Joachim Siegert

• TUD Dresden University of Technology

Introduction: Autonomic nervous system disturbances including sweating abnormalities and cardiovascular symptoms are frequent in Parkinson's disease (PD) and often precede motor involvement. Cholinergic vasomotor and sudomotor skin nerves are impaired in patients with PD even at early disease stages. We hypothesized that adrenergic pilomotor nerve...

Objective: To assess the eligibility for replacement of invasive blood pressure as measured "within" the arterial vessel (IBP) with non-invasive continuous arterial blood pressure (cNIP) monitoring during total intravenous anaesthesia (TIVA), the ability of cNiP to track fast blood pressure changes needs to be quantified. A new method of statistic...

Purpose T-cell-located CD4 antigen represents one of the therapeutic targets in rheumatoid arthritis (RA). However, up to now there is no established imaging tool to visualize this target in vivo. The aim of our study was to assess the safety and tolerability of a technetium-99 m labelled murine anti-human CD4 IgG1-Fab fragment ([99mTc]-anti-CD4-Fa...

Objective: This study aims to ascertain once and for all whether children and adolescents affected by ADHD show a higher risk for accidents, as well as investigating a possible association between the administration of ADHD-specific medication and the occurrence of accidents. Method: Two exceptionally large sets of data were implemented in this ana...

Hintergrund: Ziel der vorliegenden Arbeit war es, die Wirksamkeit ambulanter Radonbäder auf die Verordnung von Arzneimitteln, die Schmerzintensität und das Wohlbefinden bei Patienten mit rheumatischen Erkrankungen zu evaluieren. Methodik: 237 Patienten mit rheumatischen Erkrankungen (rheumatoide Arthritis, Morbus Bechterew bzw. degenerativen Wirbe...

The muscarinic receptor antagonist propiverine is unique insofar as extended-release (ER) tablets are of higher bioavailability than immediate-release (IR) tablets; this is caused by lower "first-pass" elimination of propiverine via CYP3A4 and efflux transporters in the distal small intestine and colon. Food may influence gastrointestinal transitin...

Questionnaire consisting of open-ended and closed-ended questions addressing national laws in relation to public health interventions in an influenza pandemic.

With the emergence of influenza H1N1v the world is facing its first 21st century global pandemic. Severe Acute Respiratory Syndrome (SARS) and avian influenza H5N1 prompted development of pandemic preparedness plans. National systems of public health law are essential for public health stewardship and for the implementation of public health policy....

Background and Purpose Diabetes mellitus is a chronic progressive disease with increasing prevalence leading to high costs for Health care systems. Since 2003 diabetes disease-management-programs (DMPs) have been universally introduced by the German statutory-health-insurance (SHI). In 2004 the new regulations of modernization for SHI (RoM-SHI) cam...

A 20-year-old male patient with chronic urticaria and a laboratory-confirmed Blastocystis (B.) hominis infection was treated unsuccessfully with two cycles of metronidazole. To eliminate the pruritus, which might cease with the eradication of the B. hominis infection [1], a combined drug therapy of metronidazole and paromomycin was considered. B. h...

A 20-year-old male patient with chronic urticaria and a laboratory-confirmed Blastocystis (B.) hominis infection was treated unsuccessfully with two cycles of metronidazole. To eliminate the pruritus, which might cease with the eradication of the B. hominis infection [1], a combined drug therapy of metronidazole and paromomycin was considered. B. h...

A 20-year-old male patient with chronic urticaria and a laboratory-confirmed Blastocystis (B.) hominis infection was treated unsuccessfully with two cycles of metronidazole. To eliminate the pruritus, which might cease with the eradication of the B. hominis infection [1], a combined drug therapy of metronidazole and paromomycin was considered. B. h...

A 20-year-old male patient with chronic urticaria and a laboratory-confirmed Blastocystis (B.) hominis infection was treated unsuccessfully with two cycles of metronidazole. To eliminate the pruritus, which might cease with the eradication of the B. hominis infection [1], a combined drug therapy of metronidazole and paromomycin was considered. B. h...

