Joachim Wiskemann

Joachim Wiskemann
National Center for Tumor Diseases (NCT) Heidelberg · Department of Medical Oncology

PD Dr.
Paper writing and starting a S3 Guideline on Exercise and Cancer in Germany

About

212
Publications
29,441
Reads
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4,339
Citations
Introduction
Joachim Wiskemann holds a PhD and is habilitated in sports and exercise science with an additional academic education in sports psychology. He is employed at the National Center for Tumor Diseases and Adjunct Assisstant Professor of Public Health Science at Penn State University. As head of the working group "Exercise Oncology " (Division of Medical Oncology, National Center for Tumor Diseases (NCT) and Heidelberg University Hospital) and principal/co-investigator of several exercise intervention trials in cancer patients he has substantial experience in planning and tailoring exercise programs to cancer patients´ needs and capabilities and conducted exercise studies in cancer patients for more than ten years. Dr. Wiskemann published landmark studies in the field of exercise and hemato-oncology (Blood, 2011) and provided new insights into exercise oncology in a variety of cancer entities. Based on his scientific discoveries, Joachim Wiskemann started early serving the closer and wider Heidelberg cancer community by developing a German- and maybe European-wide unique exercise care program for cancer patients including 40 hours of exercise therapy/counselling a week at the National Center for Tumor Diseases in Heidelberg (2010). Further, he established the German-wide expanding network (2011) for high qualitative exercise care in cancer patients (Netzwerk OnkoAktiv; www.nct-heidelberg.de/onkoaktiv). Along this line he also founded the National Expert Group on Physical Activity and Exercise Therapy in Cancer Patients within the German Cancer Society to build national collaborations for larger trials and politicking (2015). Recently, Dr. Wiskemann was honored with the Scientific Award 2017/2018 of the German Olympic Sports Confederation (DOSB) for his habilitation thesis 'Motor Performance as a Key Parameter in Oncology'.
Additional affiliations
May 2017 - present
Penn State Hershey Medical Center and Penn State College of Medicine
Position
  • Professor (Assistant)
December 2010 - present
National Center for Tumor Diseases (NCT) Heidelberg
Position
  • Group Leader
May 2008 - present
Universität Heidelberg
Position
  • Lecturer
Education
December 2016 - December 2017
Universität Heidelberg
Field of study
  • Sport Science
February 2006 - June 2010
Universität Heidelberg
Field of study
  • Sport Science
October 2000 - September 2005
Universität Heidelberg
Field of study
  • Sport Science/Exercise in Prevention and Rehabilitation/Psychology

Publications

Publications (212)
Article
Background People receiving hematopoietic stem cell transplantation (HSCT) endure long phases of therapy and immobility, which diminish their physical activity (PA) level leading to physical deconditioning. One of the reasons is a lack of clarity on the part of those who work in oncology clinical settings of their role in assessing, advising, and...
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Background: Pediatric cancer leads to reduced participation in exercise and only few patients comply with national physical activity recommendations. Physically inactive behavior hinders motor development and increases physical and psychological adverse effects of therapy and incidence of sequelae. Currently, there is neither nationwide coverage n...
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Purpose Most patients receiving a hematopoietic stem cell transplantation (HSCT) are able to tolerate and benefit from physical activity (PA). Therefore, it is important that health care professionals (HCPs) advise patients to perform PA before, during, and after transplantation. By understanding which medical conditions and safety issues are assoc...
Article
Zusammenfassung Onkologischen PatientInnen wird ein regelmäßiges körperliches Training explizit empfohlen. Das Hochintensive Intervalltraining (HIIT) rückt dank steigender Evidenzlage in unterschiedlichen Diagnosegruppen vermehrt in den Fokus der onkologischen Sport- und Bewegungstherapie. Die Betrachtung der aktuellen Literatur zeigt, dass das HII...
Article
Schlüter, K, Schneider, J, Rosenberger, F, and Wiskemann, J. Feasibility of high-intensity resistance training sessions in cancer survivors. J Strength Cond Res XX(X): 000-000, 2022-Moderate-intensity resistance training (MIRT) is regarded as safe in cancer survivors (CS), but for high-intensity resistance training (HIRT), evidence is lacking. Henc...
