Joanna Jedrzejewska-Szmek

University of Warsaw | UW · Institute of Experimental Physics

Translational value of mouse models of neuropsychiatric disorders depends heavily on the accuracy with which they replicate symptoms observed in the human population. In mouse models of autism spectrum disorder (ASD) these include, among others, social affiliation, and communication deficits as well as impairments in understanding and perception of...

The enlarged brains of homeotherms bring behavioural advantages, but also incur high energy expenditures. The ‘expensive brain’ (EB) hypothesis posits that the energetic costs of the enlarged brain and the resulting increased cognitive abilities (CA) were met by either increased energy turnover or reduced allocation to other expensive organs, such...

Long-lasting long-term potentiation (L-LTP) is a cellular mechanism of learning and memory storage. Studies have demonstrated a requirement for extracellular signal-regulated kinase (ERK) activation in L-LTP produced by a diversity of temporal stimulation patterns. Multiple signaling pathways converge to activate ERK, with different pathways being...

Extracellular recording is an accessible technique used in animals and humans to study the brain physiology and pathology. As the number of recording channels and their density grows it is natural to ask how much improvement the additional channels bring in and how we can optimally use the new capabilities for monitoring the brain. Here we show tha...

Being a part of a social structure is key for survival and reproduction. Living with conspecifics boosts evolutionary fitness, by providing essential information about the environment. To examine how socially passed olfactory information about the reward affects behavior of individuals we used Eco-HAB, an automated system for tracing voluntary beha...

Extracellular recording is an accessible technique used in animals and humans to study the brain physiology and pathology. As the number of recording channels and their density grows it is natural to ask how much improvement the additional channels bring in and how we can optimally use the new capabilities for monitoring the brain. Here we show tha...

Although impairments of motivational and consummatory aspects of reward behavior are core symptoms of several psychiatric disorders, the underlying neural and molecular mechanisms remain poorly understood. Here we report that blocking either c-Fos or matrix metalloproteinase 9 in the central amygdala disrupts approach motivation and appetitive disc...

Neuroinformatyka to młoda dziedzina na pograniczu informatyki, biologii, chemii, fizyki i medycyny, obejmująca wszelkie zastosowania nauk ścisłych w neurobiologii, w tym neurobiologię teoretyczną, obliczeniową, analizę sygnałów neurobiologicznych, rozwój wszelkich metod analizy danych uzyskanych w ramach badań mózgu i behawioru oraz ich zastosowani...

We present a modelling study of molecular mechanisms underlying synaptic plasticity in a morphology comprised of a single dendritic spine located in the hippocampal CA1 pyramidal neuron. We focus on Spike-Timing Dependent Plasticity (STDP) protocol and its neuromodulatory control. In agreement with experimental data, our model predicts that the tim...

Kernel Current Source Density (kCSD), which we introduced in 2012, is a kernel-based method to estimate current source density (CSD) from extracellular potentials recorded with arbitrarily placed electrodes. Estimating reconstruction errors in CSD has been an outstanding challenge. To address it, here we revisit kCSD and explore its mathematical un...

Synaptic plasticity, the activity dependent change in synaptic strength, forms the molecular foundation of learning and memory. Synaptic plasticity includes structural changes, with spines changing their size to accomodate insertion and removal of postynaptic receptors, which are correlated with functional changes. Of particular relevance for memor...

Synaptic plasticity, which underlies learning and memory, depends on calcium elevation in neurons, but the precise relationship between calcium and spatiotemporal patterns of synaptic inputs is unclear. Here, we develop a biologically realistic computational model of striatal spiny projection neurons with sophisticated calcium dynamics, based on da...

Computational models in neuroscience can be used to predict causal relationships between biological mechanisms in neurons and networks, such as the effect of blocking an ion channel or synaptic connection on neuron activity. Since developing a biophysically realistic, single neuron model is exceedingly difficult, software has been developed for aut...

In spike-timing dependent plasticity (STDP) change in synaptic strength depends on the timing of pre- vs. postsynaptic spiking activity. Since STDP is in compliance with Hebb’s postulate, it is considered one of the major mechanisms of memory storage and recall. STDP comprises a system of two coincidence detectors with N-methyl-D-aspartate receptor...

