Jin Zhang

Jin Zhang
The University of Western Ontario | UWO · Department of Chemical and Biochemical Engineering

Professor

About

63
Publications
10,131
Reads
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1,012
Citations
Introduction
Jin Zhang currently works at the Department of Chemical and Biochemical Engineering, The University of Western Ontario. Jin’s research interests lie in the interface between Nano-structures and biological systems. Her research group has been developing hetero-nanostructures with special chemical and physical properties. https://orcid.org/0000-0002-6875-8008

Publications

Publications (63)
Article
Full-text available
Fluorescence technique is one of the major solutions for achieving the continuous and noninvasive glucose sensor for diabetes. In this article, a highly sensitive nanostructured sensor is developed to detect extremely small amounts of aqueous glucose by applying fluorescence energy transfer (FRET). A one-pot method is applied to produce the dextran...
Article
Thrombin plays a key role in thrombosis and hemostasis. The abnormal level of thrombin in body fluids may lead to different diseases, such as rheumatoid arthritis, glomerulonephritis, etc. Detection of thrombin level in blood and/or urine is one of important methods for medical diagnosis. Here, a bioluminescent sensor is developed for non-invasivel...
Article
In this paper, a nanostructured biosensor is developed to detect glucose in tear by using fluorescence resonance energy transfer (FRET) quenching mechanism. The designed FRET pair, including the donor, CdSe/ZnS quantum dots (QDs), and the acceptor, dextran-binding malachite green (MG-dextran), was conjugated to concanavalin A (Con A), an enzyme wit...
Article
Full-text available
A suitable surface is vital for maintaining or even promoting cells’ function and communication. Recently, studies show that nanostructured coatings could have a potential in improving cell adhesion. However, it hardly minimizes the contamination by using traditional solution-coating technology. Matrix-assisted pulsed laser evaporation (MAPLE) tech...
Article
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Carbon-dots (CDs), the emerging fluorescent nanoparticles, show special multicolor properties, chemical stability, and biocompatibility, and are considered as the new and advanced imaging probe in replacement of molecular fluorophores and semiconductor quantum dots. However, the requirement of external high power light source limits the application...
Article
Full-text available
The early diagnosis of breast cancer highly relies on the detection of mutant DNA at low concentrations. Förster resonance energy transfer (FRET) quenching may offer a solution to quickly detect a small amount of single-strand DNA (ssDNA) through the combination of nanomaterials with special luminescence and unique structures of DNA double helix st...
Article
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Central nervous system (CNS) diseases are the leading causes of death and disabilities in the world. It is quite challenging to treat CNS diseases efficiently because of the blood–brain barrier (BBB). It is a physical barrier with tight junction proteins and high selectivity to limit the substance transportation between the blood and neural tissues...
Article
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Magnetoresistance (MR) is the variation of a material’s resistivity under the presence of external magnetic fields. Reading heads in hard disk drives (HDDs) are the most common applications of MR sensors. Since the discovery of giant magnetoresistance (GMR) in the 1980s and the application of GMR reading heads in the 1990s, the MR sensors lead to t...
Article
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Lactoferrin (LF) is one of the major functional proteins in maintaining human health due to its antioxidant, antibacterial, antiviral, and anti-inflammatory activities. Abnormal levels of LF in the human body are related to some serious diseases, such as inflammatory bowel disease, Alzheimer’s disease and dry eye disease. Recent studies indicate th...
Article
Trimethyl chitosan nanoparticles (TMC NPs), the positively charged chitosan derivative, have been used to deliver medicines to overcome the tissue barrier. Here, fluorescein-labeled TMC NPs were produced by a microemulsion method following the bioconjugation of the single-strand DNA aptamer which can specifically bind to E. coli (DH5α). TMC NPs sho...
Article
Carbon dots (CDs) with tunable photoluminescence in a large range (80 nm) are produced by a microwave-assisted polyol method. The emission of CDs in aqueous can be adjusted by simply changing the precursors’ concentrations. The CDs with tunable photoluminescence have been further functionalized to develop a homogeneous glucose biosensor by incorpor...
Article
Full-text available
