Jing Wang

Queen's University Belfast | QUB · Aerospace and Manufacturing Research Cluster

Background The prognosis for non‐small cell lung cancer (NSCLC) patients treated with standard platinum‐based chemotherapy was suboptimal, with safety concerns. Following encouraging results from a preliminary phase I study, this phase II trial investigated the efficacy and safety of first‐line sintilimab and anlotinib in metastatic NSCLC. Methods...

Oceanic internal solitary waves (ISWs) are widely distributed in oceans worldwide. ISWs exhibit significant amplitudes, high speeds, and short periods and thus have a substantial impact on the surrounding environment and engineering activities. Remote sensing plays a vital role in observing ISWs, with sensors encompassing traditional optical and sy...

This brief addresses the optimal control issue of a three-phase grid-connected voltage source inverter under electromagnetic interference. Aiming to reduce the computational burden brought by the phase-locked loop, grid voltage modulation is used to transform the nonlinear inverter system into a linear system. A novel auxiliary variable is proposed...

This paper investigates the formation control problem for nonlinear multi-agent systems exhibiting two-time-scale characteristics. Initially, a fuzzy model is introduced to capture the dynamics of the original nonlinear multi-agent systems. Subsequently, a full-order singularly perturbed system is developed to model the two-time-scale phenomenon in...

LncRNAs are long non-coding RNAs that are widely recognized as crucial regulators of gene expression and metabolic control, involved in numerous dormancy-related processes. Aestivation is a common hypometabolism strategy of sea cucumber (Apostichopus japonicus) in response to high-temperature conditions and is typically characterized by the degrada...

Mollusca represents the second-largest animal phylum but remains less explored genomically. The increase in high-quality genomes and diverse functional genomic data holds great promise for advancing our understanding of molluscan biology and evolution. To address the opportunities and challenges facing the molluscan research community in managing v...

Objective The aim of this study was to compare the diagnostic accuracy of ⁶⁸ Ga-PSMA-11 PET/CT and multiparametric MRI (mpMRI) in detecting unilateral and bilateral intra-glandular prostate cancer lesions. Methods A retrospective analysis was conducted on 73 prostate cancer patients diagnosed via biopsy, all of whom underwent both ⁶⁸ Ga-PSMA-11 PET...

This paper addresses a novel optimal fuzzy control scheme for a category of nonlinear Markov jump singularly perturbed systems with mixed zero-sum game. Firstly, a Takagi-Sugeno fuzzy structure is employed to describe the nonlinear plant. On this basis, two types of value functions for multi-player mixed zero-sum game are developed and a series of...

Creativity, both in human and diffusion models, remains an inherently abstract concept; thus, simply adding "creative" to a prompt does not yield reliable semantic recognition by the model. In this work, we concretize the abstract notion of "creative" through the TP2O task, which aims to merge two unrelated concepts, and introduce CreTok, redefinin...

Optical fiber sensors (OFSs) have attracted more and more attention in the field of in-situ ocean observation because of their advantages of the small size, light weight, low cost, and intrinsic immunity to electromagnetic interference. Here, we comprehensively reviewed the development of various advanced physical and chemical OFSs for in-situ meas...

Background Coronary artery bypass grafting (CABG) is often performed with hypothermic cardiopulmonary bypass (CPB) to reduce metabolic demands and protect the myocardium. However, hypothermia can increase bleeding risks and other complications. Methods This is a prospective, multi-center, randomized controlled trial. From September 2023 to Decembe...

Background Coronary artery bypass grafting (CABG) is often performed with hypothermic cardiopulmonary bypass (CPB) to reduce metabolic demands and protect the myocardium. However, hypothermia can increase bleeding risks and other complications. Methods This is a prospective, multi-center, randomized controlled trial. From September 2023 to December...

A robust strain sensor is demonstrated based on a microfiber Mach–Zehnder interferometer (MMZI) encapsulated by the polymer polydimethylsiloxane (PDMS). Benefiting from the low Young’s modulus of PDMS, both a robust structure and high sensitivity can be realized based on three different encapsulations. In the experiment, the proposed sensors are fa...

The generation characteristics of internal solitary waves (ISWs) in the northern Andaman Sea are studied using remote sensing data and numerical simulations. The dataset comprises 230 images taken by the Moderate Resolution Imaging Spectroradiometer (MODIS) from 2020 to 2023, which reveal two distinct propagation directions of ISWs: southeastward (...

Diffusion models often face slow convergence, and existing efficient training techniques, such as Parameter-Efficient Fine-Tuning (PEFT), are primarily designed for fine-tuning pre-trained models. However, these methods are limited in adapting models to variable sizes for real-world deployment, where no corresponding pre-trained models exist. To ad...

