Jma Hannan

• Professor
• Dean School of Pharmacy and Public Health at Independent University

Conditions like diabetes mellitus (DM), cancer, infections, inflammation, cardiovascular diseases (CVDs), and gastrointestinal (GI) disorders continue to have a major global impact on mortality and morbidity. Medicinal plants have been used since ancient times in ethnomedicine (e.g., Ayurveda, Unani, Traditional Chinese Medicine, and European Tradi...

Lipid abnormalities frequently accompany hyperglycemia and thus a primary goal in diabetes therapy is the management of dyslipidemia. Asparagus racemosus root has previously been shown to reduce postprandial blood glucose in diabetic rats by delaying carbohydrate absorption and enhancing insulin secretion. In the present study, the chronic effects...

The prevalence of type 2 diabetes (non-insulin dependent diabetes) has been universally acknowledged as a chronic public health concern and the leading cause of mortality on a global scale. Plant-based bioactive compounds have made significant contributions to the management of diabetes mellitus globally. Artocarpus heterophyllus, also known as “ka...

Background Diabetes mellitus (DM), a prevalent non-communicable disease, is a metabolic condition involving defective pancreatic β-cells and/or insulin resistance. Researchers are presently exploring traditional medicinal plants to identify alternatives for treating diabetes due to the various disadvantage of current anti-diabetic medicines. Objec...

Camellia sinensis (green tea) is used in traditional medicine to treat a wide range of ailments. In the present study, the insulin-releasing and glucose-lowering effects of the ethanol extract of Camel-lia sinensis (EECS), along with molecular mechanism/s of action, were investigated in vitro and in vivo. The insulin secretion was measured using cl...

Spirulina platensis (SP, Blue-green algae) have been accepted as a supplement for the treatment of pre and post diabetes. The present study investigated the effects of butanol fraction from ethanol extract of S. platensis on insulin release from BRIN BD11 cells, isolated mouse islets, and perfused rat pancreas, as well as glucose homeostasis in typ...

Annona squamosa, commonly known as custard apple, is traditionally used for the treatment of various diseases including diabetes, cardiovascular disease (CVD), and gastritis. This study was undertaken to investigate the effects of an ethanolic (80% v/v) extract of A. squamosa (EEAS) leaves in vitro on insulin secretion from clonal pancreatic BRIN B...

Diabetes Mellitus (DM) is a metabolic disorder that is spreading alarmingly around the globe. Type-2 DM (T2DM) is characterized by low-grade inflammation and insulin resistance and is closely linked to obesity. T2DM is mainly controlled by lifestyle/dietary changes and oral antidiabetic drugs but requires insulin in severe cases. Many of the drugs...

The efficacy of chemotherapy depends on the tumor microenvironment. This microenvironment consists of a complex cellular network that can exert both stimulatory and inhibitory effects on tumor genesis. Given the increasing interest in the effectiveness of cannabis, cannabinoids have gained much attention as a potential chemotherapy drug. Cannabinoi...

The efficacy of chemotherapy depends on the tumor microenvironment. This microenvironment consists of a complex cellular network that can exert both stimulatory and inhibitory effects on tumor genesis. Given the increasing interest in the effectiveness of cannabis, cannabinoids have gained much attention as a potential chemotherapy drug. Cannabinoi...

Diabetes mellitus is a chronic complication that affects people of all ages. The increased prevalence of diabetes worldwide has led to the development of several synthetic drugs to tackle this health problem. Such drugs, although effective as antihyperglycemic agents, are accompanied by various side effects, costly, and inaccessible to the majority...

Diabetes mellitus is one of the most frequently occurring metabolic disorders (DMs), impairing healthy life around the globe, with mild-to-severe secondary complications. DM is associated with secondary complications, including diabetic retinopathy (DR), which damages the retina and can lead to vision loss. Diabetic patients often suffer from extre...

Aim: To investigate the potential anti-inflammatory and biochemical effects of Moringa peregrina leaf extracts on testosterone-induced benign prostatic hyperplasia (BPH) in rats. Methods: Six groups of rats (each group included 5 rats) were included in this study. The groups included: 1) the control group, 2) the testosterone-induced BPH group,...

