Joana Cabral

Joana Cabral
University of Minho · Life and Health Sciences Research Institute

PhD

About

89
Publications
27,955
Reads
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3,157
Citations
Citations since 2016
72 Research Items
2748 Citations
20162017201820192020202120220200400600
20162017201820192020202120220200400600
20162017201820192020202120220200400600
20162017201820192020202120220200400600
Introduction
My main interest is to investigate the fundamental principles underlying brain function. In other words, I am curious about the most primitive biophysical mechanisms at the genesis of coordinated brain activity, ultimately leading to our thoughts and actions.
Additional affiliations
July 2017 - present
University of Minho
Position
  • Research Assistant
October 2014 - present
University of Oxford
Position
  • PostDoc Position
July 2012 - September 2014
University Pompeu Fabra
Position
  • PostDoc Position
Education
March 2008 - July 2012
University Pompeu Fabra
Field of study
  • Theoretical and Computational Neuroscience
September 2002 - July 2007
Universidade NOVA de Lisboa
Field of study
  • Biomedical Engineering

Publications

Publications (89)
Article
Traditionally, in neuroimaging, model-free analyses are used to find significant differences between brain states via signal detection theory. Depending on the a priori assumptions about the underlying data, different spatio-temporal features can be analysed. Alternatively, model-based techniques infer features from the data and compare significanc...
Preprint
Full-text available
The disconnection hypothesis of schizophrenia proposes that symptoms of the disorder arise as a result of aberrant functional integration between segregated areas of the brain. The concept of metastability characterizes the coexistence of competing tendencies for functional integration and functional segregation in the brain and is therefore well s...
Article
Full-text available
The significant link between stress and psychiatric disorders has prompted research on stress’s impact on the brain. Interestingly, previous studies on healthy subjects have demonstrated an association between perceived stress and amygdala volume, although the mechanisms by which perceived stress can affect brain function remain unknown. To better...
Preprint
Psilocybin therapy for depression has started to show promise, yet the underlying causal mechanisms are not currently known. Here we leveraged the differential outcome in responders and non-responders to psilocybin (10mg and 25mg, 7 days apart) therapy for depression - to gain new insights into regions and networks implicated in the restoration of...
Preprint
Full-text available
Introduction: Recurrence in major depression disorder (MDD) is common, but neurobiological models capturing vulnerability for recurrences are scarce. Disturbances in multiple resting-state networks have been linked to MDD, but most approaches focus on stable (vs. dynamic) network characteristics. We investigated how the brain's dynamical repertoire...
Article
Music listening plays a pivotal role for children and adolescents, yet it remains unclear how music modulates brain activity at the level of functional networks in this young population. Analysing the dynamics of brain networks occurring and dissolving over time in response to music can provide a better understanding of the neural underpinning of m...
Article
Full-text available
The past two decades have seen an explosion in the methods and directions of neuroscience research. Along with many others, complexity research has rapidly gained traction as both an independent research field and a valuable subdiscipline in computational neuroscience. In the past decade alone, several studies have suggested that psychiatric disord...
Article
Full-text available
A rich repertoire of oscillatory signals is detected from human brains with electro- and magnetoencephalography (EEG/MEG). However, the principles underwriting coherent oscillations and their link with neural activity remain under debate. Here, we revisit the mechanistic hypothesis that transient brain rhythms are a signature of metastable synchron...
Article
Full-text available
In order to survive in a complex environment, the human brain relies on the ability to flexibly adapt ongoing behaviour according to intrinsic and extrinsic signals. This capability has been linked to specific whole-brain activity patterns whose relative stability (order) allows for consistent functioning, supported by sufficient intrinsic instabil...
Preprint
Psilocybin therapy for depression has started to show promise, yet the underlying causal mechanisms are not currently known. Here we leveraged the differential outcome in responders and non-responders to psilocybin (10mg and 25mg, 7 days apart) therapy for depression - to gain new insights into regions and networks implicated in the restoration of...