An adaptive predefined-time fuzzy tracking control problem for non-strict feedback systems is investigated in this paper. Compared with some previous findings on adaptive control for the output constrained systems with input saturation, the most significant feature of this research is that the system convergence time only depends on one design para...

This article focuses on solving the secure control problem by developing a novel resilient hybrid learning scheme for discrete-time Markov jump cyber–physical systems with malicious attacks. Within the zero-sum game framework, the secure control problem is converted into solving a set of game coupled algebraic Riccati equations. However, it contain...

In this multicenter, non-inferiority, randomized trial, we randomly assigned 992 women undergoing in-vitro fertilization (IVF) with a good prognosis (aged 20-40, ≥3 transferrable cleavage-stage embryos) to strategies of blastocyst-stage (n = 497) or cleavage-stage (n = 495) single embryo transfer. Primary outcome was cumulative live-birth rate afte...

Background Left ventricular (LV) overload is a frequent complication during VA-ECMO associated with poor outcomes. Many strategies of LV unloading have been documented but lack of evidence shows which is better. We conducted a network meta-analysis to compare different LV unloading strategies. Methods We searched databases for all published studie...

WD40 Repeat Domain 5 (WDR5) is a highly conserved nuclear protein that recruits MYC oncoprotein transcription factors to chromatin to stimulate ribosomal protein gene expression. WDR5 is tethered to chromatin via an arginine-binding cavity known as the "WIN" site. Multiple pharmacological inhibitors of the WDR5-interaction site of WDR5 (WINi) have...

Background Radioactive iodine (RAI) therapy is a widely used treatment for Graves’ Hyperthyroidism (GH). However, various factors can impact the non-remission rate of GH after single RAI therapy. This study aimed to develop an online dynamic nomogram to assist physicians in providing personalized therapy for GH. Methods Data from 454 GH patients w...

Pre-trained models have become the preferred backbone due to the expansion of model parameters, with techniques like Parameter-Efficient Fine-Tuning (PEFTs) typically fixing the parameters of these models. However, pre-trained models may not always be optimal, especially when there are discrepancies between training tasks and target tasks, potentia...

In this paper, the imitation reinforcement learning-based control problem is studied for discrete-time Markov jump systems with external disturbances. First, zero-sum game method is introduced to deal with external disturbances, where control input and external disturbances are regarded as two rival players in adversarial environments. Then, the im...

A 59-year-old woman underwent radical surgery and chemotherapy for gastric adenocarcinoma. After the personalized antigen peptide tumor vaccine, a new nodular lesion, in the upper abdomen, was discovered during ⁶⁸ Ga-FAPI-04 PET/MRI follow-up. To determine possible pseudoprogression, ⁶⁸ Ga-FAPI-04 PET/MRI was repeated 39 days later, referring to im...

Ocean exploration-oriented temperature and salinity (TS) sensor based on bend-insensitive microfiber Mach-Zehnder interferometer (MMZI) is proposed and demonstrated in a marine environment. To solve the demodulation problem induced by the narrow waveband of the spectrometer used in the sea trial, a MMZI sensor is calibrated and demodulated by machi...

Objective: This study aimed to assess the relationship between implantation and soluble HLA-G (sHLA-G) expression in cleavage embryo culture medium (ECM) in conjunction with early developmental kinetics determined by time-lapse imaging (TLI). Methods: A retrospective, single-center study was conducted involving 238 embryos from 165 patients who und...

Internal solitary waves (ISWs) change the roughness of the sea surface, thus producing dark and bright bands in optical images. However, reasons for changes in imaging characteristics with the solar zenith angle remain unclear. In this paper, the optical imaging pattern of ISWs in sunglint under different zenith angles of the light source is invest...

Aims This study aimed to analyse the global prevalence and disability trends of heart failure (HF) from 1990 to 2019, considering both sexes and country‐specific economic strata. Methods This study conducted a secondary analysis employing data from the Global Burden of Disease (GBD) study. The analysis is stratified by sex and Socio‐demographic In...

The expansion of model parameters underscores the significance of pre-trained models; however, the constraints encountered during model deployment necessitate models of variable sizes. Consequently, the traditional pre-training and fine-tuning paradigm fails to address the initialization problem when target models are incompatible with pre-trained...

Aims The patient being minimally conscious state (MCS) may benefit from wake‐up interventions aimed at improving quality of life and have a higher probability of recovering higher level of consciousness compared to patients with the unresponsive wakefulness syndrome (UWS). However, differentiation of the MCS and UWS poses challenge in clinical prac...

Introduction The Agatston coronary artery calcification score (CACS) is an assessment index for coronary artery calcification (CAC). This study aims to explore the characteristics of CAC in end-stage kidney disease (ESKD) patients and establish a predictive model to assess the risk of severe CAC in patients. Methods CACS of ESKD patients was asses...

