Jie Wang

• PhD
• Professor (Associate) at Soochow University

Microbial communication monitoring is vital for understanding the mechanisms beneath gut microbiota equilibrium, infections, and biomanufacturing. Herein, we reported monitoring bacterial communication by surface-confined persistent luminescence. Specifically, we constructed core-shell structured Zn1.4Ga1.2Ge0.4O4@Zn1.4Ga1.2Ge0.4O4:Cr (ZGGO@ZGGO:Cr...

Lanthanides are widely co-doped in persistent luminescence phosphors to elevate defect concentration and enhance luminescence efficiency. However, the deleterious cross-relaxation between activators and lanthanides inevitably quench persistent luminescence, particularly in heavily doped phosphors. Herein, we reported a core-shell engineering strate...

In optical biosensing, analyte-independent factors such as autofluorescence interference and excitation source fluctuation decrease the sensitivity and accuracy. Herein, we reported a bimodal persistent luminescence strategy to design dual-emissive persistent luminescence nanoparticles (PLNPs) with built-in self-calibration to preclude interference...

Persistent luminescence nanoparticles (PLNPs) have shown special advantages in areas such as bioimaging, cancer therapy, stress sensing, and photo-biocatalysis. However, the lack of methods for controllable synthesis of PLNPs with uniform morphologies and strong persistent luminescence has seriously hindered the applications of PLNPs. Herein, we re...

Phototherapy, including photodynamic therapy (PDT) and photothermal therapy (PTT), is a non-invasive and effective approach used for cancer treatment, in which phototherapeutic agents are irradiated with an appropriate light source to produce cytotoxic reactive oxygen species (ROS) or heat to ablate cancer cells. Unfortunately, traditional photothe...

Sustained phototheranostics refers to the continuous diagnostic or therapeutic activity initiated by a single dosage of light stimulation. For instance, many optical agents stimulated by light irradiation can produce long-lived luminescence and continuously release reactive oxygen species (ROS) to realize sustained imaging-guided photodynamic thera...

Persistent luminescence phosphors (PLPs) are largely used in biomedical areas owing to their unique advantages in reducing the autofluorescence and light-scattering interference from tissues. Moreover, PLPs with long-lived luminescence in the near-infrared (NIR) region are able to be applied in deep-tissue bioimaging or therapy due to the reduced l...

Direct observation of nanoparticles with high spatial resolution at the subcellular levels is of great importance to understand the nanotoxicology and promote the biomedical applications of nanoparticles. Super-resolution fluorescence microscopy can break the diffraction resolution limit to achieve spatial resolution of tens of nanometers, making i...

Mesoporous materials are ideal carriers for guest molecules and they have been widely used in analytical science. The unique mesoporous structure provides special properties including large specific surface area, tunable pore size, and excellent pore connectivity. The structural properties of mesoporous materials have been largely made use of to im...

Bioactive metal ions play important roles in both physiological and pathological processes. Developing biosensing probes for bioactive metal ions detection can contribute to fields including disease diagnosis/therapy and studying the mechanisms of bio-logical activities. In this work, we designed a dual-aptamers-conjugated molecular modulator that...

Phosphor materials have been rapidly developed in the past decades. Developing phosphors with desired properties including strong luminescence intensity and long lifetime has attracted widespread attention. Herein, we show that hetero-valence ion doping can serve as a potent strategy to manipulate luminescence in persistent phosphors by controlling...

Latent fingerprints (LFPs) are highly specific to individuals, and LFP imaging has played an important role in areas such as forensic investigation and law enforcement. Presently, LFP imaging still faces considerable problems, including background interference and destructive and complex operations. Herein, we have designed a background-free, nonde...

Re-engineering cellular components and biological processes has received great interest and promised compelling advantages in applications ranging from basic cell biology to biomedicine. With the advent of DNA nanotechnology, the programmable self-assembly ability makes DNA an appealing candidate for rational design of artificial components with di...

Developing portable and sensitive devices for point of care (POC) detection of low abundance bioactive molecules is highly valuable in early diagnosis of disease. Herein, an ultrasensitive photonic crystal-assisted rolling circle amplification (PC-RCA) biochip was constructed and further applied to serum circulating microRNAs (miRNAs) detection. Th...

The “coffee ring effect” is a natural phenomenon where sessile drops leave ring-shaped structures on solid surfaces upon drying. It drives non-uniform deposition of suspended compounds on substrates, which adversely affects many processes, including surface-assisted biosensing and molecular self-assembly. In this study, we describe how the coffee r...

Owing to their unique pattern and abundant chemical composition, latent fingerprints (LFPs) can serve as “ID cards” and “information banks” of donors and therefore are valuable for forensic investigation, access control, and even medical diagnosis. LFP imaging has attracted considerable attention, and a great variety of contrast agents has been dev...

Here, we report the direct hydrothermal synthesis of 1D-based Zn2GeO4:Mn²⁺ persistent luminescent nanobelts (ZGO:Mn PLNBs). The ZGO:Mn PLNBs exhibit rapid growth rate, and nanobelts can be obtained after 30 min of hydrothermal treatment. The persistent luminescence performance can be fine-turned upon prolonging the hydrothermal time. Furthermore, t...

Extracellular vesicles (EVs) are involved in the regulation of cell physiological activity and the reconstruction of extracellular environment. Matrix vesicles (MVs) are a type of EVs, and they participate in the regulation of cell mineralization. Herein, bioinspired MVs embedded with black phosphorus are functionalized with cell-specific aptamer (...

