Jing Jun

Sun Yat-Sen University | SYSU · Department of Orthopaedic Surgery

Objectives This study aims to investigate if addition of fibroblast-stromal cell markers to a classification of synovial pathotypes improves their predictive value on clinical outcomes in rheumatoid arthritis (RA). Methods Active RA patients with a knee needle synovial biopsy at baseline and finished 1-year follow-up were recruited from a real-wor...

Background: Fibroblast-like synoviocytes (FLS) in rheumatoid arthritis (RA) may cause articular damage as a result of its aggressive features including direct adhesion and invasion of surface cartilage in joints. Artemether (ART), one of the artemisinin derivatives with antimalarial properties, showed inhibitory effect on inflammation and destructi...

Background Rheumatoid arthritis (RA) is a heterogeneous disease with variable prognosis. The cellular composition in synovium is the driving force of joint destruction in RA, and the predictive values of histopathological assessments on the clinical outcomes of RA have been identified. However, current synovial histopathological assessments mainly...

Objective: To investigate the expression of peroxisome proliferator-activated receptor-gamma coactivator (PGC)1β in synovium of patients with rheumatoid arthritis (RA) and its association with histological synovitis. Methods: This cross-sectional study recruited RA patients at the Department of Rheumatology, Sun Yat-Sen Memorial Hospital from May 2...

Background CD163, a hemoglobin scavenger receptor, has been identified as a marker of M2 macrophages, it can promote the release of IL-10 and carbon oxide. Researches on inflammatory diseases and tumors have suggested that CD163 plays anti-inflammatory effect and promotes tumor growth and metastasis. Rheumatoid arthritis (RA) is a chronic inflammat...

Objective: To investigate the role of transcription factor peroxisome proliferator-activated receptor-gamma coactivator-1 beta (PGC-1β) on osteoclastogenesis and related regulatory mechanism in the mouse monocyte-macrophage cell line (RAW264.7). Methods: PGC-1β expression and location in RAW264.7 cells was detected by immunofluorescence, flow cytom...

Introduction: Anti-malarial drug artesunate can suppress inflammation and prevent cartilage and bone destruction in collagen-induced arthritis model in rats-suggesting it may be a potent drug for rheumatoid arthritis (RA) therapy. We aimed to investigate its effect on the invasive property of fibroblast-like synoviocytes (FLS) from patients with R...

Background Fibroblast-like synoviocytes (FLS) play critical roles on joint inflammation and destruction of cartilage and bone in rheumatoid arthritis (RA) due to their aggressive behavior including increased migration. The Rho family of small GTPases are the master regulators of actin cytoskeleton remodeling which leads to pseudopodia formation and...

Background The tumor-like transformation of synovium, especially the lining layer, play a critical role in joint damage in rheumatoid arthritis (RA) by forming aggressive and invasive rheumatoid pannus, but the underlying mechanisms remains unknown. Mucin1(MUC1), an O-glycosylated protein participating in forming protective mucous barriers on epith...

In rheumatoid arthritis (RA), imbalanced T cells subsets play a critical role in sustaining chronic inflammatory responses in the synovium. Naïve T cells in RA patients undergo maldifferentiation, including an increase in the effector Th1/Th17 lineage and a reduction in regulatory T (Treg)cells. Upon stimulation, naïve CD4 ⁺ CD45RO ⁻ T cells from R...

Career situation of first and presenting author Student for a master or a PhD. Introduction Experiments on collagen-induced arthritis rats showed that artemether, a new antimalarial drug derived from artemisinin, can reduce inflammatory cell infiltration, tissue edema, and bone erosion in the paws, which implied its potential efficacy in rheumatoi...

Career situation of first and presenting author Resident. Introduction The underlying mechanism of excessive osteoclastogenesis causing bone erosion in rheumatoid arthritis (RA) remains elusive. PGC-1β is implicated in transcriptional regulation of osteoclastogenesis but its role in RA pathogenesis is unknown. Objectives To investigate whether PG...

Career situation of first and presenting author Young investigator. Introduction CC chemokine ligand 18 (CCL18) which is either constitutively expressed or induced in monocytes/macrophages and dendritic cells has been reported to be highly expressed in peripheral blood and synovial fluid of rheumatoid arthritis (RA) patients compared with healthy...

Objective Activation of osteoclastogenesis at the bone site in rheumatoid arthritis (RA) is well established. The mechanisms by which circulating osteoclast precursors contribute are still unclear. Peroxisome proliferator–activated receptor γ coactivator 1β (PGC‐1β) is implicated in transcriptional regulation of osteoclastogenesis in mouse models....

This article discusses the Chinese state crackdown on homosexuality during the reform period through the narratives of homosexual men who were arrested and sentenced to re-education through labour at that time. Utilising the work on morality and law by Zygmunt Bauman, it is shown that Deng Xiaoping’s proposal in 1979 to advance Chinese socialist sp...

This article is born out of an oral history study of 31 elderly homosexual men in four cities in China. It shows the ways in which major events of Chinese history since the birth of the People’s Republic in 1949 intervene in personal lives and, in turn, how personal lives are drawn into larger historical events. One of the major themes running thro...