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The diagnosis of cancer as well as accompanying acute and late effects of treatment are influencing physical activity behavior of patients with childhood cancer and survivors. Research has shown that a pediatric cancer diagnosis is associated with impairments of physical performance, and function, as well as reduced physical, and psychosocial, heal...
Article
Zusammenfassung Hintergrund Zahlreiche Studien zeigen, dass Sport und Bewegung eine signifikant positive Wirkung auf krebstherapiebedingte Nebenwirkungen haben. Trotzdem fehlt es flächendeckend an qualifizierten, onkologischen Bewegungsangeboten. Das Netzwerk OnkoAktiv (OA) vermittelt Krebspatienten daher wohnortnah an qualitätsgeprüfte Trainings-...
Article
Pancreatic cancer patients often present with an inadequate nutritional intake. At the same time, there are no standardized recommendations for nutrition intake during and after cancer treatment. In a prospective analysis of a randomized controlled trial analyzing the effects of a 6-month resistance training in pancreatic cancer patients, we assess...
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Previous research has shown that structural barriers negatively influence the physical activity (PA) behavior of cancer patients, but underlying mechanisms are unclear. The aim of the current study was to explore the potential mediating role of social-cognitive factors, namely PA self-efficacy and PA intention in this context. A total of 856 cancer...
Article
Objective: Evidence on the benefits of physical activity (PA) during cancer has caused a paradigm shift from people with cancer being advised to save energy (rest paradigm) to guidelines recommending them to engage in regular PA (activity paradigm). This study examined the rest and the activity paradigm among people with cancer based on the theory...
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Background Graft-versus-host disease (GvHD) remains a major complication and limitation to successful allogeneic hematopoietic stem cell transplantation. Treatment of GvHD is challenging due to its heterogeneous nature of presentation, with steroids remaining the established first-line treatment. Long-term doses of systemic corticosteroids have man...
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Background This study aimed to examine the effect of the combination of yoga training with high vitamin D dose supplementation on the expression and systemic levels of inflammatory cytokines and psychophysical status of breast cancer survivors. Methods Thirty volunteered breast cancer survivors (48 ± 8 years) were randomly allocated to a high dose...
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Chemotherapy-induced peripheral neuropathy (CIPN) is an adverse effect of neurotoxic antineoplastic agents commonly used to treat cancer. Patients with CIPN experience debilitating signs and symptoms, such as combinations of tingling, numbness, pain, and cramping in the hands and feet that inhibit their daily function. Among the limited prevention...
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PURPOSE Exercise has been underutilized in people with advanced or incurable cancer despite the potential to improve physical function and reduce psychosocial morbidity, especially for people with bone metastases because of concerns over skeletal complications. The International Bone Metastases Exercise Working Group (IBMEWG) was formed to develop...
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Purpose Induction of IDO depends on the activation of AhR forming the AhR/IDO axis. Activated AhR can transcribe various target genes including cytotoxic and inhibiting receptors of NK cells. We investigated whether AhR and IDO levels as well as activating (NKG2D) and inhibiting (KIR2DL1) NK cell receptors are influenced by acute exercise and diffe...
Chapter
Chemotherapy-induced peripheral neuropathy (CIPN) is a highly prevalent and dose-limiting toxicity of many widely used chemotherapy regimens for the treatment of common cancers including lung, breast, prostate, gastrointestinal, and blood cancers. Symptoms include numbness, tingling, pain, and cramping in the hands and feet, as well as impaired bal...
Chapter
Chemotherapy-induced peripheral neuropathy (CIPN) is a highly prevalent, severe, and dose-limiting toxicity of several chemotherapy regimens for the treatment of multiple cancers including lung, breast, prostate, gastrointestinal, blood, and others. Patients with CIPN may experience numbness, tingling, pain, and cramping in the hands and feet, as w...
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Background: A better understanding of the role of structural barriers for physical activity (PA) after a cancer diagnosis could help to increase PA among people with cancer. Thus, the present study aimed to identify determinants of structural barriers to PA in people with cancer and investigate the association between structural barriers and insuff...
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Background: A large body of evidence supports the positive effects of leisure time physical activity (LTPA) and exercise on cancer survivors. However, only a fraction of survivors manages to attain international PA recommendations. This can be attributed to several external and internal barriers toward PA those patients seem to encounter, with canc...