Article
Dynamic functional connectivity (dFC) in resting-state fMRI holds promise to deliver candidate biomarkers for clinical applications. However, the reliability and interpretability of dFC metrics remain contested. Despite a myriad of methodologies and resulting measures, few studies have combined metrics derived from different conceptualizations of b...
Article
Competing and complementary models of resting-state brain dynamics contribute to our phenomenological and mechanistic understanding of whole-brain coordination and communication, and provide potential evidence for differential brain functioning associated with normal and pathological behaviour. These neuroscientific theories stem from the perspecti...
Article
Full-text available
The current paper proposes a method to estimate phase to phase cross-frequency coupling between brain areas, applied to broadband signals, without any a priori hypothesis about the frequency of the synchronized components. N:m synchronization is the only form of cross-frequency synchronization that allows the exchange of information at the time res...
Preprint
Full-text available
Competing and complementary models of resting-state brain dynamics contribute to our phenomenological and mechanistic understanding of whole-brain coordination and communication, and provide potential evidence for differential brain functioning associated with normal and pathological behavior. These neuroscientific theories stem from the perspectiv...
Article
Full-text available
Schizophrenia is a chronic psychotic disorder characterized by the disruption of thought processes, perception, cognition, and behaviors, for which there is still a lack of objective and quantitative biomarkers in brain activity. Using functional magnetic resonance imaging (fMRI) data from an open-source database, this study investigated difference...
Preprint
Full-text available
Dynamic functional connectivity (dFC) in resting-state fMRI holds promise to deliver candidate biomarkers for clinical applications. However, the reliability and interpretability of dFC metrics remain contested. Despite a myriad of methodologies and resulting measures, few studies have combined metrics derived from different conceptualizations of b...
Preprint
Full-text available
A rich repertoire of oscillatory signals is detected from human brains with electro- and magnetoencephalography (EEG/MEG). However, the principles underwriting coherent oscillations and their link with neural activity remain unclear. Here, we hypothesise that the emergence of transient brain rhythms is a signature of weakly stable synchronization b...
Preprint
Full-text available
The fundamental principles driving spontaneous long-range correlations between distant brain areas - known as intrinsic functional connectivity - remain unclear. To investigate this, we develop an ultrafast functional Magnetic Resonance Imaging (fMRI) approach with unprecedented temporal resolution (38 milliseconds) in the rat brain. We detect a re...
Article
Full-text available
Computational models lie at the intersection of basic neuroscience and healthcare applications because they allow researchers to test hypotheses in silico and predict the outcome of experiments and interactions that are very hard to test in reality. Yet, what is meant by “computational model” is understood in many different ways by researchers in d...
Preprint
Full-text available
Brain activity during rest has been demonstrated to evolve through a repertoire of functional connectivity (FC) patterns, whose alterations may provide biomarkers of schizophrenia - a psychotic disorder characterized by dysfunctional brain connectivity. In this study, differences between the dynamic exploration of resting-state networks using funct...
Article
Full-text available
Coffee is the most widely consumed source of caffeine worldwide, partly due to the psychoactive effects of this methylxanthine. Interestingly, the effects of its chronic consumption on the brain’s intrinsic functional networks are still largely unknown. This study provides the first extended characterization of the effects of chronic coffee consump...
Article
Information encoding has received a wide neuroscientific attention, but the underlying rapid spatiotemporal brain dynamics remain largely unknown. Here, we investigated the rapid brain mechanisms for encoding of sounds forming a complex temporal sequence. Specifically, we used magnetoencephalography (MEG) to record the brain activity of 68 particip...
Preprint
Though the organization of functional brain networks is modular at its core, modularity does not capture the full range of dynamic interactions between individual brain areas nor at the level of subnetworks. In this paper we present a hierarchical model that represents both flexible and modular aspects of intrinsic brain organization across time by...
Article
Full-text available
Though the organization of functional brain networks is modular at its core, modularity does not capture the full range of dynamic interactions between individual brain areas nor at the level of subnetworks. In this paper we present a hierarchical model that represents both flexible and modular aspects of intrinsic brain organization across time by...