Long admired as the repository of genetic information, DNA has more recently been exploited as a powerful material for self-assembly. Taking advantage of the specificity and programmability of Watson-Crick base-pairing principle, DNA is able to form diversiform nanostructures and nanomaterials. More importantly, the assembled DNA nanomaterials can...

Persistent nanophosphors can remain luminescent after excitation ceases, thus they offer a promising way to avoid background fluorescence interference in bioimaging. In this work, Zn2GeO4:Ga,Mn (ZGO:Ga,Mn) persistent luminescence nanoparticles were developed and they were employed for time-gated imaging of latent fingerprints (LFP). The nanoparticl...

Development of a cell-free scaffold with excellent mechanical properties and osteoconductivity is a significant need for bone regeneration. Herein, a reduced graphene oxide (rGO) functionalized hierarchical macro-mesoporous bioactive glass scaffold integrated with osteoblast-specific aptamer is rationally designed to recruit and induce rapid differ...

The simultaneous quantitation of multiple steroid hormones in real-time is of great importance for medical diagnosis. In this study, a portable hormone biosensor based on duplex molecular recognition coupled with a signal-amplified substrate was successfully developed for the simultaneous visualization and quantitation of multiple steroid hormones....

Information security has attracted broad attention in today’s information age, and information encryption on paper has been widely studied since paper is still the most important information carrier. Fluorescent inks are commonly used in information encryption on paper, but they suffer from background fluorescence interference. Herein, we develop a...

Persistent luminescence nanoparticles (PLNPs) are an emerging group of promising luminescent materials that can remain luminescent after the ceases of excitation. In the past decade, PLNPs with intriguing optical properties have been developed and their applications in biomedicine have been widely studied. Due to the ultra-long decay time of persis...

To solve the challenge of poor knee repair, an aptamer-bilayer scaffold is designed for autologous mesenchymal stem cell (MSC) recruitment and osteochondral regeneration. The scaffold can efficiently recruit MSCs to the defect and induce the directional differentiation of MSCs, thus successfully achieving simultaneous regeneration of cartilage and...

Adsorbents are widely employed in both fundamental and applied research areas such as separation technology, biotechnology, and environmental science. Selectivity and reusability are two most important requirements for adsorbents. Aptamers exhibit perfect selectivity and easy regeneration, which make them uniquely effective adsorption materials. He...

Development of a portable device for the detection of multiple mRNAs is a significant need in the early diagnosis of cancer. We have designed a biochip-based mRNA detection device by combining a hydrophilic-hydrophobic micropattern with upconversion luminescence (UCL) probes. The device achieves highly sensitive detection, using the naked eye, of m...

Sepsis and bacteremia are life-threatening clinical syndrome and are associated with significant patient morbidity and mortality. The rapid and sensitive detection of pathogenic bacteria is the key to improve patient survival rates. Herein, we have rationally constructed a simple aptamer-based diagnostic platform to shorten the time needed for conf...

For adsorbents used in water remediation, the long-standing contradictions between selectivity and multiple adsorbability, and affinity and recyclability, have led to difficulties in applications towards environmental crises. In article number 1500289, Q. Yuan and co-workers create a versatile scavenger that cleverly avoids such contradictions by i...

For the water remediation techniques based on adsorption, the long‐standing contradictories between selectivity and multiple adsorbability, as well as between affinity and recyclability, have put it on weak defense amid more and more severe environment crisis. Here, a pollutant‐targeting hydrogel scavenger is reported for water remediation with bot...

Supplementary

The electrochemical applications of traditional carbon nanomaterials such as carbon nanotubes (CNTs) and graphene (G) powders are significantly impeded by their poor three-dimensional (3D) conductivity and lack of hierarchical porous structure. Here, we have constructed a 3D highly conductive CNTs networks and further combined it with mesoporous ca...

Core-satellite is one of the most powerful super structures since it leads to enhanced or completely new properties through compatibly combination of each component. Here we create a novel ceria-based core-shell-satellite supersandwich structure with near-infrared (NIR) light manipulated catalytic activity by integrating the upconversion luminescen...

Regulation of protein activity is vital for understanding the molecular mechanism of biological activities. In this work, protein activity is suppressed by proximity-dependent surface hybridization and subsequently restored by near-infrared (NIR) light stimulation. Specifically, by constructing closed-loop structures with two aptamer-based affinity...

The development of a portable and easy-to-use device for the detection of explosives with high sensitivity and selectivity is in high demand for homeland security and public safety. In this study, we demonstrate miniaturized devices depending on the upconversion ratiometric luminescent probe for point-of-care (POC) assay of explosives with the nake...

Photoluminescence is one of the most sensitive techniques for fingerprint detection, but it also suffers from background fluorescence and selectivity at the expense of generality. The method described herein integrates the advantages of near-infrared-light-mediated imaging and molecular recognition. In principle, upconversion nanoparticles (UCNPs)...

Near-infrared-light-mediated imaging and molecular recognition have been combined for the detection of latent fingerprints. Q. Yuan et al. describe in their Communication on page 1616 ff. how this general technique does not suffer from background fluorescence interference and simultaneously meets the selectivity and generality criteria for the dete...

Target practice: A novel photodynamic therapy system has been constructed by taking advantage of the specific molecular recognition of an aptamer, loading capability of a G-quadruplex, and upconversion of nanoparticles using near-infrared (NIR) light. This system selectively delivers a photosensitizer to targeted cells and upon irradiation with NIR...

A smart drug delivery system with cancer cell targeting and bioresponsive controlled drug release has been constructed by taking advantage of a protein-capped mesoporous nanovalve and a DNA aptamer.