Jin-Woo Kim

Jin-Woo Kim
University of Arkansas | U of A · Biological Engineering, Biomedical Engineering, and Nanoscience & Engineering

PhD

About

145
Publications
11,312
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3,470
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Publications

Publications (145)
Article
Many life-threatening diseases are disseminated through biological fluids, such as blood, lymph and cerebrospinal fluid. The migration of tumor cells through the vascular circulation is a mandatory step in metastasis, which is responsible for ~90% of cancer-associated mortality. Circulating pathogenic bacteria, viruses, or blood clots lead to other...
Article
Full-text available
The spread of cancer cells between organs, a process known as metastasis, is the cause of most cancer deaths1, 2. Detecting circulating tumour cells—a common marker for the development of metastasis3, 4—is difficult because ex vivo methods are not sensitive enough owing to limited blood sample volume and in vivo diagnosis is time-consuming as large...
Article
One step at a time: DNA linkers were placed at defined locations and in defined 3D orientations on a colloidal nanoparticle. Because the implemented ligand-replacement strategy was carried out sequentially, DNA linkers maximally segregated, producing a nanoparticle with linkers at 90 or 180° angles (see picture). These building blocks should enable...
Article
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Cellulose nanocrystals (CNCs) are renewable, biodegradable and biocompatible nanomaterials that exhibit unique mechanical, optical, rheological and barrier properties useful for a variety of applications. Since CNCs remain an expensive product, coupling its production to pulp and paper products could reduce the production costs. However, pulp and p...
Article
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Gold Nanoparticles (GNPs) have shown promising capabilities for use in many in-vivo applications such as gene and drug delivery, photothermal ablation of tumors, and tracking in many imaging modalities. Yet GNPs have thus far had limited use in cardiovascular medicine. Polyethylene glycol functionalized (PEGylated) GNPs have been extensively studie...
Article
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Exosomes are natural cell-derived nanovesicles of endocytic origin that enable cellular crosstalk by transferring encapsulated molecular cargos across biological barriers, thereby holding significantly complex implications in the etiology and progression of diverse disease states. Consequently, the development of exosomes-based nano-theranostic str...
Article
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Carbon nanotubes (CNTs) have attracted significant interest for various applications owing to their superior physicochemical properties. The unzipping of multi-walled carbon nanotubes was accomplished by strong acid treatment. The solution of unzipped carbon nanotubes (u-CNTs) was homogeneous and stable. The u-CNTs were characterized by Fourier tra...
Article
The field of photodynamic therapy (PDT) has continued to show promise as a potential method for treating tumors. In this work, a photosensitizer (PS) has been delivered to cancer cell lines for PDT by incorporation into the metal-organic framework (MOF) as an organic linker. By functionalizing the surface of MOF nanoparticles with maltotriose, the...
Article
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Abstract This study aims to optimize strong acid hydrolysis-based production of cellulose nanocrystals (CNCs) and cellulose nanofibers (CNFs) from pre-extracted and fully bleached kraft pulp of loblolly pinewood, the most abundant and commercially significant softwood species in southeastern United States. The effect of four parameters, including a...
Chapter
Nanoscale science and engineering in recent history has had significant impact on human society. This discipline has established novel technologies capable of modifying and enhancing clinical, industrial, and scientific methodologies, as well as imparting a new understanding to the research and scientific community on how nanoscale interactions aff...
Article
Metal–organic frameworks (MOFs) are a well‐suited platform for drug delivery systems that can affect photodynamic therapy (PDT). A well‐designed PDT delivery system to treat cancer can overcome some problems of current PDT such as prolonged photosensitivity and tumor specificity. Triple negative breast cancer (TNBC) is difficult to treat with exist...
Article
Full-text available
Production of nanocellulosic materials from loblolly pine (Pinus taeda) kraft pulp provides an opportunity to diversify the portfolio of traditional pulp and paper industries. In this study, pinewood was first subjected to dilute acid pre-extraction with 0.5% sulfuric acid in order to fractionate the hemicellulose, followed by kraft pulping and ele...