Background The aim of this study was to report aseptic, erosive polyarthritis in a patient with common variable immunodeficiency (CVID), which is quite different from the vastly more common nonerosive form. Material/Methods Peripheral blood mononuclear cells of the patient were isolated. Flow cytometry was used to analyze the proportion and functi...

Lining macrophage-like synoviocytes and sublining macrophages in synovium of the CVID patient. A paraffin section was stained with mouse anti-human monoclonal antibody preparation to CD68 (clone KP1, Invitrogen, Carlsbad, CA, USA) according to standard staining protocol.

Background Previous studies have revealed that hepatitis B virus (HBV) infection may be related to rheumatoid arthritis (RA), but there are no studies on the presence of HBV antigens or nucleic acid in synovium from patients with RA with HBV infection. In the present study, we investigated the presence of HBV in the synovium and its clinical signif...

Background Previous studies have shown that hepatitis B virus (HBV) infection may be associated with rheumatoid arthritis (RA). However, no study regarding the presence of HBV in the synovial membrane from RA patients has been reported. Objectives To investigate the presence of HBV in RA synovium and determine its influence on histopathological ch...

Background CC chemokine ligand 18 (CCL18) which is either constitutively expressed or induced in monocytes/macrophages and dendritic cells has been reported to be highly expressed in peripheral blood and synovial fluid of rheumatoid arthritis (RA) patients compared with healthy controls, indicating the possible role of CCL18 in the development and...

Background Smoking has been reported not only an established environmental risk factor for developing rheumatoid arthritis (RA), but also a predictor of radiographic progression. Nicotine, the major constituent of cigarette smoke, has been demonstrated inhibitory effect on proinflammatory cytokines through its receptor nicotinic acetylcholine recep...

Background Fibroblast-like synoviocytes (FLS) in rheumatoid arthritis (RA) manifest tumor-like properties including increased proliferation, prolonged survival, apoptosis resistance, adherence and invasiveness of adjacent tissues. Peroxisome proliferator-activated receptor-gamma coactivator-1 (PGC-1) β is a transcriptional coactivator which plays i...

Hepatitis B virus (HBV) reactivation is a well-recognized complication in patients who undergo immunosuppressive drug therapy. Although the recommendation of antiviral prophylaxis made by the American Gastroenterological Association in 2015 focuses on the risk stratification of different immunosuppressive drugs, risk factors for HBV reactivation ar...

Background Evidences show that antimalarial agents of artemisinin and its derivatives such as artesunate may inhibit proinflammatory cytokines secretion from human rheumatoid arthritis (RA) fibroblast-like synoviocytes (FLS) in vitro. It has also been demonstrated that artesunate may ameliorate the symptoms of arthritis and prevent joint damage in...

Aim: To investigate the impact of short-course tocilizumab (TCZ) on hepatitis B virus (HBV) reactivation in rheumatoid arthritis (RA) patients. Methods: RA patients with moderate to high disease activity, with at least one feature of poor prognosis and inadequate response to conventional synthetic disease-modifying antirheumatic drugs (csDMARDs)...

Background Peroxisome proliferator-activated receptor-gamma coactivator-1 (PGC-1) is a transcriptional coactivator that plays important roles in regulating energy metabolism and cytokine signaling pathways. Our previous study showed that down-regulating PGC-1β could inhibit rheumatoid arthritis fibroblast-like synoviocytes induced osteoclastogenesi...

Background CC chemokine ligand 18 (CCL18) has been reported overexpressed in numerous inflammatory disorders since 1997. However, its functional receptor, phosphatidylinositol transfer membrane-associated phosphatidylinositol transfer protein 3 (PITPNM3), has not been discovered until 2011 by our colleagues. Multiple functions of CCL18 besides its...

Background Our previous study showed approximately 11% of Chinese RA patients combined with chronic Hepatitis B virus (HBV) infection and 32% with resolved HBV infection. HBV reactivation may occur as an adverse event of biologic DMARDs and TNFIs or abatacept have been categoried as moderate risk of HBV reactivation, rituximab as high risk [1]. How...

Background Tocilizumab (TCZ) was the first approved non-TNFα bDMARD for rheumatoid arthritis (RA) in China since November 2013. However, the mean course of TCZ for most Chinese RA patients is about 3–6 months because of self-paid and expensive price, similar to the situation of other biological originator DMARDs or their biosimilar. Objectives To...

Background Our previous study showed that suppression of peroxisome proliferator-activated receptor-gamma coactivator-1β (PGC-1β) alleviated the secretion of matrix metalloproteinase (MMP)-3 from fibroblast-like synoviocytes and inhibited osteoclastogenesis in vitro. However, little was known about PGC-1β with joint destruction in RA patients. Obj...

Background Our previous study showed 11.2% of Chinese patients with rheumatoid Arthritis (RA) suffered chronic Hepatitis B virus (HBV) infection (HBsAg+) and 32.3% suffered past HBV infection (anti-HBc+/HBsAg-). Tocilizumab (TCZ) was the first non-TNFα bDMARD for refractory RA launched in China since October 2013. Little is known about its influenc...