A 20-year-old male patient with chronic urticaria and a laboratory-confirmed Blastocystis (B.) hominis infection was treated unsuccessfully with two cycles of metronidazole. To eliminate the pruritus, which might cease with the eradication of the B. hominis infection [1], a combined drug therapy of metronidazole and paromomycin was considered. B. h...

A 20-year-old male patient with chronic urticaria and a laboratory-confirmed Blastocystis (B.) hominis infection was treated unsuccessfully with two cycles of metronidazole. To eliminate the pruritus, which might cease with the eradication of the B. hominis infection [1], a combined drug therapy of metronidazole and paromomycin was considered. B. h...

A 20-year-old male patient with chronic urticaria and a laboratory-confirmed Blastocystis (B.) hominis infection was treated unsuccessfully with two cycles of metronidazole. To eliminate the pruritus, which might cease with the eradication of the B. hominis infection [1], a combined drug therapy of metronidazole and paromomycin was considered. B. h...

A 20-year-old male patient with chronic urticaria and a laboratory-confirmed Blastocystis (B.) hominis infection was treated unsuccessfully with two cycles of metronidazole. To eliminate the pruritus, which might cease with the eradication of the B. hominis infection [1], a combined drug therapy of metronidazole and paromomycin was considered. B. h...

A 20-year-old male patient with chronic urticaria and a laboratory-confirmed Blastocystis (B.) hominis infection was treated unsuccessfully with two cycles of metronidazole. To eliminate the pruritus, which might cease with the eradication of the B. hominis infection [1], a combined drug therapy of metronidazole and paromomycin was considered. B. h...

A 20-year-old male patient with chronic urticaria and a laboratory-confirmed Blastocystis (B.) hominis infection was treated unsuccessfully with two cycles of metronidazole. To eliminate the pruritus, which might cease with the eradication of the B. hominis infection [1], a combined drug therapy of metronidazole and paromomycin was considered. B. h...

Background The aim was to develop lesson plans for the subject of household economics and technology in secondary schools in Saxony, Germany. It was of great importance to focus on nutrition-related topics. Methods First, a comprehensive literature and Internet search was carried out, and experts in national health promotion institutes were contact...

Background Many health information activities related to nutrition and physical activity have been initiated in recent years by several institutions at the national and international level as well as by European networks. A multitude of projects with different scopes and methodologies has arisen. This variety makes it necessary to bring the results...

Aim Physical inactivity is considered to be a major health burden. Evidence has shown that physically active subjects have more longevity with a significant reduction of morbidity and mortality. Physical exercise prevents or reduces the deleterious effects of pathological conditions, such as arterial hypertension, coronary artery disease, atheroscl...

The sol–gel immobilisation and controlled release of various bioactive liquids (BL) from within modified silica coatings were investigated, in order to evaluate the suitability of functionalised textiles for the following applications: (1) skin-friendly textiles with antimicrobial and antiallergic effects due to immobilised natural oils such as eve...

The safety concepts applied in the development of new drugs are based on individual tests of each new chemical entity. The applicable law is codified in the German Medicines Act (AMG). Alongside animal experimentation (pharmacology and toxicology), efficacy and tolerability are evaluated in clinical trials conducted with healthy human volunteers an...

Cost-benefit analyses are helpful in setting priorities for funding health-care programs. The authors studied the cost/benefit of treatment with radium-224 compared to the treatment without radium-224 in patients with ankylosing spondylitis (AS). The data of a 2-year retrospective observational study were used to estimate cost/benefit of [224Ra] th...

Background and Purpose: Cost-benefit analyses are helpful in setting priorities for funding health-care programs. The authors studied the cost/benefit of treatment with radium-224 compared to the treatment without radium-224 in patients with ankylosing spondylitis (AS). Material and Methods: The data of a 2-year retrospective observational study we...