The progression of diabetes leads to macro and microvascular complications, including diabetic neuropathy, which is the most prevalent microvascular complication with diabetes. Clinical manifestations of diabetic neuropathy begin with the loss of distal sensory function, pain, and substantial morbidity. It has been evident that ~50% of diabetic pat...

Heritiera fomes (Sundari) have been accepted as a supplement for the treatment of pre and post diabetes. The present study investigated the effects of ethanol extract of H. fomes (EEHF) on insulin release from clonal pancreatic β-cells and mouse islets and protein glycation, starch digestion, glucose diffusion, DPP-IV enzyme activity in vitro and g...

Acacia arabica is used traditionally to treat a variety of ailments, including diabetes. This study elucidated the antidiabetic actions of A. arabica bark together with the isolation of bioactive molecules. Insulin secretion and signal transduction were measured using clonal β cells and mouse islets. Glucose uptake was assessed using 3T3-L1 adipocy...

Anemia is common nutritional disorder and it affects one third of population around the globe. Assessing nutritional status of human is an inevitable process to lead a healthy life. Females are affected significantly by anemia compare to male. According to WHO report, developing herbs-based formulation to treat anemic patients is safe and less toxi...

Spirulina platensis (S. platensis) has previously been shown in both animals and humans to be useful in the treatment of type 2 diabetes. The present study aims to elucidate the effects of ethanol extract and butanol fraction of S. platensis on insulin release and glucose homeostasis in type 2 diabetic rats, together with their mechanism of actions...

Anemia is common nutritional disorder and it affects one third of population around the globe. Assessing nutritional status of human is an inevitable process to lead a healthy life. Females are affected significantly by anemia compare to male. According to WHO report, developing herbs-based formulation to treat anemic patients is safe and less toxi...

Nigella sativa seeds are traditionally reputed as possessing anti-diabetic properties. As a result, we aim to explore the mechanism of its anti-hyperglycemic activity. The present study uses various experimental designs including gastrointestinal (GI) motility, intestinal disaccharidase activity and inhibition of carbohydrate digestion and absorpti...

Through a simple PEG-conjugation of the natural product Amorfrutin B, we enhanced its pharmacokinetic profile. The PEGylated molecule displayed significantly improved gastrointestinal absorption (p<0.05) and had a longer systemic circulation life (p<0.05). Oral glucose tolerance study showed PEGylated Amorfrutin B displayed longer protection agains...

Background [6]-Gingerol, a major component of Zingiber officinale, was previously reported to ameliorate hyperglycemia in type 2 diabetic mice. Endocrine signaling is involved in insulin secretion and is perturbed in db/db Type-2 diabetic mice. [6]-Gingerol was reported to restore the disrupted endocrine signaling in rodents. In this current study...

Background: Moringa oleifera has potential anti-hyperglycemic effects that are reported earlier by the different scientific group using animal diabetic models. We aimed to explore the possible mechanism of action of M. oleifera extract through the different method. Methods: Primarily we measured Fasting Blood Glucose and performed Glucose Tolerance...

Background: This study aims to evaluate the scientific basis of traditional application of Persicaria orientalis for reducing pain and inflammation. Methods: An in vitro method was performed to investigate the presence of the anti-inflammatory activity of methanolic crude extract of P. orientalis. In addition, an in vivo study was conducted in whic...

Background (commonly known as Bael, golden apple) was formerly described to have anti-hyperglycemic activity. The present study aimed to explore the possible effects, in depth, of Methods This research begins with fasting blood glucose and oral glucose tolerance test (OGTT) to evaluate the primary anti-hyperglycemic effect in chemically induced ty...

The study was designed to observe the anti-hyperglycemic effect of Agele marmelos as reported earlier in diabetic model rats. This study was carried out to explore the possible effects of A. marmelos extract on carbohydrate absorption and glucose utilization. We measured fasting blood glucose and performed glucose tolerance test to evaluate the pri...