Article
Background Exercise has the potential to improve physical function and quality of life in individuals with bone metastases but is often avoided due to safety concerns. This systematic review summarizes the safety, feasibility and efficacy of exercise in controlled trials that include individuals with bone metastases. Methods MEDLINE, Embase, Pubme...
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Objectives: Exercise interventions during and after treatment for pediatric cancer are associated with beneficial physical, psychological, and social effects. However, valid data about adverse events (AEs) of such interventions have rarely been evaluated. This retrospective study evaluates AEs that occurred during supervised oncological exercise pr...
Article
Purpose This systematic review and meta-analysis of randomized controlled trials determines the efficacy of face-to-face behavior change counseling (BCC) interventions on physical activity (PA) behavior in adult cancer survivors at least pre-and immediately post-intervention compared to usual care. Additionally, this review aims to answer the quest...
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Background Chemotherapy-induced peripheral neuropathy (CIPN) is a common, unpleasant and usually long-lasting side effect of neurotoxic chemotherapeutic agents. This study aimed to investigate the preventive potential of sensorimotor- (SMT) and resistance training (RT) on CIPN. Methods Patients ( N = 170) were randomised to SMT, RT or usual care (...
Preprint
Full-text available
Background This study aimed to examine the effect of a combination of yoga training with high vitamin D dose supplementation on expression and systemic levels of inflammatory cytokines and psychophysical status of breast cancer survivors. Methods Thirty volunteered breast cancer survivors (48 ± 8 yrs.) were randomly allocated to a high dose (4000...
Article
Biomarkers such as 8-oxo-2’deoxy-guanosine (8-oxo-dG), prostaglandin E2 alpha (PGE2 alpha), prostaglandin metabolites (PGEM) and 8-isoprostane (8-iso) may quantitatively reflect individual tumor risk including colorectal cancer (CRC) and may be useful in clinical management and prevention programs. To further clarify their role in a clinical settin...
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Rationale: One repetition maximum (1-RM) testing is a standard strength assessment procedure in clinical exercise intervention trials. Because no adverse events (AEs) are published, expert panels usually consider it safe for patient populations. However, we here report a vertebral fracture during 1-RM testing. Patient concerns: A 69-year-old bre...
Article
Background Muscle wasting has a negative effect on treatment toxicity and cancer prognosis. Resistance training appears to be a promising approach to counteract the loss of muscle mass. Methods Pubmed, Cochrane Library, SportDiscus and CINAHL. Randomized controlled resistance training trials with cancer survivros where eligible if lean body mass (...
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Background Research indicates reduced physical performance from diagnosis into survivorship of pediatric cancer patients. However, there is no systematic information or guideline available on the methods to assess physical performance and function in this population. The purpose was to systematically compile and describe assessments of physical per...
Article
Inzwischen belegen mehr als 700 Studien die positive Wirkung körperlicher Aktivität vor, während und nach der Krebstherapie. Trotzdem sind Physios in der Therapie oft zögerlich, aus Angst, etwas falsch zu machen. Warum aber gerade Nichtstun verheerend sein kann und wie ein sicheres Training gelingt, beleuchtet dieser Artikel.
Article
Objective This study examined cancer patients’ reporting on physicians’ physical activity (PA) counseling, its associations with patients’ PA, and comparisons of patients’ and physicians’ reports of the type(s) of PA counseling provided. Methods Patients with breast, colorectal, or prostate cancer (n=1206) participated in a nationwide cross-sectio...
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Former research has identified stigmatizing attitudes toward cancer patients in the general population. Little is known about (implicit) attitudes of physicians toward cancer patients. By using the prototype approach, the study investigated German physicians’ prototypical perceptions of cancer patients. Five hundred nineteen physicians (mean age: 4...
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Impaired postural control is often observed in response to neurotoxic chemotherapy. However, potential explanatory factors other than chemotherapy-induced peripheral neuropathy (CIPN) have not been adequately considered to date due to primarily cross-sectional study designs. Our objective was to comprehensively analyze postural control during and a...
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Exercise concomitant to radiotherapy for stable spinal metastases was demonstrated to increase bone density and reduce pain. In the DISPO-II study, the feasibility of exercise concomitant to radiotherapy for unstable spinal metastases was investigated. Here, a detailed analysis of the training program is presented. Cancer patients with spinal metas...