This article deals with the asynchronous event-triggered passive consensus issue for two-time-scale semi-Markov jump multiagent systems in continuous-time domain against denial-of-service (DoS) attacks. The multiagent systems are modeled with two-time-scale structures and the parameter changes are assumed to follow semi-Markov jump processes. For m...

Abstrct Objectives The FUWAI-SAVE system is a modified low-priming cardiopulmonary bypass (CPB) system. The study aimed to explore whether the FUWAI-SAVE system can reduce the perioperative blood transfusion and its impact on other postoperative complications during cardiac surgery. Metohds This study was a single-center, single-blind, randomized...

This chapter investigates the asynchronous \(H_{\infty }\) control problem for linear discrete hidden Markov jump singularly perturbed systems (HMJSPSs). Since the mode state of the original system is not directly available, the hidden Markov model (HMM) is used to detect the system mode information. Considering the limitation that it is difficult...

This chapter gives the \(H_{\infty }\) synchronization problem for singularly perturbed complex networks. Markov chains are used to regulate the switching random properties of the system. A mode-dependent synchronous controller is adopted, and relevant criteria are applied to make the system achieve stochastic stability and meet the \(H_{\infty }\)...

This chapter investigates the problem of \(H_{\infty }\) synchronization for semi-Markov jump singularly perturbed complex network (SPCN). Compared to the Markov jump SPCN, the semi-Markov jump one is more reasonable due to the transition probability being considered to be related to the mode of the past, in which the transition rate has the proper...

This chapter considers the robust control problem for nonlinear Markov jump singularly perturbed jump systems based on the T-S fuzzy model. To address the issue of actuator failure, fault-tolerant control and nonfragile control are adopted separately, which is more practical. For different performance indicators, new auxiliary functions are used to...

In this chapter, the \(H_{\infty }\) control problem for nonlinear hidden Markov jump singularly perturbed systems (HMJSPSs) with complex probability information is addressed based on the T-S fuzzy model. The complex probability information encompass both the transition probabilities matrix (TPM) and observation probability matrix (OPM). A novel hi...

This chapter investigates the \(H_{\infty }\) control problem of linear Markov jump singularly perturbed systems (MJSPSs), in which the complete probability information case, partial probability information case and general probability information case are fully considered. Both the mode-dependent \(H_{\infty }\) controller and mode-independent one...

This chapter focuses on the stochastic stability analysis and the stabilizing controller design problem for discrete-time Markov jump singularly perturbed systems (MJSPSs), in which the complete probability information case, partial probability information case and general probability information case are fully considered. First, by utilizing the p...

Finite-time boundedness (FTB) describes the boundedness of system states. It required that system states cannot exceed a given threshold during a finite time interval. The existing results on Markov jump singularly perturbed systems (MJSPSs) mainly focused on the stochastic stability in infinite-time interval. This chapter investigates the problem...

The coexistence of multiple-time scales dynamics phenomena and sudden changes in system structure and parameters are frequently encountered in engineering control systems. Generally, these control systems can be well modeled as singularly perturbed jump systems. During the past decades, as a class of singularly perturbed jump systems, Markov jump s...

In this section, we consider the stabilization for semi-Markov jump singularly perturbed systems (SMJSPSs) subjected to partially available transition information. The considered system includes two special cases, that is, complete probability information case and partially unknown probability information case, which is more general. In addition, w...

This chapter focuses on the issue of nonlinear semi-Markov singularly perturbed systems (SPSs) using a fuzzy model-based approach. This chapter uses semi-Markov Kernel (SMK) to calculate controller gains by using linear matrix inequality technology based on T-S fuzzy mode. In this chapter, the SMK is divided into two cases, the first section consid...

Aims This study aimed to investigate the association of soluble suppression of tumorigenicity‐2 (sST2) measured by point‐of‐care testing assay with clinical outcomes in patients hospitalized with heart failure after adjusting for other predictors including N‐terminal pro‐B‐type natriuretic peptide (NT‐proBNP) and high‐sensitivity cardiac troponin T...

This article investigates the command‐filter‐based improved predefined‐time tracking control problem for a class of switched nonlinear systems with the quantized input signal. Essentially different from most tracking control works of switched nonlinear systems under input quantization, the nonlinear decomposition method is employed to tackle the ob...

Quinoline-based fibroblast activation protein (FAP) inhibitors (FAPIs) have recently emerged as a focal point in global nuclear medicine, underscored by their promising applications in cancer theranostics and the diagnosis of various nononcological conditions. This review offers an in-depth summary of the existing literature on the evolution and us...

Radiopharmaceuticals play a critical role in nuclear medicine, providing novel tools for specifically delivering radioisotopes for the diagnosis and treatment of cancers. As the starting point for developing radiopharmaceuticals, cancer-specific biomarkers are important and receive worldwide attention. This field in China is currently experiencing...

