Joan C Vilanova

Joan C Vilanova
Universitat de Girona | UDG · Department of Medical Sciences

MD, PhD

About

283
Publications
176,918
Reads
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4,403
Citations
Citations since 2016
65 Research Items
2842 Citations
20162017201820192020202120220100200300400500
20162017201820192020202120220100200300400500
20162017201820192020202120220100200300400500
20162017201820192020202120220100200300400500
Additional affiliations
January 2015 - present
IDI-Institu Diagnòstic Imatge -Girona - Institut Català de la Salut
Position
  • Chief
January 2015 - present
Hospital Universitari de Girona Dr. Josep Trueta
Position
  • Chief Prostate Imaging Unit
November 2008 - present
Institut Català de la Salut
Position
  • Coordinator

Publications

Publications (283)
Article
Full-text available
To achieve clinical impact in daily oncological practice, emerging AI-based cancer imaging research needs to have clearly defined medical focus, AI methods, and outcomes to be estimated. AI-supported cancer imaging should predict major relevant clinical endpoints, aiming to extract associations and draw inferences in a fair, robust, and trustworthy...
Article
Full-text available
The microbiota-gut-brain axis has emerged as a novel target in depression, a disorder with low treatment efficacy. However, the field is dominated by underpowered studies focusing on major depression not addressing microbiome functionality, compositional nature, or confounding factors. We applied a multi-omics approach combining pre-clinical models...
Article
Understanding the brain changes occurring during aging can provide new insights for developing treatments that alleviate or reverse cognitive decline. Neurostimulation techniques have emerged as potential treatments for brain disorders and to improve cognitive functions. Nevertheless, given the ethical restrictions of neurostimulation approaches, i...
Article
Full-text available
Bone metastases are very common complications associated with certain types of cancers that frequently negatively impact the quality of life and functional status of patients; thus, early detection is necessary for the implementation of immediate therapeutic measures to reduce the risk of skeletal complications and improve survival and quality of l...
Preprint
Full-text available
Understanding the brain changes occurring during aging can provide new insights for developing treatments that alleviate or reverse cognitive decline. Neurostimulation techniques have emerged as potential treatments for brain disorders and to improve cognitive functions. Nevertheless, given the ethical restrictions of neurostimulation approaches, i...
Article
The current recommendation in patients with a clinical suspicion for prostate cancer is to perform systematic biopsies extended with targeted biopsies, depending on mpMRI results. Following a positive mpMRI [i.e. Prostate Imaging Reporting and Data System (PI-RADS) ≥3], three targeted biopsy approaches can be performed: visual registration of the M...
Article
Full-text available
Background Manual brain extraction from magnetic resonance (MR) images is time-consuming and prone to intra- and inter-rater variability. Several automated approaches have been developed to alleviate these constraints, including deep learning pipelines. However, these methods tend to reduce their performance in unseen magnetic resonance imaging (MR...
Article
Full-text available
Background: To develop an international, multi-site nomogram for side-specific prediction of extraprostatic extension (EPE) of prostate cancer based on clinical, biopsy, and magnetic resonance imaging- (MRI) derived data. Methods: Ten institutions from the USA and Europe contributed clinical and side-specific biopsy and MRI variables of consecut...
Preprint
Full-text available
The microbiota-gut-brain axis has emerged as a novel target in depression, a disorder with low treatment efficacy. However, the field is dominated by underpowered studies focusing on major depression not addressing microbiome functionality, compositional nature, or confounding factors. We applied a multi-omics approach combining pre-clinical models...
Article
Full-text available
Background Inhibitory control (IC) is critical to keep long-term goals in everyday life. Bidirectional relationships between IC deficits and obesity are behind unhealthy eating and physical exercise habits. Methods We studied gut microbiome composition and functionality, and plasma and faecal metabolomics in association with cognitive tests evalua...
Article
Full-text available
Normal aging causes disruptions in the brain that can lead to cognitive decline. Resting-state functional magnetic resonance imaging studies have found significant age-related alterations in functional connectivity across various networks. Nevertheless, most of the studies have focused mainly on static functional connectivity. Studying the dynamics...