Chapter
This chapter outlines the main stem cell lines and nanomaterials utilized in tissue engineering for regenerative medicine, with a distinct focus on the cardiovascular system, which is our research area of interest.
Article
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Terahertz near-field microscopy (THz-NFM) could locally probe low-energy molecular vibration dynamics below diffraction limits, showing promise to decipher intermolecular interactions of biomolecules and quantum matters with unique THz vibrational fingerprints. However, its realization has been impeded by low spatial and spectral resolutions and la...
Article
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An efficient and rapid method has been established for micron cellulose (1, 20 microns) oxidation utilizing Oxone® (KHSO5) in combination with 2,2,6,6‐tetramethylpiperidinyl‐1‐oxyl (TEMPO) and NaOCl in aqueous NaHCO3 solution (pH 7.5 to 8.5) under microwave irradiation. This method affords two different forms of nano TEMPO‐cellulose,, i.e., a water...
Article
Full-text available
Cellulose nanocrystals (CNCs) have emerged as promising materials for the fabrication of micro/nanoplatforms that can replace tissues more effectively. CNCs offer interesting properties that facilitate the enhancement of polymer properties. Cytotoxicity of rice husk-derived CNCs was evaluated through WST-1 assay in the presence of human mesenchymal...
Article
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Nitrophenols (NPs) and related derivatives are industrially important chemicals, used notably to synthesize pharmaceuticals, insecticides, herbicides, and pesticides. However, NPs and their metabolites are highly toxic and mutagenic. They pose a serious threat to human health and ecosystem. Current work was undertaken to develop a suitable visible-...
Article
Full-text available
Pinewood is an abundant source of lignocellulosic biomass that has potential to be used as renewable feedstock in biorefineries for conversion into advanced biofuels and other value-added chemicals. However, its structural recalcitrance, due to the compact packing of its major components, viz. cellulose, hemicellulose and lignin, high lignin conten...
Article
Physical and chemical cues, which have emerged as a promising strategy for regulating cellular behaviors, provide important signaling cues to living cells. Neurons are also exposed to distinguishing physical and chemical environments that can greatly influence their behaviors and functions. In this study, we proposed the laminin-coated matrix nanot...
Article
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While previous studies have shown that white-rot fungal pretreatment reduces the severity of chemical pretreatments and improves enzymatic saccharification yields, very few have investigated the synergistic effects of fungal pretreatment combined with organosolv pretreatment on lignin recovery and quality. In this study, loblolly pine chips were in...
Article
Full-text available
Recent advancements in 3D printing technology have provided a potential low-cost and time-saving alternative to conventional PDMS (polydimethylsiloxane)-based microfabrication for microfluidic systems. In addition to reducing the complexity of the fabrication procedure by eliminating such intermediate steps as molding and bonding, 3D printing also...
Chapter
While the introduction of stem cell-based therapies has significantly widened the horizons of regenerative medicine, notable problems still persist in harvesting the relevant stem cells from the body, introducing them into an optimal microenvironment, and ensuring sustainable differentiation into appropriate and functional tissue once inside the bo...
Article
Programmable biomolecules, such as DNA strands, deoxyribozymes, and restriction enzymes, have been used to solve computational problems, construct large-scale logic circuits, and program simple molecular games. Although studies have shown the potential of molecular computing, the capability of computational learning with DNA molecules, i.e., molecu...
Article
Living cells receive biochemical and physical information from the surrounding microenvironment and respond to this information. Multiscale hierarchical substrates with micro- and nanogrooves have been shown to mimic the native extracellular matrix (ECM) better than conventional nanopatterned substrates; therefore, substrates with hierarchical topo...
Article
This special section of the IEEE Transactions on Nanobioscience comprises 11 papers that are extended versions of accepted papers and abstracts from the 9th International Conference on Nano/Molecular Medicine and Engineering (IEEE-NANOMED 2015), which was held in November 15–18, 2015, at Waikiki Beach, HI, USA. Originally launched in 2006, IEEE-NAN...
Article
Human alveolar bone-derived mesenchymal stem cells (hABMSCs) are promising candidates for bone therapies, which have the capacity to differentiate into osteoblasts. Recently, secretion of inducible cytokines and growth factors from mesenchymal stem cells (MSCs) has been discovered, and we also have reported the osteogenic effects of cell physical s...
