Jindong Wang

• University of Utah

Underdetermined blind source separation (UBSS) is a critical technique in the field of intelligent mechanical operation and maintenance, allowing for the disentanglement of source signals from their mixtures without the need for prior knowledge or extensive sensor information. The accuracy of source signal recovery hinges on the estimation of the m...

Underdetermined blind source separation (UBSS) has garnered significant attention in recent years due to its ability to separate source signals without prior knowledge, even when sensors are limited. To accurately estimate the mixed matrix, various clustering algorithms are typically employed to enhance the sparsity of the mixed matrix. Traditional...

In order to effectively extract the key feature information hidden in the original vibration signal, this paper proposes a fault feature extraction method combining adaptive uniform phase local mean decomposition (AUPLMD) and refined time-shift multiscale weighted permutation entropy (RTSMWPE). The proposed method focuses on two aspects: solving th...

The bearing vibration signal of reciprocating compressor has complex, non-stationary, nonlinear, and feature coupling characteristics. A method for sub-health recognition of sliding bearings based on curve adaptive grasshopper optimization algorithm optimize the parameters of variational mode decomposition (CAGOA-VMD) and generalized refine composi...

A novel Ru-modified composite catalyst, Ru-W/Sn-AlOx, was prepared, and the effects of the catalyst on lignin depolymerization were investigated in this study. The catalyst converted approximately 95% lignin into liquid product at 300 °C in 12 h and 2/3 of the liquid product could be soluble in petroleum ether. The petroleum ether (PE) soluble prod...

In practical engineering applications, the vibration signals collected by sensors often contain outliers, resulting in the separation accuracy of source signals from the observed signals being seriously affected. The mixing matrix estimation is crucial to the underdetermined blind source separation (UBSS), determining the accuracy level of the sour...

The underdetermined blind source separation (UBSS) has been considered to be a novel signal processing technique, which can separate the fault source signals from their mixtures. The mixing matrix estimation is a major step in the UBSS, this paper focuses on boosting the accuracy level of the estimated mixing matrix in the underdetermined case. Sin...

In this study, Ni–Sn metal oxide catalysts, with strong Lewis acidity, were prepared and applied in lignin depolymerization to produce liquefied fuels. The Ni–Sn metal oxide catalysts could cleave the lignin linkages and stabilize the reaction intermediates due to the high Lewis acidity and the hydrogenation of nickel sites. When the molar ratio of...

According to the nonlinearity and nonstationarity characteristics of reciprocating compressor vibration signal, a fault feature extraction method of reciprocating compressor based on the empirical wavelet transform (EWT) and state-adaptive morphological filtering (SMF) is proposed. Firstly, an adaptive empirical wavelet transform was used to divide...

Among Alzheimer's disease (AD) patients, it is very common to develop behavioral and psychological symptoms of dementia (BPSD), which has a close relation to the excess morbidity and mortality, greater healthcare use, earlier institutionalization, and caregiver burden. With evaluation of AD patients, the present study mainly aims to investigate whe...

The existing game-theoretic approaches for network security problems mostly use the static game or the multi-stage dynamic game. However, these researches can not meet the timeliness requirment to analyze the network attack and defense. It is better to regard the attack and defense as a dynamic and real-time process, in which way the rapidity and c...

In the actual network attack and defense, the attack-defense behaviors generally change dynamically and continuously. Besides, since kinds of random disturbance is inevitable, the evolution of network security state actually is random. To model and analyze network security problems more accurately, we used the Gaussian white noise to describe the r...

Objective: Alzheimer's disease (AD) is a neurodegenerative disease characterized by progressive cognitive decline with loss of memory. The objective of this study was to investigate the role and regulatory mechanism of lncRNA-ATB in regulating amyloid-β-induced neurotoxicity in neuronal PC12 cells. Material and methods: The expression levels of...

A catalytic routine was developed for kraft lignin depolymerization in dioxane-water systems, in which the catalyst HTaMoO6 with strong Bronsted acidity and a hydrogenation catalyst (Rh/C) were employed simultaneously. The performance of the composite catalysts was tested in a series of experiments with various reaction temperatures, reaction time...