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PurposeCardiorespiratory fitness (CRF) seems to be prognostic prior to allogeneic stem cell transplantation (allo-HSCT). Influencing factors of CRF in allo-HSCT candidates have not been studied so far. Aim was to identify potentially influencing factors on CRF.Methods To assess CRF, a maximal cardiopulmonary exercise test (CPET) was performed on av...
Article
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Objectives Loss of body weight is often seen in pancreatic cancer and also predicts poor prognosis. Thus, maintaining muscle mass is an essential treatment goal. The primary aim was to investigate whether progressive resistance training impacts muscle and adipose tissue compartments. Furthermore, the effect of body composition on overall survival (...
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PurposeMost studies with cancer survivors use percentages of peak oxygen uptake (VO2peak) for intensity prescription. Lactate or ventilatory thresholds might be useful submaximal alternatives, but this has never been investigated. Therefore, we aimed at comparing three training sessions prescribed using %VO2peak (reference), lactate thresholds, and...
Chapter
Eine große Anzahl epidemiologische Studien zeigt, dass regelmäßige körperliche Bewegung das Erkrankungsrisiko für verschiedene gastrointestinale Tumorerkrankungen senken kann. Das Ausmaß der relativen Risikoreduktion liegt dabei zwischen 0 bis 21 %. Absolut gesehen lassen sich beispielsweise geschätzte 11,3 % aller Darmkrebsfälle in Deutschland auf...
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PurposeThis study explored rural-urban differences in meeting physical activity (PA) recommendations and health status in cancer survivors in central Pennsylvania and associations between PA and health status.Methods Cancer survivors (N = 2463) were identified through a state cancer registry and mailed questionnaires assessing PA and health status....
Article
Die Evidenz zur Sport- und Bewegungstherapie in der Onkologie ist in den vergangenen zwei Jahrzehnten stark angewachsen. Aktuell existieren über 700 randomisierte, kontrollierte Studien, welche die positiven Effekte an mehr als 50.000 Krebspatienten vor, während und nach einer onkologischer Behandlung untersucht haben. Die Resultate dieser Untersuc...
Article
Lung cancer patients undergoing surgery are often left physically deconditioned and/or with functional deficits. Exercise interventions may improve pulmonary and physical function before and after lung resection. We conducted a systematic review of randomized-controlled trials (RCTs) testing the impact of pre-, post-, and combined pre-and-post surg...
Article
Zusammenfassung Versorgungsforschung in der Onkologie beschäftigt sich mit allen Situationen, in denen Menschen mit Krebs konfrontiert sind. Sie betrachtet die verschiedenen Phasen der Versorgung, also Prävention/Früherkennung, Prähabilitation, Diagnostik, Therapie, Rehabilitation und Palliativversorgung ebenso wie die verschiedenen Akteure, darunt...
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Whereas the coronavirus disease (COVID-19) storm is relentlessly progressing worldwide, a great effort from scientific societies has been made in order to give recommendations for safely continuing oncological care, prioritizing the interventions according to patient’s condition, type and stage of tumor. Nevertheless, to date no specific suggestion...
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Objectives The purpose of this study was to examine the association between physicians’ exercise counseling and post‐diagnosis physical activity (PA) in patients with cancer by investigating the mediating role of patients’ satisfaction with exercise counseling as well as the moderating role of patients’ previous PA. Methods The study sample consis...
Preprint
The aim of this study was to investigate the impact of Supervised and Home-based resistance exercise on the Kynurenine pathway in patients with pancreatic cancer who underwent surgery and chemotherapy. In the SUPPORT study, adult pancreatic cancer patients were randomized to intervention programs of 6-month (1) a Supervised moderate-to-high-intensi...
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Background: Conversion of Tryptophan (TRP) to Kynurenine (KYN) has immune suppressive effects and is associated with poor prognosis and low survival of cancer patients. Physical exercise has been hypothesized to positively affect the Kynurenine pathway metabolites. The aim of this study was to investigate the impact of supervised and non-supervised...
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Full-text available
Purpose The purpose of this study was to examine and compare pre- to post-diagnosis change patterns of physical activity (PA) among breast, prostate, and colorectal cancer patients. Moreover, the study aimed to investigate sociodemographic and medical determinants of post-diagnosis PA and to identify patient subgroups at increased risk of inactivit...