Article
Full-text available
Objectives To evaluate the potential clinical and technical utility to manage in practice the use of a robotic MRI in-bore-targeted prostate biopsies in the current work-up of prostate cancer diagnosis.Methods Thirty patients with a single cancer suspicious lesion interpreted on MRI using PI-RADSv2.1 category ≥ 3 underwent in-bore robotic transrect...
Article
Full-text available
Background The measures adopted to control the spread of the COVID-19 pandemic in several countries included mobility and social restrictions that produced an immediate impact on the lifestyle of their inhabitants. Methods We assessed the association between the consequences of these measures and depressive symptomatology using a population-based...
Article
Full-text available
Immunotherapy is changing the treatment paradigm for cancer and has introduced new challenges in medical imaging. Because not all patients benefit from immunotherapy, pretreatment imaging should be performed to identify not only prognostic factors but also factors that allow prediction of response to immunotherapy. Follow-up studies must allow dete...
Article
Immunotherapy is changing the treatment paradigm for cancer and has introduced new challenges in medical imaging. Because not all patients benefit from immunotherapy, pretreatment imaging should be performed to identify not only prognostic factors but also factors that allow prediction of response to immunotherapy. Follow-up studies must allow dete...
Article
Advanced algorithms used in MV photon radiotherapy model radiation transport in any media. They represent a step forward but introduce new uncertainties and questions, including whether to report the doses to water (Dw,m) or medium (Dm,m) voxels, and the impact of fluence changes introduced by surrounding media. These aspects can compromise consist...
Article
Cerebral venous thrombosis (CVT) is uncommon, representing approximately 0,5 % of all cases of cerebrovascular disease worldwide. Many factors, alone or combined, can cause CVT. Although CVT can occur at any age, it most commonly affects neonates and young adults. CVT is difficult to diagnose clinically because patients can present with a wide spec...
Preprint
Full-text available
Normal aging causes disruptions in the brain that can lead to cognitive decline. Resting-state fMRI studies have found significant age-related alterations in functional connectivity across various networks. Nevertheless, most of the studies have focused mainly on static functional connectivity. Studying the dynamics of resting-state brain activity...
Article
Biomarkers of aging are urgently needed to identify individuals at high risk of developing age-associated disease or disability. Growing evidence from population-based studies points to whole-body magnetic resonance ima-ging's (MRI) enormous potential for quantifying subclinical disease burden and for assessing changes that occur with aging in all...
Article
Full-text available
Objectives To describe our surgical technique of “muscle‐sparing” laparoscopic radical prostatectomy and to review relevant anatomical landmarks during the procedure. Methods This was a prospective non‐controlled case series of 120 consecutive patients who underwent laparoscopic radical prostatectomy, always carried out by the same surgeon (OL). T...
Article
Full-text available
Human cancers represent complex structures, which display substantial inter- and intratumor heterogeneity in their genetic expression and phenotypic features. However, cancers usually exhibit characteristic structural, physiologic, and molecular features and display specific biological capabilities named hallmarks. Many of these tumor traits are im...
Preprint
Full-text available
Medical image synthesis has gained a great focus recently, especially after the introduction of Generative Adversarial Networks (GANs). GANs have been used widely to provide anatomically-plausible and diverse samples for augmentation and other applications, including segmentation and super resolution. In our previous work, Deep Convolutional GANs w...
Article
Cerebral venous thrombosis (CVT) is uncommon, representing approximately 0.5% of all cases of cerebrovascular disease worldwide. Many factors, alone or combined, can cause CVT. Although CVT can occur at any age, it most commonly affects neonates and young adults. CVT is difficult to diagnose clinically because patients can present with a wide spect...
Article
Full-text available
Cerebral venous thrombosis (CVT) is uncommon, representing approximately 0.5% of all cases of cerebrovascular disease worldwide. Many factors, alone or combined, can cause CVT. Although CVT can occur at any age, it most commonly affects neonates and young adults. CVT is difficult to diagnose clinically because patients can present with a wide spect...