While network attack and defense are experiencing a rapid change, the current research achievements of network security based on traditional game theory fail to characterize the real-time performance of the actual network attack-defense process accurately. Furthermore, all kinds of disturbance and accidental factors would affect the evolution of th...

Several studies have reported a significant role of high mobility group box protein 1 (HMGB1) in lung cancer. Nevertheless, there is a lack of knowledge regarding the expression of HMGB1 and its correlation with the clinicopathological features of lung cancer. In addition, the potential molecular mechanisms underlying the role of HMGB1 in lung canc...

As one of the most widely used algorithms in recommendation field, collaborative filtering (CF) predicts the unknown rating of items based on similar neighbors. Although many CF-based recommendation methods have been proposed, there still be room for improvement. Firstly, the data sparsity problem still remains a big challenge for CF algorithms to...

Lung cancer has very high mortality and glycyrrhizin was found to significantly inhibit the growth of lung cancer cells in vitro and tissues in mice. However, the detailed inhibitory role of glycyrrhizin in the growth of lung cancer is still unclear. In this study, we first found that glycyrrhizin inhibited the growth of lung tumor in PDX mice. And...

Aiming at the nonlinearity, nonstationarity and multi-component coupling characteristics of reciprocating compressor vibration signals, an integrated feature extraction method based on the variational mode decomposition (VMD) and multi-fractal detrended fluctuation analysis (MFDFA) is proposed for a fault diagnosis for a reciprocating compressor va...

The solid, super, acid catalyst S2O8²⁻/ZrO2–TiO2–SiO2, which has both a strong Brønsted acid and Lewis acid, was prepared and applied in lignin depolymerization. The results indicate that S2O8²⁻/ZrO2–TiO2–SiO2 is an effective catalyst for lignin depolymerisation since the liquid product was almost completely dissolved in ethyl acetate, indicating t...

Background: Fine needle aspiration (FNA) is widely used in the diagnosis of salivary gland lesions. Salivary gland FNAs are often difficult to diagnose because of morphologic heterogeneity, a small but significant number of the FNAs yield "atypical" diagnosis. However, systematic evaluation of the risk of malignancy (ROM) of the atypical diagnoses...

Since the characteristics opposite objectives, non-cooperation relationship and dependent strategies of network attack and defense are highly consistent with game theory, researching the decision-making methods of network defense and applying the game models to analyze the network Attack-Defense behaviors has been of concern in recent years. Howeve...

In this study, a novel catalyst, S2O8²⁻-KNO3/TiO2, which has active acidic and basic sites, was prepared and used in lignin hydrokracking with a co-catalyst, Ru/C. Ru/C is an efficient hydrogenation catalyst and S2O8²⁻-KNO3/TiO2 is a dual catalyst, which could efficiently degrade lignin. This catalytic hydrogenation system can reduce solid products...

In the present study, clonal amplifications of T-cell receptor β variable (TCR BV) linked to human cytomegalovirus (HCMV) infection were detected in recipients of allogeneic hematopoietic stem cell transplants (HSCT), and certain relationships between them were identified. Furthermore, the relationship between TCR BV sequences and HCMV infections w...

A series of rare earth metals supported on carbon nanotube (CNT) were tested for the catalytic depolymerization of lignin. The supported cerium (Ce) and lanthanum (La) on CNT were firstly characterized by TEM and N2-BET, respectively. The as-prepared catalysts were efficient to depolymerize lignin, whereas 86.1% liquefied fuel yield was obtained at...

Background: Endogenous nitric oxide (NO) is beneficial for inhibiting Rho-associated kinase 2 (ROCK2) expression. However, the effect of exogenous NO on ROCK2 expression is less investigated. Methods: Rabbits with dyslipidemia were produced and randomly assigned into untreated, atorvastatin, nitroglycerin and combined groups (n=10 in each group). M...