Hibiscus rosa-sinensis (HRS) has formerly demonstrated anti-hypoglycemic activity in type 2 diabetic rats. However, study on organ and tissue level has not been done yet. Our study is to find out, whether the antidiabetic activity is the result of inhibition of the action of gastrointestinal enzyme or decrement glucose absorption. For the investiga...

Abstract Background: The aim of the current study was to investigate the scientific basis of the traditional application of Lophopetalum javanicum for measuring anti-inflammatory and analgesic activity and phytochemical screening. Methods: Present study includes the preliminary screening of the phytochemical composition and in vivo analgesic and...

An ethanolic extract of bark of F.bengalensis was previously shown to possess hypoglycemic effects in rats. The aim of the present study was to evaluate the hypoglycemic and hypolipidemic effects of ethanolic extract of F. bengalensis bark in streptozotocin induced type 2 diabetic rats. Hypoglycemic effects were evaluated in diabetic rats at fastin...

D. indica fruit was previously reported to lower blood glucose in type 2 diabetic rats. The aim of the study was to evaluate the possible mechanism of action of the ethanol extract of the fruit. Antihyperglycemic effect was evaluated in diabetic rats at different prandial states by measuring serum glucose and insulin at different time points. Insul...

H. Rosa-sinensis leaves has earlier been shown to have hypoglycemic effect in type 2 diabetic rats. In the present work, we have investigated a) the chronic effects of the plant extract on serum glucose and lipids in type 2 rats and b) the effects on insulin release from perfused rat pancreas. The leaves of H. rosa-sinensis were extracted with 80%...

We aimed to investigate and evaluate the anti-inflammatory and analgesic effectiveness of common tree in the locality of Bangladesh, Lophopetalum javanicum. Our study includes; the investigation of the phytochemical composition and in-vivo analgesic and anti-inflammatory activity of Methanolic Extract of Lophopetalum javanicum (MELJ). On that point...

The study was designed to investigate the probable mechanisms of anti-hyperglycemic activity of B. Vulgaris. Aqueous fraction of B. Vulgaris extract was the only active fraction (50mg/kg). Plasma insulin level was found to be the highest at 30 mins after B. Vulgaris administration at a dose of 200mg/kg. B. Vulgaris treated mice were also assayed fo...

Aim: This study investigated mechanisms by which O. sanctum leaf extracts ameliorate hyperglycaemia using animal and cellular models of diabetes. Place and Duration of Study: Diabetes Research Laboratory, University of Ulster, Coleraine, United Kingdom and Research Division, BIRDEM, Dhaka, Bangladesh; 8 months. Methodology: Acute anti-diabetic effe...

We aimed to study phytochemical screening and analgesic activity of ethanol extract of Oroxylum indicum. The dried powder of the barks of the plant was extracted with 95% ethanol and was subjected to various phytochemical tests to ascertain the principle constituents contained in the extract. The result revealed the presence of alkaloids, flavonoid...

We measured a vast range of parameters, in an attempt to further elucidate previously claimed antihyperglycemic activity of Butea monosperma. Our study clearly negates the possibility of antidiabetic activity by inhibited gastrointestinal enzyme action or by reduced glucose absorption. Reduction of fasting and postprandial glucose level was reconfi...

Background: The present study was carried out to explore the potential of the ethanol extract of Ixora coccinea L. (IC) leaves as analgesic, anti-inflammatory and antipyretic agents using the hot-plate, acetic acid-induced writhing, carrageenan-induced paw edema and brewer’s yeast-induced pyrexia tests in rodents. Methods: The extract was prepared...

The Ardisia colorata is one of the rare hill-tract plants in Bangladesh. The experimental research was intended to evaluate the phytochemical and antimicrobial activity of 70% ethanolic extract of leaves and bark of Ardisia colorata . Preliminary phytochemical screening of both the leaf and bark extract revealed the presence of various classes of c...

Aims: Hiptage benghalensis is used in the traditional system of medicine. The leaf is considered one of the important plant organs for the treatment of various diseases such as rheumatism, leprosy, wounds, ulcer, burning sensation, scabies, inflammation and cough. Hence, the present studies were carried out to evaluate chemical constituents and pos...