Article
Purpose: Previous work showed that cancer patients with spinal metastases classified as stable (i.e. low fracture risk) benefit from isometric exercises for the paravertebral muscles concomitant to palliative radiotherapy in terms of bone density and pain (Rief et al. 2014). In this exploratory randomized controlled trial we investigated whether pa...
Article
Zusammenfassung Hintergrund Infolge des Einsatzes neurotoxischer Chemotherapeutika leiden viele Krebspatienten und -überlebende unter chemotherapieinduzierten peripheren Neuropathien (CIPN). Diese Nebenwirkung der Chemotherapie ist mit einem hohen Leidensdruck assoziiert und beeinträchtigt die Autonomie der Patienten. Bewegungstherapeutische Interv...
Chapter
Radiotherapy plays an important role in cancer treatment in order to prevent recurrence, to shrink the tumor volume, or to treat distant metastases. Radiation treatment with curative intent is mostly well tolerated by patients; however, side effects like fatigue or impaired physical functioning still hamper patients’ quality of life. Existing evide...
Article
Background Chemotherapy-induced peripheral neuropathy (CIPN) is a serious side effect deriving from neurotoxic chemotherapeutic agents. The underlying nerve injury can affect proprioception causing impaired postural control, gait difficulties and a higher risk of falling. Overall, the symptoms and functional limitations negatively affect patients’...
Article
Background Although physical activity (PA) is beneficial for patients with cancer, healthcare professionals (HCP) still scarcely recommend it. This study aimed to determine how HCP’ sociodemographic and professional characteristics and their subjective assessments of patient characteristics are associated with their PA recommendations to patients w...
Article
Full-text available
Background: Isometric paravertebral muscle training (IPMT) may improve mobility, pain, and quality of life (QOL) in cancer patients with spinal metastases. However, this regimen remains unproven in patients with unstable spinal metastases (USM), a population at high risk for clinical exacerbation with such interventions. Thus, we conducted this exp...
Article
Purpose: The number of cancer survivors worldwide is growing, with over 15.5 million cancer survivors in the United States alone-a figure expected to double in the coming decades. Cancer survivors face unique health challenges as a result of their cancer diagnosis and the impact of treatments on their physical and mental well-being. For example, c...
Article
Cancer survivors demonstrate a reduced maximal oxygen uptake, which is clinically relevant in terms of overall survival. However, it remains uncertain whether they attain their “true maximal oxygen uptake” in a cardiopulmonary exercise test (CPET). In the present study, a supramaximal verification bout (Verif) was applied in cancer survivors to con...
Article
Inaktivität vermeiden, mindestens 150 Minuten moderate körperliche Aktivität pro Woche, dazu zweimal wöchentlich kräftigende Übungen für die Hauptmuskulatur sowie tägliche Dehnübungen, so lauteten die Empfehlungen für Krebspatienten des American College of Sports Medicine (ACSM) aus dem Jahr 2010. Nun, etwa 10 Jahre später, am 16. Oktober 2019 wurd...
Article
Purpose: Fatigue is a common and potentially disabling symptom in patients with cancer. It can often be effectively reduced by exercise. Yet, effects of exercise interventions might differ across subgroups. We conducted a meta-analysis using individual patient data of randomized controlled trials (RCTs) to investigate moderators of exercise interv...
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Full-text available
Purpose: Evidence from preclinical studies and trials in healthy volunteers suggests that exercise may modulate the levels of tryptophan (TRP) metabolites along the kynurenine (KYN) pathway. As KYN and downstream KYN metabolites are known to promote cancer progression by inhibiting anti-tumor immune responses and by promoting the motility of cancer...
Article
Gastrointestinal(GI)-onkologische Operationen sind mit hohen Komplikationsraten und langen Hospitalisierungsdauern assoziiert. Aus anderen Indikationen ist bekannt, dass körperliches Training vor dem chirurgischen Eingriff sowohl das Komplikationsrisiko als auch die Hospitalisierungsdauer verringern kann. Hieraus ergibt sich die Frage, inwieweit si...
Article
Background The evidence of sports and exercise in cancer patients has increased enormously in recent years. Numerous studies have demonstrated the effectiveness of applied sports and exercise therapy with regard to clinically relevant endpoints and symptoms predominantly in breast and prostate cancer, as well as in hematological malignancies. Obser...