Background: Viral infections are a major cause of morbidity and mortality after hematopoietic stem cell transplantation (HSCT). The effect of herpesvirus infections in human cytomegalovirus (HCMV)-seropositive (IgG-positive/IgM-negative) HSCT recipients remains poorly understood. The risk factors associated with Epstein-Barr virus (EBV), HCMV, and...

s: AACR Special Conference on Developmental Biology and Cancer; November 30 - December 3, 2015; Boston, Massachusetts The epithelial to mesenchymal transition (EMT) is a highly conserved morphogenesis program that is essential for re-shaping and mobilizing epithelial cells during gastrulation, neural crest development and tissue regeneration. In c...

The epithelial to mesenchymal transition (EMT) is a highly conserved morphogenetic program essential for embryogenesis, regeneration and cancer metastasis. In cancer cells, EMT also triggers cellular reprogramming and chemoresistance, which underlie disease relapse and decreased survival. Hence, identifying compounds that block EMT is essential to...

Villous adenoma is a rare neoplasm in the urinary tract. It usually occurs in patients older than 50 years with a male predominance. The affected patients typically present with hematuria, irritative voiding symptoms, and mucosuria. The malignant potential of this entity has not been established, but some of the case series studies on bladder villo...

Chlorpromazine (CPZ) is a widely used antipsychotic drug with antagonistic effect on dopamine receptors. Accumulating evidence has shown that CPZ plays a neuroprotective role in various models of toxicity and apoptosis. However, the underlying mechanism contributing to this protective effect remains unclear. Here, we evaluate the effect of CPZ on m...

Synchronous or metachronous malignant pleural mesothelioma and pulmonary adenocarcinoma are vanishingly rare, most occurring with a history of significant asbestos exposure. We report a unique case of metachronous malignant pleural mesothelioma and pulmonary adenocarcinoma in a 70-year-old man with a significant history of smoking (one pack per day...

Hypertriglyceridemia (HTG), either primary or secondary, is the third leading cause of acute pancreatitis, after alcohol abuse and gallstones. Secondary causes include medications such as diuretics. Standard medical therapy in these patients often fails to quickly reduce triglycerides (TG) to desirable levels. Therapeutic plasma exchange (TPE) is s...

Female adnexal tumor of probable Wolffian origin (FATWO) and extraovarian granulosa cell tumor (GCT) are both exceptionally rare neoplasms with overlapping features and low-grade malignant potential. We report an unusual case of a stage IIIC malignant tumor of the broad ligament that rapidly progressed in a 29-year-old woman presenting with abdomin...

The Epithelial to Mesenchymal Transition (EMT) plays a crucial role during development and aberrant reactivation of EMT in tumor cells promotes metastasis and drug resistance. Mechanisms that control EMT remain incompletely understood, hampering efforts to target EMT in cancer patients. To identify upstream inducers and downstream effectors of EMT...

Park-and-ride (P&R) is a conventional way of transportation demand management that can relieve urban traffic congestion and parking pressure. Nowadays, the total usable capacity of P&R parking lots in Shanghai, China, cannot satisfy the demand. In this research, a user travel behavior survey was designed based on this phenomenon, the factors affect...

Ni-TiN composite nanocoatings were successfully deposited by magnetic pulse current deposition. The influence of magnetic intensity on the microstructure, composition, microhardness, and electrochemical properties of the coatings was investigated using a high-resolution transmission electron microscope, an X-ray diffractor, a microhardness tester,...

In order to assess network security threats better, we model the attacker's and defender's behavior based on attack-defense graph from the perspective of both attacker and defender, which lays the foundation of the further research for the scientific and precise information security threat assessment. Due to the existing problems of generating trad...

Nowadays, the network defense based on incomplete information game model ignored the type of the defender, used simple cost quantitative method, and chosen defense strategies improperly. Aiming at the problem, this paper proposed an active defense strategy selection based on static Bayesian game theory, constructed static Bayesian game model. The m...

With the development of the research in data mining, cluster analysis has been widely used in several areas. Aiming at the issue that traditional clustering methods are not appropriate to high-dimensional data, a cuckoo search fuzzy-weighting algorithm for subspace clustering is proposed on the basis of the existing soft subspace clustering algorit...