Smart textiles provide the possibility of being coated with cineole, menthol, and camphor. Due to over-the-counter availability, ethereal oils are frequently used to treat a common cold. The existing pharmaceutical forms entail the risk of oral ingestion by children, which can cause severe intoxications. This risk could be limited by a smart textil...

Zum Thema Das Urge-Syndrom (Urge-Inkontinenz und Urgency) stellt eine erhebliche Beeintrchtigung des sozialen und beruflichen Lebens der Patienten dar. Solche Strungen der Speicherfunktion der Harnblase gehen immer mit Pollakisurie, Nykturie und imperativem Harndrang, ggf. mit einer Harninkontinenz einher. Die Domne der Behandlung dieser Funktionss...

In colour-coded Duplex sonography, ultrasound contrast agents produce a significant enhancement of Doppler signals from the blood. Animal experiments were performed to examine whether a combination of colour-coded Duplex sonography and ultrasound contrast agents can also visualise movements from hollow spaces which do not normally contain scatteres...

UltraschallkontrastmiUel führen in der farbkodierten Duplexsonographie (FKDS) zu einer wesentlichen Verstärkung der Dopplersignale aus dem Blut. In einem Tierexperiment wurde geprüft, ob die Kombination von FKDS und Ultraschallkontrastmittel auch den Nachweis von Bewegungen aus Hohlräumen gestallet, in denen normalerweise keine oder nicht hinreiche...

Das Hauptwirkprinzip von Ultraschallkontrastmitteln ist die verstärkte Rückstreuung der Ultraschallwellen an der Grenzfläche zwischen Ultraschallkontrastmittel und umgebenden Gewebe. Besonders günstige Eigenschaften zeigen bei den vorgegebenen Rahmenbedingungen (Frequenzbereich medizinischer Ultraschallgeräte 2–20 MHz, Streukörper zur intravasalen...

The diagnostic use of microbubble consisting transpulmonary ultrasound contrast media in combination with color-coded duplex sonography (CCDS) has not been evaluated. Perfusion of the orthotopic kidney was therefore examined in an animal experiment with CCDS and transpulmonary echocontrast agent. The contrast agent consists of tiny stabilized air b...

Der diagnostische Einsatz von aus Luftbläschen bestehenden lungengängigen Ultraschallkontrastmitteln in Kombination mit der farbkodierten Duplexsonographie (FKDS) ist bisher nicht untersucht. Am Tierexperiment wurde deshalb die Perfusion der orthotopen Niere mit der FKDS nach Gabe eines solches Kontrastmittels untersucht. Das Kontrastmittel besteht...

The diagnostic use of microbubble consisting transpulmonary ultrasound contrast media in combination with color-coded duplex sonography (CCDS) has not been evaluated. Perfusion of the orthotopic kidney was therefore examined in an animal experiment with CCDS and transpulmonary echocontrast agent. The contrast agent consists of tiny stabilized air b...

Seit der Erstveröffentlichung über ultraschallkontrastgebende Substanzen durch Gramiak und Mitarbeiter [1] Ende der 60er Jahre wurde eine Vielzahl unterschiedlicher Ansätze zur Erzielung von Ultraschall-Kontrasteffekten publiziert [2, 4]. Diese Ansätze lassen sich in zwei große Gruppen gliedern.

In comparison to diagnostic radiology, ultrasound diagnostics has had no real contrast media. Theoretical considerations indicate that gas liquid systems seem to be favorable. The echocontrast agent SH U 454 is a system that releases minute gas bubbles that provide the contrast properties. Preclinical and clinical trials in more than 500 patients w...

Die Ultraschalldiagnostik hat sich seit ihren Anfängen durch hohe Aussagekraft, geringe Patientenbelastung und unkomplizierte Durchführbarkeit zu einer Routinemethode entwickelt. Trotz fortschreitender Entwicklung auf dem Gebiet der Gerätetechnik ergeben sich methodische Grenzen, die den Einsatz von geeigneten Ultraschallkontrastmitteln sinnvoll un...