Article
In the study of Soo Young Kim, Pill-Hoon Choung, and Jong Hoon Chung, and co-workers, the combinational use of reduced graphene oxide and pulsed electromagnetic fields is reported to enhance multidifferentiation of human stem cells, e.g., osteogenesis, neurogenesis and adipogenesis on page 2069. In particular, these days electromagnetic-field-based...
Conference Paper
Near-infrared (NIR) responsive nanoparticles (NPs) like gold nanorods (GNRs) are important in biomedical fields because of their transparency for biological tissues. Although GNRs are sought after as contrast agents for theranostics in cancer studies, capping ligands like cetyl trimethyl ammonium bromide (CTAB) used for the GNR synthesis are toxic...
Article
Electromagnetic fields (EMFs) can modulate cell proliferation, DNA replication, wound healing, cytokine expression, and the differentiation of mesenchymal stem cells (MSCs). Graphene, a 2D crystal of sp(2) -hybridized carbon atoms, has entered the spotlight in cell and tissue engineering research. However, a combination of graphene and EMFs has nev...
Patent
Full-text available
A method of producing a nanoparticle assembly. The method includes attaching a first DNA molecule to a bead to form a first DNA-bead complex; and combining a nanoparticle with the first DNA-bead complex to form a nanoparticle-DNA-bead complex having one DNA molecule attached to the nanoparticle.
Article
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Cancer nanomedicines are opening new paradigms in cancer management and recent research points to how they can vastly improve imaging and therapy through multimodality and multifunctionality. However, challenges to achieving optimal efficacy are manifold starting from processing materials and evaluating their intended effectiveness on biological ti...
Article
The papers in this special section were presented at the 8th International Conference on Nano/Molecular Medicine and Engineering (IEEE-NANOMED 2014).
Article
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Background: Cellulose is a ubiquitous, renewable and environmentally friendly biopolymer, which has high promise to fulfil the rising demand for sustainable and biocompatible materials. Particularly, the recent progress in the synthesis of highly crystalline cellulose-based nanoscale biomaterials, namely cellulose nanocrystals (CNCs), draws signifi...
Article
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Molecular motors, which are precision engineered by nature, offer exciting possibilities for bio-hybrid engineered systems. They could enable real applications ranging from micro/nano fluidics, to biosensing, to medical diagnoses. This review describes the fundamental biological insights and fascinating potentials of these remarkable sensing and ac...
Article
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Genetic material extracted from in situ microbial communities has high promise as an indicator of biological system status. However, the challenge is to access genomic information from all organisms at the population or community scale to monitor the biosystem's state. Hence, there is a need for a better diagnostic tool that provides a holistic vie...
Article
Calcium phosphate cements are highly promising for craniofacial and orthopedic repairs owing to rapidsetting and bone replacement capabilities. However, uses for tissue engineering are limited by poor strength. The objectives of this study were to develop fast-hardening composite cements composed of natural ceramics originated from horse bones and...
Article
Full-text available
Purpose: The aim of this research was to develop and evaluate natural hydroxyapatite (HA) ceramics produced from the heat treatment of pig bones. Methods: The properties of natural HA ceramics produced from pig bones were assessed in two parts. Firstly, the raw materials were characterized. A temperature of 1,200^{\circ}C was chosen as the calcinat...
Article
Full-text available
Carbon nanotubes (CNTs) have recently been in the limelight for their potential role in disease diagnostics and therapeutics, as well as in tissue engineering. Before these medical applications can be realized, there is a need to address issues like opsonization, phagocytosis by macrophages, and sequestration to the liver and spleen for eventual el...
Article
Single-walled carbon nanotubes (SWNTs) have shown promise as in vivo contrast nanoagents for medical theranostics, in particular photoacoustic and photothermal imaging and therapy, as well as targeted drug delivery systems. However, SWNTs have not proved able to evade biological obstacles, such as opsonization and phagocytosis by macrophage and non...