Abstract Very few materials show large magnetoresistance (MR) under a low magnetic field at room temperature, which causes the barrier to the development of magnetic field sensors for detecting low-level electromagnetic radiation in real- time. Here, a hybrid reduced graphene oxide (rGO)-based magnetic field sensor is produced by in situ deposition...
Article
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Quick detection of DNA sequence is vital for many fields, especially, early-stage diagnosis. Here, we develop a graphene oxide-based fluorescence quenching sensor to quickly and accurately detect small amounts of a single strand of DNA. In this paper, fluorescent magnetic nanoparticles (FMNPs) modified with target DNA sequence (DNA-t) were bound on...
Article
Upconversion nanoparticles with special fluorescence and magnetic properties have been considered an alternative contrast agent for multiple bio‐imaging techniques. It is important to understand the effects of the surface properties and dosage of upconversion nanoparticles on both the magnetic resonance (MRI) image and the photoluminescence spectru...
Article
Full-text available
Bioluminescence resonance energy transfer (BRET) techniques offer a high degree of sensitivity, reliability and ease of use for their application to sensing biomolecules. BRET is a distance dependent, non-radiative energy transfer, which uses a bioluminescent protein to excite an acceptor through the resonance energy transfer. A BRET sensor can qui...
Article
Matrix-assisted pulsed laser evaporation (MAPLE) process demonstrates a versatile and contamination free deposition. Compared to conventional laser ablation deposition, MAPLE technique can realize the retention of the properties and structures of deposited biomaterials and hybrid nanocomposites without damaging the backbone of organic macromolecule...
Article
Full-text available
Glucose sensing in diabetes diagnosis and therapy is of great importance due to the prevalence of diabetes in the world. Furthermore, glucose sensing is also critical in the food and drug industries. Sensing glucose has been accomplished through various strategies, such as electrochemical or optical methods. Novel transducers made with nanomaterial...
Article
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Conventional instruments for cancer diagnosis including magnetic resonance imaging, computed tomography scan, are expensive and require long-waiting time, whilst the outcomes have not approached to the successful early-stage diagnosis yet. Due to the special properties of graphene-based nanocomposites, e.g., good electrical and thermal conductivity...
Article
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Background Most methods for monitoring glucose level require an external energy source which may limit their application, particularly in vivo test. Bioluminescence technique offers an alternative way to provide emission light without external energy source by using bioluminescent proteins found from firefly or marine vertebrates and invertebrates....
Article
Full-text available
A one-pot process is developed to produce NaGdF4:Yb³⁺, Er3+ upconversion nanocubes (UCNCs) with amine surface modifications. The photoluminescence and magnetic properties of the amine modified unpconversion nanocubes (UCNCs) were investigated. The emissions of green light at 540 nm and red light at 660 nm are observed under infrared excitation (λex...
Article
Background: Alzheimer disease (AD) typically affects behavior, memory and thinking. The change in brain have been reported to begin approx. 10-20 years before the appearance of actual symptoms and diagnosis of AD. An early stage diagnosis and treatment of this lethal disease is the prime challenge, which is mainly halted by the lack of validated b...
Article
To prevent contact lens from biofouling and to minimize UV exposure to human eyes, a nanocomposite-based coating made of silver (Ag) nanoparticles and polyvinylpyrrolidone (PVP) is deposited on synthetic silicone hydrogels through matrix assisted pulsed laser evaporation (MAPLE) with a pulsed Nd:YAG laser at 532 nm. The average diameter of Ag NPs t...
Article
Theranostic applications of gelatin nanospheres require two major components, a method of detection and good biocompatibility. We characterized the response of UTA-6 human osteosarcoma cells to the introduction of functionalized 90 bloom-based gelatin nanospheres (158 ± 49 nm) modified with three elements in different order: (a) hybridization with...
Article
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Heteronanostructured zinc oxide nanorod (ZnO NR) array are vertically grown on polydimethylsiloxane (PDMS) through a hydrothermal method followed by an in situ deposition of silver nanoparticles (Ag NPs) through a photoreduction process. The Ag-ZnO heterostructured nanorods on PDMS are measured with an average diameter of 160 nm and an average leng...
Article
Zinc oxide (ZnO) nanoparticles incorporating with polyethylene glycol (PEG) were deposited together on the surface of silicone hydrogel through matrix-assisted pulsed laser evaporation (MAPLE). In this process, frozen nanocomposites (ZnO–PEG) in isopropanol were irradiated under a pulsed Nd:YAG laser at 532 nm for 1 h. Our results indicate that the...