Author contributions: Wang J designed and constructed vari-ous expression vectors, performed localization and ribosome profiling, analyzed the data, prepared the figures and co-wrote the manuscript; Tsai S designed the project, performed cell culture experiments, analyzed the data, prepared the figures and co-wrote the manuscript. Abstract AIM: To...

The relationship between plasma homocysteine and behavioral and psychological symptoms of dementia (BPSD) has not been specifically investigated in previous research. In this study, we compared plasma homocysteine (Hcy) among 40 Alzheimer's disease (AD) patients with BPSD, 37 AD patients without BPSD, and 39 healthy controls. Our results evidenced...

The real-time, label-free biodetection of H1N1 viruses with single-molecule sensitivity by using Si nanowires as local reporters in combination with microfluidics is presented by M. Yao, L. Li, X. Guo et al. in their Communication on pp. 5038 ff.

Probing interactions of biological systems at the molecular level is of great importance to fundamental biology, diagnosis, and drug discovery. A rational bioassay design of lithographically integrating individual point scattering sites into electrical circuits is capable of realizing real-time, label-free biodetection of influenza H1N1 viruses wit...

Individual silicon nanowires (SiNWs) doped by in situ dopant incorporation during growth of the SiNWs was investigated. Electrical charge transport measurements were taken before and after removing the material from the boron-doped SiNW surfaces by wet chemical etching. AFM (atomic force microscopy) images showed the radial cross section of the sim...

Probing interactions of biological systems at the molecular level is of great importance to fundamental biology, diagnosis, and drug discovery. A rational bioassay design of lithographically integrating individual point scattering sites into electrical circuits is capable of realizing real‐time, label‐free biodetection of influenza H1N1 viruses wit...

The use of high-quality graphene as a local probe in combination with photoexcitation is described to establish a deep mechanistic understanding of charge generation/quenching processes underlying the graphene/environment interface. By combing a no-destructive bottom-up assembly technique with senstive graphene-based transistors, a bistable [2] rot...

To ensure the security of information systems, security risk have to be accurately evaluate first. Because security risk is influenced by attackers and defenders, it is necessary to consider the costs and benefits of both sides. However, the current evaluation methods mostly focus on one side. To solve the problem, in this paper we propose a securi...

Ultrasonic electrodeposition was used to prepare nanocermet Ni-TiN composite layers on steel substrates. The action of mechanical disturbance by ultrasonic waves on electrolyte mass transfer, the inhibition of nanoparticle aggregation by ultrasonic cavitation and the effect of electric pulse parameters on the nucleation and growth of grains were in...

A semiconductor/environment interface has been formed in which suspended silicon nanowires (SiNWs) are in direct contact with photoactive TiO(2) quantum dots. The photoactivity of TiO(2) competes with the intrinsic photoresponses of p-type silicon nanowires. Rational control of the competitive mechanism realizes remarkable mirror-imaging photo-swit...

Influenza epidemics worldwide result in substantial economic and human costs annually. However, rapid and reliable flu diagnosis methods are significantly lacking. Here we have demonstrated the selective detection of influenza A viruses down to 29 viruses/μL in clinical exhaled breath condensate (EBC) samples (diluted by 100-fold) within minutes us...

The regulation of cell cycle rate is essential for the correct timing of proliferation and differentiation during development. Changes to cell cycle rate can have profound effects on the size, shape and cell types of a developing organ. We previously identified a zebrafish mutant ceylon (cey) that has a severe reduction in T cells and hematopoietic...

Numerous threats from biological aerosol exposures, such as those from H1N1 influenza, SARS, bird flu, and bioterrorism activities necessitate the development of a real-time bioaerosol sensing system, which however is a long-standing challenge in the field. Here, we developed a real-time monitoring system for airborne influenza H3N2 viruses by inte...

CPZ pretreatment inhibits the ethanol-induced apoptosis in thalamus of the rat brain. (A) The diagram shows the cross section of the brain tissue, and the region of the thalamus is pointed out. (B) TUNEL-labeled brain sections showing the region of thalamus. These brain sections were obtained from the following treatment groups: Saline (a, a'), Eth...