Our present studies were focused on the phytochemical study and probable anti-diabetic activity of the stem of Hiptage benghalensis in laboratory animals and the statistical significance of such effect. Qualitative phytochemical analysis of ethanol extract of Hiptage benghalensis for identification of steroid, carbohydrate, flavonoid, alkaloid, tan...

Diabetes is a widely prevalent endocrine disorder worldwide. In previous studies, Aloe vera has been shown to possess antidiabetic activity. Here, we aimed at discovering the underlying mechanism of its antidiabetic action. The study was carried out in accordance to recommendations of the “International Association for the study of Pain”. To evalu...

Diabetes is a globally prevalent endocrine disorder. The Psidium guajava has been shown to possess antidiabetic activity. In our study, we aimed at discovering the underlying mechanism of its antidiabetic action. The study was carried out in accordance to recommendations of the international Association for the study of Pain. To evaluate the abili...

Diabetes is a widely prevalent endocrine disorder worldwide. The Beta vulgaris has been shown to possess antidiabetic activity. Here we aimed at elucidating the underlying mechanism of its antidiabetic action. The study was carried out in accordance to recommendations of the international Association for the study of Pain. To evaluate the ability...

Diabetes is a widely prevalent endocrine disorder worldwide. Catharanthus roseus has been shown to possess antidiabetic activity. In our study, we aimed at discovering the underlying mechanism of its antidiabetic action. The study was carried out in accordance to recommendations of the international Association for the study of Pain. To evaluate t...

Barringtonia acutangula (L.) Gaertn. (Family: Lecythidaceae) has been used in different formulations in Ayurveda for the treatment of various ailments. Among many, it has been indicated for joint pain. The objective of the present study therefore was to assess the anti-nociceptive and anti-inflammatory activity of the crude ethanolic root extract o...

Aims: Punarnavasava (PNR) is an Ayurvedic formulation approved by the “National formulary of Ayurvedic Medicine 2011”, of Bangladesh. It is traditionally used in arthritic pain, lumbago and sciatia. Sparse scientific evidence is available to support the efficacy of this preparation. Hence, we planned to document scientific evidences of the pharmaco...

Ficus carica Linn is occasionally used in preparation of local traditional medicines used in the treatment of diarrhoea in Bangladesh. Our present studies make an attempt toward validating this traditional use by investigating antidiarrhoeal activity of F. carica Linn. Ethanolic extract of leaf and bark of F. carica Linn showed significant (p ≤ 0.0...

Ficus carica Linn is widely used in the preparation of local traditional medicine used for pain relief in Bangladesh. Our present studies make an attempt toward validating this traditional use by investigating anti-nociceptive and anti-inflammatory activities of F. carica Linn. Ethanolic extract of whole herb and fruits of F. carica Linn showed sig...

Kutajarishta (KTJ) is an Ayurvedic formulation approved by the "National formulary of Ayurvedic Medicine 2011", of Bangladesh. It is widely available in the Bangladeshi market as an effective preparation to treat lumbago, sciatia and arthritic pain of joints. Our present studies make an attempt toward identifying probable anti-nociceptive and anti-...

Plant polyphenolic compounds have been recognised for their ability to prevent oxidation of susceptible substances by virtue of their electron donating property due to presence of large number of phenolic hydroxyl groups. The seed of Areca catechu contains higher proportions of polyphenolic compounds mainly tannins. Our objective involves quantific...

Asparagus racemosus roots have been shown to enhance insulin secretion in perfused pancreas and isolated islets. The present study investigated the effects of ethanol extracts of A. racemosus roots on glucose homeostasis in diabetic rats, together with the effects on insulin action in 3T3 adipocytes. When administered orally together with glucose,...

The study was a prospective study carried out in the Research Division of Bangladesh Institute of Research and Rehabilitation in Diabetes, Endocrine and Metabolic Disorders (BIRDEM), Dhaka. The present study was designed to investigate the thyroid dysfunction specially total and free levels of serum T 3 and T 4, and TSH in young diabetic subjects....