Melanin is one of the representative biomarkers of malignant melanoma and a potential target for diagnosis and therapy. With advancements in chemistry and radiolabeling technologies, promising strides have been made to synthesize radiolabeled melanin-binding molecules for various applications. We present an overview of melanin-targeted radiolabeled...

Nuclear medicine in China started in 1956 and, with the rapid development of the economy and continuous breakthroughs in precision medicine, has made significant progress in recent years. Almost 13,000 staff members in nearly 1,200 hospitals serve more than 3.9 million patients each year. Over the past decade, the radiopharmaceutical industry has d...

Background: Garsorasib (D-1553), a potent KRAS G12C inhibitor, has previously demonstrated promising anti-tumor activity in KRAS G12C-mutated non-small-cell lung cancer (NSCLC) in a phase 1 study. Here we present the efficacy and safety of garsorasib in a pivotal phase 2 study. Methods: In this open-label, multicenter, single-arm phase 2 study, pat...

Background Dystrophinopathies are the most common X-linked inherited muscle diseases, and the disease-causing gene is DMD. Exonic duplications are a common type of pathogenic variants in the DMD gene, however, 5’ end exonic duplications containing exon 1 are less common. When assessing the pathogenicity of exonic duplications in the DMD gene, consi...

Early vascular-targeted drugs represented by VEGF single-pathway inhibitors pioneered the idea of regulating the tumor growth microenvironment and enhanced the chemotherapy effect in a variety of tumors. However, their shortcomings of “only winning PFS but not OS” have gradually revealed and warned that drug-resistant growth of tumors is unavoidabl...

This study utilized a data-driven Bayesian model to automatically identify distinct latent disease factors represented by overlapping glucose metabolism patterns from 18F-Fluorodeoxyglucose PET (18F-FDG PET) to analyze heterogeneity among patients with TLE. We employed unsupervised machine learning to estimate latent disease factors from 18F-FDG PE...

Purpose There is currently no consensus on the most appropriate blood transfusion strategy for older adults undergoing cardiovascular surgery. We aimed to investigate the potential benefits of the patient blood management (PBM) program specifically for advanced age patients, and to evaluate the relationship of age and PBM in cardiovascular surgery....

The uMI Panorama is a novel PET/CT system using silicon photomultiplier and application-specific integrated circuit technologies and providing exceptional spatial and time-of-flight (TOF) resolutions. The objective of this study was to assess the physical performance of the uMI Panorama in accordance with the National Electrical Manufacturers Assoc...

Introduction Accurate identification of the myocardial texture features of fat around the coronary artery on coronary computed tomography angiography (CCTA) images are crucial to improve clinical diagnostic efficiency of myocardial ischemia (MI). However, current coronary CT examination is difficult to recognize and segment the MI characteristics a...

Background Previous metabolic profiling of liver cancer has mostly used untargeted metabolomic approaches and was unable to quantitate the absolute concentrations of metabolites. In this study, we examined the association between the concentrations of 186 targeted metabolites and liver cancer risk using prediagnostic plasma samples collected up to...

Background In on-pump cardiac surgery, the albumin priming strategy could maintain colloid osmotic pressure better than crystalloid solutions and reduce excessive perioperative fluid balance. However, a high-quality meta-analysis is required to compare the safety of these approaches in perioperative red blood cell (RBC) transfusions. Owing to limit...

Optical remote sensing has been widely used to study internal solitary waves (ISWs). Wind speed has an important effect on ISW imaging of optical remote sensing. The light and dark bands of ISWs cannot be observed by optical remote sensing when the wind is too strong. The relationship between the characteristics of ISWs bands in optical remote sens...

This work investigates the control problem of discrete‐time singular Markov jump systems against denial of service attacks, in which the Markov state information is seen as restricted access. To solve this situation, a hidden Markov model is introduced. The main objective is to construct a controller with the help of hidden Markov model such that t...

The amplitude of internal solitary waves (ISWs) is a crucial parameter characterizing their properties. Leveraging machine learning and optical remote sensing images for ISW amplitude inversion has proven highly efficient. However, determining the best input features in the inversion model is often overlooked. This study addresses the feature selec...

This paper explores the issue of robust attitude control for a 2-DOF helicopter system under the fixed-time control rule. Thanks to the reinforcement-learning strategy, the optimization results for the attitude control objective have been achieved. Under the basic framework of the Actor-Critic Neural Networks, this paper not only solves a better so...

Due to the small scale and short lifetimes of mode-2 internal solitary waves (ISWs), they are seldom observed by satellite images. This study investigated the optical remote sensing imaging characteristics of mode-2 ISWs through physical simulation experiments, proposed a method for identifying mode2 ISWs in optical remote sensing images, and condu...