Joan-Francesc Barquinero

Joan-Francesc Barquinero
Autonomous University of Barcelona | UAB · Department of Animal Biology, Plant Biology and Ecology

Ph. D

About

163
Publications
22,199
Reads
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2,923
Citations
Citations since 2016
66 Research Items
1563 Citations
2016201720182019202020212022050100150200250
2016201720182019202020212022050100150200250
2016201720182019202020212022050100150200250
2016201720182019202020212022050100150200250
Additional affiliations
January 2014 - present
Autonomous University of Barcelona
Position
  • Professor (Full)
September 2011 - December 2013
Institut de Radioprotection et de Sûreté Nucléaire (IRSN)
Position
  • Principal Investigator
January 2002 - July 2002
Bundesamt für Strahlenschutz, BfS
Position
  • Reserach fellow
Education
January 1991 - December 1995
September 1984 - June 1989

Publications

Publications (163)
Article
Full-text available
To predict the health effects of accidental or therapeutic radiation exposure, one must estimate the radiation dose that person received. A well-known ionising radiation biomarker, phosphorylated γ\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrs...
Article
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Radiation therapy is widely used as an anti-neoplastic treatment despite the adverse effects it can cause in non-tumoral tissues. Radiosensitizing agents, which can increase the effect of radiation in tumor cells, such as gold nanoparticles (GNPs), have been described. To evaluate the radiosensitizing effect of 50 nm GNPs, we carried out a series o...
Preprint
Full-text available
To predict the health effects of accidental or therapeutic radiation exposure, one must estimate the radiation dose that person received. A well-known ionising radiation biomarker, phosphorylated gamma-H2AX protein, is used to evaluate cell damage and is thus suitable for the dose estimation process. In this paper, we present new Bayesian methods t...
Article
Purpose: To test the performance of different algorithms that can be used in interlaboratory comparisons based on dicentric chromosome analysis, and to evaluate the impact of considering a priori values different to calculate individual laboratory performance based on the ionizing radiation dose estimation. Methods: Mean and standard deviation e...
Article
Introduction: In the event of a radiation accident detecting γ-H2AX foci is being accepted as fast method for triage and dose assessment. However, due to their disappearance kinetics, published calibrations have been constructed at specific post-irradiation times. Objectives: To develop a surface, or tridimensional, model to estimate doses at ti...
Article
Full-text available
Purpose: Biological and/or physical assays for retrospective dosimetry are valuable tools to recover the exposure situation and to aid medical decision making. To further validate and improve such biological and physical assays, in 2019, EURADOS Working Group 10 and RENEB performed a field exercise in Lund, Sweden, to simulate various real-life ex...
Article
Full-text available
Purpose In case of a mass-casualty radiological event, there would be a need for networking to overcome surge limitations and to quickly obtain homogeneous results (reported aberration frequencies or estimated doses) among biodosimetry laboratories. These results must be consistent within such network. Inter-laboratory comparisons (ILCs) are widely...
Article
Full-text available
Experience suggests that current nuclear accident response planning in European countries mostly has a technical focus, with less attention paid to social, psychological and ethical issues. Information provided tends to be directed towards decisions made by experts, rather than for the support of affected populations. The SHAMISEN (Nuclear Emergenc...
Article
Full-text available
This paper, the last in the Special Issue (SI) on the SHAMISEN project, presents an overview of the SHAMISEN Recommendations for Preparedness and Health Surveillance of Populations Affected by a Radiation Accident. The recommendations are based on the lessons learnt from previous nuclear accidents, and the engagement activities with different stake...
Article
Full-text available
The experiences of the Chernobyl and Fukushima nuclear accidents showed that dosimetry was the essential tool in the emergency situation for decision making processes, such as evacuation and application of protective measures. However, at the consequent post-accidental phases, it was crucial also for medical health surveillance and in further adapt...
Article
Full-text available
The purpose of this study was to evaluate the relationship between blood redox status, dose and antioxidant dietary intake of different hospital staff groups exposed to low doses of ionizing radiation (LDIR) (Interventional Radiology and Cardiology, Radiation Oncology, and Nuclear Medicine) and non-exposed. Personal dose equivalent (from last year...
Article
DNA double-strand breaks are the crucial lesions underlying the formation of chromosomal aberrations, their formation and kinetics have been extensively studied, although dynamics of the repair process has not been fully understood. By using a combination of different cytogenetic techniques to analyze cells in G0, G2 and M phase, in the present stu...
Article
Purpose: To present the impact in coverage of different methods for Poisson confidence intervals and the impact in dose coverage of different uncertainty factors. A detailed explanation of the uncertainty sources in the Bayesian method is also presented. Materials and methods: The exact coverage of uncertainty Poisson confidence intervals and the d...