Article
Full-text available
MRI of articular cartilage (AC) integrity has potential to become a biomarker for osteoarthritis progression. Traditional MRI sequences evaluate AC morphology, allowing for the measurement of thickness and its change over time. In the last two decades, more advanced, dedicated MRI cartilage sequences have been developed aiming to assess AC matrix c...
Article
Whole-body magnetic resonance imaging (WB-MRI) is a powerful tool increasingly used to assess oncologic and nononcologic diseases. WB-MRI provides information about diffuse multifocal pathologies with excellent anatomical definition through high soft tissue contrast and spatial resolution as well as valuable functional information from diffusion-we...
Article
Full-text available
In recent years, several convolutional neural network (CNN) methods have been proposed for the automated white matter lesion segmentation of multiple sclerosis (MS) patient images, due to their superior performance compared with those of other state-of-the-art methods. However, the accuracies of CNN methods tend to decrease significantly when evalu...
Article
Full-text available
In addition to the classical morphological evaluation of pancreatic disease, the constant technological advances in imaging techniques based fundamentally on computed tomography and magnetic resonance imaging have enabled the quantitative functional and molecular evaluation of this organ. In many cases, this imaging-based information results in sub...
Article
Full-text available
In addition to the classical morphological evaluation of pancreatic disease, the constant technological advances in imaging techniques based fundamentally on computed tomography and magnetic resonance imaging have enabled the quantitative functional and molecular evaluation of this organ. In many cases, this imaging-based information results in sub...
Preprint
Full-text available
In recent years, several convolutional neural network (CNN) methods have been proposed for the automated white matter lesion segmentation of multiple sclerosis (MS) patient images, due to their superior performance compared with those of other state-of-the-art methods. However, the accuracies of CNN methods tend to decrease significantly when evalu...
Article
Full-text available
Imaging techniques are clinical decision-making tools in the evaluation of patients with colorectal cancer (CRC). The aim of this article is to discuss the potential of recent advances in imaging for diagnosis, prognosis, therapy planning, and assessment of response to treatment of CRC. Recent developments and new clinical applications of conventio...
Article
Full-text available
In oncology, the radiology report is a fundamental tool for communication between the radiologist, clinician, and patient. The radiology report is a document that integrates the final outcome of the radiologist's contribution to the care of the oncologic patient; therefore, the information it contains must be accurate and clear. The report must be...
Book
This atlas provides a comprehensive, state of the art review of the use of multiparametric MRI (mpMRI) for the imaging of prostate cancer, covering aspects from diagnosis and loco-regional staging through to the role of the technique after treatment and follow-up. The book contains a wealth of high-resolution images, many of them in color, and disp...
Chapter
The McNeal anatomical model considers the prostate divided into four zones in relation to the different surrounding structures as described below [1, 2].
Chapter
Correct staging of prostate carcinoma (PCa) is important for therapeutic management as it allows selection of an appropriate therapeutic option and correct therapeutic planning. The detection of extracapsular extension (ECE) of a PCa is an essential part of tumor staging because the absence of ECE (organ-confined disease) positively affects long-te...
Chapter
Full-text available
Prostate cancer (PCa) is the most common cancer in men [1]. Until a few years ago, digital rectal examination, serum prostate-specific antigen (PSA) measurement, and prostate biopsy were the main tools in the diagnosis of PCa. Now, the role of multiparametric MR (mpMR) in the detection of PCa is widely accepted, but it is also recognized that prost...
Chapter
Multiparametric MRI (mpMRI) is the method of choice to evaluate the prostate for clinically significant adenocarcinoma. The widespread implementation and acceptance of mpMRI requires a standardization of image acquisition, interpretation, and reporting to achieve an optimal test for daily practice on the work-up of prostate cancer (PCa).
Chapter
Therapeutic management for prostate cancer has different options: the androgen-deprivation therapy, the classic treatment of prostatectomy and radiotherapy, and the focal therapies, such as high-intensity focused ultrasound, cryoablation, and laser ablation. Moreover, currently active surveillance is an option for monitoring slow-growing prostate c...
Article
Full-text available
Imaging in oncology is an essential tool for patient management but its potential is being profoundly underutilized. Each of the techniques used in the diagnostic process also conveys functional information that can be relevant in treatment decision-making. New imaging algorithms and techniques enhance our knowledge about the phenotype of the tumor...
