variable name, common definition, common format and common coding scheme
Article
Full-text available
We investigated the role of maternal environmental factors in the aetiology of congenital heart disease (CHD). A population-based case-control study (242 CHD cases, 966 controls) was conducted using an iPad questionnaire for mother with linkage to maternity and first trimester prescription records. Risk of CHD was associated with low maternal educa...
Article
Objective: The aim of this study was to describe the use of prescribed contraceptives in Northern Ireland (NI) and how this varies with a woman’s age, the deprivation in the area in which she lives and characteristics of her general practice (GP). Method: A population-based cohort study was conducted including 560,074 females, aged 12–49 registered...
Article
Full-text available
Metformin affects stem cell function and has been shown to cross the human placenta at term, exposing the fetus to concentrations approaching those in the maternal circulation. Limited evidence from3 meta-analyses and a cohort study suggests that the rate of all major congenital anomalies combined is not significantly increased after exposure to me...
Article
Full-text available
Background Compared to married mothers, mothers who are not married when they register their child’s birth are at increased risk of having a low birthweight baby and infant death. Having a partner protects women from poor pregnancy outcomes to some extent but those who are living with, but not married to, their partner still do less well than those...
Article
Full-text available
Background There is great potential to use routinely collected patient health records for research if the quality of data is sufficient for this purpose. Objective To assess the accuracy of information on medications and maternal diseases reported by the mother and recorded in the NI Maternity System (NIMATS) database compared to electronic prescri...
Article
Full-text available
Background The risk of an unintended, potentially unwanted, pregnancy is related to whether or not a woman uses any method of contraception and which method she uses. We do not know if, or how, contraceptive use in Northern Ireland (NI) varies by ageor deprivation. If, as in the rest of the United Kingdom, the younger and most disadvantaged are lea...
Article
Full-text available
Objective To investigate whether exposure to metformin during the first trimester of pregnancy, for diabetes or other indications, increases the risk of all or specific congenital anomalies. Design Population based exploratory case-control study using malformed controls. Cases of 29 specific subgroups of non-genetic anomalies, and all non-geneti...
Technical Report
Full-text available
A module of questions on attitudes to data sharing was included on the 2015 Northern Ireland Life and Times survey (NILT). The NILT 2015 survey included interviews with 1202 respondents sampled via a systematic random sample of addresses taken from the Postcode Address File. The research was funded by the Northern Ireland Health and Social Care Pub...
Technical Report
Full-text available
MOTIVATION FOR THE RESEARCH We live in a society where government and other organizations routinely collect information on individuals during the course of providing services (health, education, tax, social benefits, electoral registry, driver and vehicle licensing, etc.) This information is called administrative data. When researchers analyse thes...
Article
Background: Gastroschisis, a congenital anomaly of the abdomen, is associated with young maternal age and has increased in prevalence in many countries. Maternal illness and medication exposure are among environmental risk factors implicated in its aetiology. Methods: A population-based case-malformed control study was conducted using data from...
Article
Full-text available
BACKGROUND: Gastroschisis, a congenital anomaly of the abdomen, is associated with young maternal age and has increased in prevalence in many countries. Maternal illness and medication exposure are among environmental risk factors implicated in its aetiology. METHODS: A population-based case-malformed control study was conducted using data from 18...
Article
Full-text available
Objective To capture a baseline of public attitudes in Northern Ireland towards data linkage and sharing which can then be reassessed at intervals to measure changes in public trust and understanding. ApproachThe Life and Times Survey is an annual survey of the attitudes of the public of Northern Ireland to a wide range of social issues. Questions...
Article
Background: A feasibility trial was conducted to determine the potential for telemedicine to replace alternate diabetes review appointments in the care of those with gestational diabetes (GDM). One of the aims of this study was to access concordance of clinical decision making between diabetes clinic visits and telemedicine review sessions. Methods...
Conference Paper