Article
Full-text available
The human brain is a complex system comprising subregions that dynamically exchange information between its various parts through synchronization. These dynamic, complex interactions ultimately play a role in perception, emotion, cognition, and behavior, as well as in various maladaptive neurologic and psychiatric processes. It is therefore importa...
Article
Decades of neurobiological research have disclosed the diverse manners in which the response properties of neurons are dynamically modulated to support adaptive cognitive functions. This neuromodulation is achieved through alterations in the biophysical properties of the neuron. However, changes in cognitive function do not arise directly from the...
Article
Full-text available
Body dysmorphic disorder (BDD) is characterized by preoccupations with misperceptions of one’s physical appearance. Previous neuroimaging studies in BDD have yet to examine dynamic functional connectivity (FC) patterns between brain areas, necessary to capture changes in activity in response to stimuli and task conditions. We used Leading Eigenvect...
Preprint
Full-text available
Information encoding has received a wide neuroscientific attention, but the underlying rapid spatiotemporal brain dynamics remain largely unknown. Here, we investigated the rapid brain mechanisms for encoding and prediction of sounds forming a complex temporal sequence. Specifically, we used magnetoencephalography (MEG) to record the brain activity...
Preprint
The current paper proposes a method to estimate phase to phase cross-frequency coupling between brain areas, applied to broadband signals, without any a priori hypothesis about the frequency of the synchronized components. N:m synchronization is the only form of cross-frequency synchronization that allows the exchange of information at the time res...
Preprint
Full-text available
The neuroscience of jazz improvisation has shown promising results for understanding domain-specific and domain-general processes of creativity. Here, we used fMRI to measure for the first time the dynamic neural substrates of musical creativity in 16 skilled jazz pianists while they played by memory, improvised freely (iFreely) and by melody (iMel...
Preprint
Full-text available
Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is increasingly used for the treatment of Parkinson’s Disease (PD), but despite its success, the neural mechanisms behind this surgical procedure remain partly unclear. As one working hypothesis, it was proposed that DBS works by restoring the balance of the brain’s resting-state network...
Article
Full-text available
Brain function depends on the flexible and dynamic coordination of functional subsystems within distributed neural networks operating on multiple scales. Recent progress has been made in the characterization of functional connectivity (FC) at the whole-brain scale from a dynamic, rather than static, perspective, but its validity for cognitive scien...
Preprint
Full-text available
Computational models lie at the intersection of basic neuroscience and healthcare applications because they allow researchers to test hypotheses \textit{in silico} and predict the outcome of experiments and interactions that are very hard to test in reality. Yet, what is meant by "computational model" is understood in many different ways by researc...
Preprint
Full-text available
Autism has been characterised by different behavioural and cognitive profiles compared to typically developing (TD) individuals, and increasingly these differences have been associated with differences in structural and functional brain connectivity. It is currently unknown as to whether autistic and TD listeners process music in the same way: emot...
Preprint
Full-text available
Schizophrenia remains a poorly understood disease, hence the interest in assessing and indirectly characterizing brain activity and connectivity. This paper aims to search for potential biomarkers in schizophrenia with functional magnetic resonance data, between subjects in the resting state. Firstly, we used fMRI from an open database, SchizConnec...
Preprint
Full-text available
Music is a universal non-verbal human language, built on logical structures and articulated in balanced hierarchies between sounds, offering excellent opportunities to explore how the brain creates meaning for complex spatiotemporal auditory patterns. Using the high temporal resolution of magnetoencephalography in 70 participants, we investigated t...
Preprint
Full-text available
Music listening plays a pivotal role for children and adolescents, yet surprisingly few neuroimaging studies have studied the underlying functional dynamics. We used functional magnetic resonance imaging to scan 17 preadolescents aged 10-11 years old while listening to music. We subsequently tracked the occurrence of functional brain networks over...
Article
Full-text available
Background Cognitive insight is defined as the ability to reflect upon oneself (i.e. self-reflectiveness), and to not be overly confident of one's own (incorrect) beliefs (i.e. self-certainty). These abilities are impaired in several disorders, while they are essential for the evaluation and regulation of one's behavior. We hypothesized that cognit...