Article
Full-text available
The experiences of the Chernobyl and Fukushima nuclear accidents showed that dosimetry was the essential tool in the emergency situation for decision making processes, such as evacuation and application of protective measures. However, at the consequent post-accidental phases, it was crucial also for medical health surveillance and in further adapt...
Poster
Full-text available
This infographic presents recommendations of how to measure external gamma radiation with help of a mobile app (for citizen science use and general public) developed during the SHAMISEN SINGS project (EU-funded). Designer: Maria Beltran The current version is open for gathering feedbacks (deadline till 5th of March 2020). The final versions in d...
Poster
Full-text available
This infographic presents recommendations of how to measure external gamma radiation with help of a mobile app (for citizen science use and general public) developed during the SHAMISEN SINGS project (EU-funded). Designer: Maria Beltran Translation and adaptation to Japanese by Takashi Ohba and Aya Goto (FMU). The current version is open for gat...
Poster
Full-text available
This infographic presents recommendations of how to measure external gamma radiation with help of a mobile app (for citizen science use and general public) developed during the SHAMISEN SINGS project (EU-funded). Designer: Maria Beltran Translation & adaptation to Russian by Liudmila Liutsko & Natallia Novikava The current version is open for...
Poster
Full-text available
This infographic presents recommendations of how to measure external gamma radiation with help of a mobile app (for citizen science use and general public) developed during the SHAMISEN SINGS project (EU-funded). Designer: Maria Beltran Translation and adaptation to French by Adelaida Sarukhan The current version is open for gathering feedbacks (...
Poster
Full-text available
This infographic presents recommendations of how to measure external gamma radiation with help of a mobile app (for citizen science use and general public) developed during the SHAMISEN SINGS project (EU-funded). Designer: Maria Beltran Translation and adaptation to Spanish by Adeliada Sarukhan The current version is open for gathering feedbacks...
Article
Advances in accelerator technology, which have enabled conforming radiotherapy with charged hadronic species, have brought benefits as well as potential new risks to patients. To better understand the effects of ionizing radiation on tumor and surrounding tissue, it is important to investigate and quantify the relationship between energy deposition...
Article
Purpose: The goal was to compare the micronucleus (MN) and dicentric plus ring chromosomes (D + R) assays for dose assessment in cases of partial body irradiations (PBI). Materials and methods: We constructed calibration curves for each assay at doses ranging from 0 to 5 Gy. In order to simulate partial-body exposures, blood samples from two donors...
Article
Full-text available
One of the most severe complications after successful cancer therapy is the development of therapy-related myeloid neoplasms (t-MN). Constitutional genetic variation is likely to impact on t-MN risk. We aimed to evaluate if polymorphisms in the p53 pathway can be useful for predicting t-MN susceptibility. First, an association study revealed that t...
Conference Paper
Full-text available
SHAMISEN SINGS EU-project in brief explication (published as a NOTE)
Article
Full-text available
The aim of this study was to carry out a comprehensive examination of potential genotoxic effects of low doses of tritium delivered chronically to mice and to compare these effects to the ones resulting from equivalent doses of gamma-irradiation. Mice were chronically exposed for one or eight months to either tritiated water (HTO) or organically bo...
Article
Purpose: To present Poisson exact goodness-of-fit tests as alternatives and complements to the asymptotic u-test, which is the most widely used in cytogenetic biodosimetry, to decide whether a sample of chromosomal aberrations in blood cells comes from an homogeneous or inhomogeneous exposure. Materials and Methods: Three Poisson exact goodness-of-...
Conference Paper
Full-text available
Historically, citizen-science participation was widely used in biological and ecological sciences for supporting projects related to biodiversity and environmental monitoring. The first attempts of using citizen-science for dosimetry measurements after nuclear accidents were performed by Safecast and D-shuttle projects. One key purpose of the latte...
Article
Purpose: The fluorescent in situ hybridization technique (FISH), which easily detects reciprocal translocations, is currently used to estimate doses in retrospective biological dosimetry, after suspected accidental overexposure to ionizing radiation (IR). This study of 42 cases aimed to verify the appropriateness of this assay for radiation dose re...
Book
Full-text available
SHAMISEN project "RECOMMENDATIONS and procedures for preparedness and health surveillance of populations affected by a radiation accident", draft in Japanese
Conference Paper
Full-text available
Background: Scope of the work was to draw lessons from Chernobyl and Fukushima experiences on radiation measurements and dosimetry, with a focus on the methods used to evaluate individual/group doses which are especially relevant for medical surveillance, health effects studies, and remarkably communication to stakeholders and local population. Met...