Article
With increasing miniaturization, it is extremely important to maintain the magnetization stability at small scale. Herein, more efforts and interests focus on the interface of magnetic core and semiconductor shell to obtain desired magnetic and/or luminescent properties. Here, Fe3O4 nanocubes are synthesized via a thermal decomposition followed by...
Article
Surface and interface modifications of synthetic silicone hydrogels used for wearable and implantable medical devices, e.g. catheter, contact lenses, are critical to overcome their poor mechanical properties and biofouling. In this paper, silica nanoparticles (SiO2 NPs) were incorporated within silicone hydrogels through photo-polymerization. As co...
Article
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Surface functionalization of NPs is considered a prerequisite for their biomedical applications. In general, an ideal surface of NPs should provide good water stability and chemical functionality for further functionalization and maintain the NPs' unique physical and chemical properties. Through the approaches discussed here, ligand exchange involv...
Article
Zinc oxide (ZnO) nanoparticles incorporating within polyethylene glycol (PEG) were deposited on the surface of silicone hydrogel through matrix-assisted pulsed laser evaporation (MAPLE). In this process, frozen sample was irradiated under a pulsed Nd: YAG 532nm laser for one hour. The MAPLE process is able to maintain the chemical backbone of polym...
Conference Paper
Due to the special structures of cell membrane, good internalization is one of major concerns on using large nanospheres as carriers for labeling and treatment of cancer. We herein report fluorescent gelatin nanosphers (GNs) coated with CdSe/ZnS quantum dots (QDs) to form a viable vehicle for theranostic applications. Anti-human immunoglobulin G Fa...
Article
Full-text available
Hetero-nanostructures made of NiCo and ZnO nanostructures have been deposited on a polymer substrate through a two-step method. First ZnO nanorod (NR) array was grown on polydimethylsiloxane (PDMS) substrate by a hydrothermal method. NiCo granular nanostructures were then deposited on ZnO nanorod array through the electroless polyol process with pr...
Conference Paper
NiCo nanoparticles was uniformly doped on ZnO nanorod arrays by electroless polyol method. The effect of the deposition time (t) on the structure and magnetic properties has been investigated. The Ni-rich nanocomposition is detected when t <30 min. The atomic ratio of Ni to Co is approaching to 1:1 when t increases to 60 min. In addition, NiCo-dope...
Article
In this study, biocompatible and proton-resistant CdSe quantum dots (QDs) assembled on gelatin nanospheres (GNs) have been synthesized by combining the two-step desolvation method with the layer-by-layer assembly technique. The core-shell fluorescent gelatin nanosphere consists of a gelatin core and a four-layer shell of hydrophilic CdSe QDs assemb...
Article
Quantum dots (QDs) have been encapsulated within gelatin nanoparticles (GNPs), which gives GNPs fluorescent properties and improves the biocompatibility of QDs. Hydrophilic CdSe QDs were produced through thermodecomposition following the ligand-exchange method, and were then encapsulated in GNPs. The results of high-resolution transmission electron...
Article
To improve the efficiency of topical ocular drug administration, we developed a nanocomposite contact lens to deliver hydrophilic protein drugs over a prolonged period of time. Here, an in situ route was used to encapsulate the hydrophilic protein drug bovine serum albumin (BSA) within gelatin nanoparticles (NPs), 180 ± 20 nm in diameter, which wer...
Article
Tissue-type plasminogen activator (t-PA) has shown significant effects on the treatment of common thrombosis. In this work, molecular dynamics simulations are used in protein–ligand interaction analysis to investigate the affinity of ligands for affinity chromatography. A hydrogel matrix grafted with amine (positively charged), carboxyl (negatively...
Article
Fluorescent magnetic nanoparticles (FMNPs) with a core–shell structure are synthesized through a one-pot chemical method followed by the bioconjugation of gentamycin (Gm). The average diameter of the FMNPs is estimated to be 65 ± 8 nm. The results of transmission electron microscopy (TEM), X-ray absorption near edge structure spectroscopy (XANES),...
Article
Full-text available
Iron oxide nanoparticles with superparamagnetic properties (SIONPs) have demonstrated the great capability to separate heavy metals from contaminated aqueous system, e.g., river, ground water, etc. To date, thermal decomposition methods are commonly used to synthesize highly crystalline monodisperse SIONPs with various shapes (e.g., spherical and c...
Article