Article
Single-walled carbon nanotube (SWNT) can be functionalized to target cells for drug delivery or cancer cells for their detection and therapy. Understanding their transport phenomena in vivo is a necessary step to unlock their medical potential. This work estimates the diffusion characteristics of SWNTs and their DNA-conjugated bio-hybrids under sim...
Article
Full-text available
Nanotechnology has been extensively explored for drug delivery. Here, we introduce the concept of a nanodrug based on synergy of photothermally-activated physical and biological effects in nanoparticle-drug conjugates. To prove this concept, we utilized tumor necrosis factor-alpha coated gold nanospheres (Au-TNF) heated by laser pulses. To enhance...
Article
Full-text available
Microarray is one of the most powerful detection systems with multiplexing and high throughput capability. It has significant potential as a versatile biosensing platform for environmental monitoring, pathogen detection, medical therapeutics, and drug screening to name a few. To date, however, microarray applications are still limited to preliminar...
Article
Full-text available
Bacterial infections are a primary cause of morbidity and mortality worldwide. Bacteremia is a particular concern owing to the possibility of septic shock and the development of metastatic infections. Treatment of bacteremia is increasingly compromised by the emergence of antibiotic resistant strains, creating an urgent need for alternative therapy...
Data
Transmission electron microscopy (TEM) images of silica-coated iron oxide magnetic nanoparticles (siMNP). Scale bars, 100 nm (panels, a and b) and 10 nm (panels, c–g). Silica coating efficiency was ∼100%. The majority of siMNPs contained either one MNP core (panels, e–g) or two or more MNP cores (MNP clusters) (panels, c and d). The thickness of si...
Data
Optical images of S. aureus with and without NPs. Images were obtained at the specified magnification with no NPs (control) or after incubations with nonconjugated NPs. Incubation was performed for 30 min at 37°C using 105 bacteria and 108 each nanoparticles. (TIF)
Data
Average cluster sizes of NPs around individual bacteria or small aggregates of bacteria. (TIF)
Data
Schematics of PA and PT flow cytometer/microscope. (TIF)
Data
Typical levels of laser energy fluence producing detectable PT signals from S. aureus cells labeled with non-conjugated NPs (GNTs, GNRs, GNSs, and MNPs) and dye (ICG). (TIF)
Data
(a) Experimental schematics for laser-based detection of bacteria in blood ex vivo. Typical photothermal (PT) (top) and photoacoustic (PA) (bottom) signals from blood alone (b) and from labeled individual bacteria in blood (c). (TIF)
Data
Optical (a) and fluorescent images (b,c) of individual S. aureus cells labeled with conventional dyes without antibodies: FITC (b, green) and PE (c, red). The labeling was used to identify bacteria in animal tissues and blood. (TIF)
Data
Histology of infected blood. Approximately 1000 bacteria were injected into the rat tail vein. Blood was drawn and subjected to PT mapping (a) and histological evaluation (b). Comparison of PT and histological data were used to estimate a sensitivity threshold of 0.5 CFU/mL. The images on top and bottom were obtained from the same blood sample with...
Data
Principle and animal model for in vivo PA detection, molecular targeting, and PT purging of infected blood with an extracorporeal schematic. Catheters are placed in a large artery or vein (e.g., jugular) to create a bypass. The siMNPs, conjugated with Ab against staphylococcal protein A (Spa), were injected into a tube. The distance between the inj...
Data
Absorption spectra of nanoparticles (NPs). CNT, carbon nanotubes; GNS, gold nanoshells; GNT, golden carbon nanotubes; GNR, gold nanorods; MNP, magnetic nanoparticles; and ICG, Indocyanin Green dye. (TIF)
Data
In vivo eradication of S. aureus priory labeled in vitro with real-time monitoring of therapeutic efficacy. (TIF)
Data
Light microscopy and atomic force microscopy (AFM) images of golden carbon nanotubes (GNTs) alone and on the surface of S. aureus cells. (a) Epi-fluorescence and light microscopy images after incubation with fluorescein-labeled anti-Spa Ab conjugated with GNTs. Inset is the magnified light microscopy image of the dash-box region in the fluorescence...