Investigations were carried out to evaluate the effect of Ipomoea aquatica aqueous and dichloromethane/methanol extracts on the glucose absorption using a rat intestinal preparation in situ. Extracts orally tested at the dose of 160 mg/kg exerted a significant inhibitory effect on glucose absorption when compared with control animals. The most pron...

A well known Ayurvedic formulation Ashokarista, used for menstrual disorders has been studied in a single blind randomised placebo controlled clinical trial for the treatment of menorrhagia and dysmenorrhoea. Dysmenorrhoea and menorrhagia patients who were taking Ashokarista (20 ml twice daily) for 10 menstrual cycles had an increase in haemoglobin...

Trigonella foenum-graecum (fenugreek) seeds have been documented as a traditional plant treatment for diabetes. In the present study, the antidiabetic properties of a soluble dietary fibre (SDF) fraction of T. foenum-graecum were evaluated. Administration of SDF fraction (0 x 5 g/kg body weight) to normal, type 1 or type 2 diabetic rats significant...

Asparagus racemosus root has previously been reported to reduce blood glucose in rats and rabbits. In the present study, the effects of the ethanol extract and five partition fractions of the root of A. racemosus were evaluated on insulin secretion together with exploration of their mechanisms of action. The ethanol extract and each of the hexane,...

Plantago ovata has been reported to reduce postprandial glucose concentrations in diabetic patients. In the present study, the efficacy and possible modes of action of hot-water extracts of husk of P. ovata were evaluated. The administration of P. ovata (0.5 g/kg body weight) significantly improved glucose tolerance in normal, type 1 and type 2 dia...

Ocimum sanctum leaves have previously been reported to reduce blood glucose when administered to rats and humans with diabetes. In the present study, the effects of ethanol extract and five partition fractions of O. sanctum leaves were studied on insulin secretion together with an evaluation of their mechanisms of action. The ethanol extract and ea...

The objective of the present study was to determine the acetylator status of the Bangladeshi population and to compare the findings with the acetylator status of other Asian populations. The acetylator phenotype was determined in 517 unrelated healthy Bangladeshi subjects. The phenotyping procedure was done according to Price Evans' method using th...

The soluble dietary fibre (SDF) fraction of Trigonella foenum graecum (Tf-sdf) has previously been shown to reduce postprandial elevation in blood glucose level of Type 2 model diabetic rats by delaying the digestion of sucrose. The Tf-sdf has now been investigated for its chronic effect on serum fructosamine, insulin and lipid levels, and on plate...

Water extract (kwath) of six different widely used Ayurvedic medicinal plants were tested in mice for possible neuropharmacological efficacy. In the present experiments it was observed that a number of plant tested causes a significant level of Central Nervous System (CNS) depression, in that it significantly decreased the spontaneous Motor activit...

The pharmacological effects of an Ayurvedic diuretic drug “Treenoponchomul” (TPM) was investigated in animal model. The pharmacological actions of the test drug along with that of the components thereof, on the Central Nervous System (CNS) were studied. The drug under study TPM showed little effect on the CNS, the same can not be said about the com...

The soluble dietary fibre (SDF) fraction of Trigonella foenum graecum (Tf-sdf) has previously been shown to reduce postprandial elevation in blood glucose level of Type 2 model diabetic rats by delaying the digestion of sucrose. The Tf-sdf has now been investigated for its chronic effect on serum fructosamine, insulin and lipid levels, and on plate...

Withania somnifera is a very popular medicinal plant used in countries of Indian subcontinent especially in Bangladesh and India by local healers and manufacturers of traditional medicines. The whole plant or its parts are used in preparations for various treatment purposes, especially nervous system related disorders. Present study aimed to valida...

Phyllanthus reticulatus is a reputed medicinal plant used in Bangladesh and India for the treatment of gastric complaints including colic, constipation etc. The aim of this study was to evaluate the antiviral activity of this plant against hepatitis B virus (HBV) using HBsAg positive serum sample from hepatitis B virus infected patients. Two semi-p...