Long-lasting forms of long-term potentiation (LTP) represent one of the major cellular mechanisms underlying learning and memory. One of the fundamental questions in the field of LTP is why different molecules are critical for long-lasting forms of LTP induced by diverse experimental protocols. Further complexity stems from spatial aspects of signa...

Initial conditions of cytosolic species. Initial conditions of remaining cytosolic species (Complex, pComplex, I1PKAc, PKAc-PDE4-cAMP, CaBCa, PDE1CaMCa4cAMP, Ip35PP2BCaMCa4, L, pPDE4-cAMP, PKAc, CaB) were set to 0. (PDF)

Initial conditions of species anchored in the spine head and in the dendrite membrane. Initial conditions of remaining anchored species (LRGs, LRGsβγ, pR, pLR, ppLR, pppLR, ppppLR, pR, ppR, pppR, ppppR, PKAcR, PKAcpR, PKAcppR, PKAcpppR, PKAcLR, PKAcpLR, PKAcppLR, PKAcpppLR, ppppLRGi, ppppRGi, ppppRGiβγ, ppppLRGiβγ, Giβγ, Gαi GDP, AC1Gαs GTPGαi GTPC...

Initial conditions of species anchored in the PSD. Initial conditions of remaining anchored species (Leak, ncx, ncxCa, pmca, pmcaCa, GluR1-CKCam, GluR1-CKp, GluR1-CKpCaM, GluR1-PKAc, pS831GluR1, pS831-GluR1-PKAc, pS831GluR1-PP1, pS845GluR1, pS845GluR1-CKCam, pS845GluR1-CKp, pS845GluR1-CKpCaM, pS845GluR1-PP1, pS845GluR1-PP2B, pS845pS831GluR1, pS845p...

Parameters of the norepinephrine release model fitted to Eq (1). (PDF)

Robustness of the spine signature. The kinase-to-phosphatase balance, evaluated by molecular signatures, is thought to control direction of synaptic plasticity. There are at least two ways of assessing this balance: either measuring the quantity of phosphorylated targets of kinases and phosphatases, or assessing a ratio of kinase activity to phosph...

Robustness of the spine signature threshold. (PDF)

Parameters of the signaling pathways. * Rapid dissociation after enzyme reaction prevents accumulation of these intermediate forms. ** CaMKII phosphorylation reactions involving Complex are required to produce the observed calcium sensitivity, and capture the probability that two calmodulin bound CaMKII subunits are adjacent in the holoenzyme. Abbr...

Diffusion rates of diffusible species. Abbreviations same as in S1 Table. (PDF)

The striatum is a major site of learning and memory formation for sensorimotor and cognitive association. One of the mechanisms used by the brain for memory storage is synaptic plasticity - the long lasting, activity-dependent change in synaptic strength. All forms of synaptic plasticity require an elevation in intracellular calcium, and a common h...

Interactions among signaling pathways that are activated by transmembrane receptors produce complex networks and emergent dynamical behaviors that are implicated in synaptic plasticity. Temporal dynamics and spatial aspects are critical determinants of cell responses such as synaptic plasticity, although the mapping between spatiotemporal activity...

In this article we discuss the short-term synaptic depression using a mathematical model. We derive the model of synaptic depression caused by the depletion of synaptic vesicles for the case of infinitely short stimulation time and show that the analytical formulas for the postsynaptic potential (PSP) and kinetic functions take simple closed form....

In this article we present analytical solutions of the single and pair pulse time evolution of a plastic neocortical synapse described by the TM-model. We show that this model is equivalent to the receptor-desensitization model with three kinetic states. For the TM-model we derive the analytical form of a measure of paired pulse depression. We anal...

Simultaneous variations of the event-related power changes (ERD/ERS) are often observed in a number of frequency bands. ERD/ERS measures are usually based on the relative changes of power in a given single frequency band. Within such an approach one cannot answer questions concerning the mutual relations between the band-power variations observed i...

Event related changes in the synchronization of pyramidal neurons activity are a valuable source of information about the information processing in the brain. These changes can be measured as the changes in the power of EEG or ECoG signal. This paper presents a methodology of estimating the statistical significance of those changes. It consists of...