Schematic diagram showing how the TUNEL-positive cells in the rat brain were counted. (A) All transverse sections of the brain were cut at 2 mm posterior to the bregma. (B) The slides were marked up with grid lines to separate the section into many small squares. Total numbers of the TUNEL-labeled cells were counted under the microscope with a hand...

Examples of cleaved caspase-3 scoring according to staining intensity. (A) The expression of cleaved caspase-3 was scored as negative = SI0, weak = SI1, intermediate = SI2, or strong = SI3, correlating to absence of brown (that is, blue counterstain only), light brown, brown or dark brown staining, respectively. (TIF)

Chlorpromazine (CPZ), a commonly used antipsychotic drug, was found to play a neuroprotective role in various models of toxicity. However, whether CPZ has the potential to affect brain apoptosis in vivo is still unknown. The purpose of this study was to investigate the potential effect of CPZ on the apoptosis induced by exogenous stimuli. The ethan...

Grid resource management is a core component of the grid. This paper analyzes the characteristics of the grid, and designed a Hierarchical Resource Management Framework for data resource in grid(HRMF-G). For the characteristics of the grid and the existing shortage of hierarchical resource management, we improved, respectively, the resource managem...

The existing security defensive systems, which have limitations in many ways, can not adapt to the need of future network defense. In allusion to the problem, an intelligent security defensive software is designed. It has intelligent functions such as environment awareness, self-adaptation, dynamic reconstruction, and so on.

IBM defines autonomic computing as"an approach to build computing systems that are self-managed and operate with a minimum of human interference." This paper imports the idea of autonomic computing to design Intelligent security defensive software (ISDS), which can adapt to environment by changing policy automatically. The ISDS's framework and self...

A data stream is a massive unbounded sequence of data elements continuously generated at a rapid rate. Consequently, the knowledge embedded in a data stream is more likely to be changed as time goes by. Data items that appear frequently in data streams are called frequent data items, which often play a more important role than others in data stream...

EBV is a paradigm for human tumor viruses because, although it infects most people benignly, it also can cause a variety of cancers. Both in vivo and in vitro, EBV infects B lymphocytes in G0, induces them to become blasts, and can maintain their proliferation in cell culture or in vivo as tumors. How EBV succeeds in these contrasting cellular envi...

We developed a mammalian plasmid replicon with a formerly uncharacterized origin of DNA synthesis, 8xRep*. 8xRep* functions efficiently to support once-per-cell-cycle synthesis of plasmid DNA which initiates within Rep*. By characterizing Rep*'s requirements for acting as an origin, we have uncovered several striking properties it shares with DS, t...

In distributed data stream management system, data streams are processed by many computers cooperatively. When input data streams fluctuate tempestuously, overload of some nodes may influence the ability of data processing about system. To solve this practical problem, the properties of the system were analysed. A multi-layer overlay based load bal...

Objective: The possibility of PLDD (percutaneous laser disc decompression) and an ideal non-operative method which is long everlasting effect for PLDD was investigated. Methods: 159 patients of Cervical Disc Herniation with PLDD were studied. All the herniated discs were irradiated with 10­15J/S Nd:YAG laser quantum through optical-fiber under the...

Epstein-Barr virus (EBV), provides unique advantages to understand origins of replication in higher eukaryotes. EBV establishes itself efficiently in infected B lymphocytes, where it exists as a 165 kb, circular chromosome which is duplicated once per cell cycle (Adams [1987] J Virol 61:1743-1746). Five to twenty copies of the EBV chromosome are us...

Requirements for embedded systems are very stringent and sometimes conflicting. Overheads incurred by preemptions in embedded systems under RM (Rate Monotonic) scheduling algorithm degrade their real-time performance. Because only the indispensable resources are employed, side effects of the preemptions on performance are even more. This paper crea...

In this paper a design concept is proposed to accomplish a full function Web server on a strictly limited resource space. Through this embedded Web server user can access their equipments remotely. The equipment mentioned here could be home appliances and factory devices. This paper is focused on realization of the TCP/IP suite and user development...