Objective To capture a baseline of public attitudes in Northern Ireland towards data linkage and sharing which can then be reassessed at intervals to measure changes in public trust and understanding. Approach The Life and Times Survey is an annual survey of the attitudes of the public of Northern Ireland to a wide range of social issues. Quest...
Article
Aims: Information about medication safety in pregnancy is inadequate. We aimed to develop a signal detection methodology to routinely identify unusual associations between medications and congenital anomalies using data collected by 15 European congenital anomaly registries. Methods: EUROmediCAT database data for 14,950 malformed fetuses/babies...
Article
Aim: To evaluate congenital anomaly (CA)-medication exposure associations produced by the new EUROmediCAT signal detection system and determine which require further investigation. Methods: Data from 15 EUROCAT registries (1995-2011) with medication exposures at the chemical substance (5th level of Anatomic Therapeutic Chemical classification) a...
Article
Full-text available
Background: The incidence of gestational diabetes mellitus (GDM)-hyperglycemia with onset or first recognition during pregnancy-is increasing and will have a significant impact on diabetes services. This study aimed to determine the feasibility and acceptability of using telemedicine in the diabetes care of women with GDM and the possibility of re...
Conference Paper
Background: A statistical signal detection analysis of the EUROmediCAT database identified 24 congenital anomaly (CA)-drug exposure associations, excluding antiepileptics, antidiabetics, antiasthmatics and SSRIs. The main aim is to evaluate these signals and deter- mine which are worth further investigation. Methods: A protocol was developed which...
Article
The transition from oral to injectable agents is often delayed in type 2 diabetes by both people with diabetes and their healthcare providers. This study aimed to assess the experiences of people with type 2 diabetes in order to identify improvements that could be made in the transition to injectable therapy. Both positive and negative experiences...
Article
Aim: To assess agreement between meter and diary self monitoring of blood glucose (SMBG) records, over a year, in a sample of patients with type 2 diabetes. Methods: Meter and diary records were available, for 95 individuals, who took part in the Efficacy of self monitoring of blood glucose in patients with newly diagnosed type 2 diabetes study....
Thesis
Full-text available
This work explored the validity and application of self-monitoring of blood glucose (SMBG) in diabetes mellitus from a range of perspectives, using a variety of methods. It consisted of: 1) A systematic literature review, conducted following the PRISMA guidelines, to evaluate the validity of patient generated blood glucose diaries. 2) Two second...
Article
This poster session discusses designing a physical activity intervention study for youth with Type 1 diabetes. It was presented at the Diabetes UK Professional Conference 2013, Manchester Central Convention Complex, Manchester, UK, 13-15 March 2013
Article
Aims: To synthesize evidence relating to comparisons between patient-generated blood glucose records and meter memory in diabetes and to identify any predictors of agreement. Methods: A systematic literature search was performed to identify articles comparing meter and diary records in those unaware of this assessment. Results: Eleven observat...
Article
Full-text available
It is increasingly important that people have input into the services they receive. However, research suggests that service users and their carers need support to work effectively with professionals and achieve change. Nineteen carers who represent the interests of service users with autism spectrum disorders were interviewed about services. Parent...

Questions

Question (1)
Question
Dear Experts,
I want to explore if whether a patient was given a medication or not varies depending on their individual characteristics (level 1) and those of their general practice (level 2). Level 1 covariates will be for e.g. education and age while level 2 covaraites will be practice size and urban/rural location.
I anticipate that medication use will vary depending on whether it was a nurse or GP who prescribed the medication. Ideally, I would include the GPs and Nurses as level 2 nested under their practice at level 3. However, the data I am allowed to access does not include individual prescriber id's. Instead, I will just know it was a GP or Nurse who prescribed the medication. With this limited data I cannot include the GP/Nurse prescriber as a level as GP and Nurse are the only 2 options for prescribers (not a random selection of all the possible prescribers.)
Is there any way for me to include the Nurse/GP prescriber information in my model? For each practice there will be Nurses and GPs prescribing medicatons.

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