Article
Full-text available
Mammography is the gold standard screening technique in breast cancer, but it has some limitations for women with dense breasts. In such cases, sonography is usually recommended as an additional imaging technique. A traditional sonogram produces a two-dimensional (2D) visualization of the breast and is highly operator dependent. Automated breast ul...
Article
Full-text available
Purpose: To evaluate the differences in prostate cancer detection rate and biopsy effectiveness between magnetic resonance imaging (MRI) target biopsy (TB) and transperineal standard biopsy (SB) in biopsy-naïve patients. Material and methods: Between October 2014 and April 2016, 60 men with a mean age of 64.1±6.7 (SD) years (range: 53-82 years)...
Article
Full-text available
Diagnosis and treatment of foot disease in patients with diabetes is a common clinical-radiologic challenge, particularly the differentiation of neuropathic arthropathy from osteomyelitis. Conventional clinical tests and imaging techniques have limited accuracy for evaluation of the diabetic foot. The introduction of morphologic magnetic resonance...
Data
Volume differences in mm3 (generated patients – healthy control) for the 100 generated images using three publicly available software. The green boxplots show the differences when there were MS lesions generated on the brain but not on top of that particular structure. On the other hand, red boxplots stand for lesioned structures. Acronyms from lef...
Article
Full-text available
In recent years, many automatic brain structure segmentation methods have been proposed. However, these methods are commonly tested with non-lesioned brains and the effect of lesions on their performance has not been evaluated. Here, we analyze the effect of multiple sclerosis (MS) lesions on three well-known automatic brain structure segmentation...
Article
Full-text available
Prostatic multi-parametric magnetic resonance imaging (MP-MRI) has recently had a wide development becoming a key tool in the diagnostic and therapeutic decisions in prostate cancer (Pca). The fast development both in technology and in reading (PIRADS V2) requires a continuous updating of knowledge within this area. The aim of this article is to pr...
Chapter
Full-text available
Soft tissue tumors (STT) represent a complex group of lesions that may show a broad range of differentiation. The WHO (World Health Organization) classification has been up-to-dated in 2013 for the purpose of uniformity. The major modifications from the previous edition are the addition of three new chapters: gastrointestinal stromal tumors (GIST),...
Article
Prostatic multi-parametric magnetic resonance imaging (MP-MRI) has recently had a wide development becoming a key tool in the diagnostic and therapeutic decisions in prostate cancer (Pca). The fast development both in technology and in reading (PIRADS V2) requires a continuous updating of knowledge within this area. The aim of this article is to pr...
Article
In this paper, we present a novel automated method for White Matter (WM) lesion segmentation of Multiple Sclerosis (MS) patient images. Our approach is based on a cascade of two 3D patch-wise convolutional neural networks (CNN). The first network is trained to be more sensitive revealing possible candidate lesion voxels while the second network is...
Article
Resumen Objetivo El objetivo de nuestro trabajo es evaluar la cuantificación del volumen testicular mediante segmentación en resonancia magnética (RM) y compararla con la fórmula propuesta por Lambert en ecografía (0,71 × ancho × alto × largo), que es el método utilizado como referencia. Material y métodos Se realiza un estudio prospectivo de pac...
Article
Full-text available
For various reasons, prostate cancer is a major public health problem. It is a very common cancer, but has a very low mortality rate because it comprises two types of disease: one insignificant, indolent, and much more common, and the other aggressive, significant, and much less common. The routine diagnostic approach to prostate cancer has been sy...
Article
Over the last few years, the increasing interest in brain tissue volume measurements on clinical settings has led to the development of a wide number of automated tissue segmentation methods. However, white matter lesions are known to reduce the performance of automated tissue segmentation methods, which requires manual annotation of the lesions an...
Article
Full-text available
Resulta sorprendente que una técnica única como la resonancia magnética (RM), que no requiere ser combinada con otra, que no precisa de la administración de ningún fármaco, sin radiación ionizante, con un coste muy inferior a técnicas combinadas como la tomografía por emisión de positronestomografía computarizada (PET-TC), no se haya implantado de...