Article
Full-text available
Interpersonal coordination is a core part of human interaction, and its underlying mechanisms have been extensively studied using social paradigms such as joint finger tapping. Here, individual and dyadic differences have been found to yield a range of dyadic synchronization strategies, such as mutual adaptation, leading-leading, and leading-follow...
Article
Full-text available
Functionally relevant network patterns form transiently in brain activity during rest, where a given subset of brain areas exhibits temporally synchronized BOLD signals. To adequately assess the biophysical mechanisms governing intrinsic brain activity, a detailed characterization of the dynamical features of functional networks is needed from the...
Article
Full-text available
Significance In a technical tour de force, we have created a framework demonstrating the underlying fundamental principles of bidirectional coupling of neuronal and neurotransmitter dynamical systems. Specifically, in the present study, we combined multimodal neuroimaging data to causally explain the functional effects of specific serotoninergic re...
Preprint
Full-text available
One of the defining elements of jazz is the ability to improvise. The neuroscience of jazz improvisation has shown promising results for understanding domain-specific and domain-general processes of creativity. However, until date no previous studies have examined how different modes of improvisation (musical creativity) evolve over time and which...
Article
The perception of infant emotionality, one aspect of temperament, starts to form in infancy, yet the underlying mechanisms of how infant emotionality affects adult neural dynamics remain unclear. We used a social reward task with probabilistic visual and auditory feedback (infant laughter or crying) to train 47 nulliparous women to perceive the emo...
Article
Full-text available
Human social behaviour is complex, and the biological and neural mechanisms underpinning it remain debated. A particularly interesting social phenomenon is our ability and tendency to fall into synchronization with other humans. Our ability to coordinate actions and goals relies on the ability to distinguish between and integrate self and other, wh...
Article
Full-text available
Bipolar disorder (BD) has been linked to disrupted structural and functional connectivity between prefrontal networks and limbic brain regions. Studies of patients with pediatric bipolar disorder (PBD) can help elucidate the developmental origins of altered structural connectivity underlying BD and provide novel insights into the aetiology of BD. H...
Article
Full-text available
Significance We describe a quantitative and robust definition of a brain state as an ensemble of “metastable substates,” each with a probabilistic stability and occurrence frequency. Fitting this to a generative whole-brain model provides an innovative avenue for predicting where simulated brain stimulation can force transitions between different b...
Poster
Full-text available
Composed of ~100 billion interconnected neurons, the human brain is one of the most complex networks in Nature, exhibiting a rich repertoire of non-trivial spatiotemporal patterns spanning multiple spatial and temporal scales. At the macroscopic level, patterns with well-established behavioural correlates emerge from the collective behaviour of neu...
Poster
Full-text available
An infant's temperament reflects individual differences in their emotionality – whether they are predominantly happy, signaled by smiles and laughter, or sad, signaled by crying and distress cues. Infant temperament has a measurable effect upon early mother-infant bonding (Nolvi et al., 2016). While positive infant emotionality (smiling or laughter...
Preprint
Full-text available
Human social behaviour is complex, and the biological and neural mechanisms underpinning it remain debated. A particularly interesting social phenomenon is our ability and tendency to fall into synchrony with other humans. Our ability to coordinate actions and goals relies on the ability to distinguish between and integrate self and other, which wh...
Article
Full-text available
Growing evidence from the dynamical analysis of functional neuroimaging data suggests that brain function can be understood as the exploration of a repertoire of metastable connectivity patterns (‘functional brain networks’), which potentially underlie different mental processes. The present study characterizes how the brain’s dynamical exploratio...
Article
Full-text available
The modern understanding of sleep is based on the classification of sleep into stages defined by their electroencephalography (EEG) signatures, but the underlying brain dynamics remain unclear. Here we aimed to move significantly beyond the current state-of-the-art description of sleep, and in particular to characterise the spatiotemporal complexit...