About
9
Publications
420
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13
Citations
Introduction
Skills and Expertise
Current institution
Additional affiliations
July 2023 - present
Princess Margaret Cancer Research Centre
Position
- Bioinformatics Analyst
Education
September 2020 - August 2023
September 2017 - August 2020
Publications
Publications (9)
Glioblastoma (GBM) is the most common malignancy of the central nervous system, characterized by a dismal prognosis and inevitable recurrence despite aggressive standard-of-care therapy. Extensive colonization of the surrounding brain parenchyma precludes complete surgical resection, posing a significant therapeutic challenge. While well-studied in...
The cellular and molecular heterogeneity of tumors is a major obstacle to cancer immunotherapy. Here, we use a systems biology approach to derive a signature of the main sources of heterogeneity in the tumor microenvironment (TME) from lung cancer transcriptomics. We demonstrate that this signature, which we called iHet, is conserved in different c...
Glioblastoma (GBM) is a highly lethal brain cancer, comprising about half of all central nervous system malignancies. Its recurrence and resistance to aggressive treatments, such as surgery, radiation, and chemotherapy, underscore its biological complexity. A key feature of GBM is intra-tumoral heterogeneity (ITH), stemming from a diversity of tran...
The cellular and molecular heterogeneity of tumors is a major obstacle to cancer immunotherapy. Here, we use a systems biology approach to derive a signature of the main sources of heterogeneity in the tumor microenvironment (TME) from lung cancer transcriptomic data. We demonstrate that this signature, which we called iHet, is conserved in differe...
Simple Summary
Prostate cancer is a global health burden. Multi-parametric magnetic resonance imaging is the recommended imaging modality for diagnosis. The recommended treatment differs based on tumor aggressiveness, typically assessed with the use of invasive techniques such as tumor biopsies. By studying the relationship between imaging characte...
