Jinjoo Shim

ETH Zurich | ETH Zürich · Department of Management, Technology, and Economics

Circadian rhythms govern biological patterns that follow a 24-hour cycle. Dysfunctions in circadian rhythms can contribute to various health problems, such as sleep disorders. Current circadian rhythm assessment methods, often invasive or subjective, limit circadian rhythm monitoring to laboratories. Hence, this study aims to investigate scalable c...

Recognizing the pivotal role of circadian rhythm in the human aging process and its scalability through wearables, we introduce CosinorAge, a digital biomarker of aging developed from wearable-derived circadian rhythmicity from 80,000 midlife and older adults in the UK and US. A one-year increase in CosinorAge corresponded to 8–12% higher all-cause...

BACKGROUND Prolonged systemic inflammation is recognized as a major contributor to the development of various chronic inflammatory diseases. Daily measurements of inflammatory biomarkers can significantly improve disease monitoring of systemic inflammation, thus contributing to reducing the burden on patients and the entire healthcare system. There...

Background Prolonged systemic inflammation is recognized as a major contributor to the development of various chronic inflammatory diseases. Daily measurements of inflammatory biomarkers can significantly improve disease monitoring of systemic inflammation, thus contributing to reducing the burden on patients and the health care system. There exist...

Objectives We introduce the Bitemporal Lens Model, a comprehensive methodology for chronic disease prevention using digital biomarkers. Materials and Methods The Bitemporal Lens Model integrates the change-point model, focusing on critical disease-specific parameters, and the recurrent-pattern model, emphasizing lifestyle and behavioral patterns,...

Recognizing the pivotal role of circadian rhythm in the human aging process and its scalability through wearables, we introduce CosinorAge, a novel digital biomarker of aging developed from wearable-derived circadian rhythmicity from 80,000 midlife and older adults in the UK and US. A one-year increase in CosinorAge corresponded to 8-12% higher all...

Repeated disruptions in circadian rhythms are associated with implications for health outcomes and longevity. The utilization of wearable devices in quantifying circadian rhythm to elucidate its connection to longevity, through continuously collected data remains largely unstudied. In this work, we investigate a data-driven segmentation of the 24-h...

Current measures of health and longevity are based on factors such as inflammation, biological age, and mortality. The potential of using continuously collected data from digital devices to explain these measures remains largely unstudied. In this work, we investigate a data-driven segmentation of the 24-hour physical activity profiles from wearabl...

Background Corticosteroids (CS) are often prescribed for patients (pts) with cancer to alleviate disease symptoms, manage treatment-related adverse events, or treat underlying comorbidities. Immunosuppressive properties of CS may impact the effectiveness of cancer immunotherapy (CIT) if given concomitantly. This study explored the association of ba...

Objectives: To assess the value to society of improved survival from novel immuno-oncology (I-O) treatments. Study design: Case studies of ipilimumab for the treatment of advanced unresectable melanoma and nivolumab for advanced previously treated squamous non-small cell lung cancer (NSCLC). Methods: Published data and survival analysis were u...

Objectives Little is known about the severity and long-term health and economic consequences of sarcopenia. We developed a sarcopenia index to measure severity in older Americans and estimated the long-term societal benefits generated by effective interventions to mitigate severity. DesignUsing a micro-simulation model, we quantified the potential...

Studies examining geographic variation in care for low back pain often focus on process and outcome measures conditional on patient diagnosis but generally do not take into account a physician’s ability to diagnose the root cause of low back pain. In our case study, we used increased detection of ankylosing spondylitis—a relatively rare inflammator...

27Background: Although new oncology treatments have the potential to improve patient health, these innovations take time to reach to real-world patients. In this study, we estimated how delays in the uptake of novel oncology treatments affect real-world patient survival. Methods: This retrospective cohort study used 1991-2013 data from a cancer-reg...

Background: There is considerable push to improve value in health care by simultaneously increasing quality while lowering or containing costs. However, for diseases that are best treated with comparatively expensive treatments, such as rheumatoid arthritis (RA), there could be tension between these aims. In this study, we measured geographic vari...

Objectives: To illustrate a more comprehensive view of value associated with medicines treating a highly severe illness and to apply these insights to estimate the costs and benefits of 3 treatments for multiple sclerosis (MS): Avonex, Tysabri, and Tecfidera. Study Design: Retrospective study spanning 2002 to 2013. We used economic theory to deriv...

Drawing on multiple theoretical perspectives (e.g., social comparison theory, reward theory, evolutionary theory), the present research examined the relations of self and friendship network weight status to body satisfaction, self-esteem, and depression. A diverse, population-based sample of adolescents completed measures of well-being and were mea...

Aims: (1) To illustrate a more comprehensive view of value associated with medicines treating highly severe illness. (2) To apply these insights to estimate the costs and benefits of three treatments for Multiple Sclerosis (MS): Avonex, Tysabri, and Tecfidera. Materials and Methods: Retrospective study spanning 2002-2013. We use economic theory to...

Since 2004, concerns about the safety of erythropoiesis-stimulating agents (ESAs) have resulted in label changes and restrictions on their use. We examined changes in ESA use and blood transfusions over time. The SEER-Medicare database was used to identify patients age ≥ 65 years with breast, lung, prostate, ovary, or colon cancer, diagnosed betwee...

A recent randomized trial demonstrated that for metastatic epidural spinal cord compression (MESCC), a complication of advanced prostate cancer, surgical decompression may be more effective than external beam radiation therapy (RT). We investigated predictors of MESCC, its treatment, and its impact on hospital length of stay for patients with advan...

Dieting, unhealthy weight control and muscle-enhancing behaviors are common among adolescents: friends are a probable source of influence on these behaviors. The present study uses data provided by nominated friends to examine associations between friends' disordered eating and muscle-enhancing behaviors and participants' own behaviors in a diverse...

Experiments were executed to provide new evidence relevant to the recent suggestion that fatigue should augment or retard cardiovascular response depending on the difficulty of the challenge at hand. Participants walked on a treadmill while wearing a vest fitted with 5 or 25 pounds of weight. Later, they mounted a recumbent stationary bicycle and w...