A novel method for the incorporation of highly dispersed single-walled carbon nanotubes (SWNTs) into a chi-tosan matrix is reported. This was achieved through the use of a precursor SWNT dispersion in a biocompatible surfactant solution containing cetyl trimethylammonium bromide (CTAB) and polyvinylpyrrolidone (PVP). Once a desirable degree of disp...
Article
Full-text available
Although many regenerative cell therapies are being developed to replace or regenerate ischaemic muscle, the lack of vasculature and poor persistence of the therapeutic cells represent major limiting factors to successful tissue restoration. In response to ischaemia, stromal cell-derived factor-1 (SDF-1) is up-regulated by the affected tissue to st...
Article
In this paper, the polyol process, a catalyst free, non-aqueous, and electroless process, is developed to deposit the nanostructured NixCo100−x magnetic films on aluminum nitride (AlN) substrate. Nickel (II) acetate tetrahydrate and cobalt (II) acetate tetrahydrate were reduced by ethylene glycol (EG) at 180°C, and the reduced Ni and Co nanostructu...
Article
A new method to produce elaborate nanostructure with magnetic and fluorescent properties in one entity is reported in this article. Magnetite (Fe3O4) coated with fluorescent silica (SiO2) shell was produced through the one-pot reaction, in which one reactor was utilized to realize the synthesis of superparamagnetic core of Fe3O4, the formation of S...
Article
This research project aims at the development of new biopolymer nanocomposites which enable to act as a critical component to next generation medical device. In this paper, we developed an in situ method to encapsulate model protein, bovine serum albumin (BSA), within gelatin nanoparticles (NPs). The results demonstrate that the average diameter of...
Article
This article reviews the development of a noninvasive diagnostic for diabetes by detecting ocular glucose. Early diagnosis and daily management are very important to diabetes patients to ensure a healthy life. Commercial blood glucose sensors have been used since the 1970s. Millions of diabetes patients have to prick their finger for a drop of bloo...
Article
Full-text available
Herpes simplex virus (HSV) infection is the most common cause of corneal blindness in the Western world. Despite effective anti-viral drugs such as acyclovir (ACV), disease recurrence due to the virus establishing latency within the corneal nerves and possibly cells makes treatment very challenging. Furthermore, although effective, current systemic...
Article
Full-text available
Herpes simplex virus (HSV) infection is the most common cause of corneal blindness in the Western world. Despite effective anti-viral drugs such as acyclovir (ACV), disease recurrence due to the virus establishing latency within the corneal nerves and possibly cells makes treatment very challenging. Furthermore, although effective, current systemic...
Article
Full-text available
Basic fibroblast growth factor (bFGF), a protein, plays a key role in wound healing and blood vessel regeneration. However, bFGF is easily degraded in biologic systems. Mesoporous silica nanoparticles (MSNs) with well-tailored porous structure have been used for hosting guest molecules for drug delivery. Here, we report an in situ route to load bFG...
Article
Basic fibroblast growth factor (bFGF), a protein, plays a key role in wound healing and blood vessel regeneration. However, most negative effects in vivo, or in vitro result from the over dosage of bFGF. Furthermore, it needs to keep the bFGF from protein denaturant. Thus, this study aims to develop a new delivery system based on silica nanoparticl...
Article
A simple, convenient, and general method for the synthesis of metal and metal alloy nanoparticles is presented. Irradiation of metal powders in suspension in either aqueous or organic solutions by unfocused 532 nm laser radiation produces nanoparticles with a homogeneous composition proportional to the composition of the starting metal powder mixtu...
Article
The effect of vesicle membrane structure and charge on the synthesis of gold nanoparticles was investigated. The vesicle membranes were comprised of either negatively charged soy lipids or mixtures of charge neutral and negatively charged soy lipids. Palladium ions bound to the membranes served as the catalyst for metal particle synthesis using an...
Article
The anodic oxidation of ascorbic acid (VC) and its lipophilic derivatives ascorbyl-6-caprylate (VC-8),‡ 6-laurate (VC-12) and 6-palmitate (VC-16) have been studied by cyclic voltammetry at a glassy carbon electrode in the presence of cetyltrimethylammonium bromide (CTAB) and sodium dodecyl sulfate (SDS) micelles. The peak potentials (Epa) and peak...
Article
We develop the polyol process, a catalyst free, non-aqueous, electroless process, to deposit the nanostructured NiCo magnetic films on aluminum nitride (AlN) substrate. The results indicate that NiCo films deposited on insulating AlN substrate can be achieved by polyol process and the properties of the films could exhibit interesting properties.. S...

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