Chapter
A statistical model to deal with low and high-dose exposures is presented. The model is based on a weighted Poisson distribution which allows to explain the underdispersion observed in the empirical data. A Gompertz type calibration curve is also introduced.
Article
Unrepaired DNA double-strand breaks (DSBs) induced by ionizing radiation are associated with lethal effects and genomic instability. After the initial breaks and chromatin destabilization, a set of post-translational modifications of histones occurs, including phosphorylation of serine 139 of histone H2AX (γH2AX), which leads to the formation of io...
Article
Full-text available
Purpose: A European network was initiated in 2012 by 23 partners from 16 European countries with the aim to significantly increase individualized dose reconstruction in case of large-scale radiological emergency scenarios. Results: The network was built on three complementary pillars: (1) an operational basis with seven biological and physical dosi...
Article
Full-text available
Purpose: In the frame of the QA program of RENEB, an inter-laboratory comparison (ILC) of calibration sources used in biological dosimetry was achieved to investigate the influence of calibration practices and protocols on the results of the dose estimation performance as a first step to harmonization and standardization of dosimetry and irradiatio...
Article
Full-text available
Purpose: In the framework of RENEB, several biodosimetry exercises were conducted analyzing different endpoints. Among them, the analysis of translocations is considered the most useful method for retrospective biodosimetry due to the relative stability of their frequency with post irradiation time. The aim of this study was to harmonize the accura...
Article
Full-text available
The objective of Biological Dosimetry is its applicability in radioprotection, quantifying the dose received in individuals who have been exposed to ionizing radiation. For this raison, the analysis of the frequency of chromosome aberrations present in first division metaphases from stimulated lymphocytes is accepted as being the reliable. However,...
Article
Purpose Reliable dose estimation is an important factor in appropriate dosimetric triage categorization of exposed individuals to support radiation emergency response. Materials and Methods Following work done under the EU FP7 MULTIBIODOSE and RENEB projects, formal methods for defining uncertainties on biological dose estimates are compared using...
Article
Full-text available
Purpose: The RENEB accident exercise was carried out in order to train the RENEB participants in coordinating and managing potentially large data sets that would be generated in case of a major radiological event. Materials and methods: Each participant was offered the possibility to activate the network by sending an alerting email about a simu...
Article
Full-text available
Purpose: To identify and assess, among the participants in the RENEB (Realizing the European Network of Biodosimetry) project, the emergency preparedness, response capabilities and resources that can be deployed in the event of a radiological or nuclear accident/incident affecting a large number of individuals. These capabilities include available...
Article
Purpose: To establish a training data set of digital images and to investigate the scoring criteria and dose assessment of the dicentric assay within the European network of biodosimetry (RENEB), a web based scoring inter-comparison was undertaken by 17 RENEB partners. Materials and methods: Two sets of 50 high resolution images were uploaded on...
Article
Mitotic Index (MI) estimation expressed as percentage of mitosis plays an important role as quality control endpoint. To this end, MI is applied to check the lot of media and reagents to be used throughout the assay and also to check cellular viability after blood sample shipping, indicating satisfactory/unsatisfactory conditions for the progressio...
Article
In a similar way to high-dose exposures to low-LET radiations, cells show difficulties reaching mitosis after high-LET radiation exposure. For this reason, techniques have been proposed that are able to analyze chromosome aberrations in interphase by prematurely condensing the chromosomes (PCC-techniques). Few dose-effect curves for high-LET radiat...
Article
Full-text available
Normal tissue toxicity after radiotherapy shows variability between patients, indicating inter-individual differences in radiosensitivity. Genetic variation probably contributes to these differences. The aim of the present study was to determine if two cell lines, one radiosensitive (RS) and another radioresistant (RR), showed differences in DNA re...
Article
Full-text available
The purpose of this study was to compare cytogenetic data in a patient before and after treatment with radioiodine to evaluate the assays in the context of biological dosimetry. We studied a 34-year-old male patient who underwent a total thyroidectomy followed by ablation therapy with (131)I (19.28 GBq) for a papillary thyroid carcinoma. The patien...
Article
Full-text available
In case of external overexposure to ionizing radiation, an estimation of its genotoxic effects on exposed individuals can be made retrospectively by the measurement of radiation-induced chromosome aberrations on circulating lymphocytes. Compared with external irradiation, intakes of radionuclides may, however, lead to specific features influencing...