Joachim Degwert

SIT Skin Invest. & Technol. Hamburg GmbH · Dermatological CRO

Dietary consumption of food supplements has been found to modulate skin functions and can therefore be useful in the treatment of skin aging. However, there is only a limited number of clinical studies supporting these claims. In this double-blind, placebo-controlled study, the effectiveness of the specific bioactive collagen peptide (BCP) VERISOL®...

Various dietary supplements are claimed to have cutaneous anti-aging properties; however, there are a limited number of research studies supporting these claims. The objective of this research was to study the effectiveness of collagen hydrolysate (CH) composed of specific collagen peptides on skin biophysical parameters related to cutaneous aging....

It is well established that decorative cosmetics can enhance female facial attractiveness. In this study, we investigated the effects of a cleanser and a decent foundation on attractiveness of female faces. Comparative rating of a set of facial photographs by a group of lay persons revealed that the cleansing product was significantly reducing the...

Development of cosmetic products and household detergents necessitates comparative study designs to assess the skin tolerance of products. In initial tests, the epicutaneous patch test for irritation is widely used. This study was conducted to develop a protocol that would facilitate a comparison of results obtained when tests are conducted by diff...

Synopsis A multicentre study for measuring skin hydration with 349 volunteers was carried out in six different laboratories. The purpose of the study was to investigate physical‐, physiological‐ and product‐dependent parameters of three test emulsions (base, base + moisturizer and base + moisturizer + lipids) in a double‐blind study. A comparison b...

Dendritic cells (DC) are highly specialized antigen-presenting cells (APC) located in many non-lymphoid tissues and a specialized form of DC-the Langerhans cell (LC)-is found in the skin. The functionality of LC as APC is crucial for the induction of an allergic contact dermatitis. For a long time LC research has been hampered by the limiting numbe...

Epidermal mRNA for interleukin 1beta (IL-1beta) has been shown to be increased following exposure of mouse skin to sensitizing compounds. In addition, this early upregulation of IL-1beta was specific for contact sensitizers, while expression of IL-1beta was unaffected by irritants. Langerhans cells are the major source of IL-1beta within the epider...

IL-15 is a pleiotropic cytokine with IL-2-like functions. As IL-15 was shown to be mitogenic for T cells, we wondered whether human blood-derived dendritic cells (DC), as the primary stimulators of T cell responses, are able to produce IL-15. To test our hypothesis, DC were grown under serum-free conditions from human peripheral blood using granulo...

Dendritic cells (DCs) are highly specialized antigen presenting sells (APCs) initiating primary T-lymphocyte associated immune responses. DCs are located in many non- lymphoid tissues and a specialized form of DCs — the Langerhans cell (LC) — is found in the skin. The functionality of LCs as APCs is crucial for the induction of an allergic contact...

Dendritic cells (DCs) are highly specialized antigen presenting cells (APCs) initiating primary T-lymphocyte associated immune responses1. DCs are located in many non-lymphoid tissues and a specialized form of DCs - the Langerhans cells (LCs) - is found in the skin. Here they fulfill their in vivo functions by capturing antigens in the epidermis an...

Dendritic cells (DCs) are a family of specialized cells distributed in various tissues with stimulatory capacities for primary and secondary immune responses especially by antigen presentation to T-lymphocytes. The isolation of skin associated DCs from skin biopsies is hampered by the limited numbers of DCs and tedious isolation procedures. Recentl...

The aim of this study was to evaluate procedures for the assessment of the immunoprotective capacities of topical sunscreens, using cell cultures. The exposure of humans to solar or ultraviolet radiation has been shown to induce numerous changes at the level of the immunoresponsiveness of the skin, which could be described as immune suppression. In...

The present studies were aimed at evaluating procedures for assessing the immunmodulatory effects of chemicals and preparations on macrophage differentiation and lymphocyte proliferation in cell cultures. The effects of 10 drugs and anti-inflammatory agents were monitored by determining thymidine incorporation into phytohaemagglutinin (PHA)-stimula...

The composition of alpha and beta TCR genes was analyzed in a murine BSA-specific Ts cell clone with cytolytic potential. The isolated poly(A)+ mRNA from Ts cell clone BVI/5 was used to construct a cDNA library in the bacteriophage lambda gt11. Full-length cDNA clones specific for TCR alpha and TCR beta genes have been detected and isolated by hybr...

Two BSA-specific Ts cell clones have been isolated from CBA/J mice tolerized by low doses of BSA. Together with one Ts cell clone isolated from an immune animal, they have recently been characterized with regard to phenotypes and in vitro functions. In the present report the in vivo effector functions of two of them (Ts cell clones BVI/5 and HF1.MS...

The suppressive activity of two bovine serum albumin-specific class II-restricted T suppressor cell clones (BVI/5 and 83/2-D11) was compared to that of a feeder cell-independent, IL 2-dependent subline (HF1.IL-2) of an originally antigen-dependent class II-restricted Ts cell clone (HF1). No soluble suppressor factors can be found in BVI/5 and 83/2-...

This communication describes a newly isolated T-suppressor (Ts) cell clone, BVI/5, derived from a CBA/J mouse tolerized to low doses of bovine serum albumin (BSA). The cells are Thy-1.2+, Lyt-1.1-, Lyt-2.1+, and express endogenous derived I-Ak and I-Ek molecules. BVI/5 Ts cells show antigen-specific I-Ek-restricted proliferation in the presence of...

Three bovine serum albumin-specific Lyt-2+ T suppressor (Ts) cell clones from CBA/J mice have been analyzed with regard to expression of L3T4 molecules. All three Ts-cell clones can be stained with monoclonal antibodies (mAb) to L3T4. Tested for the two clones restricted to recognition of Ek determinants, antigen-specific proliferation on antigen-p...

Zusammenfassung: Zur Verifizierung der möglichen Wirkungen eines funktionalen Nahrungsmittels wurde eine 16-wöchige placebo- kontrollierte, randomisierte klinische Doppelblindstudie mit 50 freiwilligen Probanden durchgeführt. Das Ziel der Prüfung war die Untersuchung eines möglichen protektiven Effekts der oralen Anwendung eines gewerblich erhältli...